Structural basis of cellular dNTP regulation by SAMHD1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 41, 2014, Pages E4305-E4314

  Ji, Xiaoyun ^a   Tang, Chenxiang ^a   Zhao, Qi ^a   Wang, Wei ^a   Xiong, Yong ^a   Goff, Stephen P ^b  

^a YALE UNIVERSITY   (United States)

^b Columbia University ^*  (United States)

Author keywords

Allosteric regulation; Dntp metabolism; Hiv restriction factor; Tetramerization; Triphosphohydrolase

Indexed keywords

GUANOSINE TRIPHOSPHATE; LIGAND; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NUCLEOTIDE; RIBONUCLEOTIDE REDUCTASE; SAMHD1 PROTEIN, HUMAN;

BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; HUMAN; HYDROLYSIS; KINETICS; METABOLISM; PROTEIN MULTIMERIZATION; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC SITE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; KINETICS; LIGANDS; MODELS, MOLECULAR; MONOMERIC GTP-BINDING PROTEINS; NUCLEOTIDES; PROTEIN MULTIMERIZATION; RIBONUCLEOTIDE REDUCTASES; SUBSTRATE SPECIFICITY;

EID: 84907937909     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412289111     Document Type: Article

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