Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

Nature Communications

Volumn 4, Issue , 2013, Pages

  Zhu, Chunfeng ^a   Gao, Wenying ^b   Zhao, Ke ^b   Qin, Xiaohong ^a   Zhang, Yinjie ^c   Peng, Xin ^a   Zhang, Lei ^a   Dong, Yuhui ^d   Zhang, Wenyan ^b   Li, Peng ^b   Wei, Wei ^b,e   Gong, Yong ^d   Yu, Xiao Fang ^a,b,e  

^a TIANJIN UNIVERSITY   (China)

^b THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^c NANKAI UNIVERSITY   (China)

^d INSTITUTE OF HIGH ENERGY PHYSICS   (China)

^e JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BRILLIANT BLUE; DEOXYGUANOSINE TRIPHOSPHATE; ENHANCED GREEN FLUORESCENT PROTEIN; PHOSPHATASE; SAM DOMAIN AND HD DOMAIN CONTAINING PROTEIN 1; TETRAMER; UNCLASSIFIED DRUG;

CRYSTAL STRUCTURE; ENZYME ACTIVITY; MOLECULAR ANALYSIS; SUBSTRATE;

3' UNTRANSLATED REGION; ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; EXPRESSION VECTOR; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HYDROGEN BOND; HYDROLYSIS; MACROPHAGE; MISSENSE MUTATION; MOLECULAR SIZE; MOLECULAR WEIGHT; MONOCYTE; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; ULTRACENTRIFUGATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ALLOSTERIC SITE; CATALYTIC DOMAIN; DEOXYGUANINE NUCLEOTIDES; HEK293 CELLS; HIV-1; HUMANS; HYDROLYSIS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MONOMERIC GTP-BINDING PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; STATIC ELECTRICITY; U937 CELLS; ULTRACENTRIFUGATION;

EID: 84887670233     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3722     Document Type: Article

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