Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for werner syndrome

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 66 A, Issue 3, 2011, Pages 264-278

  Labbé, Adam ^a   Garand, Chantal ^a   Cogger, Victoria C ^b   Paquet, Eric R ^a   Desbiens, Myriam ^a   Le Couteur, David G ^b   Lebel, Michel ^a  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Metabolism; Microarrays; Mouse model; Resveratrol; Werner syndrome

Indexed keywords

MUS;

ANTINEOPLASTIC AGENT; RESVERATROL; STILBENE DERIVATIVE;

ANIMAL; ARTICLE; C57BL MOUSE; DISEASE MODEL; FATTY LIVER; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; INFLAMMATION; INSULIN RESISTANCE; MOUSE; WERNER SYNDROME;

ANIMALS; ANTICARCINOGENIC AGENTS; DISEASE MODELS, ANIMAL; FATTY LIVER; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; INFLAMMATION; INSULIN RESISTANCE; MICE; MICE, INBRED C57BL; STILBENES; WERNER SYNDROME;

EID: 79955125211     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glq184     Document Type: Article

References (54)

1. Lebel M, Leder P. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A. 1998;95: 13097-13102. (Pubitemid 28509530)
2. Epstein CJ, Martin GM, Schultz AL, Motulsky AG. Werner's syndrome: a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine. 1966;45:177-221.
3. Goto M, Miller RW, Ishikawa Y, Sugano H. Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiol Biomarkers Prev. 1996;5:239-246.
4. Yu CE, Oshima J, Fu YH, et al. Positional cloning of the Werner's syndrome gene. Science. 1996;272:258-262. (Pubitemid 26119137)
5. Kamath-Loeb AS, Shen JC, Loeb LA, Fry M. Werner syndrome protein. II. Characterization of the integral 3'→5' DNA exonuclease. J Biol Chem. 1998;273:34145-34150.
6. Shen JC, Gray MD, Oshima J, Kamath-Loeb AS, Fry M, Loeb LA. Werner syndrome protein. I. DNA helicase and DNA exonuclease reside on the same polypeptide. J Biol Chem. 1998;273:34139-34144.
7. Huang S, Beresten S, Li B, Oshima J, Ellis NA, Campisi J. Characterization of the human and mouse WRN 3'→5' exonuclease. Nucleic Acids Res. 2000;28:2396-2405. (Pubitemid 30349046)
8. Balajee AS, Machwe A, May A, et al. The Werner syndrome protein is involved in RNA polymerase II transcription. Mol Biol Cell. 1999; 10:2655-2668. (Pubitemid 29393518)
9. Brosh RM Jr, Orren DK, Nehlin JO, et al. Functional and physical interaction between WRN helicase and human replication protein A. J Biol Chem. 1999;274:18341-18350.
10. Lebel M, Spillare EA, Harris CC, Leder P. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J Biol Chem. 1999;274:37795-37799. (Pubitemid 30026842)
11. Orren DK, Brosh RM Jr, Nehlin JO, Machwe A, Gray MD, Bohr VA. Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO. Nucleic Acids Res. 1999;27:3557-3566. (Pubitemid 29414685)
12. Brosh RM Jr, von Kobbe C, Sommers JA, et al. Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. EMBO J. 2001;20:5791-5801. (Pubitemid 33010054)
13. Prince PR, Emond MJ, Monnat RJ Jr. Loss of Werner syndrome protein function promotes aberrant mitotic recombination. Genes Dev. 2001;15:933-938. (Pubitemid 32323543)
14. Saintigny Y, Makienko K, Swanson C, Emond MJ, Monnat RJ Jr. Homologous recombination resolution defect in Werner syndrome. Mol Cell Biol. 2002;22:6971-6978.
15. Opresko PL, Otterlei M, Graakjaer J, et al. The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol Cell. 2004;14:763-774. (Pubitemid 38780850)
16. Laud PR, Bailey SM, Multani AS, et al. Elevated telomere-telomere recombination correlates with increased cellular immortalization and transformation in G5 Terc-/- Wrn-/- mouse cells. Genes Dev. 2005;19: 2560-2570.
17. Sharma A, Awasthi S, Harrod CK, et al. The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication. J Biol Chem. 2007;282:12048-12057. (Pubitemid 47100668)
18. Turaga RVN, Paquet ER, Sild M, et al. The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses. Cell Cycle. 2009;8:2080-2092.
19. Lebel M, Lavoie J, Gaudreault I, Bronsard M, Drouin R. Genetic cooperation between the Werner syndrome protein and poly(ADPribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. Am J Pathol. 2003;162:1559-1569. (Pubitemid 36512839)
20. Massip L, Garand C, Turaga RVN, Deschênes F, Thorin E, Lebel M. Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue. Exp Gerontol. 2006;41:157-168. (Pubitemid 43165689)
21. Massip L, Garand C, Paquet E, et al. Vitamin C restores healthy aging in a mouse model for Werner Syndrome. FASEB J. 2010;24:158-172.
22. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365:1415-1428. (Pubitemid 40523737)
23. Lebel M, Massip L, Garand C, Thorin E. Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin. Ann N Y Acad Sci. 2010;1197:40-44.
24. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337-342. (Pubitemid 44764104)
25. Pearson KJ, Baur JA, Lewis KN, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008;8:157-168.
26. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419. (Pubitemid 15018832)
27. Kujoth GC, Hiona A, Pugh TD, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005;309: 481-484. (Pubitemid 40994689)
28. Warren A, Bertolino P, Cogger VC, McLean AJ, Fraser R, Le Couteur DG. Hepatic pseudocapillarization in aged mice. Exp Gerontol. 2005; 40:807-812. (Pubitemid 41416543)
29. Kanehisa M, Araki M, Goto S, et al. KEGG for linking genomes to life and the environment. Nucleic Acids Res. 2008;36 (Database issue): D480-D484. (Pubitemid 351149770)
30. Hilmer SN, Cogger VC, Fraser R, McLean AJ, Sullivan D, Le Couteur DG. Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology. 2005;42:1349-1354. (Pubitemid 43260037)
31. Brunt EM. Nonalcoholic steatohepatitis: definition and pathology. Semin Liver Dis. 2001;21:3-16. (Pubitemid 32240482)
32. Bokko PB, Francione L, Bandala-Sanchez E, et al. Diverse cytopa-thologies in mitochondrial disease are caused by AMP-activated protein kinase signaling. Mol Biol Cell. 2007;18:1874-1886. (Pubitemid 46717567)
33. Steinberg GR. Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exercise. Appl Physiol Nutr Metab. 2009;34:315-322.
34. Harikumar KB, Aggarwal BB. Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle. 2008;7:1020-1035.
35. Hong SW, Jung KH, Zheng HM, et al. The protective effect of resveratrol on dimethylnitrosamine-induced liver fibrosis in rats. Arch Pharm Res. 2010;33:601-609.
36. Lebel M, Cardiff RD, Leder P. Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase. Cancer Res. 2001;61:1816-1819. (Pubitemid 32691990)
37. Fröjdö S, Durand C, Pirola L. Metabolic effects of resveratrol in mammals - A link between improved insulin action and aging. Curr Aging Sci. 2008;1:145-151.
38. Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 2009;9:407-416.
39. Rutter GA, Da Silva Xavier G, Leclerc I. Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J. 2003;375:1-16. (Pubitemid 37255376)
40. Spanier G, Xu H, Xia N, et al. Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase sub-unit (Nox4). J Physiol Pharmacol. 2009;60:111-116.
41. Ryan MJ, Jackson JR, Hao Y, et al. Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice. J Gerontol A Biol Sci Med Sci. 2010;65:815-831.
42. Bishayee A, Barnes KF, Bhatia D, Darvesh AS, Carroll RT. Resveratrol suppresses oxidative stress and inflammatory response in diethyl-nitrosamine- initiated rat hepatocarcinogenesis. Cancer Prev Res. 2010; 3:753-763.
43. Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae life span. Nature. 2003; 425:191-196. (Pubitemid 37150899)
44. Wood JG, Rogina B, Lavu S, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004;430:686-689. (Pubitemid 39061685)
45. Uhl M, Csernok A, Aydin S, Kreienberg R, Wiesmüller L, Gatz SA. Role of SIRT1 in homologous recombination. DNA Repair (Amst). 2010;9:383-393.
46. Wang C, Li Q, Redden DT, Weindruch R, Allison DB. Statistical methods for testing effects on "maximum life span". Mech Ageing Dev. 2004;125:629-632. (Pubitemid 39371158)
47. Wakeling LA, Ions LJ, Ford D. Could Sirtl-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions? Age (Dordr). 2009;31:327-341.
48. Moore G, Knoblaugh S, Gollahon K, Rabinovitch P, Ladiges W. Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic diet. Mech Ageing Dev. 2008;129:201-206.
49. Do GM, Kwon EY, Kim HJ, et al. Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice. Biochem Biophys Res Commun. 2008;374:55-59.
50. Noll C, Hamelet J, Ducros V, et al. Resveratrol supplementation worsen the dysregulation of genes involved in hepatic lipid homeostasis observed in hyperhomocysteinemic mice. Food Chem Toxicol. 2009;47:230-236.
51. Goto M. Werner's syndrome: from clinics to genetics. Clin Exp Rheumatol. 2000;18:760-766.
52. Zantour B, Messaoud R, Zouali M, et al. Werner's syndrome and endocrine disorders. Ann Endocrinol (Paris). 2003;64:205-209. (Pubitemid 36876640)
53. Davis T, Kipling D. Werner Syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome? Rejuvenation Res. 2006;9:402-407. (Pubitemid 44168875)
54. Hashizume H, Sato K, Takagi H, et al. Werner syndrome as a possible cause of non-alcoholic steatohepatitis. J Clin Pathol. 2009;62: 1043-1045.