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Volumn 15, Issue 10, 2015, Pages

Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits

Author keywords

Adiponectin; Beta cell function; Body mass index; Fat distribution; Fat percent; Genome wide association study; Insulin resistance; Leptin; Non alcoholic fatty liver disease; Obesity; Pericardial fat; Sexual dimorphism; Subcutaneous fat; Type 2 diabetes; Visceral fat; Waist to hip ratio

Indexed keywords

ADIPONECTIN;

EID: 84941915615     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-015-0648-8     Document Type: Review
Times cited : (51)

References (134)
  • 1
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • COI: 1:CAS:528:DC%2BD28XhtlShtrzP, PID: 17167471
    • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444(7121):840–6. doi:10.1038/nature05482.
    • (2006) Nature , vol.444 , Issue.7121 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 2
    • 52949145686 scopus 로고    scopus 로고
    • Management of obesity in adults: European clinical practice guidelines
    • PID: 20054170
    • Tsigos C, Hainer V, Basdevant A, et al. Management of obesity in adults: European clinical practice guidelines. Obes Facts. 2008;1(2):106–16. doi:10.1159/000126822.
    • (2008) Obes Facts , vol.1 , Issue.2 , pp. 106-116
    • Tsigos, C.1    Hainer, V.2    Basdevant, A.3
  • 3
    • 79960895140 scopus 로고    scopus 로고
    • Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
    • COI: 1:CAS:528:DC%2BC3MXotV2itrY%3D, PID: 21706003
    • Kilpelainen TO, Zillikens MC, Stancakova A, et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet. 2011;43(8):753–60. doi:10.1038/ng.866.
    • (2011) Nat Genet , vol.43 , Issue.8 , pp. 753-760
    • Kilpelainen, T.O.1    Zillikens, M.C.2    Stancakova, A.3
  • 4
    • 84863684047 scopus 로고    scopus 로고
    • Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women
    • COI: 1:CAS:528:DC%2BC38XnslOlt70%3D, PID: 22589738
    • Fox CS, Liu Y, White CC, et al. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genet. 2012;8(5):e1002695. doi:10.1371/journal.pgen.1002695.
    • (2012) PLoS Genet , vol.8 , Issue.5 , pp. e1002695
    • Fox, C.S.1    Liu, Y.2    White, C.C.3
  • 5
    • 34347351228 scopus 로고    scopus 로고
    • Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    • PID: 17576866
    • Fox CS, Massaro JM, Hoffmann U, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007;116(1):39–48. doi:10.1161/CIRCULATIONAHA.106.675355.
    • (2007) Circulation , vol.116 , Issue.1 , pp. 39-48
    • Fox, C.S.1    Massaro, J.M.2    Hoffmann, U.3
  • 6
    • 80052895204 scopus 로고    scopus 로고
    • A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes
    • COI: 1:CAS:528:DC%2BC3MXhtFymsbbF, PID: 21771975
    • Chung CM, Lin TH, Chen JW, et al. A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes. Diabetes. 2011;60(9):2417–23. doi:10.2337/db10-1321.
    • (2011) Diabetes , vol.60 , Issue.9 , pp. 2417-2423
    • Chung, C.M.1    Lin, T.H.2    Chen, J.W.3
  • 7
    • 84859238629 scopus 로고    scopus 로고
    • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
    • COI: 1:CAS:528:DC%2BC38XlsFaltbs%3D, PID: 22479202
    • Dastani Z, Hivert MF, Timpson N, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012;8(3):e1002607. doi:10.1371/journal.pgen.1002607.
    • (2012) PLoS Genet , vol.8 , Issue.3 , pp. e1002607
    • Dastani, Z.1    Hivert, M.F.2    Timpson, N.3
  • 8
    • 74749102353 scopus 로고    scopus 로고
    • Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals
    • COI: 1:CAS:528:DC%2BC3cXhtlyqs74%3D, PID: 20018283
    • Heid IM, Henneman P, Hicks A, et al. Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis. 2010;208(2):412–20. doi:10.1016/j.atherosclerosis.2009.11.035.
    • (2010) Atherosclerosis , vol.208 , Issue.2 , pp. 412-420
    • Heid, I.M.1    Henneman, P.2    Hicks, A.3
  • 9
    • 77957750180 scopus 로고    scopus 로고
    • Adiponectin concentrations: a genome-wide association study
    • COI: 1:CAS:528:DC%2BC3cXht1CgtrbP, PID: 20887962
    • Jee SH, Sull JW, Lee JE, et al. Adiponectin concentrations: a genome-wide association study. Am J Hum Genet. 2010;87(4):545–52. doi:10.1016/j.ajhg.2010.09.004.
    • (2010) Am J Hum Genet , vol.87 , Issue.4 , pp. 545-552
    • Jee, S.H.1    Sull, J.W.2    Lee, J.E.3
  • 10
    • 84857533640 scopus 로고    scopus 로고
    • CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population
    • COI: 1:CAS:528:DC%2BC38XmtlGhsw%3D%3D, PID: 22065538
    • Morisaki H, Yamanaka I, Iwai N, et al. CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population. Hum Mutat. 2012;33(2):402–10. doi:10.1002/humu.21652.
    • (2012) Hum Mutat , vol.33 , Issue.2 , pp. 402-410
    • Morisaki, H.1    Yamanaka, I.2    Iwai, N.3
  • 11
    • 84893008349 scopus 로고    scopus 로고
    • A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2
    • COI: 1:CAS:528:DC%2BC2cXht1Ogt7k%3D, PID: 24105470
    • Wu Y, Gao H, Li H, et al. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. Hum Mol Genet. 2014;23(4):1108–19. doi:10.1093/hmg/ddt488.
    • (2014) Hum Mol Genet , vol.23 , Issue.4 , pp. 1108-1119
    • Wu, Y.1    Gao, H.2    Li, H.3
  • 12
    • 78649476050 scopus 로고    scopus 로고
    • Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ
    • COI: 1:CAS:528:DC%2BC3cXhsVyhsrzE, PID: 20876611
    • Wu Y, Li Y, Lange EM, et al. Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ. Hum Mol Genet. 2010;19(24):4955–64. doi:10.1093/hmg/ddq423.
    • (2010) Hum Mol Genet , vol.19 , Issue.24 , pp. 4955-4964
    • Wu, Y.1    Li, Y.2    Lange, E.M.3
  • 13
    • 74249100913 scopus 로고    scopus 로고
    • A genome-wide association study reveals variants in ARL15 that influence adiponectin levels
    • PID: 20011104
    • Richards JB, Waterworth D, O'Rahilly S, et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 2009;5(12):e1000768. doi:10.1371/journal.pgen.1000768.
    • (2009) PLoS Genet , vol.5 , Issue.12 , pp. e1000768
    • Richards, J.B.1    Waterworth, D.2    O'Rahilly, S.3
  • 14
    • 84863689970 scopus 로고    scopus 로고
    • Genome-wide association of pericardial fat identifies a unique locus for ectopic fat
    • COI: 1:CAS:528:DC%2BC38XnslOltrc%3D, PID: 22589742
    • Fox CS, White CC, Lohman K, et al. Genome-wide association of pericardial fat identifies a unique locus for ectopic fat. PLoS Genet. 2012;8(5):e1002705. doi:10.1371/journal.pgen.1002705.
    • (2012) PLoS Genet , vol.8 , Issue.5 , pp. e1002705
    • Fox, C.S.1    White, C.C.2    Lohman, K.3
  • 15
    • 79953745343 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    • COI: 1:CAS:528:DC%2BC3MXjslKlsL4%3D, PID: 21423719
    • Speliotes EK, Yerges-Armstrong LM, Wu J, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet. 2011;7(3):e1001324. doi:10.1371/journal.pgen.1001324.
    • (2011) PLoS Genet , vol.7 , Issue.3 , pp. e1001324
    • Speliotes, E.K.1    Yerges-Armstrong, L.M.2    Wu, J.3
  • 17
    • 0030989520 scopus 로고    scopus 로고
    • Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses’ Health Study
    • COI: 1:STN:280:DyaK2s3lt1Ohsg%3D%3D, PID: 9098178
    • Carey VJ, Walters EE, Colditz GA, et al. Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses’ Health Study. Am J Epidemiol. 1997;145(7):614–9.
    • (1997) Am J Epidemiol , vol.145 , Issue.7 , pp. 614-619
    • Carey, V.J.1    Walters, E.E.2    Colditz, G.A.3
  • 18
    • 15744387573 scopus 로고    scopus 로고
    • Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men
    • COI: 1:CAS:528:DC%2BD2MXis1Sktbo%3D, PID: 15755822
    • Wang Y, Rimm EB, Stampfer MJ, et al. Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr. 2005;81(3):555–63.
    • (2005) Am J Clin Nutr , vol.81 , Issue.3 , pp. 555-563
    • Wang, Y.1    Rimm, E.B.2    Stampfer, M.J.3
  • 19
    • 84968822322 scopus 로고    scopus 로고
    • Belgium: International Diabetes Federation
    • International Diabetes Federation. IDF Diabetes Atlas update poster teB, Belgium: International Diabetes Federation, 2014. http://www.idf.org/diabetesatlas.
    • (2014) IDF Diabetes Atlas update poster teB
  • 20
    • 0033645239 scopus 로고    scopus 로고
    • Parental transmission of type 2 diabetes: the Framingham Offspring Study
    • COI: 1:CAS:528:DC%2BD3cXos1ejsbw%3D, PID: 11118026
    • Meigs JB, Cupples LA, Wilson PW. Parental transmission of type 2 diabetes: the Framingham Offspring Study. Diabetes. 2000;49(12):2201–7.
    • (2000) Diabetes , vol.49 , Issue.12 , pp. 2201-2207
    • Meigs, J.B.1    Cupples, L.A.2    Wilson, P.W.3
  • 21
    • 0032953097 scopus 로고    scopus 로고
    • Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance—a population-based twin study
    • COI: 1:CAS:528:DyaK1MXhtFajsbk%3D, PID: 10064092
    • Poulsen P, Kyvik KO, Vaag A, et al. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance—a population-based twin study. Diabetologia. 1999;42(2):139–45.
    • (1999) Diabetologia , vol.42 , Issue.2 , pp. 139-145
    • Poulsen, P.1    Kyvik, K.O.2    Vaag, A.3
  • 22
    • 0022589555 scopus 로고
    • A twin study of human obesity
    • COI: 1:STN:280:DyaL283isl2lsg%3D%3D, PID: 3712713
    • Stunkard AJ, Foch TT, Hrubec Z. A twin study of human obesity. JAMA. 1986;256(1):51–4.
    • (1986) JAMA , vol.256 , Issue.1 , pp. 51-54
    • Stunkard, A.J.1    Foch, T.T.2    Hrubec, Z.3
  • 23
    • 40049088818 scopus 로고    scopus 로고
    • Immigrants from the Middle-East have a different form of type 2 diabetes compared with Swedish patients
    • COI: 1:CAS:528:DC%2BD1cXkvFOksLg%3D, PID: 18307458
    • Glans F, Elgzyri T, Shaat N, et al. Immigrants from the Middle-East have a different form of type 2 diabetes compared with Swedish patients. Diabet Med. 2008;25(3):303–7. doi:10.1111/j.1464-5491.2007.02366.x.
    • (2008) Diabet Med , vol.25 , Issue.3 , pp. 303-307
    • Glans, F.1    Elgzyri, T.2    Shaat, N.3
  • 24
    • 0030843960 scopus 로고    scopus 로고
    • Genetic and environmental factors in relative body weight and human adiposity
    • COI: 1:STN:280:DyaK1c7otVSruw%3D%3D, PID: 9519560
    • Maes HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behav Genet. 1997;27(4):325–51.
    • (1997) Behav Genet , vol.27 , Issue.4 , pp. 325-351
    • Maes, H.H.1    Neale, M.C.2    Eaves, L.J.3
  • 25
    • 55649114631 scopus 로고    scopus 로고
    • Sex-specific genetic effects influence variation in body composition
    • COI: 1:CAS:528:DC%2BD1cXhtlCjs7%2FN, PID: 18839131
    • Zillikens MC, Yazdanpanah M, Pardo LM, et al. Sex-specific genetic effects influence variation in body composition. Diabetologia. 2008;51(12):2233–41. doi:10.1007/s00125-008-1163-0.
    • (2008) Diabetologia , vol.51 , Issue.12 , pp. 2233-2241
    • Zillikens, M.C.1    Yazdanpanah, M.2    Pardo, L.M.3
  • 26
    • 80054707972 scopus 로고    scopus 로고
    • Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study
    • COI: 1:CAS:528:DC%2BC3MXht12js7rM, PID: 21826484
    • Almgren P, Lehtovirta M, Isomaa B, et al. Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study. Diabetologia. 2011;54(11):2811–9. doi:10.1007/s00125-011-2267-5.
    • (2011) Diabetologia , vol.54 , Issue.11 , pp. 2811-2819
    • Almgren, P.1    Lehtovirta, M.2    Isomaa, B.3
  • 27
    • 84899676296 scopus 로고    scopus 로고
    • Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus
    • PID: 24808896
    • Moreno-Indias I, Cardona F, Tinahones FJ, et al. Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus. Front Microbiol. 2014;5:190. doi:10.3389/fmicb.2014.00190.
    • (2014) Front Microbiol , vol.5 , pp. 190
    • Moreno-Indias, I.1    Cardona, F.2    Tinahones, F.J.3
  • 28
    • 64549104842 scopus 로고    scopus 로고
    • The use of animal models in the study of diabetes mellitus
    • COI: 1:CAS:528:DC%2BD1MXltFyisr8%3D, PID: 19414410
    • Chatzigeorgiou A, Halapas A, Kalafatakis K, et al. The use of animal models in the study of diabetes mellitus. In Vivo. 2009;23(2):245–58.
    • (2009) In Vivo , vol.23 , Issue.2 , pp. 245-258
    • Chatzigeorgiou, A.1    Halapas, A.2    Kalafatakis, K.3
  • 29
    • 0032751471 scopus 로고    scopus 로고
    • Epigenetic inheritance at the agouti locus in the mouse
    • COI: 1:CAS:528:DyaK1MXnt1Gns7w%3D, PID: 10545949
    • Morgan HD, Sutherland HG, Martin DI, et al. Epigenetic inheritance at the agouti locus in the mouse. Nat Genet. 1999;23(3):314–8. doi:10.1038/15490.
    • (1999) Nat Genet , vol.23 , Issue.3 , pp. 314-318
    • Morgan, H.D.1    Sutherland, H.G.2    Martin, D.I.3
  • 30
    • 52449123919 scopus 로고    scopus 로고
    • Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity
    • COI: 1:CAS:528:DC%2BD1cXhtFemsbnK, PID: 18779842
    • Farooqi IS, O'Rahilly S. Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity. Nat Clin Pract Endocrinol Metab. 2008;4(10):569–77. doi:10.1038/ncpendmet0966.
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , Issue.10 , pp. 569-577
    • Farooqi, I.S.1    O'Rahilly, S.2
  • 31
    • 0343953074 scopus 로고    scopus 로고
    • Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
    • COI: 1:CAS:528:DC%2BD3cXkvFWgs74%3D, PID: 10903343
    • Farooqi IS, Yeo GS, Keogh JM, et al. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest. 2000;106(2):271–9. doi:10.1172/JCI9397.
    • (2000) J Clin Invest , vol.106 , Issue.2 , pp. 271-279
    • Farooqi, I.S.1    Yeo, G.S.2    Keogh, J.M.3
  • 32
    • 84896495361 scopus 로고    scopus 로고
    • Many faces of monogenic diabetes
    • PID: 24843749
    • Schwitzgebel VM. Many faces of monogenic diabetes. J Diabetes Investig. 2014;5(2):121–33. doi:10.1111/jdi.12197.
    • (2014) J Diabetes Investig , vol.5 , Issue.2 , pp. 121-133
    • Schwitzgebel, V.M.1
  • 33
    • 77954407332 scopus 로고    scopus 로고
    • Genomewide association studies and assessment of the risk of disease
    • COI: 1:CAS:528:DC%2BC3cXptFWmt7w%3D, PID: 20647212
    • Manolio TA. Genomewide association studies and assessment of the risk of disease. N Engl J Med. 2010;363(2):166–76. doi:10.1056/NEJMra0905980.
    • (2010) N Engl J Med , vol.363 , Issue.2 , pp. 166-176
    • Manolio, T.A.1
  • 34
    • 75749086085 scopus 로고    scopus 로고
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    • COI: 1:CAS:528:DC%2BC3cXntVCqsw%3D%3D, PID: 20081858
    • Dupuis J, Langenberg C, Prokopenko I, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42(2):105–16. doi:10.1038/ng.520.
    • (2010) Nat Genet , vol.42 , Issue.2 , pp. 105-116
    • Dupuis, J.1    Langenberg, C.2    Prokopenko, I.3
  • 35
    • 72449122779 scopus 로고    scopus 로고
    • Parental origin of sequence variants associated with complex diseases
    • COI: 1:CAS:528:DC%2BD1MXhsFOhtbvJ, PID: 20016592
    • Kong A, Steinthorsdottir V, Masson G, et al. Parental origin of sequence variants associated with complex diseases. Nature. 2009;462(7275):868–74. doi:10.1038/nature08625.
    • (2009) Nature , vol.462 , Issue.7275 , pp. 868-874
    • Kong, A.1    Steinthorsdottir, V.2    Masson, G.3
  • 36
    • 84868337361 scopus 로고    scopus 로고
    • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38XhtFOgsLfP, PID: 22885922, This is a large GWAS of mainly European cases and controls identifying 10 additional loci associated with T2D susceptibility
    • Morris AP, Voight BF, Teslovich TM, et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet. 2012;44(9):981–90. doi:10.1038/ng.2383. This is a large GWAS of mainly European cases and controls identifying 10 additional loci associated with T2D susceptibility.
    • (2012) Nat Genet , vol.44 , Issue.9 , pp. 981-990
    • Morris, A.P.1    Voight, B.F.2    Teslovich, T.M.3
  • 37
    • 77954143522 scopus 로고    scopus 로고
    • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    • COI: 1:CAS:528:DC%2BC3cXnvFykt70%3D, PID: 20581827
    • Voight BF, Scott LJ, Steinthorsdottir V, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010;42(7):579–89. doi:10.1038/ng.609.
    • (2010) Nat Genet , vol.42 , Issue.7 , pp. 579-589
    • Voight, B.F.1    Scott, L.J.2    Steinthorsdottir, V.3
  • 38
    • 42349106044 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXltFylurY%3D, PID: 18372903
    • Zeggini E, Scott LJ, Saxena R, et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008;40(5):638–45. doi:10.1038/ng.120.
    • (2008) Nat Genet , vol.40 , Issue.5 , pp. 638-645
    • Zeggini, E.1    Scott, L.J.2    Saxena, R.3
  • 39
    • 84655162045 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in East Asians
    • COI: 1:CAS:528:DC%2BC3MXhs1eitr7P
    • Cho YS, Chen CH, Hu C, et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in East Asians. Nat Genet. 2012;44(1):67–72. doi:10.1038/ng.1019.
    • (2012) Nat Genet , vol.44 , Issue.1 , pp. 67-72
    • Cho, Y.S.1    Chen, C.H.2    Hu, C.3
  • 40
    • 84872033833 scopus 로고    scopus 로고
    • A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans
    • COI: 1:CAS:528:DC%2BC3sXlt1KjsQ%3D%3D, PID: 22961080
    • Li H, Gan W, Lu L, et al. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes. 2013;62(1):291–8. doi:10.2337/db12-0454.
    • (2013) Diabetes , vol.62 , Issue.1 , pp. 291-298
    • Li, H.1    Gan, W.2    Lu, L.3
  • 41
    • 77954172286 scopus 로고    scopus 로고
    • Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3cXntlCquro%3D, PID: 20418489
    • Qi L, Cornelis MC, Kraft P, et al. Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet. 2010;19(13):2706–15. doi:10.1093/hmg/ddq156.
    • (2010) Hum Mol Genet , vol.19 , Issue.13 , pp. 2706-2715
    • Qi, L.1    Cornelis, M.C.2    Kraft, P.3
  • 42
    • 78049438674 scopus 로고    scopus 로고
    • Identification of new genetic risk variants for type 2 diabetes
    • PID: 20862305
    • Shu XO, Long J, Cai Q, et al. Identification of new genetic risk variants for type 2 diabetes. PLoS Genet. 2010;6(9):e1001127. doi:10.1371/journal.pgen.1001127.
    • (2010) PLoS Genet , vol.6 , Issue.9 , pp. e1001127
    • Shu, X.O.1    Long, J.2    Cai, Q.3
  • 43
    • 77649214654 scopus 로고    scopus 로고
    • A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese
    • PID: 20174558
    • Tsai FJ, Yang CF, Chen CC, et al. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet. 2010;6(2):e1000847. doi:10.1371/journal.pgen.1000847.
    • (2010) PLoS Genet , vol.6 , Issue.2 , pp. e1000847
    • Tsai, F.J.1    Yang, C.F.2    Chen, C.C.3
  • 44
    • 77957553197 scopus 로고    scopus 로고
    • A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
    • COI: 1:CAS:528:DC%2BC3cXhtFWksrfE, PID: 20818381
    • Yamauchi T, Hara K, Maeda S, et al. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet. 2010;42(10):864–8. doi:10.1038/ng.660.
    • (2010) Nat Genet , vol.42 , Issue.10 , pp. 864-868
    • Yamauchi, T.1    Hara, K.2    Maeda, S.3
  • 45
    • 67650248695 scopus 로고    scopus 로고
    • Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
    • COI: 1:CAS:528:DC%2BD1MXos1Gjsr4%3D, PID: 19401414
    • Takeuchi F, Serizawa M, Yamamoto K, et al. Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes. 2009;58(7):1690–9. doi:10.2337/db08-1494.
    • (2009) Diabetes , vol.58 , Issue.7 , pp. 1690-1699
    • Takeuchi, F.1    Serizawa, M.2    Yamamoto, K.3
  • 46
    • 80053385333 scopus 로고    scopus 로고
    • Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
    • COI: 1:CAS:528:DC%2BC3MXhtV2gtrfK, PID: 21874001
    • Kooner JS, Saleheen D, Sim X, et al. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet. 2011;43(10):984–9. doi:10.1038/ng.921.
    • (2011) Nat Genet , vol.43 , Issue.10 , pp. 984-989
    • Kooner, J.S.1    Saleheen, D.2    Sim, X.3
  • 47
    • 84874418247 scopus 로고    scopus 로고
    • Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21
    • COI: 1:CAS:528:DC%2BC3sXjsFGqsL0%3D, PID: 23209189
    • Tabassum R, Chauhan G, Dwivedi OP, et al. Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. Diabetes. 2013;62(3):977–86. doi:10.2337/db12-0406.
    • (2013) Diabetes , vol.62 , Issue.3 , pp. 977-986
    • Tabassum, R.1    Chauhan, G.2    Dwivedi, O.P.3
  • 48
    • 79960905856 scopus 로고    scopus 로고
    • Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County Texas
    • COI: 1:STN:280:DC%2BC3MnmtlWgsw%3D%3D
    • Parra EJ, Below JE, Krithika S, et al. Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County Texas. Diabetol. 2011;54(8):2038–46. doi:10.1007/s00125-011-2172-y.
    • (2011) Diabetol , vol.54 , Issue.8 , pp. 2038-2046
    • Parra, E.J.1    Below, J.E.2    Krithika, S.3
  • 49
    • 84855405312 scopus 로고    scopus 로고
    • A genome-wide association search for type 2 diabetes genes in African Americans
    • COI: 1:CAS:528:DC%2BC38XptF2muw%3D%3D, PID: 22238593
    • Palmer ND, McDonough CW, Hicks PJ, et al. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One. 2012;7(1):e29202. doi:10.1371/journal.pone.0029202.
    • (2012) PLoS One , vol.7 , Issue.1 , pp. e29202
    • Palmer, N.D.1    McDonough, C.W.2    Hicks, P.J.3
  • 50
    • 84895868553 scopus 로고    scopus 로고
    • Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
    • This is a recent trans-ethnic GWAS of T2D including cases and controls of European, east Asian, south Asian, Mexican and Mexican American ancestry. Seven additional T2D susceptibility loci were identified in this study
    • Replication DIG, Meta-analysis C. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014;46(3):234–44. doi:10.1038/ng.2897. This is a recent trans-ethnic GWAS of T2D including cases and controls of European, east Asian, south Asian, Mexican and Mexican American ancestry. Seven additional T2D susceptibility loci were identified in this study.
    • (2014) Nat Genet , vol.46 , Issue.3 , pp. 234-244
    • Replication, D.I.G.1    Meta-analysis, C.2
  • 51
    • 44749085712 scopus 로고    scopus 로고
    • Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?
    • COI: 1:CAS:528:DC%2BD1cXmslWgs7w%3D, PID: 18504548
    • Florez JC. Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia. 2008;51(7):1100–10. doi:10.1007/s00125-008-1025-9.
    • (2008) Diabetologia , vol.51 , Issue.7 , pp. 1100-1110
    • Florez, J.C.1
  • 52
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • COI: 1:CAS:528:DC%2BC3cXht1KmsL%2FN, PID: 20935630
    • Speliotes EK, Willer CJ, Berndt SI, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42(11):937–48. doi:10.1038/ng.686.
    • (2010) Nat Genet , vol.42 , Issue.11 , pp. 937-948
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3
  • 53
    • 34547625955 scopus 로고    scopus 로고
    • Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    • PID: 17658951
    • Scuteri A, Sanna S, Chen WM, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007;3(7):e115. doi:10.1371/journal.pgen.0030115.
    • (2007) PLoS Genet , vol.3 , Issue.7 , pp. e115
    • Scuteri, A.1    Sanna, S.2    Chen, W.M.3
  • 54
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • COI: 1:CAS:528:DC%2BD2sXltVentL0%3D, PID: 17434869
    • Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889–94. doi:10.1126/science.1141634.
    • (2007) Science , vol.316 , Issue.5826 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3
  • 55
    • 44349142294 scopus 로고    scopus 로고
    • Common variants near MC4R are associated with fat mass, weight and risk of obesity
    • COI: 1:CAS:528:DC%2BD1cXmsVejsLo%3D, PID: 18454148
    • Loos RJ, Lindgren CM, Li S, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet. 2008;40(6):768–75. doi:10.1038/ng.140.
    • (2008) Nat Genet , vol.40 , Issue.6 , pp. 768-775
    • Loos, R.J.1    Lindgren, C.M.2    Li, S.3
  • 56
    • 58149163142 scopus 로고    scopus 로고
    • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    • COI: 1:CAS:528:DC%2BD1cXhsV2hsrnK, PID: 19079261
    • Willer CJ, Speliotes EK, Loos RJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41(1):25–34. doi:10.1038/ng.287.
    • (2009) Nat Genet , vol.41 , Issue.1 , pp. 25-34
    • Willer, C.J.1    Speliotes, E.K.2    Loos, R.J.3
  • 57
    • 58149163141 scopus 로고    scopus 로고
    • Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    • COI: 1:CAS:528:DC%2BD1cXhsV2hsrjO, PID: 19079260
    • Thorleifsson G, Walters GB, Gudbjartsson DF, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2009;41(1):18–24. doi:10.1038/ng.274.
    • (2009) Nat Genet , vol.41 , Issue.1 , pp. 18-24
    • Thorleifsson, G.1    Walters, G.B.2    Gudbjartsson, D.F.3
  • 58
    • 84923171580 scopus 로고    scopus 로고
    • Genetic studies of body mass index yield new insights for obesity biology
    • COI: 1:CAS:528:DC%2BC2MXislehtL8%3D, PID: 25673413, This is the most recent GWAS in up to 339,224 individuals identifying 56 additional loci (97 loci in total) associated with BMI
    • Locke AE, Kahali B, Berndt SI. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518(7538):197–206. doi:10.1038/nature14177. This is the most recent GWAS in up to 339,224 individuals identifying 56 additional loci (97 loci in total) associated with BMI.
    • (2015) Nature , vol.518 , Issue.7538 , pp. 197-206
    • Locke, A.E.1    Kahali, B.2    Berndt, S.I.3
  • 59
    • 67651236725 scopus 로고    scopus 로고
    • Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution
    • PID: 19557161
    • Lindgren CM, Heid IM, Randall JC, et al. Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genet. 2009;5(6):e1000508. doi:10.1371/journal.pgen.1000508.
    • (2009) PLoS Genet , vol.5 , Issue.6 , pp. e1000508
    • Lindgren, C.M.1    Heid, I.M.2    Randall, J.C.3
  • 60
    • 67651216024 scopus 로고    scopus 로고
    • NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium
    • PID: 19557197
    • Heard-Costa NL, Zillikens MC, Monda KL, et al. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet. 2009;5(6):e1000539. doi:10.1371/journal.pgen.1000539.
    • (2009) PLoS Genet , vol.5 , Issue.6 , pp. e1000539
    • Heard-Costa, N.L.1    Zillikens, M.C.2    Monda, K.L.3
  • 61
    • 78049349396 scopus 로고    scopus 로고
    • Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
    • COI: 1:CAS:528:DC%2BC3cXht1Kms7vO, PID: 20935629
    • Heid IM, Jackson AU, Randall JC, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010;42(11):949–60. doi:10.1038/ng.685.
    • (2010) Nat Genet , vol.42 , Issue.11 , pp. 949-960
    • Heid, I.M.1    Jackson, A.U.2    Randall, J.C.3
  • 62
    • 84923169934 scopus 로고    scopus 로고
    • New genetic loci link adipose and insulin biology to body fat distribution
    • COI: 1:CAS:528:DC%2BC2MXisleht7w%3D, PID: 25673412, This is the most recent GWAS in up to 224,459 individuals identifying 33 additional loci (49 loci in total) associated with WHRadjBMI
    • Shungin D, Winkler TW, Croteau-Chonka DC. New genetic loci link adipose and insulin biology to body fat distribution. Nature. 2015;518(7538):187–96. doi:10.1038/nature14132. This is the most recent GWAS in up to 224,459 individuals identifying 33 additional loci (49 loci in total) associated with WHRadjBMI.
    • (2015) Nature , vol.518 , Issue.7538 , pp. 187-196
    • Shungin, D.1    Winkler, T.W.2    Croteau-Chonka, D.C.3
  • 63
    • 41749090524 scopus 로고    scopus 로고
    • Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants
    • PID: 18159244
    • Hinney A, Nguyen TT, Scherag A, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One. 2007;2(12):e1361. doi:10.1371/journal.pone.0001361.
    • (2007) PLoS One , vol.2 , Issue.12 , pp. e1361
    • Hinney, A.1    Nguyen, T.T.2    Scherag, A.3
  • 64
    • 59149097625 scopus 로고    scopus 로고
    • Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
    • COI: 1:CAS:528:DC%2BD1MXntFGktg%3D%3D, PID: 19151714
    • Meyre D, Delplanque J, Chevre JC, et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet. 2009;41(2):157–9. doi:10.1038/ng.301.
    • (2009) Nat Genet , vol.41 , Issue.2 , pp. 157-159
    • Meyre, D.1    Delplanque, J.2    Chevre, J.C.3
  • 65
    • 77952405825 scopus 로고    scopus 로고
    • Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups
    • PID: 20421936
    • Scherag A, Dina C, Hinney A, et al. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups. PLoS Genet. 2010;6(4):e1000916. doi:10.1371/journal.pgen.1000916.
    • (2010) PLoS Genet , vol.6 , Issue.4 , pp. e1000916
    • Scherag, A.1    Dina, C.2    Hinney, A.3
  • 66
    • 80052840370 scopus 로고    scopus 로고
    • Genome-wide population-based association study of extremely overweight young adults—the GOYA study
    • COI: 1:CAS:528:DC%2BC3MXht1OmsrbN, PID: 21935397
    • Paternoster L, Evans DM, Nohr EA, et al. Genome-wide population-based association study of extremely overweight young adults—the GOYA study. PLoS One. 2011;6(9):e24303. doi:10.1371/journal.pone.0024303.
    • (2011) PLoS One , vol.6 , Issue.9 , pp. e24303
    • Paternoster, L.1    Evans, D.M.2    Nohr, E.A.3
  • 67
    • 79955711085 scopus 로고    scopus 로고
    • A genome-wide association study on obesity and obesity-related traits
    • COI: 1:CAS:528:DC%2BC3MXls1Kku7o%3D, PID: 21552555
    • Wang K, Li WD, Zhang CK, et al. A genome-wide association study on obesity and obesity-related traits. PLoS One. 2011;6(4):e18939. doi:10.1371/journal.pone.0018939.
    • (2011) PLoS One , vol.6 , Issue.4 , pp. e18939
    • Wang, K.1    Li, W.D.2    Zhang, C.K.3
  • 68
    • 84878569025 scopus 로고    scopus 로고
    • Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity
    • COI: 1:CAS:528:DC%2BC3sXltlOnsb8%3D, PID: 23563609
    • Wheeler E, Huang N, Bochukova EG, et al. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. Nat Genet. 2013;45(5):513–7. doi:10.1038/ng.2607.
    • (2013) Nat Genet , vol.45 , Issue.5 , pp. 513-517
    • Wheeler, E.1    Huang, N.2    Bochukova, E.G.3
  • 69
    • 84878594902 scopus 로고    scopus 로고
    • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
    • COI: 1:CAS:528:DC%2BC3sXltlOmtL4%3D, PID: 23563607
    • Berndt SI, Gustafsson S, Magi R, et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet. 2013;45(5):501–12. doi:10.1038/ng.2606.
    • (2013) Nat Genet , vol.45 , Issue.5 , pp. 501-512
    • Berndt, S.I.1    Gustafsson, S.2    Magi, R.3
  • 70
    • 84862777036 scopus 로고    scopus 로고
    • Meta-analysis identifies common variants associated with body mass index in East Asians
    • COI: 1:CAS:528:DC%2BC38XisVKkt7o%3D, PID: 22344219
    • Wen W, Cho YS, Zheng W, et al. Meta-analysis identifies common variants associated with body mass index in East Asians. Nat Genet. 2012;44(3):307–11. doi:10.1038/ng.1087.
    • (2012) Nat Genet , vol.44 , Issue.3 , pp. 307-311
    • Wen, W.1    Cho, Y.S.2    Zheng, W.3
  • 71
    • 84884607859 scopus 로고    scopus 로고
    • Genome-wide association of body fat distribution in African ancestry populations suggests new loci
    • COI: 1:CAS:528:DC%2BC3sXhsVagtLjJ, PID: 23966867
    • Liu CT, Monda KL, Taylor KC, et al. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9(8):e1003681. doi:10.1371/journal.pgen.1003681.
    • (2013) PLoS Genet , vol.9 , Issue.8 , pp. e1003681
    • Liu, C.T.1    Monda, K.L.2    Taylor, K.C.3
  • 72
    • 84878720938 scopus 로고    scopus 로고
    • A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
    • COI: 1:CAS:528:DC%2BC3sXlsl2gtLs%3D, PID: 23583978
    • Monda KL, Chen GK, Taylor KC, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013;45(6):690–6. doi:10.1038/ng.2608.
    • (2013) Nat Genet , vol.45 , Issue.6 , pp. 690-696
    • Monda, K.L.1    Chen, G.K.2    Taylor, K.C.3
  • 73
    • 84865640231 scopus 로고    scopus 로고
    • Variability in the heritability of body mass index: a systematic review and meta-regression
    • Elks CE, den Hoed M, Zhao JH, et al. Variability in the heritability of body mass index: a systematic review and meta-regression. Front Endocrinol (Lausanne). 2012;3:29. doi:10.3389/fendo.2012.00029.
    • (2012) Front Endocrinol (Lausanne) , vol.3 , pp. 29
    • Elks, C.E.1    den Hoed, M.2    Zhao, J.H.3
  • 74
    • 84860350999 scopus 로고    scopus 로고
    • A genome-wide association meta-analysis identifies new childhood obesity loci
    • COI: 1:CAS:528:DC%2BC38XltFOgsbw%3D, PID: 22484627
    • Bradfield JP, Taal HR, Timpson NJ, et al. A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet. 2012;44(5):526–31. doi:10.1038/ng.2247.
    • (2012) Nat Genet , vol.44 , Issue.5 , pp. 526-531
    • Bradfield, J.P.1    Taal, H.R.2    Timpson, N.J.3
  • 75
    • 84881581499 scopus 로고    scopus 로고
    • Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course
    • COI: 1:CAS:528:DC%2BC3sXht1CktLvE, PID: 23669352
    • Graff M, Ngwa JS, Workalemahu T, et al. Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum Mol Genet. 2013;22(17):3597–607. doi:10.1093/hmg/ddt205.
    • (2013) Hum Mol Genet , vol.22 , Issue.17 , pp. 3597-3607
    • Graff, M.1    Ngwa, J.S.2    Workalemahu, T.3
  • 76
    • 84892389710 scopus 로고    scopus 로고
    • EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children
    • PID: 24348519
    • Namjou B, Keddache M, Marsolo K, et al. EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. Front Genet. 2013;4:268. doi:10.3389/fgene.2013.00268.
    • (2013) Front Genet , vol.4 , pp. 268
    • Namjou, B.1    Keddache, M.2    Marsolo, K.3
  • 77
    • 67349188883 scopus 로고    scopus 로고
    • A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    • COI: 1:CAS:528:DC%2BD1MXltValt7k%3D, PID: 19396169
    • Cho YS, Go MJ, Kim YJ, et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet. 2009;41(5):527–34. doi:10.1038/ng.357.
    • (2009) Nat Genet , vol.41 , Issue.5 , pp. 527-534
    • Cho, Y.S.1    Go, M.J.2    Kim, Y.J.3
  • 78
    • 34249777814 scopus 로고    scopus 로고
    • Variation in FTO contributes to childhood obesity and severe adult obesity
    • COI: 1:CAS:528:DC%2BD2sXlvVSgtL0%3D, PID: 17496892
    • Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet. 2007;39(6):724–6. doi:10.1038/ng2048.
    • (2007) Nat Genet , vol.39 , Issue.6 , pp. 724-726
    • Dina, C.1    Meyre, D.2    Gallina, S.3
  • 79
    • 84862564504 scopus 로고    scopus 로고
    • Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
    • COI: 1:CAS:528:DC%2BC38XjsF2qtLc%3D, PID: 22109280
    • Li H, Kilpelainen TO, Liu C, et al. Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia. 2012;55(4):981–95. doi:10.1007/s00125-011-2370-7.
    • (2012) Diabetologia , vol.55 , Issue.4 , pp. 981-995
    • Li, H.1    Kilpelainen, T.O.2    Liu, C.3
  • 80
    • 84862822438 scopus 로고    scopus 로고
    • Common variants at CDKAL1 and KLF9 are associated with body mass index in East Asian populations
    • COI: 1:CAS:528:DC%2BC38XisVKktrk%3D, PID: 22344221
    • Okada Y, Kubo M, Ohmiya H, et al. Common variants at CDKAL1 and KLF9 are associated with body mass index in East Asian populations. Nat Genet. 2012;44(3):302–6. doi:10.1038/ng.1086.
    • (2012) Nat Genet , vol.44 , Issue.3 , pp. 302-306
    • Okada, Y.1    Kubo, M.2    Ohmiya, H.3
  • 81
    • 84879326263 scopus 로고    scopus 로고
    • The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis
    • PID: 23824655
    • Fall T, Hagg S, Magi R, et al. The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med. 2013;10(6):e1001474. doi:10.1371/journal.pmed.1001474.
    • (2013) PLoS Med , vol.10 , Issue.6 , pp. e1001474
    • Fall, T.1    Hagg, S.2    Magi, R.3
  • 82
    • 36749041363 scopus 로고    scopus 로고
    • The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    • COI: 1:CAS:528:DC%2BD2sXhtlGmtLbI, PID: 17991826
    • Gerken T, Girard CA, Tung YC, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. 2007;318(5855):1469–72. doi:10.1126/science.1151710.
    • (2007) Science , vol.318 , Issue.5855 , pp. 1469-1472
    • Gerken, T.1    Girard, C.A.2    Tung, Y.C.3
  • 83
    • 77649303960 scopus 로고    scopus 로고
    • Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats
    • PID: 20098739
    • Tung YC, Ayuso E, Shan X, et al. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One. 2010;5(1):e8771. doi:10.1371/journal.pone.0008771.
    • (2010) PLoS One , vol.5 , Issue.1 , pp. e8771
    • Tung, Y.C.1    Ayuso, E.2    Shan, X.3
  • 84
    • 84897855294 scopus 로고    scopus 로고
    • Obesity-associated variants within FTO form long-range functional connections with IRX3
    • COI: 1:CAS:528:DC%2BC2cXks1Wlsbk%3D, PID: 24646999
    • Smemo S, Tena JJ, Kim KH, et al. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014;507(7492):371–5. doi:10.1038/nature13138.
    • (2014) Nature , vol.507 , Issue.7492 , pp. 371-375
    • Smemo, S.1    Tena, J.J.2    Kim, K.H.3
  • 85
    • 75749112078 scopus 로고    scopus 로고
    • Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs
    • COI: 1:CAS:528:DC%2BC3cXht1Kks7g%3D
    • Been LF, Nath SK, Ralhan SK, et al. Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs. Obesity (Silver Spring). 2010;18(2):425–9. doi:10.1038/oby.2009.254.
    • (2010) Obesity (Silver Spring) , vol.18 , Issue.2 , pp. 425-429
    • Been, L.F.1    Nath, S.K.2    Ralhan, S.K.3
  • 86
    • 77749233777 scopus 로고    scopus 로고
    • Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a Chinese population
    • COI: 1:CAS:528:DC%2BC3cXjs1Kqtbo%3D, PID: 20061430
    • Cheung CY, Tso AW, Cheung BM, et al. Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a Chinese population. J Clin Endocrinol Metab. 2010;95(3):1395–403. doi:10.1210/jc.2009-1465.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.3 , pp. 1395-1403
    • Cheung, C.Y.1    Tso, A.W.2    Cheung, B.M.3
  • 87
    • 84858282155 scopus 로고    scopus 로고
    • Implication of European-derived adiposity loci in African Americans
    • COI: 1:CAS:528:DC%2BC38XktVansbs%3D
    • Hester JM, Wing MR, Li J, et al. Implication of European-derived adiposity loci in African Americans. Int J Obes (Lond). 2012;36(3):465–73. doi:10.1038/ijo.2011.131.
    • (2012) Int J Obes (Lond) , vol.36 , Issue.3 , pp. 465-473
    • Hester, J.M.1    Wing, M.R.2    Li, J.3
  • 88
    • 0031662163 scopus 로고    scopus 로고
    • A frameshift mutation in human MC4R is associated with a dominant form of obesity
    • COI: 1:CAS:528:DyaK1cXms1amsLo%3D, PID: 9771699
    • Vaisse C, Clement K, Guy-Grand B, et al. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet. 1998;20(2):113–4. doi:10.1038/2407.
    • (1998) Nat Genet , vol.20 , Issue.2 , pp. 113-114
    • Vaisse, C.1    Clement, K.2    Guy-Grand, B.3
  • 89
    • 34547831224 scopus 로고    scopus 로고
    • The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals
    • COI: 1:CAS:528:DC%2BD2sXpsF2qtbw%3D
    • Young EH, Wareham NJ, Farooqi S, et al. The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Int J Obes (Lond). 2007;31(9):1437–41. doi:10.1038/sj.ijo.0803609.
    • (2007) Int J Obes (Lond) , vol.31 , Issue.9 , pp. 1437-1441
    • Young, E.H.1    Wareham, N.J.2    Farooqi, S.3
  • 90
    • 0041624549 scopus 로고    scopus 로고
    • Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter
    • COI: 1:CAS:528:DC%2BD3sXmtlyhtr4%3D, PID: 12904474
    • Liu H, Kishi T, Roseberry AG, et al. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci. 2003;23(18):7143–54.
    • (2003) J Neurosci , vol.23 , Issue.18 , pp. 7143-7154
    • Liu, H.1    Kishi, T.2    Roseberry, A.G.3
  • 91
    • 84893640057 scopus 로고    scopus 로고
    • Neural melanocortin receptors in obesity and related metabolic disorders
    • COI: 1:CAS:528:DC%2BC3sXoslWlu7g%3D, PID: 23680515
    • Girardet C, Butler AA. Neural melanocortin receptors in obesity and related metabolic disorders. Biochim Biophys Acta. 2014;1842(3):482–94. doi:10.1016/j.bbadis.2013.05.004.
    • (2014) Biochim Biophys Acta , vol.1842 , Issue.3 , pp. 482-494
    • Girardet, C.1    Butler, A.A.2
  • 92
    • 67349277177 scopus 로고    scopus 로고
    • Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling
    • COI: 1:CAS:528:DC%2BD1MXmsVSgtrs%3D, PID: 19463742
    • Chai B, Li JY, Zhang W, et al. Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling. Peptides. 2009;30(6):1098–104. doi:10.1016/j.peptides.2009.03.006.
    • (2009) Peptides , vol.30 , Issue.6 , pp. 1098-1104
    • Chai, B.1    Li, J.Y.2    Zhang, W.3
  • 93
    • 77956709758 scopus 로고    scopus 로고
    • Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling
    • COI: 1:CAS:528:DC%2BC3cXhtFGjtLjO, PID: 20603172
    • Chai B, Li JY, Zhang W, et al. Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling. Peptides. 2010;31(10):1888–93. doi:10.1016/j.peptides.2010.06.028.
    • (2010) Peptides , vol.31 , Issue.10 , pp. 1888-1893
    • Chai, B.1    Li, J.Y.2    Zhang, W.3
  • 94
    • 84555186717 scopus 로고    scopus 로고
    • Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians
    • COI: 1:CAS:528:DC%2BC38XltFSns70%3D, PID: 22106157
    • Thearle MS, Muller YL, Hanson RL, et al. Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians. Diabetes. 2012;61(1):250–7. doi:10.2337/db11-0708.
    • (2012) Diabetes , vol.61 , Issue.1 , pp. 250-257
    • Thearle, M.S.1    Muller, Y.L.2    Hanson, R.L.3
  • 95
    • 32544451924 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD28XhslCjtrw%3D, PID: 16415884
    • Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 2006;38(3):320–3. doi:10.1038/ng1732.
    • (2006) Nat Genet , vol.38 , Issue.3 , pp. 320-323
    • Grant, S.F.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 96
    • 34548790660 scopus 로고    scopus 로고
    • The importance of TCF7L2
    • COI: 1:CAS:528:DC%2BD2sXht1CltrrI, PID: 17888129
    • Weedon MN. The importance of TCF7L2. Diabet Med. 2007;24(10):1062–6. doi:10.1111/j.1464-5491.2007.02258.x.
    • (2007) Diabet Med , vol.24 , Issue.10 , pp. 1062-1066
    • Weedon, M.N.1
  • 97
    • 64649096898 scopus 로고    scopus 로고
    • Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function
    • COI: 1:CAS:528:DC%2BD1MXktleitbs%3D, PID: 19336690
    • Gloyn AL, Braun M, Rorsman P. Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function. Diabetes. 2009;58(4):800–2. doi:10.2337/db09-0099.
    • (2009) Diabetes , vol.58 , Issue.4 , pp. 800-802
    • Gloyn, A.L.1    Braun, M.2    Rorsman, P.3
  • 98
    • 70349557826 scopus 로고    scopus 로고
    • Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
    • COI: 1:CAS:528:DC%2BD1MXhtV2gsb%2FL, PID: 19734900
    • Rung J, Cauchi S, Albrechtsen A, et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet. 2009;41(10):1110–5. doi:10.1038/ng.443.
    • (2009) Nat Genet , vol.41 , Issue.10 , pp. 1110-1115
    • Rung, J.1    Cauchi, S.2    Albrechtsen, A.3
  • 99
    • 84859575363 scopus 로고    scopus 로고
    • Genetic determinants of common obesity and their value in prediction
    • COI: 1:CAS:528:DC%2BC38XlvFKlsrs%3D, PID: 22498250
    • Loos RJ. Genetic determinants of common obesity and their value in prediction. Best Pract Res Clin Endocrinol Metab. 2012;26(2):211–26. doi:10.1016/j.beem.2011.11.003.
    • (2012) Best Pract Res Clin Endocrinol Metab , vol.26 , Issue.2 , pp. 211-226
    • Loos, R.J.1
  • 100
    • 84861614905 scopus 로고    scopus 로고
    • A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
    • COI: 1:CAS:528:DC%2BC38XmvFCjtbw%3D, PID: 22581228
    • Manning AK, Hivert MF, Scott RA, et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet. 2012;44(6):659–69. doi:10.1038/ng.2274.
    • (2012) Nat Genet , vol.44 , Issue.6 , pp. 659-669
    • Manning, A.K.1    Hivert, M.F.2    Scott, R.A.3
  • 101
    • 84865693929 scopus 로고    scopus 로고
    • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
    • COI: 1:CAS:528:DC%2BC38XhtFOgsbzJ, PID: 22885924
    • Scott RA, Lagou V, Welch RP, et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet. 2012;44(9):991–1005. doi:10.1038/ng.2385.
    • (2012) Nat Genet , vol.44 , Issue.9 , pp. 991-1005
    • Scott, R.A.1    Lagou, V.2    Welch, R.P.3
  • 102
    • 0031918624 scopus 로고    scopus 로고
    • The IRS-signalling system: a network of docking proteins that mediate insulin action
    • COI: 1:CAS:528:DyaK1cXjtlOnsr4%3D, PID: 9609109
    • White MF. The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol Cell Biochem. 1998;182(1-2):3–11.
    • (1998) Mol Cell Biochem , vol.182 , Issue.1-2 , pp. 3-11
    • White, M.F.1
  • 103
    • 0038811794 scopus 로고    scopus 로고
    • Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study
    • COI: 1:CAS:528:DC%2BD3sXntlamsbk%3D, PID: 12716671
    • Snijder MB, Dekker JM, Visser M, et al. Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study. Am J Clin Nutr. 2003;77(5):1192–7.
    • (2003) Am J Clin Nutr , vol.77 , Issue.5 , pp. 1192-1197
    • Snijder, M.B.1    Dekker, J.M.2    Visser, M.3
  • 104
    • 0842333101 scopus 로고    scopus 로고
    • Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn study
    • PID: 14747216
    • Snijder MB, Dekker JM, Visser M, et al. Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn study. Diabetes Care. 2004;27(2):372–7.
    • (2004) Diabetes Care , vol.27 , Issue.2 , pp. 372-377
    • Snijder, M.B.1    Dekker, J.M.2    Visser, M.3
  • 105
    • 0035433418 scopus 로고    scopus 로고
    • Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein
    • COI: 1:CAS:528:DC%2BD3MXlslKnu7g%3D, PID: 11473043
    • Slosberg ED, Desai UJ, Fanelli B, et al. Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein. Diabetes. 2001;50(8):1813–20.
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1813-1820
    • Slosberg, E.D.1    Desai, U.J.2    Fanelli, B.3
  • 106
    • 49349084320 scopus 로고    scopus 로고
    • Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver
    • COI: 1:CAS:528:DC%2BD1cXhtFCqtr3F, PID: 18657188
    • Desbuquois B, Bereziat V, Authier F, et al. Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver. FEBS J. 2008;275(17):4363–77. doi:10.1111/j.1742-4658.2008.06583.x.
    • (2008) FEBS J , vol.275 , Issue.17 , pp. 4363-4377
    • Desbuquois, B.1    Bereziat, V.2    Authier, F.3
  • 107
    • 77955505564 scopus 로고    scopus 로고
    • Biological, clinical and population relevance of 95 loci for blood lipids
    • COI: 1:CAS:528:DC%2BC3cXhtVSmurfI, PID: 20686565
    • Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466(7307):707–13. doi:10.1038/nature09270.
    • (2010) Nature , vol.466 , Issue.7307 , pp. 707-713
    • Teslovich, T.M.1    Musunuru, K.2    Smith, A.V.3
  • 108
    • 84879677633 scopus 로고    scopus 로고
    • Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits
    • COI: 1:CAS:528:DC%2BC3sXhtFGjsLrP, PID: 23754948
    • Randall JC, Winkler TW, Kutalik Z, et al. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet. 2013;9(6):e1003500. doi:10.1371/journal.pgen.1003500.
    • (2013) PLoS Genet , vol.9 , Issue.6 , pp. e1003500
    • Randall, J.C.1    Winkler, T.W.2    Kutalik, Z.3
  • 109
    • 84876219189 scopus 로고    scopus 로고
    • Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased beta-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort
    • COI: 1:CAS:528:DC%2BC3sXmtFegsrY%3D, PID: 23457408
    • Harder MN, Ribel-Madsen R, Justesen JM, et al. Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased beta-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort. J Clin Endocrinol Metab. 2013;98(4):E801–6. doi:10.1210/jc.2012-4169.
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.4 , pp. E801-E806
    • Harder, M.N.1    Ribel-Madsen, R.2    Justesen, J.M.3
  • 110
    • 6944241725 scopus 로고    scopus 로고
    • Increased adipose tissue expression of Grb14 in several models of insulin resistance
    • PID: 15059968
    • Cariou B, Capitaine N, Le Marcis V, et al. Increased adipose tissue expression of Grb14 in several models of insulin resistance. FASEB J. 2004;18(9):965–7. doi:10.1096/fj.03-0824fje.
    • (2004) FASEB J , vol.18 , Issue.9 , pp. 965-967
    • Cariou, B.1    Capitaine, N.2    Le Marcis, V.3
  • 111
    • 10744225161 scopus 로고    scopus 로고
    • Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice
    • COI: 1:CAS:528:DC%2BD2cXhtV2qsb0%3D, PID: 14749734
    • Cooney GJ, Lyons RJ, Crew AJ, et al. Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice. EMBO J. 2004;23(3):582–93. doi:10.1038/sj.emboj.7600082.
    • (2004) EMBO J , vol.23 , Issue.3 , pp. 582-593
    • Cooney, G.J.1    Lyons, R.J.2    Crew, A.J.3
  • 112
    • 67649612829 scopus 로고    scopus 로고
    • Molecular determinants of Grb14-mediated inhibition of insulin signaling
    • COI: 1:CAS:528:DC%2BD1MXotlGju7w%3D, PID: 19359342
    • Goenaga D, Hampe C, Carre N, et al. Molecular determinants of Grb14-mediated inhibition of insulin signaling. Mol Endocrinol. 2009;23(7):1043–51. doi:10.1210/me.2008-0360.
    • (2009) Mol Endocrinol , vol.23 , Issue.7 , pp. 1043-1051
    • Goenaga, D.1    Hampe, C.2    Carre, N.3
  • 113
    • 0034253787 scopus 로고    scopus 로고
    • ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family
    • COI: 1:CAS:528:DC%2BD3cXlsVKltbk%3D, PID: 10936055
    • Clark ME, Kelner GS, Turbeville LA, et al. ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family. Genomics. 2000;67(3):343–50. doi:10.1006/geno.2000.6246.
    • (2000) Genomics , vol.67 , Issue.3 , pp. 343-350
    • Clark, M.E.1    Kelner, G.S.2    Turbeville, L.A.3
  • 114
    • 70349833653 scopus 로고    scopus 로고
    • Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients—EUGENE2 study
    • PID: 19789630
    • Boesgaard TW, Gjesing AP, Grarup N, et al. Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients—EUGENE2 study. PLoS One. 2009;4(9):e7236. doi:10.1371/journal.pone.0007236.
    • (2009) PLoS One , vol.4 , Issue.9 , pp. e7236
    • Boesgaard, T.W.1    Gjesing, A.P.2    Grarup, N.3
  • 115
    • 84879203883 scopus 로고    scopus 로고
    • PPARG2 Pro12Ala and ADAMTS9 rs4607103 as “insulin resistance loci” and “insulin secretion loci” in Italian individuals. The GENFIEV study and the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 4
    • COI: 1:STN:280:DC%2BC3s7ktlWltg%3D%3D, PID: 23161442
    • Trombetta M, Bonetti S, Boselli ML, et al. PPARG2 Pro12Ala and ADAMTS9 rs4607103 as “insulin resistance loci” and “insulin secretion loci” in Italian individuals. The GENFIEV study and the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 4. Acta Diabetol. 2013;50(3):401–8. doi:10.1007/s00592-012-0443-9.
    • (2013) Acta Diabetol , vol.50 , Issue.3 , pp. 401-408
    • Trombetta, M.1    Bonetti, S.2    Boselli, M.L.3
  • 116
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    • PID: 15111519
    • Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047–53.
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3
  • 117
    • 49249138836 scopus 로고    scopus 로고
    • Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance
    • COI: 1:CAS:528:DC%2BD1cXpvVOls7k%3D, PID: 18492747
    • Hivert MF, Sullivan LM, Fox CS, et al. Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance. J Clin Endocrinol Metab. 2008;93(8):3165–72. doi:10.1210/jc.2008-0425.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.8 , pp. 3165-3172
    • Hivert, M.F.1    Sullivan, L.M.2    Fox, C.S.3
  • 118
    • 43449090395 scopus 로고    scopus 로고
    • Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity
    • COI: 1:CAS:528:DC%2BD1cXls1yrsro%3D
    • Hung J, McQuillan BM, Thompson PL, et al. Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity. Int J Obes (Lond). 2008;32(5):772–9. doi:10.1038/sj.ijo.0803793.
    • (2008) Int J Obes (Lond) , vol.32 , Issue.5 , pp. 772-779
    • Hung, J.1    McQuillan, B.M.2    Thompson, P.L.3
  • 119
    • 34250854033 scopus 로고    scopus 로고
    • Associations of adiponectin with metabolic and vascular risk parameters in the British Regional Heart Study reveal stronger links to insulin resistance-related than to coronory heart disease risk-related parameters
    • COI: 1:CAS:528:DC%2BD2sXmvVOntbg%3D
    • Wannamethee SG, Tchernova J, Whincup P, et al. Associations of adiponectin with metabolic and vascular risk parameters in the British Regional Heart Study reveal stronger links to insulin resistance-related than to coronory heart disease risk-related parameters. Int J Obes (Lond). 2007;31(7):1089–98. doi:10.1038/sj.ijo.0803544.
    • (2007) Int J Obes (Lond) , vol.31 , Issue.7 , pp. 1089-1098
    • Wannamethee, S.G.1    Tchernova, J.2    Whincup, P.3
  • 120
    • 0037031088 scopus 로고    scopus 로고
    • Adiponectin and development of type 2 diabetes in the Pima Indian population
    • COI: 1:CAS:528:DC%2BD38XltV2qs7Y%3D, PID: 12114044
    • Lindsay RS, Funahashi T, Hanson RL, et al. Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet. 2002;360(9326):57–8. doi:10.1016/S0140-6736(02)09335-2.
    • (2002) Lancet , vol.360 , Issue.9326 , pp. 57-58
    • Lindsay, R.S.1    Funahashi, T.2    Hanson, R.L.3
  • 121
    • 1842864234 scopus 로고    scopus 로고
    • Plasma adiponectin levels and risk of myocardial infarction in men
    • COI: 1:CAS:528:DC%2BD2cXjt1Wrt7Y%3D, PID: 15082700
    • Pischon T, Girman CJ, Hotamisligil GS, et al. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA. 2004;291(14):1730–7. doi:10.1001/jama.291.14.1730.
    • (2004) JAMA , vol.291 , Issue.14 , pp. 1730-1737
    • Pischon, T.1    Girman, C.J.2    Hotamisligil, G.S.3
  • 122
    • 0037452139 scopus 로고    scopus 로고
    • Adiponectin and protection against type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BD3sXkvVOlsQ%3D%3D, PID: 12547549
    • Spranger J, Kroke A, Mohlig M, et al. Adiponectin and protection against type 2 diabetes mellitus. Lancet. 2003;361(9353):226–8. doi:10.1016/S0140-6736(03)12255-6.
    • (2003) Lancet , vol.361 , Issue.9353 , pp. 226-228
    • Spranger, J.1    Kroke, A.2    Mohlig, M.3
  • 123
    • 0034999667 scopus 로고    scopus 로고
    • Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia
    • COI: 1:CAS:528:DC%2BD3MXjs1OmsL0%3D, PID: 11344187
    • Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001;86(5):1930–5. doi:10.1210/jcem.86.5.7463.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.5 , pp. 1930-1935
    • Weyer, C.1    Funahashi, T.2    Tanaka, S.3
  • 124
    • 33745192633 scopus 로고    scopus 로고
    • Leptin and adiponectin in relation to body fat percentage, waist to hip ratio and the apoB/apoA1 ratio in Asian Indian and Caucasian men and women
    • Smith J, Al-Amri M, Sniderman A, et al. Leptin and adiponectin in relation to body fat percentage, waist to hip ratio and the apoB/apoA1 ratio in Asian Indian and Caucasian men and women. Nutr Metab (Lond). 2006;3:18. doi:10.1186/1743-7075-3-18.
    • (2006) Nutr Metab (Lond) , vol.3 , pp. 18
    • Smith, J.1    Al-Amri, M.2    Sniderman, A.3
  • 125
    • 17944362243 scopus 로고    scopus 로고
    • The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome
    • COI: 1:CAS:528:DC%2BD3MXmvFCku7w%3D, PID: 11549668
    • Comuzzie AG, Funahashi T, Sonnenberg G, et al. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab. 2001;86(9):4321–5. doi:10.1210/jcem.86.9.7878.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.9 , pp. 4321-4325
    • Comuzzie, A.G.1    Funahashi, T.2    Sonnenberg, G.3
  • 126
    • 34248187069 scopus 로고    scopus 로고
    • Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease
    • COI: 1:CAS:528:DC%2BD2sXltlantLc%3D, PID: 17303804
    • Menzaghi C, Trischitta V, Doria A. Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes. 2007;56(5):1198–209. doi:10.2337/db06-0506.
    • (2007) Diabetes , vol.56 , Issue.5 , pp. 1198-1209
    • Menzaghi, C.1    Trischitta, V.2    Doria, A.3
  • 127
    • 18644369745 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians
    • COI: 1:CAS:528:DC%2BD38XnvVemtrk%3D, PID: 12354786
    • Vasseur F, Helbecque N, Dina C, et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet. 2002;11(21):2607–14.
    • (2002) Hum Mol Genet , vol.11 , Issue.21 , pp. 2607-2614
    • Vasseur, F.1    Helbecque, N.2    Dina, C.3
  • 128
    • 38149068433 scopus 로고    scopus 로고
    • The small G proteins of the Arf family and their regulators
    • COI: 1:CAS:528:DC%2BD2sXhtlCisrrK, PID: 17506703
    • Gillingham AK, Munro S. The small G proteins of the Arf family and their regulators. Annu Rev Cell Dev Biol. 2007;23:579–611. doi:10.1146/annurev.cellbio.23.090506.123209.
    • (2007) Annu Rev Cell Dev Biol , vol.23 , pp. 579-611
    • Gillingham, A.K.1    Munro, S.2
  • 129
    • 34147139995 scopus 로고    scopus 로고
    • The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane
    • COI: 1:CAS:528:DC%2BD2sXkt1ahtrw%3D, PID: 17398095
    • Hofmann I, Thompson A, Sanderson CM, et al. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. Curr Biol. 2007;17(8):711–6. doi:10.1016/j.cub.2007.03.007.
    • (2007) Curr Biol , vol.17 , Issue.8 , pp. 711-716
    • Hofmann, I.1    Thompson, A.2    Sanderson, C.M.3
  • 130
    • 78649468820 scopus 로고    scopus 로고
    • The genetics of type 2 diabetes: what have we learned from GWAS?
    • COI: 1:CAS:528:DC%2BC3MXmvVCitw%3D%3D, PID: 21091714
    • Billings LK, Florez JC. The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci. 2010;1212:59–77. doi:10.1111/j.1749-6632.2010.05838.x.
    • (2010) Ann N Y Acad Sci , vol.1212 , pp. 59-77
    • Billings, L.K.1    Florez, J.C.2
  • 131
    • 78649842241 scopus 로고    scopus 로고
    • Genomics, type 2 diabetes, and obesity
    • COI: 1:CAS:528:DC%2BC3cXhsFGkt7zO, PID: 21142536
    • McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med. 2010;363(24):2339–50. doi:10.1056/NEJMra0906948.
    • (2010) N Engl J Med , vol.363 , Issue.24 , pp. 2339-2350
    • McCarthy, M.I.1
  • 132
    • 84898416576 scopus 로고    scopus 로고
    • Gender differences in non-glycemic responses to improved insulin sensitivity by pioglitazone treatment in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXls1Wiu70%3D, PID: 23389468
    • Arnetz L, Dorkhan M, Alvarsson M, et al. Gender differences in non-glycemic responses to improved insulin sensitivity by pioglitazone treatment in patients with type 2 diabetes. Acta Diabetol. 2014;51(2):185–92. doi:10.1007/s00592-013-0457-y.
    • (2014) Acta Diabetol , vol.51 , Issue.2 , pp. 185-192
    • Arnetz, L.1    Dorkhan, M.2    Alvarsson, M.3
  • 133
    • 34548588284 scopus 로고    scopus 로고
    • Sexual dimorphism of body composition
    • PID: 17875489
    • Wells JC. Sexual dimorphism of body composition. Best Pract Res Clin Endocrinol Metab. 2007;21(3):415–30. doi:10.1016/j.beem.2007.04.007.
    • (2007) Best Pract Res Clin Endocrinol Metab , vol.21 , Issue.3 , pp. 415-430
    • Wells, J.C.1
  • 134
    • 2942650969 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • COI: 1:CAS:528:DC%2BD2cXmtlGqt7s%3D, PID: 15181022
    • Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89(6):2548–56. doi:10.1210/jc.2004-0395.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.6 , pp. 2548-2556
    • Kershaw, E.E.1    Flier, J.S.2


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