Inverse susceptibility to oxidative death of lymphocytes obtained from Alzheimer's patients and skin cancer survivors: Increased apoptosis in Alzheimer's and reduced necrosis in cancer

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 67 A, Issue 10, 2012, Pages 1036-1040

  Behrens, Maria I ^a,b,c   Silva, Monica ^b   Salech, Felipe ^d   Ponce, Daniela P ^d   Merino, Daniela ^a   Sinning, Mariana ^a,c   Xiong, Chengjie ^e,f   Roe, Catherine M ^e,g   Quest, Andrew F G ^b,d  

^a HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSIDAD DEL DESARROLLO   (Chile)

^d UNIVERSITY OF CHILE   (Chile)

^e Division of Biostatistics ^*  (Chile)

^f Division of Biostatistics   (Chile)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer; Apoptosis; Cancer; Cell death; Necrosis

Indexed keywords

3 AMINOBENZAMIDE; 3-AMINOBENZAMIDE; BENZAMIDE DERIVATIVE; ENZYME INHIBITOR; HYDROGEN PEROXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARP1 PROTEIN, HUMAN;

AGED; AGING; ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; CASE CONTROL STUDY; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; HUMAN; IN VITRO STUDY; LYMPHOCYTE; MALE; METABOLISM; MIDDLE AGED; NECROSIS; OXIDATIVE STRESS; PATHOLOGY; SKIN TUMOR;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; APOPTOSIS; BENZAMIDES; CASE-CONTROL STUDIES; CELL SURVIVAL; ENZYME INHIBITORS; FEMALE; HUMANS; HYDROGEN PEROXIDE; LYMPHOCYTES; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; NECROSIS; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; SKIN NEOPLASMS;

EID: 84866120008     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glr258     Document Type: Article

References (31)

1. Selkoe DJ. Alzheimer's disease. Cold Spring Harb Perspect Biol. 2011; 3(7).
2. Martin GM. The 2008 American Federation For Aging Annual Research Conference: aging and cancer: two sides of the same coin? J Gerontol A Biol Sci Med Sci. 2009;64(6):615-617.
3. Tirumalasetti F, Han L, Birkett DP. The relationship between cancer and Alzheimer's disease. J Am Geriatr Soc. 1991;39(8):840.
4. DeSouky AL. The relationship between cancer and Alzheimer's disease. J Am Geriatr Soc. 1992;40(10):1075.
5. Yamada M, Sasaki H, Mimori Y, et al. Prevalence and risks of dementia in the Japanese population: RERF's adult health study Hiroshima subjects. Radiation Effects Research Foundation. J Am Geriatr Soc. 1999;47(2):189-195. (Pubitemid 29082719)
6. Roe CM, Behrens MI, Xiong C, Miller JP, Morris JC. Alzheimer disease and cancer. Neurology. 2005;64(5):895-898. (Pubitemid 40316334)
7. Roe CM, Fitzpatrick AL, Xiong C, et al. Cancer linked to Alzheimer disease but not vascular dementia. Neurology. 2010;74(2):106-112.
8. Mao P, Reddy PH. Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: implications for early intervention and therapeutics. Biochim Biophys Acta. 2011;1812(11):1359-1370.
9. Behrens MI, Lendon C, Roe CM. A common biological mechanism in cancer and Alzheimer's disease? Curr Alzheimer Res. 2009;6(3): 196-204.
10. Behrens MI, Roe CM, Quest AFG, Morris JC. Is there a link between dementia and cancer. J Aging Health. 2010;6(3):361-364.
11. Li T, Wen H, Brayton C, et al. Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci. 2007;27(40):10849-10859. (Pubitemid 47535873)
12. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939-944. (Pubitemid 14076461)
13. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43(11):2412-2414. (Pubitemid 23346995)
14. Behrens MI, Silva M, Schmied A, et al. Age-dependent increases in apoptosis/necrosis ratios in human lymphocytes exposed to oxidative stress. J Gerontol A Biol Sci Med Sci. 2011;66(7):732-740.
15. Tabares-Seisdedos R, Dumont N, Baudot A, et al. No paradox, no progress: inverse cancer comorbidity in people with other complex diseases. Lancet Oncol. 2011;12(6):604-608.
16. Kim MY, Zhang T, Kraus WL. Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal. Genes Dev. 2005;19(17): 1951-1967.
17. Artus C, Boujrad H, Bouharrour A, et al. AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J. 2010;29(9):1585-1599.
18. Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA. Histone H2AX: the missing link in AIF-mediated caspase-independent programmed necrosis. Cell Cycle. 2010;9(16):3166-3173.
19. Wang Y, Kim NS, Haince JF, et al. Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal. 2011;4(167):ra20.
20. Cregan SP, Dawson VL, Slack RS. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene. 2004;23(16):2785-2796. (Pubitemid 38638842)
21. Boujrad H, Gubkina O, Robert N, Krantic S, Susin SA. AIF-mediated programmed necrosis: a highly regulated way to die. Cell Cycle. 2007;6(21):2612-2619. (Pubitemid 350224042)
22. Andrabi SA, Dawson TM, Dawson VL. Mitochondrial and nuclear cross talk in cell death: parthanatos. Ann N Y Acad Sci. 2008;1147: 233-241.
23. Calvert H, Azzariti A. The clinical development of inhibitors of poly(ADP-ribose) polymerase. Ann Oncol. 2011;22(suppl 1):i53-i59.
24. Siegel C, McCullough LD. NAD+ depletion or PAR polymer formation: which plays the role of executioner in ischaemic cell death? Acta Physiol (Oxf). 2011;203(1):225-234.
25. Abeti R, Abramov AY, Duchen MR. Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. Brain. 2011;134(Pt 6):1658-1672.
26. Burstein HJ. Novel agents and future directions for refractory breast cancer. Semin Oncol. 2011;38(suppl 2):S17-S24.
27. Liu HP, Lin WY, Wu BT, et al. Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease. J Clin Lab Anal. 2010;24(3):182-186.
28. Mao P, Reddy PH. Is multiple sclerosis a mitochondrial disease? Bio-chim Biophys Acta. 2010;1802(1):66-79.
29. Eskelinen EL, Saftig P. Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta. 2009;1793(4):664-673.
30. Tsujimoto Y, Shimizu S. Another way to die: autophagic programmed cell death. Cell Death Differ. 2005;12(suppl 2):1528-1534. (Pubitemid 41553989)
31. Troncoso R, Vicencio JM, Parra V, et al. Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc Res. 2011 Dec 29. [Epub ahead of print].