Downregulation of SAMHD1 expression correlates with promoter DNA methylation in Sézary syndrome patients

Journal of Investigative Dermatology

Volumn 134, Issue 2, 2014, Pages 562-565

  De Silva, Suresh ^a   Wang, Feifei ^a   Hake, Timothy S ^b   Porcu, Pierluigi ^b,c,d   Wong, Henry K ^a,b,c   Wu, Li ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c Department of Internal Medicine ^*  (United States)

^d Oncology and Bone Marrow Transplantation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEXAROTENE; CD4 ANTIGEN; CD8 ANTIGEN; DNA; INTERFERON; MESSENGER RNA; METHOTREXATE; PROTEIN; SAMHD 1 PROTEIN; UNCLASSIFIED DRUG;

CANCER CHEMOTHERAPY; CANCER CLASSIFICATION; CANCER PATIENT; CANCER STAGING; CASE REPORT; CD4 CD8 RATIO; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LETTER; MYCOSIS FUNGOIDES; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; SEZARY CELL; SEZARY SYNDROME;

DNA METHYLATION; DOWN-REGULATION; HUMANS; LEUKOCYTES; MONOMERIC GTP-BINDING PROTEINS; PROMOTER REGIONS, GENETIC; SEZARY SYNDROME;

EID: 84892783703     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.311     Document Type: Letter

References (15)

1. Baldauf HM, Pan X, Erikson E et al. (2012) SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells. Nat Med 18:1682-9
2. Baylin SB, Jones PA (2011) A decade of exploring the cancer epigenome-biological and translational implications. Nat Rev Cancer 11:726-34
3. De Silva S, Hoy H, Hake TS et al. (2013) Promoter methylation regulates SAMHD1 gene expression in human CD4+ T cells. J Biol Chem 288:9284-92
4. Descours B, Cribier A, Chable-Bessia C et al. (2012) SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells. Retrovirology 9:87
5. Goldstone DC, Ennis-Adeniran V, Hedden JJ et al. (2011) HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 480:379-82
6. Hrecka K, Hao C, Gierszewska M et al. (2011) Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 474:658-61
7. Imielinski M, Berger AH, Hammerman PS et al. (2012) Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 150:1107-20
8. Jones S, Zhang X, Parsons DW et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321:1801-6
9. Laguette N, Sobhian B, Casartelli N et al. (2011) SAMHD1 is the dendritic- and myeloid-cellspecific HIV-1 restriction factor counteracted by Vpx. Nature 474:654-7
10. Lahouassa H, Daddacha W, Hofmann H et al. (2012) SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol 13: 223-8
11. Parsons DW, Jones S, Zhang X et al. (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807-12
12. Parsons DW, Li M, Zhang X et al. (2011) The genetic landscape of the childhood cancer medulloblastoma. Science 331:435-9
13. Sjoblom T, Jones S, Wood LD et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314: 268-74
14. van Doorn R, Zoutman WH, Dijkman R et al. (2005) Epigenetic profiling of cutaneous T-cell lymphoma: Promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. J Clin Oncol 23:3886-96
15. Wong HK, Mishra A, Hake T et al. (2011) Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome). Br J Haematol 155:150-66