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Volumn 29, Issue 1, 2009, Pages 172-186

Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor β signaling

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; GENE PRODUCT; LAMIN A; LAMIN B; NEUROSERPIN; PROTEIN ETS1; PROTEIN TFAP2A; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; ETS1 PROTEIN, HUMAN; PROTEIN C JUN; SMAD2 PROTEIN, HUMAN; SMAD3 PROTEIN, HUMAN; TFAP2A PROTEIN, HUMAN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR ETS 1;

EID: 58149468095     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01038-08     Document Type: Article
Times cited : (173)

References (57)
  • 1
    • 0035070927 scopus 로고    scopus 로고
    • Targets of transcriptional regulation by transforming growth factor beta: Expression profile analysis using oligonucleotide arrays
    • Akiyoshi, S., M. Ishii, N. Nemoto, M. Kawabata, H. Aburatani, and K. Miyazono. 2001. Targets of transcriptional regulation by transforming growth factor beta: expression profile analysis using oligonucleotide arrays. Jpn. J. Cancer Res. 92:257-268.
    • (2001) Jpn. J. Cancer Res , vol.92 , pp. 257-268
    • Akiyoshi, S.1    Ishii, M.2    Nemoto, N.3    Kawabata, M.4    Aburatani, H.5    Miyazono, K.6
  • 4
    • 0037067653 scopus 로고    scopus 로고
    • E2F4/5 and p107 as Smad cofactors linking the TGF-β receptor to c-myc repression
    • Chen, C. R., Y. Kang, P. M. Siegel, and J. Massague. 2002. E2F4/5 and p107 as Smad cofactors linking the TGF-β receptor to c-myc repression. Cell 110:19-32.
    • (2002) Cell , vol.110 , pp. 19-32
    • Chen, C.R.1    Kang, Y.2    Siegel, P.M.3    Massague, J.4
  • 5
    • 0031008431 scopus 로고    scopus 로고
    • Regulation of K3 keratin gene transcription by Sp1 and AP-2 in differentiating rabbit corneal epithelial cells
    • Chen, T. T., R. L. Wu, F. Castro-Munozledo, and T. T. Sun. 1997. Regulation of K3 keratin gene transcription by Sp1 and AP-2 in differentiating rabbit corneal epithelial cells. Mol. Cell. Biol. 17:3056-3064.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 3056-3064
    • Chen, T.T.1    Wu, R.L.2    Castro-Munozledo, F.3    Sun, T.T.4
  • 6
    • 3042752956 scopus 로고    scopus 로고
    • Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: A role in NIS expression regulation?
    • Chiefari, E., A. Brunetti, F. Arturi, J. M. Bidart, D. Russo, M. Schlumberger, and S. Filetti. 2002. Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation? BMC Cancer 2:35.
    • (2002) BMC Cancer , vol.2 , pp. 35
    • Chiefari, E.1    Brunetti, A.2    Arturi, F.3    Bidart, J.M.4    Russo, D.5    Schlumberger, M.6    Filetti, S.7
  • 7
    • 0038274163 scopus 로고    scopus 로고
    • Links between tumor suppressors: P53 is required for TGF-β gene responses by cooperating with Smads
    • Cordenonsi, M., S. Dupont, S. Maretto, A. Insinga, C. Imbriano, and S. Piccolo. 2003. Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads. Cell 113:301-314.
    • (2003) Cell , vol.113 , pp. 301-314
    • Cordenonsi, M.1    Dupont, S.2    Maretto, S.3    Insinga, A.4    Imbriano, C.5    Piccolo, S.6
  • 9
    • 0037036387 scopus 로고    scopus 로고
    • Ets1 is an effector of the transforming growth factor β (TGF-β) signaling pathway and an antagonist of the profibrotic effects of TGF-β
    • Czuwara-Ladykowska, J., V. I. Sementchenko, D. K. Watson, and M. Tro-janowska. 2002. Ets1 is an effector of the transforming growth factor β (TGF-β) signaling pathway and an antagonist of the profibrotic effects of TGF-β. J. Biol. Chem. 277:20399-20408.
    • (2002) J. Biol. Chem , vol.277 , pp. 20399-20408
    • Czuwara-Ladykowska, J.1    Sementchenko, V.I.2    Watson, D.K.3    Tro-janowska, M.4
  • 10
    • 0028829465 scopus 로고
    • Functional analysis of the transforming growth factor β responsive elements in the WAF1/Cip1/p21 promoter
    • Datto, M. B., Y. Yu, and X. F. Wang. 1995. Functional analysis of the transforming growth factor β responsive elements in the WAF1/Cip1/p21 promoter. J. Biol. Chem. 270:28623-28628.
    • (1995) J. Biol. Chem , vol.270 , pp. 28623-28628
    • Datto, M.B.1    Yu, Y.2    Wang, X.F.3
  • 11
    • 0034612231 scopus 로고    scopus 로고
    • Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter
    • Denissova, N. G., C. Pouponnot, J. Long, D. He, and F. Liu. 2000. Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter. Proc. Natl. Acad. Sci. USA 97:6397-6402.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6397-6402
    • Denissova, N.G.1    Pouponnot, C.2    Long, J.3    He, D.4    Liu, F.5
  • 13
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • Dennler, S., S. Itoh, D. Vivien, P. ten Dijke, S. Huet, and J.-M. Gauthier. 1998. Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17:3091-3100.
    • (1998) EMBO J , vol.17 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    ten Dijke, P.4    Huet, S.5    Gauthier, J.-M.6
  • 14
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-indepen-dent pathways in TGF-β family signalling
    • Derynck, R., and Y. E. Zhang. 2003. Smad-dependent and Smad-indepen-dent pathways in TGF-β family signalling. Nature 425:577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 15
    • 2942529276 scopus 로고    scopus 로고
    • The biology of the Ets1 proto-oncogene
    • Dittmer, J. 2003. The biology of the Ets1 proto-oncogene. Mol. Cancer 2:29.
    • (2003) Mol. Cancer , vol.2 , pp. 29
    • Dittmer, J.1
  • 17
    • 35448997708 scopus 로고    scopus 로고
    • Transforming growth factor-β promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1
    • Ehata, S., A. Hanyu, M. Hayashi, H. Aburatani, Y. Kato, M. Fujime, M. Saitoh, K. Miyazawa, T. Imamura, and K. Miyazono. 2007. Transforming growth factor-β promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1. Cancer Res. 67:9694-9703.
    • (2007) Cancer Res , vol.67 , pp. 9694-9703
    • Ehata, S.1    Hanyu, A.2    Hayashi, M.3    Aburatani, H.4    Kato, Y.5    Fujime, M.6    Saitoh, M.7    Miyazawa, K.8    Imamura, T.9    Miyazono, K.10
  • 18
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-β signaling through Smads
    • Feng, X. H., and R. Derynck. 2005. Specificity and versatility in TGF-β signaling through Smads. Annu. Rev. Cell Dev. Biol. 21:659-693.
    • (2005) Annu. Rev. Cell Dev. Biol , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 19
    • 1542314236 scopus 로고    scopus 로고
    • Transforming growth factor 3 -mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element
    • Frederick, J. P., N. T. Liberati, D. S. Waddell, Y. Shi, and X. F. Wang. 2004. Transforming growth factor 3 -mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol. Cell. Biol. 24:2546-2559.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 2546-2559
    • Frederick, J.P.1    Liberati, N.T.2    Waddell, D.S.3    Shi, Y.4    Wang, X.F.5
  • 23
    • 33747836850 scopus 로고    scopus 로고
    • CEAS: Cis-regulatory element annotation system
    • Ji, X., W. Li, J. Song, L. Wei, and X. S. Liu. 2006. CEAS: cis-regulatory element annotation system. Nucleic Acids Res. 34:W551-W554.
    • (2006) Nucleic Acids Res , vol.34
    • Ji, X.1    Li, W.2    Song, J.3    Wei, L.4    Liu, X.S.5
  • 26
    • 0032516862 scopus 로고    scopus 로고
    • Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin, and bone morphogenetic protein-inducible enhancer
    • Jonk, L. J., S. Itoh, C. H. Heldin, P. ten Dijke, and W. Kruijer. 1998. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin, and bone morphogenetic protein-inducible enhancer. J. Biol. Chem. 273:21145-21152.
    • (1998) J. Biol. Chem , vol.273 , pp. 21145-21152
    • Jonk, L.J.1    Itoh, S.2    Heldin, C.H.3    ten Dijke, P.4    Kruijer, W.5
  • 27
    • 33846010529 scopus 로고    scopus 로고
    • An integrated map of p53-binding sites and histone modification in the human ENCODE regions
    • Kaneshiro, K., S. Tsutsumi, S. Tsuji, K. Shirahige, and H. Aburatani. 2007. An integrated map of p53-binding sites and histone modification in the human ENCODE regions. Genomics 89:178-188.
    • (2007) Genomics , vol.89 , pp. 178-188
    • Kaneshiro, K.1    Tsutsumi, S.2    Tsuji, S.3    Shirahige, K.4    Aburatani, H.5
  • 28
    • 0038369998 scopus 로고    scopus 로고
    • A self-enabling TGF-β response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    • Kang, Y., C. R. Chen, and J. Massague. 2003. A self-enabling TGF-β response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell 11:915-926.
    • (2003) Mol. Cell , vol.11 , pp. 915-926
    • Kang, Y.1    Chen, C.R.2    Massague, J.3
  • 29
    • 0026334362 scopus 로고
    • Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor β
    • Keeton, M. R., S. A. Curriden, A. J. van Zonneveld, and D. J. Loskutoff. 1991. Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor β . J. Biol. Chem. 266:23048-23052.
    • (1991) J. Biol. Chem , vol.266 , pp. 23048-23052
    • Keeton, M.R.1    Curriden, S.A.2    van Zonneveld, A.J.3    Loskutoff, D.J.4
  • 30
    • 0030872367 scopus 로고    scopus 로고
    • Dro-sophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
    • Kim, J., K. Johnson, H. J. Chen, S. Carroll, and A. Laughon. 1997. Dro-sophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388:304-308.
    • (1997) Nature , vol.388 , pp. 304-308
    • Kim, J.1    Johnson, K.2    Chen, H.J.3    Carroll, S.4    Laughon, A.5
  • 33
    • 0032110463 scopus 로고    scopus 로고
    • Smad2 and Smad3 positivelyand negatively regulateTGF-β-dependent tran-scription through the forkhead DNA-binding protein FAST2
    • Labbé, E., C. Silvestri, P. A. Hoodless, J. L. Wrana, and L. Attisano. 1998. Smad2 and Smad3 positivelyand negatively regulateTGF-β-dependent tran-scription through the forkhead DNA-binding protein FAST2. Mol. Cell 2:109-120.
    • (1998) Mol. Cell , vol.2 , pp. 109-120
    • Labbé, E.1    Silvestri, C.2    Hoodless, P.A.3    Wrana, J.L.4    Attisano, L.5
  • 34
    • 0026340586 scopus 로고
    • The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain
    • Lazzaro, D., M. Price, M. de Felice, and R. Di Lauro. 1991. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 113:1093-1104.
    • (1991) Development , vol.113 , pp. 1093-1104
    • Lazzaro, D.1    Price, M.2    de Felice, M.3    Di Lauro, R.4
  • 35
    • 24344483878 scopus 로고    scopus 로고
    • Smad4 dependency defines two classes of transforming growth factor β (TGF-β) target genes and distinguishes TGF-β -induced epithelial-mesenchymal transition from its antiproliferative and migratory responses
    • Levy, L., and C. S. Hill. 2005. Smad4 dependency defines two classes of transforming growth factor β (TGF-β) target genes and distinguishes TGF-β -induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol. Cell. Biol. 25:8108-8125.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 8108-8125
    • Levy, L.1    Hill, C.S.2
  • 36
    • 0030946933 scopus 로고    scopus 로고
    • E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth fac-tor β through E2F binding sites
    • Li, J. M., P. P. Hu, X. Shen, Y. Yu, and X. F. Wang. 1997. E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth fac-tor β through E2F binding sites. Proc. Natl. Acad. Sci. USA 94:4948-4953.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4948-4953
    • Li, J.M.1    Hu, P.P.2    Shen, X.3    Yu, Y.4    Wang, X.F.5
  • 37
    • 0035824687 scopus 로고    scopus 로고
    • Transforming growth factor β regulates parathyroid hormone-related protein expression in MDA-MB-231 breast cancer cells through a novel Smad/Ets synergism
    • Lindemann, R. K., P. Ballschmieter, A. Nordheim, and J. Dittmer. 2001.Transforming growth factor β regulates parathyroid hormone-related protein expression in MDA-MB-231 breast cancer cells through a novel Smad/Ets synergism. J. Biol. Chem. 276:46661-46670.
    • (2001) J. Biol. Chem , vol.276 , pp. 46661-46670
    • Lindemann, R.K.1    Ballschmieter, P.2    Nordheim, A.3    Dittmer, J.4
  • 38
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • Massagué, J., J. Seoane, and D. Wotton. 2005. Smad transcription factors. Genes Dev. 19:2783-2810.
    • (2005) Genes Dev , vol.19 , pp. 2783-2810
    • Massagué, J.1    Seoane, J.2    Wotton, D.3
  • 40
    • 33846869745 scopus 로고    scopus 로고
    • AP2 transcription factors regulate expression of CRABPII in hormone responsive breast carcinoma
    • McPherson, L. A., G. W. Woodfield, and R. J. Weigel. 2007. AP2 transcription factors regulate expression of CRABPII in hormone responsive breast carcinoma. J. Surg. Res. 138:71-78.
    • (2007) J. Surg. Res , vol.138 , pp. 71-78
    • McPherson, L.A.1    Woodfield, G.W.2    Weigel, R.J.3
  • 41
    • 0032499789 scopus 로고    scopus 로고
    • Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members
    • Moustakas, A., and D. Kardassis. 1998. Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc. Natl. Acad. Sci. USA 95:6733-6738.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6733-6738
    • Moustakas, A.1    Kardassis, D.2
  • 42
    • 0033584854 scopus 로고    scopus 로고
    • Regulation of Smad7 promoter by direct association with Smad3 and Smad4
    • Nagarajan, R. P., J. Zhang, W. Li, and Y. Chen. 1999. Regulation of Smad7 promoter by direct association with Smad3 and Smad4. J. Biol. Chem. 274: 33412-33418.
    • (1999) J. Biol. Chem , vol.274 , pp. 33412-33418
    • Nagarajan, R.P.1    Zhang, J.2    Li, W.3    Chen, Y.4
  • 43
    • 0034703083 scopus 로고    scopus 로고
    • Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-β
    • Pardali, K., A. Kurisaki, A. Moren, P. ten Dijke, D. Kardassis, and A. Moustakas. 2000. Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-β. J. Biol. Chem. 275:29244-29256.
    • (2000) J. Biol. Chem , vol.275 , pp. 29244-29256
    • Pardali, K.1    Kurisaki, A.2    Moren, A.3    ten Dijke, P.4    Kardassis, D.5    Moustakas, A.6
  • 44
    • 33749344476 scopus 로고    scopus 로고
    • Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription
    • Ross, S., E. Cheung, T. G. Petrakis, M. Howell, W. L. Kraus, and C. S. Hill. 2006. Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J. 25:4490-4502.
    • (2006) EMBO J , vol.25 , pp. 4490-4502
    • Ross, S.1    Cheung, E.2    Petrakis, T.G.3    Howell, M.4    Kraus, W.L.5    Hill, C.S.6
  • 45
    • 1642332084 scopus 로고    scopus 로고
    • Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • Seoane, J., H. V. Le, L. Shen, S. A. Anderson, and J. Massague. 2004. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117:211-223.
    • (2004) Cell , vol.117 , pp. 211-223
    • Seoane, J.1    Le, H.V.2    Shen, L.3    Anderson, S.A.4    Massague, J.5
  • 46
    • 34548496683 scopus 로고    scopus 로고
    • Differential regulation of epithelial and mesenchymal markers by δEF1 proteins in epithelial mes-enchymal transition induced by TGF-β
    • Shirakihara, T., M. Saitoh, and K. Miyazono. 2007. Differential regulation of epithelial and mesenchymal markers by δEF1 proteins in epithelial mes-enchymal transition induced by TGF-β. Mol. Biol. Cell 18:3533-3544.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 3533-3544
    • Shirakihara, T.1    Saitoh, M.2    Miyazono, K.3
  • 47
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
    • Siegel, P. M., and J. Massague. 2003. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nat. Rev. Cancer 3:807-821.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 50
    • 0032979988 scopus 로고    scopus 로고
    • Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β
    • Wong, C., E. M. Rougier-Chapman, J. P. Frederick, M. B. Datto, N. T. Liberati, J. M. Li, and X. F. Wang. 1999. Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β. Mol. Cell. Biol. 19:1821-1830.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 1821-1830
    • Wong, C.1    Rougier-Chapman, E.M.2    Frederick, J.P.3    Datto, M.B.4    Liberati, N.T.5    Li, J.M.6    Wang, X.F.7
  • 51
    • 38149019302 scopus 로고    scopus 로고
    • Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor β transcriptional program
    • Xi, Q., W. He, X. H. Zhang, H. V. Le, and J. Massague. 2008. Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor β transcriptional program. J. Biol. Chem. 283:1146-1155.
    • (2008) J. Biol. Chem , vol.283 , pp. 1146-1155
    • Xi, Q.1    He, W.2    Zhang, X.H.3    Le, H.V.4    Massague, J.5
  • 52
    • 0030697971 scopus 로고    scopus 로고
    • Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein
    • Yingling, J. M., M. B. Datto, C. Wong, J. P. Frederick, N. T. Liberati, and X. F. Wang. 1997. Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein. Mol. Cell. Biol. 17:7019-7028.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 7019-7028
    • Yingling, J.M.1    Datto, M.B.2    Wong, C.3    Frederick, J.P.4    Liberati, N.T.5    Wang, X.F.6
  • 55
    • 0031012251 scopus 로고    scopus 로고
    • AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression
    • Zeng, Y. X., K. Somasundaram, and W. S. el-Deiry. 1997. AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression. Nat. Genet. 15:78-82.
    • (1997) Nat. Genet , vol.15 , pp. 78-82
    • Zeng, Y.X.1    Somasundaram, K.2    el-Deiry, W.S.3
  • 57
    • 0032572723 scopus 로고    scopus 로고
    • Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
    • Zhang, Y., X. H. Feng, and R. Derynck. 1998. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature 394:909-913.
    • (1998) Nature , vol.394 , pp. 909-913
    • Zhang, Y.1    Feng, X.H.2    Derynck, R.3


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