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Volumn 206, Issue , 2011, Pages 13-37

The biology of HDAC in cancer: The nuclear and epigenetic components

Author keywords

Epigenetic therapy; Hallmarks of cancer; Malignancies; Tumorigenesis

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; ROMIDEPSIN; SIRTUIN 1; TRICHOSTATIN A; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VORINOSTAT;

EID: 80054720150     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-21631-2_2     Document Type: Article
Times cited : (100)

References (139)
  • 1
    • 77952270503 scopus 로고    scopus 로고
    • Class i histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma
    • Adams H, Fritzsche FR, Dirnhofer S, Kristiansen G, Tzankov A (2010) Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Expert Opin Ther Targets 14(6):577-584
    • (2010) Expert Opin Ther Targets , vol.14 , Issue.6 , pp. 577-584
    • Adams, H.1    Fritzsche, F.R.2    Dirnhofer, S.3    Kristiansen, G.4    Tzankov, A.5
  • 2
    • 0034817075 scopus 로고    scopus 로고
    • ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain
    • DOI 10.1128/MCB.21.19.6470-6483.2001
    • Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW (2001) ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol 21(19):6470-6483 (Pubitemid 32927415)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.19 , pp. 6470-6483
    • Amann, J.M.1    Nip, J.2    Strom, D.K.3    Lutterbach, B.4    Harada, H.5    Lenny, N.6    Downing, J.R.7    Meyers, S.8    Hiebert, S.W.9
  • 3
    • 0036598992 scopus 로고    scopus 로고
    • Targeting death and decoy receptors of the tumour-necrosis factor superfamily
    • Ashkenazi A (2002) Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer 2(6):420-430 (Pubitemid 37328939)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.6 , pp. 420-430
    • Ashkenazi, A.1
  • 4
    • 33744522801 scopus 로고    scopus 로고
    • Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARα as a component of the N-CoR co-repressor complex to repress transcription in vivo
    • DOI 10.1016/j.bbrc.2006.05.047, PII S0006291X06010904
    • Atsumi A, Tomita A, Kiyoi H, Naoe T (2006) Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo. Biochem Biophys Res Commun 345(4):1471-1480 (Pubitemid 43817898)
    • (2006) Biochemical and Biophysical Research Communications , vol.345 , Issue.4 , pp. 1471-1480
    • Atsumi, A.1    Tomita, A.2    Kiyoi, H.3    Naoe, T.4
  • 6
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • DOI 10.1038/nrc1093
    • Bergers G, Benjamin LE (2003) Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3(6):401-410 (Pubitemid 37328844)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 7
    • 78649304686 scopus 로고    scopus 로고
    • Role of histone deacetylases and their inhibitors in cancer biology and treatment
    • Beumer JH, Tawbi H (2010) Role of histone deacetylases and their inhibitors in cancer biology and treatment. Curr Clin Pharmacol 5(3):196-208
    • (2010) Curr Clin Pharmacol , vol.5 , Issue.3 , pp. 196-208
    • Beumer, J.H.1    Tawbi, H.2
  • 8
    • 41549156540 scopus 로고    scopus 로고
    • Deletion of histone deacetylase 3 reveals critical roles in S phase progression and dna damage control
    • DOI 10.1016/j.molcel.2008.02.030, PII S1097276508002074
    • Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW (2008) Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell 30(1):61-72 (Pubitemid 351470157)
    • (2008) Molecular Cell , vol.30 , Issue.1 , pp. 61-72
    • Bhaskara, S.1    Chyla, B.J.2    Amann, J.M.3    Knutson, S.K.4    Cortez, D.5    Sun, Z.-W.6    Hiebert, S.W.7
  • 9
    • 40449132791 scopus 로고    scopus 로고
    • Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling
    • DOI 10.1158/0008-5472.CAN-07-2822
    • Bicaku E, Marchion DC, Schmitt ML, Munster PN (2008) Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res 68(5):1513-1519 (Pubitemid 351346860)
    • (2008) Cancer Research , vol.68 , Issue.5 , pp. 1513-1519
    • Bicaku, E.1    Marchion, D.C.2    Schmitt, M.L.3    Munster, P.N.4
  • 10
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re- expression of genes silenced in cancer
    • DOI 10.1038/5047
    • Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB (1999) Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21(1):103-107 (Pubitemid 29036293)
    • (1999) Nature Genetics , vol.21 , Issue.1 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 11
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • DOI 10.1038/nature04478, PII NATURE04478
    • Carmeliet P (2005) Angiogenesis in life, disease and medicine. Nature 438(7070):932-936 (Pubitemid 43093958)
    • (2005) Nature , vol.438 , Issue.7070 , pp. 932-936
    • Carmeliet, P.1
  • 13
    • 4544358659 scopus 로고    scopus 로고
    • Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development
    • DOI 10.1128/MCB.24.19.8467-8476.2004
    • Chang S, McKinsey TA, Zhang CL, Richardson JA, Hill JA, Olson EN (2004) Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol 24(19):8467-8476 (Pubitemid 39245069)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.19 , pp. 8467-8476
    • Chang, S.1    McKinsey, T.A.2    Zhang, C.L.3    Richardson, J.A.4    Hill, J.A.5    Olson, E.N.6
  • 14
    • 33746228132 scopus 로고    scopus 로고
    • Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10
    • DOI 10.1016/j.cell.2006.05.040, PII S0092867406008130
    • Chang S, Young BD, Li S, Qi X, Richardson JA, Olson EN (2006) Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell 126(2):321-334 (Pubitemid 44092958)
    • (2006) Cell , vol.126 , Issue.2 , pp. 321-334
    • Chang, S.1    Young, B.D.2    Li, S.3    Qi, X.4    Richardson, J.A.5    Olson, E.N.6
  • 15
  • 17
    • 27144453009 scopus 로고    scopus 로고
    • Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors
    • DOI 10.1002/jcb.20544
    • Cho HH, Park HT, Kim YJ, Bae YC, Suh KT, Jung JS (2005) Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors. J Cell Biochem 96(3):533-542 (Pubitemid 41504651)
    • (2005) Journal of Cellular Biochemistry , vol.96 , Issue.3 , pp. 533-542
    • Cho, H.H.1    Park, H.T.2    Kim, Y.J.3    Bae, Y.C.4    Suh, K.T.5    Jung, J.S.6
  • 18
    • 56649111200 scopus 로고    scopus 로고
    • HDAC inhibition upregulates the expression of angiostatic ADAMTS1
    • Chou CW, Chen CC (2008) HDAC inhibition upregulates the expression of angiostatic ADAMTS1. FEBS Lett 582(29):4059-4065
    • (2008) FEBS Lett , vol.582 , Issue.29 , pp. 4059-4065
    • Chou, C.W.1    Chen, C.C.2
  • 19
    • 0033079605 scopus 로고    scopus 로고
    • The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene
    • DOI 10.1016/S0968-0004(98)01343-7, PII S0968000498013437
    • Christofori G, Semb H (1999) The role of the cell-adhesion molecule E-cadherin as a tumoursuppressor gene. Trends Biochem Sci 24(2):73-76 (Pubitemid 29346577)
    • (1999) Trends in Biochemical Sciences , vol.24 , Issue.2 , pp. 73-76
    • Christofori, G.1    Semb, H.2
  • 21
    • 0033593036 scopus 로고    scopus 로고
    • Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: The case of HIC-1 and γFBP-B
    • DOI 10.1073/pnas.96.26.14831
    • Deltour S, Guerardel C, Leprince D (1999) Recruitment of SMRT/N-CoR-mSin3A-HDACrepressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. Proc Natl Acad Sci USA 96(26):14831-14836 (Pubitemid 30019725)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.26 , pp. 14831-14836
    • Deltour, S.1    Guerardel, C.2    Leprince, D.3
  • 22
    • 67349201377 scopus 로고    scopus 로고
    • Targeting tumor angiogenesis with histone deacetylase inhibitors
    • Ellis L, Hammers H, Pili R (2009) Targeting tumor angiogenesis with histone deacetylase inhibitors. Cancer Lett 280(2):145-153
    • (2009) Cancer Lett , vol.280 , Issue.2 , pp. 145-153
    • Ellis, L.1    Hammers, H.2    Pili, R.3
  • 24
    • 34548075217 scopus 로고    scopus 로고
    • Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-α levels and transcriptional activity: A result of hyperacetylation and inhibition of chaperone function of heat shock protein 90
    • DOI 10.1158/1078-0432.CCR-06-3093
    • Fiskus W, Ren Y, Mohapatra A, Bali P, Mandawat A, Rao R, Herger B, Yang Y, Atadja P, Wu J, Bhalla K (2007) Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90. Clin Cancer Res 13(16):4882-4890 (Pubitemid 47294796)
    • (2007) Clinical Cancer Research , vol.13 , Issue.16 , pp. 4882-4890
    • Fiskus, W.1    Ren, Y.2    Mohapatra, A.3    Bali, P.4    Mandawat, A.5    Rao, R.6    Herger, B.7    Yang, Y.8    Atadja, P.9    Wu, J.10    Bhalla, K.11
  • 25
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1(1):27-31
    • (1995) Nat Med , vol.1 , Issue.1 , pp. 27-31
    • Folkman, J.1
  • 26
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • DOI 10.1038/339058a0
    • Folkman J, Watson K, Ingber D, Hanahan D (1989) Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339(6219):58-61 (Pubitemid 19115892)
    • (1989) Nature , vol.339 , Issue.6219 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 27
    • 28544444366 scopus 로고    scopus 로고
    • Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
    • DOI 10.1158/0008-5472.CAN-05-1923
    • Ford J, Jiang M, Milner J (2005) Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res 65(22):10457-10463 (Pubitemid 41743740)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10457-10463
    • Ford, J.1    Jiang, M.2    Milner, J.3
  • 33
    • 67650572769 scopus 로고    scopus 로고
    • Epigenetic control of skull morphogenesis by histone deacetylase 8
    • Haberland M, Mokalled MH, Montgomery RL, Olson EN (2009b) Epigenetic control of skull morphogenesis by histone deacetylase 8. Genes Dev 23(14):1625-1630
    • (2009) Genes Dev , vol.23 , Issue.14 , pp. 1625-1630
    • Haberland, M.1    Mokalled, M.H.2    Montgomery, R.L.3    Olson, E.N.4
  • 34
    • 57749170458 scopus 로고    scopus 로고
    • The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
    • Haberland M, Montgomery RL, Olson EN (2009c) The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 10(1):32-42
    • (2009) Nat Rev Genet , vol.10 , Issue.1 , pp. 32-42
    • Haberland, M.1    Montgomery, R.L.2    Olson, E.N.3
  • 35
    • 1842631408 scopus 로고    scopus 로고
    • Upregulation and nuclear recruitment of HDACl in hormone refractory prostate cancer
    • DOI 10.1002/pros.20022
    • Halkidou K, Gaughan L, Cook S, Leung HY, Neal DE, Robson CN (2004) Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate 59(2):177-189 (Pubitemid 38481229)
    • (2004) Prostate , vol.59 , Issue.2 , pp. 177-189
    • Halkidou, K.1    Gaughan, L.2    Cook, S.3    Leung, H.Y.4    Neal, D.E.5    Robson, C.N.6
  • 36
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57-70 (Pubitemid 30046295)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 37
    • 77955616882 scopus 로고    scopus 로고
    • Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin
    • Hayashi A, Horiuchi A, Kikuchi N, Hayashi T, Fuseya C, Suzuki A, Konishi I, Shiozawa T (2010) Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin. Int J Cancer 127(6):1332-1346
    • (2010) Int J Cancer , vol.127 , Issue.6 , pp. 1332-1346
    • Hayashi, A.1    Horiuchi, A.2    Kikuchi, N.3    Hayashi, T.4    Fuseya, C.5    Suzuki, A.6    Konishi, I.7    Shiozawa, T.8
  • 39
    • 27744463434 scopus 로고    scopus 로고
    • Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance
    • Hirokawa Y, Arnold M, Nakajima H, Zalcberg J, Maruta H (2005) Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifenresistance. Cancer Biol Ther 4(9):956-960 (Pubitemid 41598590)
    • (2005) Cancer Biology and Therapy , vol.4 , Issue.9 , pp. 956-960
    • Hirokawa, Y.1    Arnold, M.2    Nakajima, H.3    Zalcberg, J.4    Maruta, H.5
  • 40
    • 33749572938 scopus 로고    scopus 로고
    • Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells
    • DOI 10.1158/1535-7163.MCT-05-0480
    • Hrzenjak A, Moinfar F, Kremser ML, Strohmeier B, Staber PB, Zatloukal K, Denk H (2006) Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells. Mol Cancer Ther 5(9):2203-2210 (Pubitemid 44530456)
    • (2006) Molecular Cancer Therapeutics , vol.5 , Issue.9 , pp. 2203-2210
    • Hrzenjak, A.1    Moinfar, F.2    Kremser, M.-L.3    Strohmeier, B.4    Staber, P.B.5    Zatloukal, K.6    Denk, H.7
  • 43
    • 33746144518 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
    • DOI 10.1158/0008-5472.CAN-05-4563
    • Inoue S, Mai A, Dyer MJ, Cohen GM (2006) Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosisinducing ligand-induced apoptosis. Cancer Res 66(13):6785-6792 (Pubitemid 44085638)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6785-6792
    • Inoue, S.1    Mai, A.2    Dyer, M.J.S.3    Cohen, G.M.4
  • 45
    • 4744368147 scopus 로고    scopus 로고
    • Histone deacetylase 7 associates with hypoxia-inducible factor 1α and increases transcriptional activity
    • DOI 10.1074/jbc.M406320200
    • Kato H, Tamamizu-Kato S, Shibasaki F (2004) Histone deacetylase 7 associates with hypoxiainducible factor 1alpha and increases transcriptional activity. J Biol Chem 279(40):41966-41974 (Pubitemid 39313647)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.40 , pp. 41966-41974
    • Kato, H.1    Tamamizu-Kato, S.2    Shibasaki, F.3
  • 46
    • 33751169387 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 (HIF-1)
    • Ke Q, Costa M (2006) Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 70(5):1469-1480.
    • (2006) Mol Pharmacol , vol.70 , Issue.5 , pp. 1469-1480
    • Ke, Q.1    Costa, M.2
  • 47
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • DOI 10.1038/nrc905
    • Kerbel R, Folkman J (2002) Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2(10):727-739 (Pubitemid 37328908)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.10 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 48
    • 34547753111 scopus 로고    scopus 로고
    • Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide
    • DOI 10.1093/jnci/djm044
    • Keshelava N, Davicioni E, Wan Z, Ji L, Sposto R, Triche TJ, Reynolds CP (2007) Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide. J Natl Cancer Inst 99(14):1107-1119 (Pubitemid 47241395)
    • (2007) Journal of the National Cancer Institute , vol.99 , Issue.14 , pp. 1107-1119
    • Keshelava, N.1    Davicioni, E.2    Wan, Z.3    Ji, L.4    Sposto, R.5    Triche, T.J.6    Reynolds, C.P.7
  • 49
    • 34548226848 scopus 로고    scopus 로고
    • Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: Implications for therapy
    • Khabele D, Son DS, Parl AK, Goldberg GL, Augenlicht LH, Mariadason JM, Rice VM (2007) Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Cancer Biol Ther 6(5):795-801 (Pubitemid 47328364)
    • (2007) Cancer Biology and Therapy , vol.6 , Issue.5 , pp. 795-801
    • Khabele, D.1    Son, D.-S.2    Parl, A.K.3    Goldberg, G.L.4    Augenlicht, L.H.5    Mariadason, J.M.6    Rice, V.M.7
  • 51
    • 1342310915 scopus 로고    scopus 로고
    • Downregulation of gelsolin and retinoic acid receptor beta expression in gastric cancer tissues through histone deacetylase 1
    • Kim JH, Choi YK, Kwon HJ, Yang HK, Choi JH, Kim DY (2004) Downregulation of gelsolin and retinoic acid receptor beta expression in gastric cancer tissues through histone deacetylase 1. J Gastroenterol Hepatol 19(2):218-224
    • (2004) J Gastroenterol Hepatol , vol.19 , Issue.2 , pp. 218-224
    • Kim, J.H.1    Choi, Y.K.2    Kwon, H.J.3    Yang, H.K.4    Choi, J.H.5    Kim, D.Y.6
  • 54
    • 70449675089 scopus 로고    scopus 로고
    • HDAC2: A critical factor in health and disease
    • Kramer OH (2009) HDAC2: a critical factor in health and disease. Trends Pharmacol Sci 30(12):647-655
    • (2009) Trends Pharmacol Sci , vol.30 , Issue.12 , pp. 647-655
    • Kramer, O.H.1
  • 55
    • 0034269239 scopus 로고    scopus 로고
    • Global role for chromatin remodeling enzymes in mitotic gene expression
    • Krebs JE, Fry CJ, Samuels ML, Peterson CL (2000) Global role for chromatin remodeling enzymes in mitotic gene expression. Cell 102(5):587-598
    • (2000) Cell , vol.102 , Issue.5 , pp. 587-598
    • Krebs, J.E.1    Fry, C.J.2    Samuels, M.L.3    Peterson, C.L.4
  • 60
    • 0016711859 scopus 로고
    • Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis
    • Leder A, Orkin S, Leder P (1975) Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis. Science 190(4217):893-894
    • (1975) Science , vol.190 , Issue.4217 , pp. 893-894
    • Leder, A.1    Orkin, S.2    Leder, P.3
  • 62
    • 77951938407 scopus 로고    scopus 로고
    • Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1alpha to reverse HRE site in the promoter
    • Lee KJ, Lee KY, Lee YM (2010) Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1alpha to reverse HRE site in the promoter. Biochim Biophys Acta 1803(5):608-616
    • (2010) Biochim Biophys Acta , vol.1803 , Issue.5 , pp. 608-616
    • Lee, K.J.1    Lee, K.Y.2    Lee, Y.M.3
  • 63
    • 33748706179 scopus 로고    scopus 로고
    • A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity
    • DOI 10.1101/gad.1455006
    • Li Y, Kao GD, Garcia BA, Shabanowitz J, Hunt DF, Qin J, Phelan C, Lazar MA (2006) A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev 20(18):2566-2579 (Pubitemid 44396841)
    • (2006) Genes and Development , vol.20 , Issue.18 , pp. 2566-2579
    • Li, Y.1    Kao, G.D.2    Garcia, B.A.3    Shabanowitz, J.4    Hunt, D.F.5    Qin, J.6    Phelan, C.7    Lazar, M.A.8
  • 65
    • 0035913911 scopus 로고    scopus 로고
    • Negative control of p53 by Sir2α promotes cell survival under stress
    • DOI 10.1016/S0092-8674(01)00524-4
    • Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107(2):137-148 (Pubitemid 33035941)
    • (2001) Cell , vol.107 , Issue.2 , pp. 137-148
    • Luo, J.1    Nikolaev, A.Y.2    Imai, S.-I.3    Chen, D.4    Su, F.5    Shiloh, A.6    Guarente, L.7    Gu, W.8
  • 66
    • 70349100446 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Current status and overview of recent clinical trials
    • Ma X, Ezzeldin HH, Diasio RB (2009) Histone deacetylase inhibitors: current status and overview of recent clinical trials. Drugs 69(14):1911-1934
    • (2009) Drugs , vol.69 , Issue.14 , pp. 1911-1934
    • Ma, X.1    Ezzeldin, H.H.2    Diasio, R.B.3
  • 67
    • 49449094483 scopus 로고    scopus 로고
    • Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development
    • MacDonald JL, Roskams AJ (2008) Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development. Dev Dyn 237(8):2256-2267
    • (2008) Dev Dyn , vol.237 , Issue.8 , pp. 2256-2267
    • MacDonald, J.L.1    Roskams, A.J.2
  • 68
    • 0036667393 scopus 로고    scopus 로고
    • Drug inhibition of angiogenesis
    • DOI 10.1016/S1471-4892(02)00184-4
    • Madhusudan S, Harris AL (2002) Drug inhibition of angiogenesis. Curr Opin Pharmacol 2(4):403-414 (Pubitemid 34830971)
    • (2002) Current Opinion in Pharmacology , vol.2 , Issue.4 , pp. 403-414
    • Madhusudan, S.1    Harris, A.L.2
  • 69
    • 0035794552 scopus 로고    scopus 로고
    • A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: Inhibition of the myogenic program
    • DOI 10.1093/emboj/20.7.1739
    • Mal A, Sturniolo M, Schiltz RL, Ghosh MK, Harter ML (2001) A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program. EMBO J 20(7):1739-1753 (Pubitemid 32299410)
    • (2001) EMBO Journal , vol.20 , Issue.7 , pp. 1739-1753
    • Mal, A.1    Sturniolo, M.2    Schiltz, R.L.3    Ghosh, M.K.4    Harter, M.L.5
  • 74
    • 77952853306 scopus 로고    scopus 로고
    • Histone deacetylases and epigenetic therapies of hematological malignancies
    • Mercurio C, Minucci S, Pelicci PG (2010) Histone deacetylases and epigenetic therapies of hematological malignancies. Pharmacol Res 62(1):18-34
    • (2010) Pharmacol Res , vol.62 , Issue.1 , pp. 18-34
    • Mercurio, C.1    Minucci, S.2    Pelicci, P.G.3
  • 75
    • 0035962644 scopus 로고    scopus 로고
    • Histone deacetylases: A common molecular target for differentiation treatment of acute myeloid leukemias?
    • DOI 10.1038/sj.onc.1204336
    • Minucci S, Nervi C, Lo Coco F, Pelicci PG (2001) Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias? Oncogene 20(24):3110-3115 (Pubitemid 32553566)
    • (2001) Oncogene , vol.20 , Issue.24 , pp. 3110-3115
    • Minucci, S.1    Nervi, C.2    Lo Coco, F.3    Pelicci, P.G.4
  • 77
    • 41149162821 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1α, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: Correlation with poor prognosis with possible regulation
    • DOI 10.1097/MPA.0b013e31815f2c2a, PII 0000667620080400000022
    • Miyake K, Yoshizumi T, Imura S, Sugimoto K, Batmunkh E, Kanemura H, Morine Y, Shimada M (2008) Expression of hypoxia-inducible factor-1alpha, histone deacetylase 1, and metastasisassociated protein 1 in pancreatic carcinoma: correlation with poor prognosis with possible regulation. Pancreas 36(3):e1-e9 (Pubitemid 351440946)
    • (2008) Pancreas , vol.36 , Issue.3
    • Miyake, K.1    Yoshizumi, T.2    Imura, S.3    Sugimoto, K.4    Batmunkh, E.5    Kanemura, H.6    Morine, Y.7    Shimada, M.8
  • 78
    • 0035674462 scopus 로고    scopus 로고
    • Angiogenesis in hematologic malignancies
    • DOI 10.1007/s00277-001-0398-3
    • Moehler TM, Neben K, Ho AD, Goldschmidt H (2001) Angiogenesis in hematologic malignancies. Ann Hematol 80(12):695-705 (Pubitemid 34041426)
    • (2001) Annals of Hematology , vol.80 , Issue.12 , pp. 695-705
    • Moehler, T.M.1    Neben, K.2    Ho, A.D.3    Goldschmidt, H.4
  • 81
    • 66049101024 scopus 로고    scopus 로고
    • Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development
    • Montgomery RL, Hsieh J, Barbosa AC, Richardson JA, Olson EN (2009) Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc Natl Acad Sci USA 106(19):7876-7881
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.19 , pp. 7876-7881
    • Montgomery, R.L.1    Hsieh, J.2    Barbosa, A.C.3    Richardson, J.A.4    Olson, E.N.5
  • 85
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
    • DOI 10.1111/j.1349-7006.2007.00550.x
    • Moustakas A, Heldin CH (2007) Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 98(10):1512-1520 (Pubitemid 47308444)
    • (2007) Cancer Science , vol.98 , Issue.10 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.-H.2
  • 86
    • 0035577768 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells
    • Munster PN, Troso-Sandoval T, Rosen N, Rifkind R, Marks PA, Richon VM (2001) The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells. Cancer Res 61(23):8492-8497 (Pubitemid 33131130)
    • (2001) Cancer Research , vol.61 , Issue.23 , pp. 8492-8497
    • Munster, P.N.1    Troso-Sandoval, T.2    Rosen, N.3    Rifkind, R.4    Marks, P.A.5    Richon, V.M.6
  • 90
    • 4544322261 scopus 로고    scopus 로고
    • Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients
    • DOI 10.1002/ijc.20395
    • Osada H, Tatematsu Y, Saito H, Yatabe Y, Mitsudomi T, Takahashi T (2004) Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients. Int J Cancer 112(1):26-32 (Pubitemid 39249488)
    • (2004) International Journal of Cancer , vol.112 , Issue.1 , pp. 26-32
    • Osada, H.1    Tatematsu, Y.2    Saito, H.3    Yatabe, Y.4    Mitsudomi, T.5    Takahashi, T.6
  • 91
    • 0019198985 scopus 로고
    • The value of estrogen and progesterone receptors in the treatment of breast cancer
    • Osborne CK, Yochmowitz MG, Knight WA 3rd, McGuire WL (1980) The value of estrogen and progesterone receptors in the treatment of breast cancer. Cancer 46(12 Suppl):2884-2888 (Pubitemid 11205652)
    • (1980) Cancer , vol.46 , Issue.12 SUPPL. , pp. 2884-2888
    • Osborne, C.K.1    Yochmowitz, M.G.2    Knight III, W.A.3    McGuire, W.L.4
  • 92
    • 30544445468 scopus 로고    scopus 로고
    • Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
    • DOI 10.1038/sj.onc.1209049, PII 1209049
    • Ota H, Tokunaga E, Chang K, Hikasa M, Iijima K, Eto M, Kozaki K, Akishita M, Ouchi Y, Kaneki M (2006) Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras- MAPK signaling in human cancer cells. Oncogene 25(2):176-185 (Pubitemid 43083679)
    • (2006) Oncogene , vol.25 , Issue.2 , pp. 176-185
    • Ota, H.1    Tokunaga, E.2    Chang, K.3    Hikasa, M.4    Iijima, K.5    Eto, M.6    Kozaki, K.7    Akishita, M.8    Ouchi, Y.9    Kaneki, M.10
  • 95
    • 34249289041 scopus 로고    scopus 로고
    • Snail, ZEB and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • DOI 10.1038/nrc2131, PII NRC2131
    • Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7(6):415-428 (Pubitemid 46809165)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.6 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 97
    • 34548700155 scopus 로고    scopus 로고
    • The HDAC inhibitor trichostatin a inhibits growth of small cell lung cancer cells
    • DOI 10.1016/j.jss.2006.12.555, PII S0022480406011802
    • Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H (2007) The HDAC inhibitor trichostatin A inhibits growth of small cell lung cancer cells. J Surg Res 142(2):219-226 (Pubitemid 47418819)
    • (2007) Journal of Surgical Research , vol.142 , Issue.2 , pp. 219-226
    • Platta, C.S.1    Greenblatt, D.Y.2    Kunnimalaiyaan, M.3    Chen, H.4
  • 98
    • 51749123773 scopus 로고    scopus 로고
    • Valproic acid induces Notch1 signaling in small cell lung cancer cells
    • Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H (2008) Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res 148(1):31-37
    • (2008) J Surg Res , vol.148 , Issue.1 , pp. 31-37
    • Platta, C.S.1    Greenblatt, D.Y.2    Kunnimalaiyaan, M.3    Chen, H.4
  • 99
    • 33749006252 scopus 로고    scopus 로고
    • Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1α
    • DOI 10.1158/0008-5472.CAN-05-4598
    • Qian DZ, Kachhap SK, Collis SJ, Verheul HM, Carducci MA, Atadja P, Pili R (2006) Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha. Cancer Res 66(17):8814-8821 (Pubitemid 44449199)
    • (2006) Cancer Research , vol.66 , Issue.17 , pp. 8814-8821
    • Qian, D.Z.1    Kachhap, S.K.2    Collis, S.J.3    Verheul, H.M.W.4    Carducci, M.A.5    Atadja, P.6    Pili, R.7
  • 102
    • 34248631385 scopus 로고    scopus 로고
    • The role of histone deacetylases (HDACs) in human cancer
    • DOI 10.1016/j.molonc.2007.01.001, PII S1574789107000026
    • Ropero S, Esteller M (2007) The role of histone deacetylases (HDACs) in human cancer. Mol Oncol 1(1):19-25 (Pubitemid 46776612)
    • (2007) Molecular Oncology , vol.1 , Issue.1 , pp. 19-25
    • Ropero, S.1    Esteller, M.2
  • 106
    • 22444433425 scopus 로고    scopus 로고
    • Release of methyl CpG binding proteins and histone deacetylase 1 from the estrogen receptor α (ER) promoter upon reactivation in ER-negative human breast cancer cells
    • DOI 10.1210/me.2004-0011
    • Sharma D, Blum J, Yang X, Beaulieu N, Macleod AR, Davidson NE (2005) Release of methyl CpG binding proteins and histone deacetylase 1 from the Estrogen receptor alpha (ER) promoter upon reactivation in ER-negative human breast cancer cells. Mol Endocrinol 19(7):1740-1751 (Pubitemid 41007887)
    • (2005) Molecular Endocrinology , vol.19 , Issue.7 , pp. 1740-1751
    • Sharma, D.1    Blum, J.2    Yang, X.3    Beaulieu, N.4    Macleod, A.R.5    Davidson, N.E.6
  • 108
    • 44449135127 scopus 로고    scopus 로고
    • HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin
    • Svechnikova I, Almqvist PM, Ekstrom TJ (2008) HDAC inhibitors effectively induce cell typespecific differentiation in human glioblastoma cell lines of different origin. Int J Oncol 32(4):821-827 (Pubitemid 351780592)
    • (2008) International Journal of Oncology , vol.32 , Issue.4 , pp. 821-827
    • Svechnikova, I.1    Almqvist, P.M.2    Ekstrom, T.J.3
  • 109
    • 0003019001 scopus 로고
    • Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds
    • Tanaka M, Levy J, Terada M, Breslow R, Rifkind RA, Marks PA (1975) Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds. Proc Natl Acad Sci USA 72(3):1003-1006
    • (1975) Proc Natl Acad Sci USA , vol.72 , Issue.3 , pp. 1003-1006
    • Tanaka, M.1    Levy, J.2    Terada, M.3    Breslow, R.4    Rifkind, R.A.5    Marks, P.A.6
  • 110
    • 0037315894 scopus 로고    scopus 로고
    • Disruption of differentiation in human cancer: AML shows the way
    • DOI 10.1038/nrc989
    • Tenen DG (2003) Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer 3(2):89-101 (Pubitemid 37328876)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.2 , pp. 89-101
    • Tenen, D.G.1
  • 111
    • 67349237892 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor induced modulation of anti-estrogen therapy
    • Thomas S, Munster PN (2009) Histone deacetylase inhibitor induced modulation of anti-estrogen therapy. Cancer Lett 280(2):184-191
    • (2009) Cancer Lett , vol.280 , Issue.2 , pp. 184-191
    • Thomas, S.1    Munster, P.N.2
  • 112
    • 1842557733 scopus 로고    scopus 로고
    • Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases
    • DOI 10.1128/MCB.24.8.3132-3139.2004
    • Tou L, Liu Q, Shivdasani RA (2004) Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol 24(8):3132-3139 (Pubitemid 38452059)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.8 , pp. 3132-3139
    • Tou, L.1    Liu, Q.2    Shivdasani, R.A.3
  • 114
    • 41449083867 scopus 로고    scopus 로고
    • Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
    • DOI 10.1161/CIRCRESAHA.107.164558
    • Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T, Bober E (2008) Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res 102(6):703-710 (Pubitemid 351457857)
    • (2008) Circulation Research , vol.102 , Issue.6 , pp. 703-710
    • Vakhrusheva, O.1    Smolka, C.2    Gajawada, P.3    Kostin, S.4    Boettger, T.5    Kubin, T.6    Braun, T.7    Bober, E.8
  • 121
    • 67349160499 scopus 로고    scopus 로고
    • HDAC expression and clinical prognosis in human malignancies
    • Weichert W (2009) HDAC expression and clinical prognosis in human malignancies. Cancer Lett 280(2):168-176
    • (2009) Cancer Lett , vol.280 , Issue.2 , pp. 168-176
    • Weichert, W.1
  • 122
    • 38949086502 scopus 로고    scopus 로고
    • Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
    • DOI 10.1038/sj.bjc.6604199, PII 6604199
    • Weichert W, Roske A, Gekeler V, Beckers T, Stephan C, Jung K, Fritzsche FR, Niesporek S, Denkert C, Dietel M, Kristiansen G (2008a) Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br J Cancer 98(3):604-610 (Pubitemid 351214528)
    • (2008) British Journal of Cancer , vol.98 , Issue.3 , pp. 604-610
    • Weichert, W.1    Roske, A.2    Gekeler, V.3    Beckers, T.4    Stephan, C.5    Jung, K.6    Fritzsche, F.R.7    Niesporek, S.8    Denkert, C.9    Dietel, M.10    Kristiansen, G.11
  • 123
    • 41549159879 scopus 로고    scopus 로고
    • Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: Specific role of class I histone deacetylases in vitro and in vivo
    • DOI 10.1158/1078-0432.CCR-07-0990
    • Weichert W, Roske A, Niesporek S, Noske A, Buckendahl AC, Dietel M, Gekeler V, Boehm M, Beckers T, Denkert C (2008b) Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin Cancer Res 14(6):1669-1677 (Pubitemid 351469450)
    • (2008) Clinical Cancer Research , vol.14 , Issue.6 , pp. 1669-1677
    • Weichert, W.1    Roske, A.2    Niesporek, S.3    Noske, A.4    Buckendahl, A.-C.5    Dietel, M.6    Gekeler, V.7    Boehm, M.8    Beckers, T.9    Denkert, C.10
  • 127
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action
    • DOI 10.1038/sj.onc.1210620, PII 1210620
    • Xu WS, Parmigiani RB, Marks PA (2007) Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 26(37):5541-5552 (Pubitemid 47255934)
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 129
    • 0037455825 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor trichostatin a induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells
    • DOI 10.1002/ijc.10699
    • Yamashita Y, Shimada M, Harimoto N, Rikimaru T, Shirabe K, Tanaka S, Sugimachi K (2003) Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. Int J Cancer 103(5):572-576 (Pubitemid 36091459)
    • (2003) International Journal of Cancer , vol.103 , Issue.5 , pp. 572-576
    • Yamashita, Y.-I.1    Shimada, M.2    Harimoto, N.3    Rikimaru, T.4    Shirabe, K.5    Tanaka, S.6    Sugimachi, K.7
  • 130
    • 33646537522 scopus 로고    scopus 로고
    • Down-regulation of histone deacetylases stimulates adipocyte differentiation
    • Yoo EJ, Chung JJ, Choe SS, Kim KH, Kim JB (2006) Down-regulation of histone deacetylases stimulates adipocyte differentiation. J Biol Chem 281(10):6608-6615
    • (2006) J Biol Chem , vol.281 , Issue.10 , pp. 6608-6615
    • Yoo, E.J.1    Chung, J.J.2    Choe, S.S.3    Kim, K.H.4    Kim, J.B.5
  • 131
    • 65349096174 scopus 로고    scopus 로고
    • A c-Myc-SIRT1 feedback loop regulates cell growth and transformation
    • Yuan J, Minter-Dykhouse K, Lou Z (2009) A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol 185(2):203-211
    • (2009) J Cell Biol , vol.185 , Issue.2 , pp. 203-211
    • Yuan, J.1    Minter-Dykhouse, K.2    Lou, Z.3
  • 132
    • 79955801797 scopus 로고    scopus 로고
    • Combined effects of all-trans-retinoic acid and trichostatin A on the induction of differentiation of thyroid carcinoma cells
    • Yuan GB, Kuang AR, Fan Q, Yu LB, Mi YX (2010) Combined effects of all-trans-retinoic acid and trichostatin A on the induction of differentiation of thyroid carcinoma cells. Chin J Cancer 29(4):379-384
    • (2010) Chin J Cancer , vol.29 , Issue.4 , pp. 379-384
    • Yuan, G.B.1    Kuang, A.R.2    Fan, Q.3    Yu, L.B.4    Mi, Y.X.5
  • 133
    • 0037162697 scopus 로고    scopus 로고
    • Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
    • DOI 10.1016/S0092-8674(02)00861-9
    • Zhang CL, McKinsey TA, Chang S, Antos CL, Hill JA, Olson EN (2002) Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell 110(4):479-488 (Pubitemid 35232291)
    • (2002) Cell , vol.110 , Issue.4 , pp. 479-488
    • Zhang, C.L.1    McKinsey, T.A.2    Chang, S.3    Antos, C.L.4    Hill, J.A.5    Olson, E.N.6
  • 136
    • 77957982588 scopus 로고    scopus 로고
    • MicroRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity
    • Zhang J, Yang Y, Yang T, Liu Y, Li A, Fu S, Wu M, Pan Z, Zhou W (2010) microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. Br J Cancer 103(8):1215-1220
    • (2010) Br J Cancer , vol.103 , Issue.8 , pp. 1215-1220
    • Zhang, J.1    Yang, Y.2    Yang, T.3    Liu, Y.4    Li, A.5    Fu, S.6    Wu, M.7    Pan, Z.8    Zhou, W.9
  • 137
    • 2342603414 scopus 로고    scopus 로고
    • Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis
    • DOI 10.1016/S1535-6108(04)00114-X, PII S153561080400114X
    • Zhu P, Martin E, Mengwasser J, Schlag P, Janssen KP, Gottlicher M (2004) Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. Cancer Cell 5(5):455-463 (Pubitemid 38610247)
    • (2004) Cancer Cell , vol.5 , Issue.5 , pp. 455-463
    • Zhu, P.1    Martin, E.2    Mengwasser, J.3    Schlag, P.4    Janssen, K.-P.5    Gottlicher, M.6


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