메뉴 건너뛰기




Volumn 24, Issue 10, 2007, Pages 1062-1066

The importance of TCF7L2

Author keywords

Genetic association study; TCF7L2; Type 2 diabetes

Indexed keywords

METFORMIN; PLACEBO; PROTEIN DERIVATIVE; TCF7L2 PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 34548790660     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2007.02258.x     Document Type: Review
Times cited : (71)

References (35)
  • 2
    • 34249888775 scopus 로고    scopus 로고
    • Diabetes Genetics Initiative of Broad Institute of Harvard, MIT, Lund University and Novartis Institutes for BioMedical Research. Science
    • Diabetes Genetics Initiative of Broad Institute of Harvard, MIT, Lund University and Novartis Institutes for BioMedical Research. Genome-wide association analysis identifies loci for Type 2 diabetes and triglyceride levels. Science 2007 316 : 1331 1336.
    • (2007) Genome-wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels , vol.316 , pp. 1331-1336
  • 5
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007 445 : 881 885.
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3    Dina, C.4    Shen, L.5    Serre, D.6
  • 8
    • 33750602980 scopus 로고    scopus 로고
    • Association analysis of 6736 UK subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk
    • Groves CJ, Zeggini E, Minton JA, Frayling TM, Weedon MN, Rayner NW et al. Association analysis of 6736 UK subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 2006 55 : 2640 2644.
    • (2006) Diabetes , vol.55 , pp. 2640-2644
    • Groves, C.J.1    Zeggini, E.2    Minton, J.A.3    Frayling, T.M.4    Weedon, M.N.5    Rayner, N.W.6
  • 9
    • 33845936147 scopus 로고    scopus 로고
    • Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population
    • Chandak GR, Janipalli CS, Bhaskar S, Kulkarni SR, Mohankrishna P, Hattersley AT et al. Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia 2007 50 : 63 67.
    • (2007) Diabetologia , vol.50 , pp. 63-67
    • Chandak, G.R.1    Janipalli, C.S.2    Bhaskar, S.3    Kulkarni, S.R.4    Mohankrishna, P.5    Hattersley, A.T.6
  • 10
    • 34147119644 scopus 로고    scopus 로고
    • Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population
    • Hayashi T, Iwamoto Y, Kaku K, Hirose H, Maeda S. Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population. Diabetologia 2007 50 : 980 984.
    • (2007) Diabetologia , vol.50 , pp. 980-984
    • Hayashi, T.1    Iwamoto, Y.2    Kaku, K.3    Hirose, H.4    Maeda, S.5
  • 11
    • 33847618213 scopus 로고    scopus 로고
    • A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population
    • Horikoshi M, Hara K, Ito C, Nagai R, Froguel P, Kadowaki T. A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population. Diabetologia 2007 50 : 747 751.
    • (2007) Diabetologia , vol.50 , pp. 747-751
    • Horikoshi, M.1    Hara, K.2    Ito, C.3    Nagai, R.4    Froguel, P.5    Kadowaki, T.6
  • 12
    • 33847014094 scopus 로고    scopus 로고
    • Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with Type 2 diabetes and age of onset in Mexican Americans
    • Lehman DM, Hunt KJ, Leach RJ, Hamlington J, Arya R, Abboud HE et al. Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with Type 2 diabetes and age of onset in Mexican Americans. Diabetes 2007 56 : 389 393.
    • (2007) Diabetes , vol.56 , pp. 389-393
    • Lehman, D.M.1    Hunt, K.J.2    Leach, R.J.3    Hamlington, J.4    Arya, R.5    Abboud, H.E.6
  • 14
    • 33750584981 scopus 로고    scopus 로고
    • Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with Type 2 diabetes in the Amish: Replication and evidence for a role in both insulin secretion and insulin resistance
    • Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD et al. Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with Type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 2006 55 : 2654 2659.
    • (2006) Diabetes , vol.55 , pp. 2654-2659
    • Damcott, C.M.1    Pollin, T.I.2    Reinhart, L.J.3    Ott, S.H.4    Shen, H.5    Silver, K.D.6
  • 15
    • 33750587754 scopus 로고    scopus 로고
    • Association of transcription factor 7-like 2 (TCF7L2) variants with Type 2 diabetes in a Finnish Sample
    • Scott LJ, Bonnycastle LL, Willer CJ, Sprau AG, Jackson AU, Narisu N et al. Association of transcription factor 7-like 2 (TCF7L2) variants with Type 2 diabetes in a Finnish Sample. Diabetes 2006 55 : 2649 2653.
    • (2006) Diabetes , vol.55 , pp. 2649-2653
    • Scott, L.J.1    Bonnycastle, L.L.2    Willer, C.J.3    Sprau, A.G.4    Jackson, A.U.5    Narisu, N.6
  • 16
    • 33845933521 scopus 로고    scopus 로고
    • TCF7L2 and type 2 diabetes - We WNT to know - Commentary
    • Smith U. TCF7L2 and type 2 diabetes - we WNT to know - commentary. Diabetologia 2007 50 : 5 7.
    • (2007) Diabetologia , vol.50 , pp. 5-7
    • Smith, U.1
  • 17
    • 4444342868 scopus 로고    scopus 로고
    • Expression profiling and functional analysis of Wnt signaling mechanisms in mesenchymal stem cells
    • Etheridge SL, Spencer GJ, Heath DJ, Genever PG. Expression profiling and functional analysis of Wnt signaling mechanisms in mesenchymal stem cells. Stem Cells 2004 22 : 849 860.
    • (2004) Stem Cells , vol.22 , pp. 849-860
    • Etheridge, S.L.1    Spencer, G.J.2    Heath, D.J.3    Genever, P.G.4
  • 19
    • 25844530871 scopus 로고    scopus 로고
    • Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function
    • Papadopoulou S, Edlund H. Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 2005 54 : 2844 2851.
    • (2005) Diabetes , vol.54 , pp. 2844-2851
    • Papadopoulou, S.1    Edlund, H.2
  • 20
    • 33746075560 scopus 로고    scopus 로고
    • TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
    • the Diabetes Prevention Program Research Group.
    • Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PIW, Shuldiner AR et al., the Diabetes Prevention Program Research Group. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 2006 355 : 241 250.
    • (2006) N Engl J Med , vol.355 , pp. 241-250
    • Florez, J.C.1    Jablonski, K.A.2    Bayley, N.3    Pollin, T.I.4    De Bakker, P.I.W.5    Shuldiner, A.R.6
  • 21
    • 33750892139 scopus 로고    scopus 로고
    • Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with Type 2 diabetes and reduce the insulin response to glucose in non-diabetic individuals
    • Saxena R, Gianniny L, Burtt NP, Lyssenko V, Giuducci C, Sjogren M et al. Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with Type 2 diabetes and reduce the insulin response to glucose in non-diabetic individuals. Diabetes 2006 55 : 2890 2895.
    • (2006) Diabetes , vol.55 , pp. 2890-2895
    • Saxena, R.1    Gianniny, L.2    Burtt, N.P.3    Lyssenko, V.4    Giuducci, C.5    Sjogren, M.6
  • 23
    • 33845542020 scopus 로고    scopus 로고
    • Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in non-diabetic women
    • Munoz J, Lok KH, Gower BA, Fernandez JR, Hunter GR, Lara-Castro C et al. Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in non-diabetic women. Diabetes 2006 55 : 3630 3634.
    • (2006) Diabetes , vol.55 , pp. 3630-3634
    • Munoz, J.1    Lok, K.H.2    Gower, B.A.3    Fernandez, J.R.4    Hunter, G.R.5    Lara-Castro, C.6
  • 24
    • 33845534950 scopus 로고    scopus 로고
    • TCF7L2 variation predicts hyperglycemia incidence in a French general population: The Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study
    • for the DSG.
    • Cauchi S, Meyre D, Choquet H, Dina C, Born C, Marre M et al. for the DSG. TCF7L2 variation predicts hyperglycemia incidence in a French general population: The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study. Diabetes 2006 55 : 3189 3192.
    • (2006) Diabetes , vol.55 , pp. 3189-3192
    • Cauchi, S.1    Meyre, D.2    Choquet, H.3    Dina, C.4    Born, C.5    Marre, M.6
  • 25
    • 33947607216 scopus 로고    scopus 로고
    • Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys
    • Marzi C, Huth C, Kolz M, Grallert H, Meisinger C, Wichmann HE et al. Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys. Horm Metab Res 2007 39 : 46 52.
    • (2007) Horm Metab Res , vol.39 , pp. 46-52
    • Marzi, C.1    Huth, C.2    Kolz, M.3    Grallert, H.4    Meisinger, C.5    Wichmann, H.E.6
  • 26
  • 28
    • 33746686369 scopus 로고    scopus 로고
    • Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations
    • the Neonatal Diabetes International Collaborative Group.
    • Pearson ER, Flechtner I, Njolstad PR, Malecki MT, Flanagan SE, Larkin B et al., the Neonatal Diabetes International Collaborative Group. Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 2006 355 : 467 477.
    • (2006) N Engl J Med , vol.355 , pp. 467-477
    • Pearson, E.R.1    Flechtner, I.2    Njolstad, P.R.3    Malecki, M.T.4    Flanagan, S.E.5    Larkin, B.6
  • 29
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of Type 2 diabetes with lifestyle intervention or metformin
    • Diabetes Prevention Program Research Group.
    • Diabetes Prevention Program Research Group. Reduction in the incidence of Type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002 346 : 393 403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
  • 30
    • 33748773883 scopus 로고    scopus 로고
    • Predictive genetic testing for type 2 diabetes - May raise unrealistic expectations
    • Janssens A, Gwinn M, Valdez R, Narayan KMV, Khoury MJ. Predictive genetic testing for type 2 diabetes - may raise unrealistic expectations. Br Med J 2006 333 : 509 510.
    • (2006) Br Med J , vol.333 , pp. 509-510
    • Janssens, A.1    Gwinn, M.2    Valdez, R.3    Narayan, K.M.V.4    Khoury, M.J.5
  • 31
    • 33750876203 scopus 로고    scopus 로고
    • Combining information from common Type 2 diabetes risk polymorphisms improves disease prediction
    • Weedon MN, McCarthy MI, Hitman G, Walker M, Groves CJ, Zeggini E et al. Combining information from common Type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med 2006 3 : e374.
    • (2006) PLoS Med , vol.3
    • Weedon, M.N.1    McCarthy, M.I.2    Hitman, G.3    Walker, M.4    Groves, C.J.5    Zeggini, E.6
  • 32
    • 1542314297 scopus 로고    scopus 로고
    • Revisiting the clinical validity of multiplex genetic testing in complex diseases.
    • Janssens A, Pardo MC, Steyerberg EW, van Duijn CM. Revisiting the clinical validity of multiplex genetic testing in complex diseases. Am J Human Genet 2004 74 : 585 588.
    • (2004) Am J Human Genet , vol.74 , pp. 585-588
    • Janssens, A.1    Pardo, M.C.2    Steyerberg, E.W.3    Van Duijn, C.M.4
  • 33
    • 27544432314 scopus 로고    scopus 로고
    • How many genes underlie the occurrence of common complex diseases in the population?
    • Yang QH, Khoury MJ, Friedman JM, Little J, Flanders WD. How many genes underlie the occurrence of common complex diseases in the population? Int J Epidemiol 2005 34 : 1129 1137.
    • (2005) Int J Epidemiol , vol.34 , pp. 1129-1137
    • Yang, Q.H.1    Khoury, M.J.2    Friedman, J.M.3    Little, J.4    Flanders, W.D.5
  • 34
    • 0037370188 scopus 로고    scopus 로고
    • Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes
    • Yang Q, Khoury MJ, Botto L, Friedman JM, Flanders WD. Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes. Am J Hum Genet 2003 72 : 636 649.
    • (2003) Am J Hum Genet , vol.72 , pp. 636-649
    • Yang, Q.1    Khoury, M.J.2    Botto, L.3    Friedman, J.M.4    Flanders, W.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.