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Volumn 65 A, Issue 11, 2010, Pages 1145-1156

Vasoprotective effects of life span-extending peripubertal GH replacement in lewis dwarf rats

Author keywords

GH deficiency; GH replacement; IGF 1 deficiency; Oxidative stress; Vasoprotection

Indexed keywords

RATTUS;

EID: 77958061482     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glq147     Document Type: Article
Times cited : (42)

References (51)
  • 1
    • 0025333249 scopus 로고
    • Premature mortality due to cardiovascular disease in hypopituitarism
    • Rosen T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet. 1990;336(8710):285-288.
    • (1990) Lancet , vol.336 , Issue.8710 , pp. 285-288
    • Rosen, T.1    Bengtsson, B.A.2
  • 4
    • 0035835469 scopus 로고    scopus 로고
    • Association between premature mortality and hypopituitarism
    • West Midlands Prospective Hypo-pituitary Study Group
    • Tomlinson JW, Holden N, Hills RK, et al. Association between premature mortality and hypopituitarism. West Midlands Prospective Hypo-pituitary Study Group. Lancet. 2001;357(9254):425-431.
    • (2001) Lancet , vol.357 , Issue.9254 , pp. 425-431
    • Tomlinson, J.W.1    Holden, N.2    Hills, R.K.3
  • 5
    • 0142056143 scopus 로고    scopus 로고
    • Serum insulin-like growth factor i and risk for heart failure in elderly individuals without a previous myocardial infarction: The Framingham Heart Study
    • Vasan RS, Sullivan LM, D'Agostino RB, et al. Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study. Ann Intern Med. 2003;139(8):642-648.
    • (2003) Ann Intern Med , vol.139 , Issue.8 , pp. 642-648
    • Vasan, R.S.1    Sullivan, L.M.2    D'Agostino, R.B.3
  • 6
    • 0842291511 scopus 로고    scopus 로고
    • The prospective association of serum insulin-like growth factor i (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: The Rancho Bernardo Study
    • Laughlin GA, Barrett-Connor E, Criqui MH, Kritz-Silverstein D. The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study. J Clin Endocrinol Metab. 2004;89(1):114-120.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.1 , pp. 114-120
    • Laughlin, G.A.1    Barrett-Connor, E.2    Criqui, M.H.3    Kritz-Silverstein, D.4
  • 8
    • 0035811073 scopus 로고    scopus 로고
    • Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
    • Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci \USA. 2001;98(12):6736-6741.
    • (2001) Proc Natl Acad Sci \USA , vol.98 , Issue.12 , pp. 6736-6741
    • Flurkey, K.1    Papaconstantinou, J.2    Miller, R.A.3    Harrison, D.E.4
  • 9
    • 0036606952 scopus 로고    scopus 로고
    • A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan
    • Carter CS, Ramsey MM, Sonntag WE. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet. 2002;18(6):295-301.
    • (2002) Trends Genet , vol.18 , Issue.6 , pp. 295-301
    • Carter, C.S.1    Ramsey, M.M.2    Sonntag, W.E.3
  • 10
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • Holzenberger M, Dupont J, Ducos B, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003; 421(6919):182-187.
    • (2003) Nature , vol.421 , Issue.6919 , pp. 182-187
    • Holzenberger, M.1    Dupont, J.2    Ducos, B.3
  • 11
    • 22144444220 scopus 로고    scopus 로고
    • Adult-onset growth hormone and insulin-like growth factor i defciency reduces neoplastic disease, modifes age-related pathology, and increases life span
    • Sonntag WE, Carter CS, Ikeno Y, et al. Adult-onset growth hormone and insulin-like growth factor I defciency reduces neoplastic disease, modifes age-related pathology, and increases life span. Endocrinology. 2005;146(7):2920-2932.
    • (2005) Endocrinology , vol.146 , Issue.7 , pp. 2920-2932
    • Sonntag, W.E.1    Carter, C.S.2    Ikeno, Y.3
  • 12
    • 73949158849 scopus 로고    scopus 로고
    • Early-onset GH defciency results in spatial memory impairment in mid-life and is prevented by GH supplementation
    • Nieves-Martinez E, Sonntag WE, Wilson A, et al. Early-onset GH defciency results in spatial memory impairment in mid-life and is prevented by GH supplementation. J Endocrinol. 2010;204(1): 31-36.
    • (2010) J Endocrinol. , vol.204 , Issue.1 , pp. 31-36
    • Nieves-Martinez, E.1    Sonntag, W.E.2    Wilson, A.3
  • 13
    • 57049132064 scopus 로고    scopus 로고
    • Endothelial function and vascular oxidative stress in long-lived GH/IGF-defcient Ames dwarf mice
    • Csiszar A, Labinskyy N, Perez V, et al. Endothelial function and vascular oxidative stress in long-lived GH/IGF-defcient Ames dwarf mice. Am J Physiol Heart Circ Physiol. 2008;295(5): H1882-H1894.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295 , Issue.5
    • Csiszar, A.1    Labinskyy, N.2    Perez, V.3
  • 14
    • 0036227606 scopus 로고    scopus 로고
    • Effects of GH replacement on endothelial function and large-artery stiffness in GH-defcient adults: A randomized, double-blind, placebo-controlled study
    • Smith JC, Evans LM, Wilkinson I, et al. Effects of GH replacement on endothelial function and large-artery stiffness in GH-defcient adults: a randomized, double-blind, placebo-controlled study. Clin Endocrinol (Oxf). 2002;56(4):493-501.
    • (2002) Clin Endocrinol (Oxf) , vol.56 , Issue.4 , pp. 493-501
    • Smith, J.C.1    Evans, L.M.2    Wilkinson, I.3
  • 15
    • 0032953347 scopus 로고    scopus 로고
    • Scanlon MF Endothelial dysfunction in hypopituitary adults with growth hormone defciency
    • Evans LM, Davies JS, Goodfellow J, Rees JA, Scanlon MF Endothelial dysfunction in hypopituitary adults with growth hormone defciency. Clin Endocrinol (Oxf). 1999;50(4):457-464.
    • (1999) Clin Endocrinol (Oxf) , vol.50 , Issue.4 , pp. 457-464
    • Evans, L.M.1    Davies, J.S.2    Goodfellow, J.3    Rees, J.A.4
  • 16
    • 0034067830 scopus 로고    scopus 로고
    • The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone defciency
    • Evans LM, Davies JS, Anderson RA, et al. The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone defciency. Eur J Endocrinol. 2000;142(3): 254-262.
    • (2000) Eur J Endocrinol , vol.142 , Issue.3 , pp. 254-262
    • Evans, L.M.1    Davies, J.S.2    Anderson, R.A.3
  • 17
    • 36349028053 scopus 로고    scopus 로고
    • IGF-1 reduces infammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-defcient mice
    • Sukhanov S, Higashi Y, Shai SY, et al. IGF-1 reduces infammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-defcient mice. Arterioscler Thromb Vasc Biol. 2007;27(12):2684-2690.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , Issue.12 , pp. 2684-2690
    • Sukhanov, S.1    Higashi, Y.2    Shai, S.Y.3
  • 18
    • 71949085261 scopus 로고    scopus 로고
    • Growth hormone-releasing peptide-2 suppresses vascular oxidative stress in ApoE-/-mice but does not reduce atherosclerosis
    • Titterington JS, Sukhanov S, Higashi Y, Vaughn C, Bowers C, Delafontaine P. Growth hormone-releasing peptide-2 suppresses vascular oxidative stress in ApoE-/-mice but does not reduce atherosclerosis. Endocrinology. 2009;150(12):5478-5487.
    • (2009) Endocrinology , vol.150 , Issue.12 , pp. 5478-5487
    • Titterington, J.S.1    Sukhanov, S.2    Higashi, Y.3    Vaughn, C.4    Bowers, C.5    Delafontaine, P.6
  • 19
    • 0023770734 scopus 로고
    • Growth hormone-defcient dwarfsm in the rat: A new mutation
    • Charlton HM, Clark RG, Robinson IC, et al. Growth hormone-defcient dwarfsm in the rat: a new mutation. J Endocrinol. 1988;119(1):51-58.
    • (1988) J Endocrinol , vol.119 , Issue.1 , pp. 51-58
    • Charlton, H.M.1    Clark, R.G.2    Robinson, I.C.3
  • 20
    • 0036233996 scopus 로고    scopus 로고
    • Models of growth hormone and IGF-1 defciency: Applications to studies of aging processes and life-span determination
    • Carter CS, Ramsey MM, Ingram RL, et al. Models of growth hormone and IGF-1 defciency: applications to studies of aging processes and life-span determination. J Gerontol A Biol Sci. 2002;57(5): B177-B188.
    • (2002) J Gerontol A Biol Sci , vol.57 , Issue.5
    • Carter, C.S.1    Ramsey, M.M.2    Ingram, R.L.3
  • 21
    • 69449102250 scopus 로고    scopus 로고
    • Adult-onset defciency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum
    • Hua K, Forbes ME, Lichtenwalner RJ, Sonntag WE, Riddle DR. Adult-onset defciency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum. Glia. 2009; 57(10):1062-1071.
    • (2009) Glia , vol.57 , Issue.10 , pp. 1062-1071
    • Hua, K.1    Forbes, M.E.2    Lichtenwalner, R.J.3    Sonntag, W.E.4    Riddle, D.R.5
  • 22
    • 0036773552 scopus 로고    scopus 로고
    • Growth hormone-defcient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis
    • Ramsey MM, Ingram RL, Cashion AB, et al. Growth hormone-defcient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis. Endocrinology. 2002; 143(10):4139-4142.
    • (2002) Endocrinology , vol.143 , Issue.10 , pp. 4139-4142
    • Ramsey, M.M.1    Ingram, R.L.2    Cashion, A.B.3
  • 24
    • 0041915623 scopus 로고    scopus 로고
    • High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase
    • Ungvari Z, Csiszar A, Huang A, Kaminski PM, Wolin MS, Koller A. High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase. Circulation. 2003;108(10):1253-1258.
    • (2003) Circulation , vol.108 , Issue.10 , pp. 1253-1258
    • Ungvari, Z.1    Csiszar, A.2    Huang, A.3    Kaminski, P.M.4    Wolin, M.S.5    Koller, A.6
  • 25
    • 67650659852 scopus 로고    scopus 로고
    • Anti-oxidative and anti-infammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
    • Csiszar A, Labinskyy N, Jimenez R, et al. Anti-oxidative and anti-infammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech Ageing Dev. 2009;130(8):518-527.
    • (2009) Mech Ageing Dev , vol.130 , Issue.8 , pp. 518-527
    • Csiszar, A.1    Labinskyy, N.2    Jimenez, R.3
  • 26
    • 0037076784 scopus 로고    scopus 로고
    • Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function
    • Csiszar A, Ungvari Z, Edwards JG, et al. Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res. 2002;90(11):1159-1166.
    • (2002) Circ Res. , vol.90 , Issue.11 , pp. 1159-1166
    • Csiszar, A.1    Ungvari, Z.2    Edwards, J.G.3
  • 29
    • 34547178903 scopus 로고    scopus 로고
    • Increased mitochondrial H2O2 production promotes endothelial NF-kB activation in aged rat arteries
    • Ungvari ZI, Orosz Z, Labinskyy N, et al. Increased mitochondrial H2O2 production promotes endothelial NF-kB activation in aged rat arteries. Am J Physiol Heart Circ Physiol. 2007;293(1):H37-H47.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , Issue.1
    • Ungvari, Z.I.1    Orosz, Z.2    Labinskyy, N.3
  • 30
    • 33749365317 scopus 로고    scopus 로고
    • Resveratrol attenuates TNF-{alpha}-induced activation of coronary arterial endothelial cells: Role of NF-{kappa}B inhibition
    • Csiszar A, Smith K, Labinskyy N, Orosz Z, Rivera A, Ungvari Z. Resveratrol attenuates TNF-{alpha}-induced activation of coronary arterial endothelial cells: role of NF-{kappa}B inhibition. Am J Physiol. 2006;291(4):H1694-H1699.
    • (2006) Am J Physiol , vol.291 , Issue.4
    • Csiszar, A.1    Smith, K.2    Labinskyy, N.3    Orosz, Z.4    Rivera, A.5    Ungvari, Z.6
  • 31
    • 0027135152 scopus 로고
    • Normative data for insulin-like growth factors (IGFs), IGF-binding proteins, and growth hormone-binding protein in a healthy Spanish pediatric population: Age-and sex-related changes
    • Argente J, Barrios V, Pozo J, et al. Normative data for insulin-like growth factors (IGFs), IGF-binding proteins, and growth hormone-binding protein in a healthy Spanish pediatric population: age-and sex-related changes. J Clin Endocrinol Metab. 1993;77(6):1522-1528.
    • (1993) J Clin Endocrinol Metab , vol.77 , Issue.6 , pp. 1522-1528
    • Argente, J.1    Barrios, V.2    Pozo, J.3
  • 32
    • 32444443844 scopus 로고    scopus 로고
    • Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin-II-expression in senescent rats
    • Groban L, Pailes NA, Bennett CD, et al. Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin-II- expression in senescent rats. J Gerontol A Biol Sci Med Sci. 2006;61(1):28-35.
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , Issue.1 , pp. 28-35
    • Groban, L.1    Pailes, N.A.2    Bennett, C.D.3
  • 33
    • 0030795556 scopus 로고    scopus 로고
    • Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1
    • Sonntag WE, Lynch CD, Cooney PT, Hutchins PM. Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1. Endocrinology. 1997;138(8):3515-3520.
    • (1997) Endocrinology , vol.138 , Issue.8 , pp. 3515-3520
    • Sonntag, W.E.1    Lynch, C.D.2    Cooney, P.T.3    Hutchins, P.M.4
  • 34
    • 0018892174 scopus 로고
    • The neuroendocrine system and aging
    • Everitt AV The neuroendocrine system and aging. Gerontology. 1980;26(2):108-119.
    • (1980) Gerontology , vol.26 , Issue.2 , pp. 108-119
    • Everitt, A.V.1
  • 35
    • 0346665823 scopus 로고    scopus 로고
    • Decreased plasma and tissue levels of vitamin C in a rat model of aging: Implications for antioxidative defense
    • van der Loo B, Bachschmid M, Spitzer V, Brey L, Ullrich V, Luscher TF. Decreased plasma and tissue levels of vitamin C in a rat model of aging: implications for antioxidative defense. Biochem Biophys Res Commun. 2003;303(2):483-487.
    • (2003) Biochem Biophys Res Commun , vol.303 , Issue.2 , pp. 483-487
    • Van Der Loo, B.1    Bachschmid, M.2    Spitzer, V.3    Brey, L.4    Ullrich, V.5    Luscher, T.F.6
  • 36
    • 0346996706 scopus 로고    scopus 로고
    • Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line
    • Thum T, Tsikas D, Frolich JC, Borlak J. Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line. FEBS Lett. 2003;555(3):567-571.
    • (2003) FEBS Lett , vol.555 , Issue.3 , pp. 567-571
    • Thum, T.1    Tsikas, D.2    Frolich, J.C.3    Borlak, J.4
  • 38
    • 0035053197 scopus 로고    scopus 로고
    • Cardiac mass and function, carotid artery intima-media thickness, and lipoprotein levels in growth hormone-defcient adolescents
    • Lanes R, Gunczler P, Lopez E, Esaa S, Villaroel O, Revel-Chion R. Cardiac mass and function, carotid artery intima-media thickness, and lipoprotein levels in growth hormone-defcient adolescents. J Clin Endocrinol Metab. 2001;86(3):1061-1065.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.3 , pp. 1061-1065
    • Lanes, R.1    Gunczler, P.2    Lopez, E.3    Esaa, S.4    Villaroel, O.5    Revel-Chion, R.6
  • 39
    • 18844459887 scopus 로고    scopus 로고
    • Common carotid intima-media thickness in growth hormone (GH)-defcient adolescents: A prospective study after GH withdrawal and restarting GH replacement
    • Colao A, Di Somma C, Rota F, et al. Common carotid intima-media thickness in growth hormone (GH)-defcient adolescents: a prospective study after GH withdrawal and restarting GH replacement. J Clin Endocrinol Metab. 2005;90(5):2659-2665.
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.5 , pp. 2659-2665
    • Colao, A.1    Di Somma, C.2    Rota, F.3
  • 41
    • 35948943202 scopus 로고    scopus 로고
    • Management of growth hormone deficiency in adults
    • DOI 10.1016/j.ghir.2007.05.005, PII S109663740700072X
    • Nilsson AG, Svensson J, Johannsson G. Management of growth hormone defciency in adults. Growth Horm IGF Res. 2007;17(6):441-462. (Pubitemid 350063727)
    • (2007) Growth Hormone and IGF Research , vol.17 , Issue.6 , pp. 441-462
    • Nilsson, A.G.1    Svensson, J.2    Johannsson, G.3
  • 42
    • 77953741269 scopus 로고    scopus 로고
    • Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
    • Ungvari Z, Bagi Z, Feher A, et al. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol. 2010;299(1):H18-H24.
    • (2010) Am J Physiol Heart Circ Physiol. , vol.299 , Issue.1
    • Ungvari, Z.1    Bagi, Z.2    Feher, A.3
  • 43
    • 24344509883 scopus 로고    scopus 로고
    • The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
    • Lemieux ME, Yang X, Jardine K, et al. The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals. Mech Ageing Dev. 2005;126(10):1097-1105.
    • (2005) Mech Ageing Dev , vol.126 , Issue.10 , pp. 1097-1105
    • Lemieux, M.E.1    Yang, X.2    Jardine, K.3
  • 44
    • 77953386141 scopus 로고    scopus 로고
    • Local IGF1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity
    • Vinciguerra M, Santini MP, Claycomb WC, Ladurner AG, Rosenthal N. Local IGF1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging. 2010; 2(1):43-62.
    • (2010) Aging. , vol.2 , Issue.1 , pp. 43-62
    • Vinciguerra, M.1    Santini, M.P.2    Claycomb, W.C.3    Ladurner, A.G.4    Rosenthal, N.5
  • 45
    • 70350464512 scopus 로고    scopus 로고
    • Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
    • Ungvari Z, Labinskyy N, Mukhopadhyay P, et al. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol. 2009;297(5):H1876-H1881.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297 , Issue.5
    • Ungvari, Z.1    Labinskyy, N.2    Mukhopadhyay, P.3
  • 46
    • 67650091375 scopus 로고    scopus 로고
    • Resveratrol induces mitochondrial biogenesis in endothelial cells
    • Csiszar A, Labinskyy N, Pinto JT, et al. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol. 2009;297(1):H13-H20.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297 , Issue.1
    • Csiszar, A.1    Labinskyy, N.2    Pinto, J.T.3
  • 47
    • 13844277026 scopus 로고    scopus 로고
    • Local expression of GH and IGF-1 in the hippocampus of GH-defcient long-lived mice
    • Sun LY, Al-Regaiey K, Masternak MM, Wang J, Bartke A. Local expression of GH and IGF-1 in the hippocampus of GH-defcient long-lived mice. Neurobiol Aging. 2005;26(6):929-937.
    • (2005) Neurobiol Aging , vol.26 , Issue.6 , pp. 929-937
    • Sun, L.Y.1    Al-Regaiey, K.2    Masternak, M.M.3    Wang, J.4    Bartke, A.5
  • 48
    • 34548614737 scopus 로고    scopus 로고
    • Loss of pregnancy-associated plasma protein A extends lifespan in mice
    • Conover CA, Bale LK. Loss of pregnancy-associated plasma protein A extends lifespan in mice. Aging Cell. 2007;6(5):727-729.
    • (2007) Aging Cell , vol.6 , Issue.5 , pp. 727-729
    • Conover, C.A.1    Bale, L.K.2
  • 49
    • 33646177079 scopus 로고    scopus 로고
    • Caloric restriction and growth hormone receptor knockout: Effects on expression of genes involved in insulin action in the heart
    • Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, et al. Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Exp Gerontol. 2006;41(4):417-429.
    • (2006) Exp Gerontol , vol.41 , Issue.4 , pp. 417-429
    • Masternak, M.M.1    Al-Regaiey, K.A.2    Del Rosario Lim, M.M.3
  • 50
    • 0033323818 scopus 로고    scopus 로고
    • Growth hormone (GH) defciency (GHD) of childhood onset: Reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults
    • Maghnie M, Strigazzi C, Tinelli C, et al. Growth hormone (GH) defciency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults. J Clin Endocrinol Metab. 1999;84(4):1324-1328.
    • (1999) J Clin Endocrinol Metab , vol.84 , Issue.4 , pp. 1324-1328
    • Maghnie, M.1    Strigazzi, C.2    Tinelli, C.3


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