TGF-β induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways

Kidney International

Volumn 66, Issue 2, 2004, Pages 605-613

  Nakagawa, Takahiko ^a   Li, Jin H ^b   Garcia, Gabriela ^b   Mu, Wei ^b   Piek, Ester ^b   Böttinger, Erwin P ^b   Chen, Yan ^b   Zhu, Hong J ^b   Kang, Duk Hee ^b   Schreiner, George F ^b   Lan, Hui Y ^b   Johnson, Richard J ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b NONE

Author keywords

Endothelial cell proliferation; sFlt 1; Smad KO cell; TSP 1; VEGF

Indexed keywords

SMAD PROTEIN; SMAD7 PROTEIN; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; FIBROBLAST; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; WILD TYPE;

EID: 3242757526     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2004.00780.x     Document Type: Article

References (48)

1. KANG DH, ANDERSON S, KIM YG, et al: Impaired angiogenesis in the aging kidney: Vascular endothelial growth factor and thrombospondin-1 in renal disease. Am J Kidney Dis 37:601-611, 2001
2. KANG DH, JOLY AH, OH SW, et al: Impaired angiogenesis in the remnant kidney model: I. Potential role of vascular endothelial growth factor and thrombospondin-1. J Am Soc Nephrol 12:1434-1447, 2001
3. MARTIN A, KOMADA MR, SANE DC: Abnormal angiogenesis in diabetes mellitus. Med Res Rev 23:117-145, 2003
4. STREIT M, DETMAR M: Angiogenesis, lymphangiogenesis, and melanoma metastasis. Oncogene 22:3172-3179, 2003
5. BAUMGARTNER I, ISNER JM: Stimulation of peripheral angiogenesis by vascular endothelial growth factor (VEGF). VASA 27:201-206, 1998
6. KANG DH, HUGHES J, MAZZALI M, et al: Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function. J Am Soc Nephrol 12:1448-1457, 2001
7. KANG DH, KANELLIS J, HUGO C, et al: Role of the microvascular endothelium in progressive renal disease. J Am Soc Nephrol 13:806-816, 2002
8. RODRIGUEZ-MANZANEQUE JC, LANE TF, ORTEGA MA, et al: Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci USA 98:12485-12490, 2001
9. INOKI I, SHIOMI T, HASHIMOTO G, et al: Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J 16:219-221, 2002
10. HUGO C, KANG DH, JOHNSON RJ: Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney model. Nephron 90:460-470, 2002
11. HUGO C, SHANKLAND SJ, PICHLER RH, et al: Thrombospondin 1 precedes and predicts the development of tubulointerstitial fibrosis in glomerular disease in the rat. Kidney Int 53:302-311, 1998
12. YAMAGUCHI S, IWATA K, SHIBUYA M: Soluble Flt-1 (soluble VEGFR-1), a potent natural antiangiogenic molecule in mammals, is phylogenetically conserved in avians. Biochem Biophys Res Commun 291:554-559, 2002
13. GRAUBERT MD, ORTEGA MA, KESSEL B, et al: Vascular repair after menstruation involves regulation of vascular endothelial growth factor-receptor phosphorylation by sFLT-1. Am J Pathol 158:1399-1410, 2001
14. MAYNARD SE, MIN JY, MERCHAN J, et al: Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111:649-658, 2003
15. BELGORE FM, LIP GY, BAREFORD D, et al: Plasma levels of vascular endothelial growth factor (VEGF) and its receptor, Flt-1, in haematological cancers: A comparison with breast cancer. Am J Hematol 66:59-61, 2001
16. GOLDFARB S, ZIYADEH FN: TGF-beta: A crucial component of the pathogenesis of diabetic nephropathy. Trans Am Clin Climatol Assoc 112:27-32, 2001
17. CHEN S, HONG SW, IGLESIAS-DE LA CRUZ MC, et al: The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy. Ren Fail 23:471-481, 2001
18. GAGLIANO N, AROSIO B, SANTAMBROGIO D, et al: Age-dependent expression of fibrosis-related genes and collagen deposition in rat kidney cortex. J Gerontol A Biol Sci Med Sci 55:B365-B372, 2000
19. CRUZ CI, RUIZ-TORRES P, DEL MORAL RG, et al: Age-related progressive renal fibrosis in rats and its prevention with ACE inhibitors and taurine. Am J Physiol Renal Physiol 278:F122-F129, 2000
20. RUIZ-TORRES MP, BOSCH RJ, O'VALLE F, et al: Age-related increase in expression of TGF-beta1 in the rat kidney: Relationship to morphologic changes. J Am Soc Nephrol 9:782-791, 1998
21. HENNESSY A, ORANGE S, WILLIS N, et al: Transforming growth factor-beta 1 does not relate to hypertension in preeclampsia. Clin Exp Pharmacol Physiol 29:968-971, 2002
22. SHAARAWY M, EL MELEIGY M, RASHEED K: Maternal serum transforming growth factor beta-2 in preeclampsia and eclampsia, a potential biomarker for the assessment of disease severity and fetal outcome. J Soc Gynecol Investig 8:27-31, 2001
23. HAYASHIDA T, DECAESTECKER M, SCHNAPER HW: Cross-talk between ERK MAP kinase and Smad-signaling pathways enhances TGF-beta dependent responses in human mesangial cells. FASEB J 17:1576-1578, 2003
24. PIEK E, JU WJ, HEYER J, et al: Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem 276:19945-19953, 2001
25. LI JH, ZHU HJ, HUANG XR, et al: Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol 13:1464-1472, 2002
26. ZHU HJ, IARIA J, SIZELAND AM: Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways. J Biol Chem 274:32258-32264, 1999
27. KANG DH, NAKAGAWA T, FENG L, et al: Nitric oxide modulates vascular disease in the remnant kidney model. Am J Pathol 161:239-248, 2002
28. BURCHARDT M, BURCHARDT T, CHEN MW, et al: Expression of messenger ribonucleic acid splice variants for vascular endothelial growth factor in the penis of adult rats and humans. Biol Reprod 60:398-404, 1999
29. HUGO C, PICHLER R, MEEK R, et al: Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo. Kidney Int 48:1846-1856, 1995
30. KANELLIS J, WATANABE S, LI JH, et al: Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension 41:1287-1293, 2003
31. YAMAMOTO T, KOZAWA O, TANABE K, et al: Involvement of p38 MAP kinase in TGF-beta-stimulated VEGF synthesis in aortic smooth muscle cells. J Cell Biochem 82:591-598, 2001
32. PEPPER MS: Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev 8:21-43, 1997
33. ROBERTS AB, SPORN MB, ASSOIAN RK, et al: Transforming growth factor type beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 83:4167-4171, 1986
34. VAN ROYEN N, HOEFER I, BUSCHMANN I, et al: Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation. FASEB J 16:432-434, 2002
35. YANG EY, MOSES HL: Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane. J Cell Biol 111:731-741, 1990
36. CHEUNG WH, LEE KM, FUNG KP, et al: TGF-beta1 is the factor secreted by proliferative chondrocytes to inhibit neo-angiogenesis. J Cell Biochem (Suppl) 36:79-88, 2001
37. PARSONS-WINGERTER P, ELLIOTT KE, FARR AG, et al: Generational analysis reveals that TGF-beta1 inhibits the rate of angiogenesis in vivo by selective decrease in the number of new vessels. Microvasc Res 59:221-232, 2000
38. BOTTINGER EP, BITZER M: TGF-beta signaling in renal disease. J Am Soc Nephrol 13:2600-2610, 2002
39. SCHNAPER HW, HAYASHIDA T, HUBCHAK SC, et al: TGF-beta signal transduction and mesangial cell fibrogenesis. Am J Physiol Renal Physiol 284:F243-F252, 2003
40. SANCHEZ-ELSNER T, BOTELLA LM, VELASCO B, et al: Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J Biol Chem 276:38527-38535, 2001
41. MATTOT V, MOONS L, LUPU F, et al: Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice. J Am Soc Nephrol 13:1548-1560, 2002
42. KANG DH, KIM YG, ANDOH TF, et al: Post-cyclosporine-mediated hypertension and nephropathy: Amelioration by vascular endothelial growth factor. Am J Physiol Renal Physiol 280:F727-F736, 2001
43. MANDRIOTA SJ, MENOUD PA, PEPPER MS: Transforming growth factor beta 1 down-regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells. J Biol Chem 271:11500-11505, 1996
44. WALTENBERGER J, MAYR U, PENTZ S, et al: Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia. Circulation 94:1647-1654, 1996
45. GERBER HP, CONDORELLI F, PARK J, et al: Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes, Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem 272:23659-23667, 1997
46. NOMURA M, LI E: Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature 393:786-790, 1998
47. ASHCROFT GS, YANG X, GLICK AB, et al: Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1:260-266, 1999
48. SCHWARTE-WALDHOFF I, VOLPERT OV, BOUCK NP, et al: Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis. Proc Natl Acad Sci USA 97:9624-9629, 2000