메뉴 건너뛰기




Volumn 1, Issue DEC, 2009, Pages

Resveratrol preserves cerebrovascular density and cognitive function in aging mice

Author keywords

Aging; Antioxidant; Cerebrovascular system; Cholinergic system; French paradox; Maze learning; Microvessels; Resveratrol

Indexed keywords


EID: 79960215837     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/neuro.24.004.2009     Document Type: Article
Times cited : (104)

References (69)
  • 1
    • 34250860632 scopus 로고    scopus 로고
    • Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons
    • Alvira, D., Yeste-Velasco, M., Folch, J., Verdaguer, E., Canudas, A. M., Pallas, M., and Camins, A. (2007). Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons. Neuroscience 147, 746-756.
    • (2007) Neuroscience , vol.147 , pp. 746-756
    • Alvira, D.1    Yeste-Velasco, M.2    Folch, J.3    Verdaguer, E.4    Canudas, A.M.5    Pallas, M.6    Camins, A.7
  • 2
    • 0028852719 scopus 로고
    • Effect of long-term treatment with the dihydropyridine-type calcium channel blocker darodipine (PY 108-068) on the cerebral capillary network in aged rats
    • Amenta, F., Ferrante, F., Mancini, M., Sabbatini, M., Vega, J. A., and Zaccheo, D. (1995). Effect of long-term treatment with the dihydropyridine-type calcium channel blocker darodipine (PY 108-068) on the cerebral capillary network in aged rats. Mech. Ageing Dev. 78, 27-37.
    • (1995) Mech. Ageing Dev. , vol.78 , pp. 27-37
    • Amenta, F.1    Ferrante, F.2    Mancini, M.3    Sabbatini, M.4    Vega, J.A.5    Zaccheo, D.6
  • 5
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: the in vivo evidence
    • Baur, J. A., and Sinclair, D. A. (2006). Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 5, 493-506.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 7
    • 0028350718 scopus 로고
    • Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders
    • Buee, L., Hof, P. R., Bouras, C., Delacourte, A., Perl, D. P., Morrison, J. H., and Fillit, H. M. (1994). Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders. Acta Neuropathol. 87, 469-480.
    • (1994) Acta Neuropathol , vol.87 , pp. 469-480
    • Buee, L.1    Hof, P.R.2    Bouras, C.3    Delacourte, A.4    Perl, D.P.5    Morrison, J.H.6    Fillit, H.M.7
  • 8
    • 0019853779 scopus 로고
    • Changes with age in cerebral capillary morphology
    • Burns, E. M., Kruckeberg, T. W., and Gaetano, P. K. (1981). Changes with age in cerebral capillary morphology. Neurobiol. Aging 2, 283-291.
    • (1981) Neurobiol. Aging , vol.2 , pp. 283-291
    • Burns, E.M.1    Kruckeberg, T.W.2    Gaetano, P.K.3
  • 9
    • 4143140856 scopus 로고    scopus 로고
    • trans-3,4 5'-Trihydroxystibene inhibits hypoxiainducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells
    • Cao, Z., Fang, J., Xia, C., Shi, X., and Jiang, B. H. (2004). trans-3,4,5'-Trihydroxystibene inhibits hypoxiainducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells. Clin. Cancer Res. 10, 5253-5263.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5253-5263
    • Cao, Z.1    Fang, J.2    Xia, C.3    Shi, X.4    Jiang, B.H.5
  • 10
    • 28844474597 scopus 로고    scopus 로고
    • SIRT1 protects against microglia-dependent amyloidbeta toxicity through inhibiting NFkappaB signaling
    • Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L. F., Kwon, H., Yi, S., Mucke, L., and Gan, L. (2005). SIRT1 protects against microglia-dependent amyloidbeta toxicity through inhibiting NFkappaB signaling. J. Biol. Chem. 280, 40364-40374.
    • (2005) J. Biol. Chem. , vol.280 , pp. 40364-40374
    • Chen, J.1    Zhou, Y.2    Mueller-Steiner, S.3    Chen, L.F.4    Kwon, H.5    Yi, S.6    Mucke, L.7    Gan, L.8
  • 11
    • 0023472509 scopus 로고
    • Neuron numbers and dendritic extent in normal aging and Alzheimer's disease
    • Coleman, P. D., and Flood, D. G. (1987). Neuron numbers and dendritic extent in normal aging and Alzheimer's disease. Neurobiol. Aging 8, 521-545.
    • (1987) Neurobiol. Aging , vol.8 , pp. 521-545
    • Coleman, P.D.1    Flood, D.G.2
  • 13
    • 19444364321 scopus 로고    scopus 로고
    • Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption: a potential mechanism for resveratrol preconditioning of the heart
    • Das, S., Alagappan, V. K., Bagchi, D., Sharma, H. S., Maulik, N., and Das, D. K. (2005). Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption: a potential mechanism for resveratrol preconditioning of the heart. Vascul. Pharmacol. 42, 281-289.
    • (2005) Vascul. Pharmacol. , vol.42 , pp. 281-289
    • Das, S.1    Alagappan, V.K.2    Bagchi, D.3    Sharma, H.S.4    Maulik, N.5    Das, D.K.6
  • 14
    • 0030660255 scopus 로고    scopus 로고
    • Cerebrovascular hypoperfusion: a risk factor for Alzheimer's disease? Animal model and postmortem human studies
    • De Jong, G. I., De Vos, R. A., Steur, E. N., and Luiten, P. G. (1997). Cerebrovascular hypoperfusion: a risk factor for Alzheimer's disease? Animal model and postmortem human studies. Ann. N. Y. Acad. Sci. 826, 56-74.
    • (1997) Ann. N. Y. Acad. Sci. , vol.826 , pp. 56-74
    • De Jong, G.I.1    De Vos, R.A.2    Steur, E.N.3    Luiten, P.G.4
  • 15
    • 0037199790 scopus 로고    scopus 로고
    • The effect of n-3 polyunsaturated fatty acid-rich diets on cognitive and cerebrovascular parameters in chronic cerebral hypoperfusion
    • de Wilde, M. C., Farkas, E., Gerrits, M., Kiliaan, A. J., and Luiten, P. G. (2002). The effect of n-3 polyunsaturated fatty acid-rich diets on cognitive and cerebrovascular parameters in chronic cerebral hypoperfusion. Brain Res. 947, 166-173.
    • (2002) Brain Res , vol.947 , pp. 166-173
    • de Wilde, M.C.1    Farkas, E.2    Gerrits, M.3    Kiliaan, A.J.4    Luiten, P.G.5
  • 16
    • 49749094366 scopus 로고    scopus 로고
    • Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors
    • Dong, W., Li, N., Gao, D., Zhen, H., Zhang, X., and Li, F. (2008). Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors. J. Vasc. Surg. 48, 709-714.
    • (2008) J. Vasc. Surg. , vol.48 , pp. 709-714
    • Dong, W.1    Li, N.2    Gao, D.3    Zhen, H.4    Zhang, X.5    Li, F.6
  • 17
    • 0037240518 scopus 로고    scopus 로고
    • The neurobiology of memory changes in normal aging
    • Erickson, C. A., and Barnes, C. A. (2003). The neurobiology of memory changes in normal aging. Exp. Gerontol. 38, 61-69.
    • (2003) Exp. Gerontol. , vol.38 , pp. 61-69
    • Erickson, C.A.1    Barnes, C.A.2
  • 18
    • 0034603411 scopus 로고    scopus 로고
    • Are Alzheimer's disease, hypertension, and cerebrocapillary damage related?
    • Farkas, E., De Vos, R. A., Jansen Steur, E. N., and Luiten, P. G. (2000). Are Alzheimer's disease, hypertension, and cerebrocapillary damage related? Neurobiol. Aging 21, 235-243.
    • (2000) Neurobiol Aging , vol.21 , pp. 235-243
    • Farkas, E.1    De Vos, R.A.2    Jansen Steur, E.N.3    Luiten, P.G.4
  • 19
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • Farkas, E., and Luiten, P. G. (2001). Cerebral microvascular pathology in aging and Alzheimer's disease. Prog. Neurobiol. 64, 575-611.
    • (2001) Prog. Neurobiol. , vol.64 , pp. 575-611
    • Farkas, E.1    Luiten, P.G.2
  • 20
    • 33947646259 scopus 로고    scopus 로고
    • Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases
    • Farkas, E., Luiten, P. G., and Bari, F. (2007). Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res. Rev. 54, 162-180.
    • (2007) Brain Res. Rev , vol.54 , pp. 162-180
    • Farkas, E.1    Luiten, P.G.2    Bari, F.3
  • 21
    • 0037701180 scopus 로고    scopus 로고
    • Beta-amyloid peptide-induced blood-brain barrier disruption facilitates T-cell entry into the rat brain
    • Farkas, I. G., Czigner, A., Farkas, E., Dobo, E., Soos, K., Penke, B., Endresz, V., and Mihaly, A. (2003). Beta-amyloid peptide-induced blood-brain barrier disruption facilitates T-cell entry into the rat brain. Acta Histochem. 105, 115-125.
    • (2003) Acta Histochem , vol.105 , pp. 115-125
    • Farkas, I.G.1    Czigner, A.2    Farkas, E.3    Dobo, E.4    Soos, K.5    Penke, B.6    Endresz, V.7    Mihaly, A.8
  • 22
    • 0027319292 scopus 로고
    • Endotheliumdependent vasorelaxing activity of wine and other grape products
    • Fitzpatrick, D. F., Hirschfield, S. L., and Coffey, R. G. (1993). Endotheliumdependent vasorelaxing activity of wine and other grape products. Am. J. Physiol. 265, H774-778.
    • (1993) Am. J. Physiol. , vol.265
    • Fitzpatrick, D.F.1    Hirschfield, S.L.2    Coffey, R.G.3
  • 23
    • 0027447124 scopus 로고
    • Inhibition of human LDL oxidation by resveratrol
    • Frankel, E. N., Waterhouse, A. L., and Kinsella, J. E. (1993). Inhibition of human LDL oxidation by resveratrol. Lancet 341, 1103-1104.
    • (1993) Lancet , vol.341 , pp. 1103-1104
    • Frankel, E.N.1    Waterhouse, A.L.2    Kinsella, J.E.3
  • 24
    • 0034645693 scopus 로고    scopus 로고
    • Biological effects of resveratrol
    • Fremont, L. (2000). Biological effects of resveratrol. Life Sci. 66, 663-673.
    • (2000) Life Sci , vol.66 , pp. 663-673
    • Fremont, L.1
  • 25
    • 0033591299 scopus 로고    scopus 로고
    • Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids
    • Fremont, L., Belguendouz, L., and Delpal, S. (1999). Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci. 64, 2511-2521.
    • (1999) Life Sci , vol.64 , pp. 2511-2521
    • Fremont, L.1    Belguendouz, L.2    Delpal, S.3
  • 26
    • 0031444281 scopus 로고    scopus 로고
    • Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor
    • Gehm, B. D., McAndrews, J. M., Chien, P. Y., and Jameson, J. L. (1997). Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. U.S.A. 94, 14138-14143.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 14138-14143
    • Gehm, B.D.1    McAndrews, J.M.2    Chien, P.Y.3    Jameson, J.L.4
  • 27
    • 28444471173 scopus 로고    scopus 로고
    • Glucose and age-related changes in memory
    • Gold, P. E. (2005). Glucose and age-related changes in memory. Neurobiol. Aging 26(Suppl. 1), 60-64.
    • (2005) Neurobiol. Aging , vol.26 , Issue.SUPPL. 1 , pp. 60-64
    • Gold, P.E.1
  • 28
    • 34249932116 scopus 로고    scopus 로고
    • Regional differences in hippocampal PKA immunoreactivity after training and reversal training in a spatial Y-maze task
    • Havekes, R., Timmer, M., and Van der Zee, E. A. (2007). Regional differences in hippocampal PKA immunoreactivity after training and reversal training in a spatial Y-maze task. Hippocampus 17, 338-348.
    • (2007) Hippocampus , vol.17 , pp. 338-348
    • Havekes, R.1    Timmer, M.2    Van der Zee, E.A.3
  • 29
    • 0021997441 scopus 로고
    • A modifi ed histochemical technique to visualize acetylcholinesterase-containing axons
    • Hedreen, J. C., Bacon, S. J., and Price, D. L. (1985). A modifi ed histochemical technique to visualize acetylcholinesterase-containing axons. J. Histochem. Cytochem. 33, 134-140.
    • (1985) J. Histochem. Cytochem. , vol.33 , pp. 134-140
    • Hedreen, J.C.1    Bacon, S.J.2    Price, D.L.3
  • 31
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola, C. (2004). Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat. Rev. Neurosci. 5, 347-360.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 32
    • 0035964450 scopus 로고    scopus 로고
    • Resveratrol and quercetin inhibit angiogenesis in vitro
    • Igura, K., Ohta, T., Kuroda, Y., and Kaji, K. (2001). Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 171, 11-16.
    • (2001) Cancer Lett , vol.171 , pp. 11-16
    • Igura, K.1    Ohta, T.2    Kuroda, Y.3    Kaji, K.4
  • 34
    • 0033090615 scopus 로고    scopus 로고
    • Relaxant effect of trans-resveratrol on isolated porcine coronary arteries
    • Jager, U., and Nguyen-Duong, H. (1999). Relaxant effect of trans-resveratrol on isolated porcine coronary arteries. Arzneimittelforschung 49, 207-211.
    • (1999) Arzneimittelforschung , vol.49 , pp. 207-211
    • Jager, U.1    Nguyen-Duong, H.2
  • 35
    • 0037446328 scopus 로고    scopus 로고
    • Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death
    • Jang, J. H. and Surh, Y. J. (2003). Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death. Free Radic. Biol. Med. 34, 1100-1110.
    • (2003) Free Radic. Biol. Med. , vol.34 , pp. 1100-1110
    • Jang, J.H.1    Surh, Y.J.2
  • 37
    • 0033769915 scopus 로고    scopus 로고
    • Capillary changes in hippocampal CA1 and CA3 areas of the aging rhesus monkey
    • Keuker, J. I., Luiten, P. G., and Fuchs, E. (2000). Capillary changes in hippocampal CA1 and CA3 areas of the aging rhesus monkey. Acta Neuropathol. 100, 665-672.
    • (2000) Acta Neuropathol , vol.100 , pp. 665-672
    • Keuker, J.I.1    Luiten, P.G.2    Fuchs, E.3
  • 39
    • 33744475759 scopus 로고    scopus 로고
    • Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
    • Kolthur-Seetharam, U., Dantzer, F., McBurney, M. W., de Murcia, G., and Sassone-Corsi, P. (2006). Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle 5, 873-877.
    • (2006) Cell Cycle , vol.5 , pp. 873-877
    • Kolthur-Seetharam, U.1    Dantzer, F.2    McBurney, M.W.3    de Murcia, G.4    Sassone-Corsi, P.5
  • 40
    • 0031839670 scopus 로고    scopus 로고
    • Resveratrol, a phytoestrogen found in red wine A possible explanation for the conundrum of the 'French paradox'?
    • Kopp, P. (1998). Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? Eur. J. Endocrinol. 138, 619-620.
    • (1998) Eur. J. Endocrinol. , vol.138 , pp. 619-620
    • Kopp, P.1
  • 41
    • 33645958280 scopus 로고    scopus 로고
    • Vascular dysfunction in aging: potential effects of resveratrol, an anti-infl ammatory phytoestrogen
    • Labinskyy, N., Csiszar, A., Veress, G., Stef, G., Pacher, P., Oroszi, G., Wu, J., and Ungvari, Z. (2006). Vascular dysfunction in aging: potential effects of resveratrol, an anti-infl ammatory phytoestrogen. Curr. Med. Chem. 13, 989-996.
    • (2006) Curr. Med. Chem. , vol.13 , pp. 989-996
    • Labinskyy, N.1    Csiszar, A.2    Veress, G.3    Stef, G.4    Pacher, P.5    Oroszi, G.6    Wu, J.7    Ungvari, Z.8
  • 42
    • 0342615044 scopus 로고    scopus 로고
    • Ultrastructural changes in microvessel with age in the hippocampus of senescence-accelerated mouse (SAM)-P/10
    • Lee, E. Y., Lee, S. Y., Lee, T. S., Chi, J. G., Choi, W., and Suh, Y. H. (2000). Ultrastructural changes in microvessel with age in the hippocampus of senescence-accelerated mouse (SAM)-P/10. Exp. Aging Res. 26, 3-14.
    • (2000) Exp. Aging Res. , vol.26 , pp. 3-14
    • Lee, E.Y.1    Lee, S.Y.2    Lee, T.S.3    Chi, J.G.4    Choi, W.5    Suh, Y.H.6
  • 43
    • 33646526704 scopus 로고    scopus 로고
    • Neuroprotective effects of resveratrol on cerebral ischemiainduced neuron loss mediated by free radical scavenging and cerebral blood fl ow elevation
    • Lu, K. T., Chiou, R. Y., Chen, L. G., Chen, M. H., Tseng, W. T., Hsieh, H. T., and Yang, Y. L. (2006). Neuroprotective effects of resveratrol on cerebral ischemiainduced neuron loss mediated by free radical scavenging and cerebral blood fl ow elevation. J. Agric. Food Chem. 54, 3126-3131.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 3126-3131
    • Lu, K.T.1    Chiou, R.Y.2    Chen, L.G.3    Chen, M.H.4    Tseng, W.T.5    Hsieh, H.T.6    Yang, Y.L.7
  • 44
    • 0032831782 scopus 로고    scopus 로고
    • Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood fl ow in aged rats
    • Lynch, C. D., Cooney, P. T., Bennett, S. A., Thornton, P. L., Khan, A. S., Ingram, R. L., and Sonntag, W. E. (1999). Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood fl ow in aged rats. Neurobiol. Aging 20, 191-200.
    • (1999) Neurobiol. Aging , vol.20 , pp. 191-200
    • Lynch, C.D.1    Cooney, P.T.2    Bennett, S.A.3    Thornton, P.L.4    Khan, A.S.5    Ingram, R.L.6    Sonntag, W.E.7
  • 45
    • 33746054173 scopus 로고    scopus 로고
    • Cigarette smoke exposure impairs VEGF-induced endothelial cell migration: role of NO and reactive oxygen species
    • Michaud, S. E., Dussault, S., Groleau, J., Haddad, P., and Rivard, A. (2006). Cigarette smoke exposure impairs VEGF-induced endothelial cell migration: role of NO and reactive oxygen species. J. Mol. Cell. Cardiol. 41, 275-284.
    • (2006) J. Mol. Cell. Cardiol. , vol.41 , pp. 275-284
    • Michaud, S.E.1    Dussault, S.2    Groleau, J.3    Haddad, P.4    Rivard, A.5
  • 46
    • 0035175365 scopus 로고    scopus 로고
    • Protective effect of resveratrol on oxidative damage in male and female stroke-prone spontaneously hypertensive rats
    • Mizutani, K., Ikeda, K., Kawai, Y., and Yamori, Y. (2001). Protective effect of resveratrol on oxidative damage in male and female stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 28, 55-59.
    • (2001) Clin. Exp. Pharmacol. Physiol. , vol.28 , pp. 55-59
    • Mizutani, K.1    Ikeda, K.2    Kawai, Y.3    Yamori, Y.4
  • 47
    • 33845942205 scopus 로고    scopus 로고
    • Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
    • Okawara, M., Katsuki, H., Kurimoto, E., Shibata, H., Kume, T., and Akaike, A. (2007). Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochem. Pharmacol. 73, 550-560.
    • (2007) Biochem. Pharmacol. , vol.73 , pp. 550-560
    • Okawara, M.1    Katsuki, H.2    Kurimoto, E.3    Shibata, H.4    Kume, T.5    Akaike, A.6
  • 52
    • 5444251163 scopus 로고    scopus 로고
    • Growth hormone treatment 936. attenuates age-related changes in hippocampal short-term plasticity and spatial learning
    • Ramsey, M. M., Weiner, J. L., Moore, T. P., Carter, C. S., and Sonntag, W. E. (2004). Growth hormone treatment 936. attenuates age-related changes in hippocampal short-term plasticity and spatial learning. Neuroscience 129, 119-127.
    • (2004) Neuroscience , vol.129 , pp. 119-127
    • Ramsey, M.M.1    Weiner, J.L.2    Moore, T.P.3    Carter, C.S.4    Sonntag, W.E.5
  • 54
    • 0026651085 scopus 로고
    • Wine, alcohol, platelets, and the French paradox for coronary heart disease
    • Renaud, S., and de Lorgeril, M. (1992). Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339, 1523-1526.
    • (1992) Lancet , vol.339 , pp. 1523-1526
    • Renaud, S.1    de Lorgeril, M.2
  • 56
    • 56349157854 scopus 로고    scopus 로고
    • Benefi ts from dietary polyphenols for brain aging and Alzheimer's disease
    • Rossi, L., Mazzitelli, S., Arciello, M., Capo, C. R., and Rotilio, G. (2008). Benefi ts from dietary polyphenols for brain aging and Alzheimer's disease. Neurochem. Res. 33, 2390-2400.
    • (2008) Neurochem. Res. , vol.33 , pp. 2390-2400
    • Rossi, L.1    Mazzitelli, S.2    Arciello, M.3    Capo, C.R.4    Rotilio, G.5
  • 57
    • 34249720541 scopus 로고    scopus 로고
    • Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats
    • Rush, J. W., Quadrilatero, J., Levy, A. S. and Ford, R. J. (2007). Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats. Exp. Biol. Med. 232, 814-822.
    • (2007) Exp. Biol. Med. , vol.232 , pp. 814-822
    • Rush, J.W.1    Quadrilatero, J.2    Levy, A.S.3    Ford, R.J.4
  • 58
    • 0034523517 scopus 로고    scopus 로고
    • The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing
    • Sonntag, W. E., Lynch, C., Thornton, P., Khan, A., Bennett, S., and Ingram, R. (2000). The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing. J. Anat. 197(Pt 4) 575-585.
    • (2000) J. Anat. , vol.197 , Issue.PART 4 , pp. 575-585
    • Sonntag, W.E.1    Lynch, C.2    Thornton, P.3    Khan, A.4    Bennett, S.5    Ingram, R.6
  • 59
    • 0030795556 scopus 로고    scopus 로고
    • Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1
    • Sonntag, W. E., Lynch, C. D., Cooney, P. T., and Hutchins, P. M. (1997). Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1. Endocrinology 138, 3515-3520.
    • (1997) Endocrinology , vol.138 , pp. 3515-3520
    • Sonntag, W.E.1    Lynch, C.D.2    Cooney, P.T.3    Hutchins, P.M.4
  • 60
    • 0344826082 scopus 로고    scopus 로고
    • Prevention of age-related spatial memory defi cits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment
    • Stackman, R. W., Eckenstein, F., Frei, B., Kulhanek, D., Nowlin, J., and Quinn, J. F. (2003). Prevention of age-related spatial memory defi cits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment. Exp. Neurol. 184, 510-520.
    • (2003) Exp. Neurol. , vol.184 , pp. 510-520
    • Stackman, R.W.1    Eckenstein, F.2    Frei, B.3    Kulhanek, D.4    Nowlin, J.5    Quinn, J.F.6
  • 61
    • 33748509090 scopus 로고    scopus 로고
    • Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance
    • Stef, G., Csiszar, A., Lerea, K., Ungvari, Z., and Veress, G. (2006). Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance. J. Cardiovasc. Pharmacol. 48, 1-5.
    • (2006) J. Cardiovasc. Pharmacol. , vol.48 , pp. 1-5
    • Stef, G.1    Csiszar, A.2    Lerea, K.3    Ungvari, Z.4    Veress, G.5
  • 62
    • 0037143657 scopus 로고    scopus 로고
    • CD40 ligand inhibits endothelial cell migration by increasing production of endothelial reactive oxygen species
    • Urbich, C., Dernbach, E., Aicher, A., Zeiher, A. M., and Dimmeler, S. (2002). CD40 ligand inhibits endothelial cell migration by increasing production of endothelial reactive oxygen species. Circulation 106, 981-986.
    • (2002) Circulation , vol.106 , pp. 981-986
    • Urbich, C.1    Dernbach, E.2    Aicher, A.3    Zeiher, A.M.4    Dimmeler, S.5
  • 63
    • 67949114536 scopus 로고    scopus 로고
    • Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis
    • Van der Borght, K., Kobor-Nyakas, D. E., Klauke, K., Eggen, B. J., Nyakas, C., Van der Zee, E. A., and Meerlo, P. (2009). Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis. Hippocampus 19, 928-936.
    • (2009) Hippocampus , vol.19 , pp. 928-936
    • Van der Borght, K.1    Kobor-Nyakas, D.E.2    Klauke, K.3    Eggen, B.J.4    Nyakas, C.5    Van der Zee, E.A.6    Meerlo, P.7
  • 64
    • 0033993607 scopus 로고    scopus 로고
    • Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats
    • Virgili, M., and Contestabile, A. (2000). Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats. Neurosci. Lett. 281, 123-126.
    • (2000) Neurosci. Lett. , vol.281 , pp. 123-126
    • Virgili, M.1    Contestabile, A.2
  • 65
    • 0037184675 scopus 로고    scopus 로고
    • Resveratrol protects against global cerebral ischemic injury in gerbils
    • Wang, Q., Xu, J., Rottinghaus, G. E., Simonyi, A., Lubahn, D., Sun, G. Y., and Sun, A. Y. (2002). Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res. 958, 439-447.
    • (2002) Brain Res , vol.958 , pp. 439-447
    • Wang, Q.1    Xu, J.2    Rottinghaus, G.E.3    Simonyi, A.4    Lubahn, D.5    Sun, G.Y.6    Sun, A.Y.7
  • 66
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., and Sinclair, D. (2004). Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686-689.
    • (2004) Nature , vol.430 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3    Howitz, K.4    Helfand, S.L.5    Tatar, M.6    Sinclair, D.7
  • 67
    • 0035405365 scopus 로고    scopus 로고
    • Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review)
    • Wu, J. M., Wang, Z. R., Hsieh, T. C., Bruder, J. L., Zou, J. G. and Huang, Y. Z. (2001). Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review). Int. J. Mol. Med. 8, 3-17.
    • (2001) Int. J. Mol. Med. , vol.8 , pp. 3-17
    • Wu, J.M.1    Wang, Z.R.2    Hsieh, T.C.3    Bruder, J.L.4    Zou, J.G.5    Huang, Y.Z.6
  • 68
    • 44949127922 scopus 로고    scopus 로고
    • Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation
    • Zhang, H., Schools, G. P., Lei, T., Wang, W., Kimelberg, H. K., and Zhou, M. (2008). Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation. Exp. Neurol. 212, 44-52.
    • (2008) Exp. Neurol. , vol.212 , pp. 44-52
    • Zhang, H.1    Schools, G.P.2    Lei, T.3    Wang, W.4    Kimelberg, H.K.5    Zhou, M.6
  • 69
    • 38149090292 scopus 로고    scopus 로고
    • The bloodbrain barrier in health and chronic neurodegenerative disorders
    • Zlokovic, B. V. (2008). The bloodbrain barrier in health and chronic neurodegenerative disorders. Neuron 57, 178-201.
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.