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Volumn 14, Issue 5, 2015, Pages 1087-1094

Targeting Wnts at the Source-New Mechanisms, New Biomarkers, New Drugs

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; NEW DRUG; NOTCH RECEPTOR; PROTEIN INHIBITOR; WNT PROTEIN; ANTINEOPLASTIC AGENT; TUMOR MARKER;

EID: 84942508634     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-14-1038     Document Type: Article
Times cited : (92)

References (73)
  • 1
    • 84871846692 scopus 로고    scopus 로고
    • WNT signalling pathways as therapeutic targets in cancer
    • Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 2013;13:11-26.
    • (2013) Nat Rev Cancer , vol.13 , pp. 11-26
    • Anastas, J.N.1    Moon, R.T.2
  • 2
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/b-catenin signaling and disease
    • Clevers H, Nusse R. Wnt/b-catenin signaling and disease. Cell 2012;149: 1192-205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 3
    • 84903767326 scopus 로고    scopus 로고
    • Can we safely target the WNT pathway?
    • Kahn M. Can we safely target the WNT pathway? Nat Rev Drug Discov 2014;13:513-32.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 513-532
    • Kahn, M.1
  • 4
    • 51149118892 scopus 로고    scopus 로고
    • Deciphering the function of canonicalWnt signals indevelopment and disease: Conditional loss- And gainof-function mutations of b-catenin in mice
    • Grigoryan T, Wend P, Klaus A, Birchmeier W. Deciphering the function of canonicalWnt signals indevelopment and disease: conditional loss- and gainof-function mutations of b-catenin in mice. Genes Dev 2008;22:2308-41.
    • (2008) Genes Dev , vol.22 , pp. 2308-2341
    • Grigoryan, T.1    Wend, P.2    Klaus, A.3    Birchmeier, W.4
  • 5
    • 77953715690 scopus 로고    scopus 로고
    • WntTargeting signaling: Can we safely eradicate cancer stem cells?
    • Takahashi-Yanaga F, Kahn M. Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin Cancer Res 2010;16:3153-62.
    • (2010) Clin Cancer Res , vol.16 , pp. 3153-3162
    • Takahashi-Yanaga, F.1    Kahn, M.2
  • 6
    • 84875249240 scopus 로고    scopus 로고
    • 2,3,6-Trisubstituted quinoxaline derivative, a small molecule inhibitor of the Wnt/beta-catenin signaling pathway, suppresses cell proliferation and enhances radiosensitivity in A549/Wnt2 cells
    • Lee SB, Gong Y-D, Park YI, Dong M-S. 2,3,6-Trisubstituted quinoxaline derivative, a small molecule inhibitor of the Wnt/beta-catenin signaling pathway, suppresses cell proliferation and enhances radiosensitivity in A549/Wnt2 cells. Biochem Biophys Res Commun 2013;431: 746-52.
    • (2013) Biochem Biophys Res Commun , vol.431 , pp. 746-752
    • Lee, S.B.1    Gong, Y.-D.2    Park, Y.I.3    Dong, M.-S.4
  • 7
  • 9
    • 58249122326 scopus 로고    scopus 로고
    • Small moleculemediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
    • Chen B, Dodge ME, Tang W, Ma Z, Fan C-W, Wei S, et al. Small moleculemediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 2009;5:100-7.
    • (2009) Nat Chem Biol , vol.5 , pp. 100-107
    • Chen, B.1    Dodge, M.E.2    Tang, W.3    Ma, Z.4    Fan, C.-W.5    Wei, S.6
  • 10
    • 84877720042 scopus 로고    scopus 로고
    • A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth
    • Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, et al. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res 2013;73:3132-44.
    • (2013) Cancer Res , vol.73 , pp. 3132-3144
    • Lau, T.1    Chan, E.2    Callow, M.3    Waaler, J.4    Boggs, J.5    Blake, R.A.6
  • 11
    • 84908185262 scopus 로고    scopus 로고
    • Safely targeting cancer stem cells via selective catenin coactivator antagonism
    • Lenz H-J, Kahn M. Safely targeting cancer stem cells via selective catenin coactivator antagonism. Cancer Sci 2014;105:1087-92.
    • (2014) Cancer Sci , vol.105 , pp. 1087-1092
    • Lenz, H.-J.1    Kahn, M.2
  • 12
    • 84914125317 scopus 로고    scopus 로고
    • Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels
    • Chang M-K, Kramer I, Huber T, Kinzel B, Guth-Gundel S, Leupin O, et al. Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels. Proc Natl Acad Sci U S A 2014;111:E5187-95.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. E5187-E5195
    • Chang, M.-K.1    Kramer, I.2    Huber, T.3    Kinzel, B.4    Guth-Gundel, S.5    Leupin, O.6
  • 14
    • 77957266335 scopus 로고    scopus 로고
    • Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
    • Ettenberg SA, Charlat O, Daley MP, Liu S, Vincent KJ, Stuart DD, et al. Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. Proc Natl Acad Sci U S A 2010;107:15473-8.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15473-15478
    • Ettenberg, S.A.1    Charlat, O.2    Daley, M.P.3    Liu, S.4    Vincent, K.J.5    Stuart, D.D.6
  • 15
    • 84863938543 scopus 로고    scopus 로고
    • Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
    • Gurney A, Axelrod F, Bond CJ, Cain J, Chartier C, Donigan L, et al. Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci U S A 2012;109:11717-22.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 11717-11722
    • Gurney, A.1    Axelrod, F.2    Bond, C.J.3    Cain, J.4    Chartier, C.5    Donigan, L.6
  • 16
    • 0035811492 scopus 로고    scopus 로고
    • Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
    • Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 2001;412:86-90.
    • (2001) Nature , vol.412 , pp. 86-90
    • Dann, C.E.1    Hsieh, J.C.2    Rattner, A.3    Sharma, D.4    Nathans, J.5    Leahy, D.J.6
  • 17
    • 84900796850 scopus 로고    scopus 로고
    • The potential of targeting Wnt/b-catenin in colon cancer
    • Sebio A, Kahn M, Lenz H-J. The potential of targeting Wnt/b-catenin in colon cancer. Expert Opin Ther Targets 2014;18:611-5.
    • (2014) Expert Opin Ther Targets , vol.18 , pp. 611-615
    • Sebio, A.1    Kahn, M.2    Lenz, H.-J.3
  • 18
    • 84945121486 scopus 로고    scopus 로고
    • Abstract B79: A first-in-human Phase 1 study of anti-cancer stem cell (CSC) agent OMP-54F28 (FZD8-Fc) targeting the WNT pathway in patients with advanced solid tumors
    • Smith DC, Gordon M, Messersmith W, Chugh R, Mendelson D, Dupont J, et al. Abstract B79: a first-in-human Phase 1 study of anti-cancer stem cell (CSC) agent OMP-54F28 (FZD8-Fc) targeting the WNT pathway in patients with advanced solid tumors. Mol Cancer Ther 2014;12:B79-9.
    • (2014) Mol Cancer Ther , vol.12 , pp. B79-B79
    • Smith, D.C.1    Gordon, M.2    Messersmith, W.3    Chugh, R.4    Mendelson, D.5    Dupont, J.6
  • 22
    • 84865281576 scopus 로고    scopus 로고
    • The unusual case of porcupine
    • Lum L, Clevers H. The unusual case of porcupine. Science 2012;337: 922-3.
    • (2012) Science , vol.337 , pp. 922-923
    • Lum, L.1    Clevers, H.2
  • 23
    • 84884558970 scopus 로고    scopus 로고
    • CoAStearoyldesaturase is required to produce active, lipid-modified Wnt proteins
    • Rios-Esteves J, Resh MD. Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins. Cell Rep 2013;4:1072-81.
    • (2013) Cell Rep , vol.4 , pp. 1072-1081
    • Rios-Esteves, J.1    Resh, M.D.2
  • 24
    • 33751318469 scopus 로고    scopus 로고
    • Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion
    • Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, Kondoh H, et al. Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev Cell 2006;11:791-801.
    • (2006) Dev Cell , vol.11 , pp. 791-801
    • Takada, R.1    Satomi, Y.2    Kurata, T.3    Ueno, N.4    Norioka, S.5    Kondoh, H.6
  • 25
    • 77956942286 scopus 로고    scopus 로고
    • WLSdependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification
    • Coombs GS, Yu J, Canning CA, Veltri CA, Covey TM, Cheong JK, et al. WLSdependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. J Cell Sci 2010;123:3357-67.
    • (2010) J Cell Sci , vol.123 , pp. 3357-3367
    • Coombs, G.S.1    Yu, J.2    Canning, C.A.3    Veltri, C.A.4    Covey, T.M.5    Cheong, J.K.6
  • 26
    • 84872528453 scopus 로고    scopus 로고
    • Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer
    • Proffitt KD, Madan B, Ke Z, Pendharkar V, Ding L, Lee MA, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res 2013;73:502-7.
    • (2013) Cancer Res , vol.73 , pp. 502-507
    • Proffitt, K.D.1    Madan, B.2    Ke, Z.3    Pendharkar, V.4    Ding, L.5    Lee, M.A.6
  • 28
    • 84867280731 scopus 로고    scopus 로고
    • Precise regulation of porcupine activity is required for physiological Wnt signaling
    • Proffitt KD, Virshup DM. Precise regulation of porcupine activity is required for physiological Wnt signaling. J Biol Chem 2012;287: 34167-78.
    • (2012) J Biol Chem , vol.287 , pp. 34167-34178
    • Proffitt, K.D.1    Virshup, D.M.2
  • 29
    • 84864313614 scopus 로고    scopus 로고
    • A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities
    • Najdi R, Proffitt K, Sprowl S, Kaur S, Yu J, Covey TM, et al. A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. Differentiation 2012;84:203-13.
    • (2012) Differentiation , vol.84 , pp. 203-213
    • Najdi, R.1    Proffitt, K.2    Sprowl, S.3    Kaur, S.4    Yu, J.5    Covey, T.M.6
  • 30
    • 84890281677 scopus 로고    scopus 로고
    • Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
    • Liu J, Pan S, Hsieh MH, Ng N, Sun F, Wang T, et al. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A 2013;110:20224-9.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 20224-20229
    • Liu, J.1    Pan, S.2    Hsieh, M.H.3    Ng, N.4    Sun, F.5    Wang, T.6
  • 32
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006;127:469-80.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 33
    • 84901386333 scopus 로고    scopus 로고
    • Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts
    • Kabiri Z, Kabiri Z, Greicius G, Greicius G, Madan B, Madan B, et al. Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. Development 2014;141:2206-15.
    • (2014) Development , vol.141 , pp. 2206-2215
    • Kabiri, Z.1    Kabiri, Z.2    Greicius, G.3    Greicius, G.4    Madan, B.5    Madan, B.6
  • 36
    • 84982958966 scopus 로고    scopus 로고
    • Oncomed nternet. ited 2014 Sep 10 Available from investor.shareholder.com.
    • Oncomed. FDA Removes Partial Clinical Hold on OncoMed's Ipafricept [Internet]. investor.shareholder.com. 2014 [cited 2014 Sep 10]. Available from: http://investor.shareholder.com/oncomed/releasedetail.cfm?ReleaseID?869239
    • (2014) FDA Removes Partial Clinical Hold on OncoMed's Ipafricept [Internet]
  • 38
    • 84865517676 scopus 로고    scopus 로고
    • Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
    • Koo B-K, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, et al. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature 2012;488:665-9.
    • (2012) Nature , vol.488 , pp. 665-669
    • Koo, B.-K.1    Spit, M.2    Jordens, I.3    Low, T.Y.4    Stange, D.E.5    Van De, W.M.6
  • 39
    • 84860765166 scopus 로고    scopus 로고
    • ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
    • Hao H-X, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature 2012;485:195-200.
    • (2012) Nature , vol.485 , pp. 195-200
    • Hao, H.-X.1    Xie, Y.2    Zhang, Y.3    Charlat, O.4    Oster, E.5    Avello, M.6
  • 41
    • 84872329672 scopus 로고    scopus 로고
    • Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers
    • 167ra4
    • Kinde I, Bettegowda C, Wang Y, Wu J, Agrawal N, Shih I-M, et al. Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers. Sci Transl Med 2013;5:167ra4.
    • (2013) Sci Transl Med , vol.5
    • Kinde, I.1    Bettegowda, C.2    Wang, Y.3    Wu, J.4    Agrawal, N.5    Shih, I.-M.6
  • 46
    • 84901680089 scopus 로고    scopus 로고
    • Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
    • Wang K, Yuen ST, Xu J, Lee SP, Yan HHN, Shi ST, et al. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nat Genet 2014;46:573-82.
    • (2014) Nat Genet , vol.46 , pp. 573-582
    • Wang, K.1    Yuen, S.T.2    Xu, J.3    Lee, S.P.4    Yan, H.H.N.5    Shi, S.T.6
  • 47
    • 84907270779 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of gastric adenocarcinoma
    • Atlas Cancer Genome Research Network
    • Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 2014;513:202-9.
    • (2014) Nature , vol.513 , pp. 202-209
  • 48
    • 5044244757 scopus 로고    scopus 로고
    • R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis
    • Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell 2004;7:525-34.
    • (2004) Dev Cell , vol.7 , pp. 525-534
    • Kazanskaya, O.1    Glinka, A.2    Del Barco Barrantes, I.3    Stannek, P.4    Niehrs, C.5    Wu, W.6
  • 49
    • 84893947796 scopus 로고    scopus 로고
    • The R-spondin/Lgr5/Rnf43 module: Regulator of Wnt signal strength
    • de Lau W, Peng WC, Gros P, Clevers H. The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes Dev 2014;28:305-16.
    • (2014) Genes Dev , vol.28 , pp. 305-316
    • De Lau, W.1    Peng, W.C.2    Gros, P.3    Clevers, H.4
  • 50
    • 84889080287 scopus 로고    scopus 로고
    • Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin
    • Xie Y, Zamponi R, Charlat O, Ramones M, Swalley S, Jiang X, et al. Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin. EMBO Rep 2013;14:1120-6.
    • (2013) EMBO Rep , vol.14 , pp. 1120-1126
    • Xie, Y.1    Zamponi, R.2    Charlat, O.3    Ramones, M.4    Swalley, S.5    Jiang, X.6
  • 54
    • 33747891694 scopus 로고    scopus 로고
    • Impaired notch signaling promotes de novo squamous cell carcinoma formation
    • Proweller A, Tu L, Lepore JJ, Cheng L, Lu MM, Seykora J, et al. Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res 2006;66:7438-44.
    • (2006) Cancer Res , vol.66 , pp. 7438-7444
    • Proweller, A.1    Tu, L.2    Lepore, J.J.3    Cheng, L.4    Lu, M.M.5    Seykora, J.6
  • 55
    • 22344436360 scopus 로고    scopus 로고
    • p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
    • Devgan V, Mammucari C, Millar SE, Brisken C, Dotto GP. p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev 2005;19:1485-95.
    • (2005) Genes Dev , vol.19 , pp. 1485-1495
    • Devgan, V.1    Mammucari, C.2    Millar, S.E.3    Brisken, C.4    Dotto, G.P.5
  • 56
    • 84899747138 scopus 로고    scopus 로고
    • Identification of genomic alterations in oesophageal squamous cell cancer
    • Song Y, Li L, Ou Y, Gao Z, Li E, Li X, et al. Identification of genomic alterations in oesophageal squamous cell cancer. Nature 2014;509:91-5.
    • (2014) Nature , vol.509 , pp. 91-95
    • Song, Y.1    Li, L.2    Ou, Y.3    Gao, Z.4    Li, E.5    Li, X.6
  • 57
    • 84874645357 scopus 로고    scopus 로고
    • Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation
    • Morris LGT, Kaufman AM, Gong Y, Ramaswami D, Walsh LA, Turcan ?, et al. Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat Genet 2013;45:253-61.
    • (2013) Nat Genet , vol.45 , pp. 253-261
    • Morris, L.G.T.1    Kaufman, A.M.2    Gong, Y.3    Ramaswami, D.4    Walsh, L.A.5    Ş, T.6
  • 58
    • 84888363600 scopus 로고    scopus 로고
    • CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome
    • Guen VJ, Gamble C, Flajolet M, Unger S, Thollet A, Ferandin Y, et al. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Proc Natl Acad Sci U S A 2013;110: 19525-30.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 19525-19530
    • Guen, V.J.1    Gamble, C.2    Flajolet, M.3    Unger, S.4    Thollet, A.5    Ferandin, Y.6
  • 59
    • 39749126187 scopus 로고    scopus 로고
    • Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations
    • Unger S, Bohm D, Kaiser FJ, Kaulfuss S, Borozdin W, Buiting K, et al. Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations. Nat Genet 2008;40:287-9.
    • (2008) Nat Genet , vol.40 , pp. 287-289
    • Unger, S.1    Bohm, D.2    Kaiser, F.J.3    Kaulfuss, S.4    Borozdin, W.5    Buiting, K.6
  • 60
    • 84880935149 scopus 로고    scopus 로고
    • Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections
    • Tornesello ML, Buonaguro L, Tatangelo F, Botti G, Izzo F, Buonaguro FM. Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections. Genomics 2013;102:74-83.
    • (2013) Genomics , vol.102 , pp. 74-83
    • Tornesello, M.L.1    Buonaguro, L.2    Tatangelo, F.3    Botti, G.4    Izzo, F.5    Buonaguro, F.M.6
  • 61
    • 34249061491 scopus 로고    scopus 로고
    • Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
    • Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, et al. Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science 2007;316:1043-6.
    • (2007) Science , vol.316 , pp. 1043-1046
    • Major, M.B.1    Camp, N.D.2    Berndt, J.D.3    Yi, X.4    Goldenberg, S.J.5    Hubbert, C.6
  • 62
    • 12144291274 scopus 로고    scopus 로고
    • Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
    • Suzuki H, Watkins DN, Jair K-W, Schuebel KE, Markowitz SD, Chen WD, et al. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 2004;36:417-22.
    • (2004) Nat Genet , vol.36 , pp. 417-422
    • Suzuki, H.1    Watkins, D.N.2    Jair, K.-W.3    Schuebel, K.E.4    Markowitz, S.D.5    Chen, W.D.6
  • 63
    • 84893363725 scopus 로고    scopus 로고
    • Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
    • Voloshanenko O, Erdmann G, Dubash TD, Augustin I, Metzig M, Moffa G, et al. Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nat Commun 2013;4:2610.
    • (2013) Nat Commun , vol.4 , pp. 2610
    • Voloshanenko, O.1    Erdmann, G.2    Dubash, T.D.3    Augustin, I.4    Metzig, M.5    Moffa, G.6
  • 64
    • 84555189571 scopus 로고    scopus 로고
    • RNAscope: A novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues
    • Wang F, Flanagan J, Su N, Wang L-C, Bui S, Nielson A, et al. RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues. J Mol Diagn 2012;14:22-9.
    • (2012) J Mol Diagn , vol.14 , pp. 22-29
    • Wang, F.1    Flanagan, J.2    Wang, L.-C.3    Bui, S.4    Nielson, A.5
  • 66
    • 84866092742 scopus 로고    scopus 로고
    • Secreted and transmembrane wnt inhibitors and activators
    • Cruciat C-M, Niehrs C. Secreted and transmembrane wnt inhibitors and activators. Cold Spring Harb Perspect Biol 2013;5:a015081-1.
    • (2013) Cold Spring Harb Perspect Biol , vol.5 , pp. a015081-a015081
    • Cruciat, C.-M.1    Niehrs, C.2
  • 67
    • 0039174251 scopus 로고    scopus 로고
    • Secreted Frizzled-related protein-1 binds directly to wingless and is a biphasic modulator of Wnt signaling
    • Uren A, Reichsman F, Anest V, Taylor WG, Muraiso K, Bottaro DP, et al. Secreted Frizzled-related protein-1 binds directly to wingless and is a biphasic modulator of Wnt signaling. J Biol Chem 2000;275:4374-82.
    • (2000) J Biol Chem , vol.275 , pp. 4374-4382
    • Uren, A.1    Reichsman, F.2    Anest, V.3    Taylor, W.G.4    Muraiso, K.5    Bottaro, D.P.6
  • 68
    • 84886996419 scopus 로고    scopus 로고
    • Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/b-catenin signaling
    • Xavier CP, Melikova M, Chuman Y, Uren A, Baljinnyam B, Rubin JS. Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/b-catenin signaling. Cell Signal 2014;26:94-101.
    • (2014) Cell Signal , vol.26 , pp. 94-101
    • Xavier, C.P.1    Melikova, M.2    Chuman, Y.3    Uren, A.4    Baljinnyam, B.5    Rubin, J.S.6
  • 69
    • 65249167488 scopus 로고    scopus 로고
    • Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
    • Kansara M, Tsang M, Kodjabachian L, Sims NA, Trivett MK, Ehrich M, et al. Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest 2009;119:837-51.
    • (2009) J Clin Invest , vol.119 , pp. 837-851
    • Kansara, M.1    Tsang, M.2    Kodjabachian, L.3    Sims, N.A.4    Trivett, M.K.5    Ehrich, M.6
  • 70
    • 28344433041 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers
    • Taniguchi H, Yamamoto H, Hirata T, Miyamoto N, Oki M, Nosho K, et al. Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. Oncogene 2005;24:7946-52.
    • (2005) Oncogene , vol.24 , pp. 7946-7952
    • Taniguchi, H.1    Yamamoto, H.2    Hirata, T.3    Miyamoto, N.4    Oki, M.5    Nosho, K.6
  • 71
    • 77955321041 scopus 로고    scopus 로고
    • Identification of Wnt family inhibitors: A pituitary tumor directed whole genome approach
    • Elston MS, Clifton-Bligh RJ. Identification of Wnt family inhibitors: a pituitary tumor directed whole genome approach. Mol Cell Endocrinol 2010;326:48-54.
    • (2010) Mol Cell Endocrinol , vol.326 , pp. 48-54
    • Elston, M.S.1    Clifton-Bligh, R.J.2
  • 72
    • 84925812252 scopus 로고    scopus 로고
    • Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression
    • Stewart J, James J, McCluggage GW, McQuaid S, Arthur K, Boyle D, et al. Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression. Mod Pathol 2015; 28:428-36.
    • (2015) Mod Pathol , vol.28 , pp. 428-436
    • Stewart, J.1    James, J.2    McCluggage, G.W.3    McQuaid, S.4    Arthur, K.5    Boyle, D.6
  • 73
    • 84862907854 scopus 로고    scopus 로고
    • Wholeexome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
    • Wu J, Jiao Y, Dal Molin M, Maitra A, de Wilde RF, Wood LD, et al. Wholeexome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A 2011;108:21188-93.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 21188-21193
    • Wu, J.1    Jiao, Y.2    Dal Molin, M.3    Maitra, A.4    De Wilde, R.F.5    Wood, L.D.6


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