Cyclin L2 is a critical HIV dependency factor in macrophages that controls samhd1 abundance

Cell Host and Microbe

Volumn 17, Issue 1, 2015, Pages 98-106

  Kyei, George Boateng ^a   Cheng, Xiaogang ^a   Ramani, Rashmi ^a   Ratner, Lee ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN L2; CYCLINE; DCAF1 PROTEIN; PROTEASOME; SAMHD1 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; CCNL2 PROTEIN, HUMAN; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; SAMHD1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN INTERACTION; TWO HYBRID SYSTEM; VIRUS ATTENUATION; VIRUS REPLICATION; YEAST; CELL CULTURE; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PROTEIN ANALYSIS; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; SIMIAN IMMUNODEFICIENCY VIRUS;

CELLS, CULTURED; CYCLINS; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; MACROPHAGES; MONOMERIC GTP-BINDING PROTEINS; PROTEIN INTERACTION MAPPING; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES; VIRUS REPLICATION;

EID: 84920901203     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2014.11.009     Document Type: Article

References (36)

1. J. Ahn, C. Hao, J. Yan, M. DeLucia, J. Mehrens, C. Wang, A.M. Gronenborn, and J. Skowronski HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1 J. Biol. Chem. 287 2012 12550 12558
2. H.M. Baldauf, X. Pan, E. Erikson, S. Schmidt, W. Daddacha, M. Burggraf, K. Schenkova, I. Ambiel, G. Wabnitz, and T. Gramberg SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells Nat. Med. 18 2012 1682 1687
3. A. Brandariz-Nuñez, J.C. Valle-Casuso, T.E. White, N. Laguette, M. Benkirane, J. Brojatsch, and F. Diaz-Griffero Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac Retrovirology 9 2012 49
4. J. Chua, and V. Deretic Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles J. Biol. Chem. 279 2004 36982 36992
5. A. Cribier, B. Descours, A.L. Valadão, N. Laguette, and M. Benkirane Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1 Cell Reports 3 2013 1036 1043
6. R.C. Dale, H. Gornall, D. Singh-Grewal, M. Alcausin, G.I. Rice, and Y.J. Crow Familial Aicardi-Goutières syndrome due to SAMHD1 mutations is associated with chronic arthropathy and contractures Am. J. Med. Genet. A. 152A 2010 938 942
7. K. de Graaf, P. Hekerman, O. Spelten, A. Herrmann, L.C. Packman, K. Büssow, G. Müller-Newen, and W. Becker Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors J. Biol. Chem. 279 2004 4612 4624
8. M. DeLucia, J. Mehrens, Y. Wu, and J. Ahn HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation J. Biol. Chem. 288 2013 19116 19126
9. O.I. Fregoso, J. Ahn, C. Wang, J. Mehrens, J. Skowronski, and M. Emerman Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1 PLoS Pathog. 9 2013 e1003496
10. D.C. Goldstone, V. Ennis-Adeniran, J.J. Hedden, H.C. Groom, G.I. Rice, E. Christodoulou, P.A. Walker, G. Kelly, L.F. Haire, and M.W. Yap HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase Nature 480 2011 379 382
11. D. Gritenaite, L.N. Princz, B. Szakal, S.C. Bantele, L. Wendeler, S. Schilbach, B.H. Habermann, J. Matos, M. Lisby, D. Branzei, and B. Pfander A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication Genes Dev. 28 2014 1604 1619
12. H. Guo, W. Wei, Z. Wei, X. Liu, S.L. Evans, W. Yang, H. Wang, Y. Guo, K. Zhao, J.Y. Zhou, and X.F. Yu Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation PLoS ONE 8 2013 e66201
13. A. Herrmann, K. Fleischer, H. Czajkowska, G. Müller-Newen, and W. Becker Characterization of cyclin L1 as an immobile component of the splicing factor compartment FASEB J. 21 2007 3142 3152
14. K. Hrecka, C. Hao, M. Gierszewska, S.K. Swanson, M. Kesik-Brodacka, S. Srivastava, L. Florens, M.P. Washburn, and J. Skowronski Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein Nature 474 2011 658 661
15. S. Kretschmer, C. Wolf, N. König, W. Staroske, J. Guck, M. Häusler, H. Luksch, L.A. Nguyen, B. Kim, and D. Alexopoulou SAMHD1 prevents autoimmunity by maintaining genome stability Ann. Rheum. Dis. 2014 10.1136/annrheumdis-2013-204845 Published online January 29, 2014
16. N. Laguette, B. Sobhian, N. Casartelli, M. Ringeard, C. Chable-Bessia, E. Ségéral, A. Yatim, S. Emiliani, O. Schwartz, and M. Benkirane SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx Nature 474 2011 654 657
17. N. Laguette, C. Brégnard, P. Hue, J. Basbous, A. Yatim, M. Larroque, F. Kirchhoff, A. Constantinou, B. Sobhian, and M. Benkirane Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing Cell 156 2014 134 145
18. H.L. Li, T.S. Wang, X.Y. Li, N. Li, D.Z. Huang, Q. Chen, and Y. Ba Overexpression of cyclin L2 induces apoptosis and cell-cycle arrest in human lung cancer cells Chin. Med. J. (Engl.) 120 2007 905 909
19. L.Y. Liou, C.H. Herrmann, and A.P. Rice Transient induction of cyclin T1 during human macrophage differentiation regulates human immunodeficiency virus type 1 Tat transactivation function J. Virol. 76 2002 10579 10587
20. L.Y. Liou, C.H. Herrmann, and A.P. Rice Human immunodeficiency virus type 1 infection induces cyclin T1 expression in macrophages J. Virol. 78 2004 8114 8119
21. L.Y. Liou, R.E. Haaland, C.H. Herrmann, and A.P. Rice Cyclin T1 but not cyclin T2a is induced by a post-transcriptional mechanism in PAMP-activated monocyte-derived macrophages J. Leukoc. Biol. 79 2006 388 396
22. P. Loyer, J.H. Trembley, J.A. Grenet, A. Busson, A. Corlu, W. Zhao, M. Kocak, V.J. Kidd, and J.M. Lahti Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection J. Biol. Chem. 283 2008 7721 7732
23. E. Olivetta, and M. Federico HIV-1 Nef protects human-monocyte-derived macrophages from HIV-1-induced apoptosis Exp. Cell Res. 312 2006 890 900
24. G.I. Rice, J. Bond, A. Asipu, R.L. Brunette, I.W. Manfield, I.M. Carr, J.C. Fuller, R.M. Jackson, T. Lamb, and T.A. Briggs Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response Nat. Genet. 41 2009 829 832
25. B. Romani, and E.A. Cohen Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase Curr Opin Virol 2 2012 755 763
26. D. Rossi SAMHD1: a new gene for CLL Blood 123 2014 951 952
27. S. Srivastava, S.K. Swanson, N. Manel, L. Florens, M.P. Washburn, and J. Skowronski Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection PLoS Pathog. 4 2008 e1000059
28. C. St Gelais, S. de Silva, S.M. Amie, C.M. Coleman, H. Hoy, J.A. Hollenbaugh, B. Kim, and L. Wu SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons Retrovirology 9 2012 105
29. C. St Gelais, S. de Silva, J.C. Hach, T.E. White, F. Diaz-Griffero, J.S. Yount, and L. Wu Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1 J. Virol. 88 2014 5834 5844
30. F. Ueno, H. Shiota, M. Miyaura, A. Yoshida, A. Sakurai, J. Tatsuki, A.H. Koyama, H. Akari, A. Adachi, and M. Fujita Vpx and Vpr proteins of HIV-2 up-regulate the viral infectivity by a distinct mechanism in lymphocytic cells Microbes Infect. 5 2003 387 395
31. W. Wei, H. Guo, X. Han, X. Liu, X. Zhou, W. Zhang, and X.F. Yu A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest Cell. Microbiol. 14 2012 1745 1756
32. S. Welbourn, S.M. Dutta, O.J. Semmes, and K. Strebel Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1 J. Virol. 87 2013 11516 11524
33. T.E. White, A. Brandariz-Nuñez, J.C. Valle-Casuso, S. Amie, L.A. Nguyen, B. Kim, M. Tuzova, and F. Diaz-Griffero The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation Cell Host Microbe 13 2013 441 451
34. L. Yang, N. Li, C. Wang, Y. Yu, L. Yuan, M. Zhang, and X. Cao Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells J. Biol. Chem. 279 2004 11639 11648
35. C. Zhu, W. Gao, K. Zhao, X. Qin, Y. Zhang, X. Peng, L. Zhang, Y. Dong, W. Zhang, and P. Li Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase Nat. Commun. 4 2013 2722
36. L. Zhuo, J. Gong, R. Yang, Y. Sheng, L. Zhou, X. Kong, and K. Cao Inhibition of proliferation and differentiation and promotion of apoptosis by cyclin L2 in mouse embryonic carcinoma P19 cells Biochem. Biophys. Res. Commun. 390 2009 451 457