Regulation of deoxynucleotide metabolism in cancer: Novel mechanisms and therapeutic implications

Molecular Cancer

Volumn 14, Issue 1, 2015, Pages

  Kohnken, Rebecca ^a   Kodigepalli, Karthik M ^a   Wu, Li ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Cancer; Cell proliferation; Intracellular dNTP; Regulation; SAMHD1

Indexed keywords

CYCLIN DEPENDENT KINASE; DEOXYRIBONUCLEOTIDE; FLUOROURACIL; FORODESINE; GEMCITABINE; HYDROXYUREA; MESSENGER RNA; METHOTREXATE; SAMHD1 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; SAMHD1 PROTEIN, HUMAN;

AICARDI GOUTIERES SYNDROME; APOPTOSIS; AUTOIMMUNE DISEASE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CANCER THERAPY; CARCINOGENESIS; CELL CYCLE ARREST; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA DAMAGE; DNA METHYLATION; DOWN REGULATION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; HYDROLYSIS; LYMPHOMA; MALIGNANT TRANSFORMATION; MOLECULARLY TARGETED THERAPY; MUTAGENESIS; NONHUMAN; NUCLEOTIDE METABOLISM; REVIEW; SOLID TUMOR; TUMOR GROWTH; VIRUS INFECTION; CELL PROLIFERATION; DNA REPLICATION; GENETICS; METABOLISM; MUTATION; NEOPLASM; PATHOLOGY;

CELL PROLIFERATION; DEOXYRIBONUCLEOTIDES; DNA REPLICATION; GENOMIC INSTABILITY; HUMANS; MONOMERIC GTP-BINDING PROTEINS; MUTATION; NEOPLASMS;

EID: 84942510717     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/s12943-015-0446-6     Document Type: Review

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