Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 31, 2013, Pages 12649-12654

  Jiang, Xiaomo ^a   Hao, Huai Xiang ^a   Growney, Joseph D ^b   Woolfenden, Steve ^b   Bottiglio, Cindy ^b   Ng, Nicholas ^c   Lu, Bo ^a   Hsieh, Mindy H ^c   Bagdasarian, Linda ^b   Meyer, Ronald ^b   Smith, Timothy R ^c   Avello, Monika ^a   Charlat, Olga ^a   Xie, Yang ^a   Porter, Jeffery A ^a   Pan, Shifeng ^c   Liu, Jun ^c   McLaughlin, Margaret E ^b   Cong, Feng ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BIOLOGICAL MARKER; DOXYCYCLINE; FRIZZLED PROTEIN; RING FINGER PROTEIN; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE E3; WNT PROTEIN;

ARTICLE; CANCER CELL; CANCER THERAPY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN HEK293; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULARLY TARGETED THERAPY; PANCREAS ADENOCARCINOMA; PANCREAS TUMOR; PATIENT SELECTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; BETA CATENIN; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CLINICAL TRIALS, PHASE I AS TOPIC; DNA-BINDING PROTEINS; FRIZZLED RECEPTORS; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MUTATION; ONCOGENE PROTEINS; PANCREATIC NEOPLASMS; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84881112879     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1307218110     Document Type: Article

References (42)

1. Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Ann Rev Cell Dev Biol 20:781-810.
2. Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127(3): 469-480.
3. MacDonald BT, Tamai K, He X (2009) Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev Cell 17(1):9-26.
4. Herr P, Hausmann G, Basler K (2012) WNT secretion and signalling in human disease. Trends Mol Med 18(8):483-493.
5. Takada R, et al. (2006) Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion. Dev Cell 11(6):791-801.
6. Anastas JN, Moon RT (2013) WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 13(1):11-26.
7. Huang SM, et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461(7264):614-620.
8. Takada K, et al. (2012) Targeted disruption of the BCL9/beta-catenin complex inhibits oncogenic Wnt signaling. Sci Transl Med 4(148):148ra117.
9. Ettenberg SA, et al. (2010) Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. Proc Natl Acad Sci USA 107(35):15473-15478.
10. Gong Y, et al. (2010) Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies. PLoS ONE 5(9):e12682.
11. Gurney A, et al. (2012) Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci USA 109(29):11717-11722.
12. Chen B, et al. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5(2):100-107.
13. Hao HX, et al. (2012) ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature 485(7397):195-200.
14. Koo BK, et al. (2012) Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature 488(7413):665-669.
15. Furukawa T, et al. (2011) Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas. Sci Rep 1:161.
16. Wu J, et al. (2011) Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci USA 108(52):21188-21193.
17. Brugge WR (2008) Management and outcomes of pancreatic cystic lesions. Dig Liver Dis 40(11):854-859.
18. Matthaei H, Schulick RD, Hruban RH, Maitra A (2011) Cystic precursors to invasive pancreatic cancer. Nat Rev Gastroenterol Hepatol 8(3):141-150.
19. Hruban RH, Maitra A, Kern SE, Goggins M (2007) Precursors to pancreatic cancer. Gastroenterol Clin North Am 36(4):831-849, vi.
20. Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA (2006) Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 20(10):1218-1249.
21. He TC, et al. (1998) Identification of c-MYC as a target of the APC pathway. Science 281(5382):1509-1512.
22. Scholer-Dahirel A, et al. (2011) Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling. Proc Natl Acad Sci USA 108(41):17135-17140.
23. Luo X, Hofmann K (2001) The protease-associated domain: A homology domain associated with multiple classes of proteases. Trends Biochem Sci 26(3):147-148.
24. Murtaugh LC, Law AC, Dor Y, Melton DA (2005) Beta-catenin is essential for pancreatic acinar but not islet development. Development 132(21):4663-4674.
25. Papadopoulou S, Edlund H (2005) Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 54(10):2844-2851.
26. Dessimoz J, Bonnard C, Huelsken J, Grapin-Botton A (2005) Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development. Curr Biol 15(18):1677-1683.
27. Wells JM, et al. (2007) Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol 7:4.
28. Heiser PW, Lau J, Taketo MM, Herrera PL, Hebrok M (2006) Stabilization of betacatenin impacts pancreas growth. Development 133(10):2023-2032.
29. Keefe MD, et al. (2012) β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice. Dis Model Mech 5(4):503-514.
30. Kopp JL, et al. (2012) Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell 22(6):737-750.
31. Guerra C, et al. (2007) Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11(3):291-302.
32. Habbe N, et al. (2008) Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci USA 105(48):18913-18918.
33. De La OJP, et al. (2008) Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci USA 105(48):18907-18912.
34. Zhu L, Shi G, Schmidt CM, Hruban RH, Konieczny SF (2007) Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol 171(1):263-273.
35. Morris JP, 4th, Wang SC, Hebrok M (2010) KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer 10(10): 683-695.
36. Al-Aynati MM, Radulovich N, Riddell RH, Tsao MS (2004) Epithelial-cadherin and betacatenin expression changes in pancreatic intraepithelial neoplasia. Clin Cancer Res 10(4):1235-1240.
37. Zeng G, et al. (2006) Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma. Neoplasia 8(4):279-289.
38. Pasca di Magliano M, et al.; Pasca di MM et al (2007) Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. PLoS ONE 2(11):e1155.
39. Wang L, et al. (2009) Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. Cancer Cell 15(3):207-219.
40. Kinde I, et al. (2013) Evaluation of DNA from the papanicolaou test to detect ovarian and endometrial cancers. Sci Transl Med 5(167):167ra4.
41. Ryland GL, et al. (2013) RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary. J Pathol 229(3):469-476.
42. Ong CK, et al. (2012) Exome sequencing of liver fluke-associated cholangiocarcinoma. Nat Genet 44(6):690-693.