Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

EMBO Reports

Volumn 14, Issue 12, 2013, Pages 1120-1126

  Xie, Yang ^a   Zamponi, Raffaella ^a   Charlat, Olga ^a   Ramones, Melissa ^a   Swalley, Susanne ^a   Jiang, Xiaomo ^a   Rivera, Daniel ^a   Tschantz, William ^a   Lu, Bo ^a   Quinn, Lisa ^a   Dimitri, Chris ^a   Parker, Jefferson ^a   Jeffery, Doug ^a   Wilcox, Sheri K ^b   Watrobka, Mike ^b   Lemotte, Peter ^a   Granda, Brian ^a   Porter, Jeffrey A ^a   Myer, Vic E ^a   Loew, Andreas ^a   Cong, Feng ^a,c   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b SomaLogic Inc   (United States)

^c Forma Therapeutics   (United States)

Author keywords

LGR4; R spondin; RNF43; Wnt; ZNRF3

Indexed keywords

LGR4 PROTEIN; MEMBRANE PROTEIN; R SPONDIN PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; WNT PROTEIN; ZNRF3 PROTEIN; G PROTEIN COUPLED RECEPTOR; LGR4 PROTEIN, HUMAN; PROTEIN BINDING; RSPO1 PROTEIN, HUMAN; THROMBOSPONDIN; UBIQUITIN PROTEIN LIGASE; ZINC AND RING FINGER 3 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; BINDING SITE; CHEMISTRY; HEK293 CELL LINE; METABOLISM; WNT SIGNALING PATHWAY;

AMINO ACID MOTIFS; BINDING SITES; HEK293 CELLS; HUMANS; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; THROMBOSPONDINS; UBIQUITIN-PROTEIN LIGASES; WNT SIGNALING PATHWAY;

EID: 84889080287     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2013.167     Document Type: Article

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