Genome-wide association of pericardial fat identifies a unique locus for Ectopic fat

PLoS Genetics

Volumn 8, Issue 5, 2012, Pages

  Fox, Caroline S ^a,b   White, Charles C ^a,c   Lohman, Kurt ^d   Heard Costa, Nancy ^e   Cohen, Paul ^b   Zhang, Yingying ^f   Johnson, Andrew D ^a   Emilsson, Valur ^g   Liu, Ching Ti ^a,c   Chen, Y D Ida ^h   Taylor, Kent D ^h   Allison, Matthew ⁱ   Budoff, Matthew ^j   Rotter, Jerome I ^h   Carr, J Jeffrey ^d   Hoffmann, Udo ^k   Ding, Jingzhong ^d   Cupples, L Adrienne ^a,c   Liu, Yongmei ^d  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g ICELANDIC HEART ASSOCIATION   (Iceland)

^h CEDARS SINAI MEDICAL CENTER   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^k MASSACHUSETTS GENERAL HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; ADULT; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY FAT DISTRIBUTION; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHINESE; DISEASE ASSOCIATION; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE LOCUS; GENETIC ASSOCIATION; GENOME ANALYSIS; GENOTYPE; HISPANIC; HUMAN; INTRAABDOMINAL FAT; MALE; MOUSE; NONHUMAN; RACE DIFFERENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRIB2 GENE; ANIMAL; ASIAN; ATHEROSCLEROSIS; CAUCASIAN; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY DISEASE; GENE EXPRESSION REGULATION; GENETICS; META ANALYSIS; METABOLISM; MIDDLE AGED; NEGRO; OBESITY; PERICARDIUM; QUANTITATIVE TRAIT LOCUS;

MUS;

SIGNAL PEPTIDE; TRIB2 PROTEIN, HUMAN;

ADIPOSE TISSUE; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ANIMALS; ASIAN CONTINENTAL ANCESTRY GROUP; ATHEROSCLEROSIS; BODY FAT DISTRIBUTION; BODY MASS INDEX; CORONARY DISEASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HISPANIC AMERICANS; HUMANS; INTRA-ABDOMINAL FAT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MIDDLE AGED; OBESITY; PERICARDIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84863689970     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002705     Document Type: Article

References (57)

1. Cornier MA, Despres JP, Davis N, Grossniklaus DA, Klein S, et al. (2011) Assessing Adiposity: A Scientific Statement From the American Heart Association. Circulation.
2. Bjorntorp P, (1991) Metabolic implications of body fat distribution. Diabetes Care 14: 1132-1143.
3. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, et al. (2007) Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 116: 39-48.
4. Montani JP, Carroll JF, Dwyer TM, Antic V, Yang Z, et al. (2004) Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord 28 (Suppl 4): S58-S65.
5. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, et al. (2008) Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation 117: 605-613.
6. Ding J, Hsu FC, Harris TB, Liu Y, Kritchevsky SB, et al. (2009) The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr 90: 499-504.
7. Henrichot E, Juge-Aubry CE, Pernin A, Pache JC, Velebit V, et al. (2005) Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis? Arterioscler Thromb Vasc Biol 25: 2594-2599.
8. Barandier C, Montani JP, Yang Z, (2005) Mature adipocytes and perivascular adipose tissue stimulate vascular smooth muscle cell proliferation: effects of aging and obesity. Am J Physiol Heart Circ Physiol 289: H1807-H1813.
9. Atwood LD, Heard-Costa NL, Cupples LA, Jaquish CE, Wilson PW, et al. (2002) Genomewide Linkage Analysis of Body Mass Index across 28 Years of the Framingham Heart Study. Am J Hum Genet 71: 1044-1050.
10. Sellers TA, Drinkard C, Rich SS, Potter JD, Jeffery RW, et al. (1994) Familial aggregation and heritability of waist-to-hip ratio in adult women: the Iowa Women's Health Study. Int J Obes Relat Metab Disord 18: 607-613.
11. Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, et al. (2011) Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet 7: e1001324 doi:10.1371/journal.pgen.1001324.
12. Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, et al. (2010) Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 42: 949-960.
13. Kilpelainen TO, Zillikens MC, Stancakova A, Finucane FM, Ried JS, et al. (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet 43: 753-760.
14. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42: 937-948.
15. Kan MC, Oruganty-Das A, Cooper-Morgan A, Jin G, Swanger SA, et al. (2010) CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion. Mol Cell Biol 30: 5658-5671.
16. Schunkert H, Konig IR, Kathiresan S, Reilly MP, Assimes TL, et al. (2011) Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 43: 333-338.
17. Ding J, Kritchevsky SB, Harris TB, Burke GL, Detrano RC, et al. (2008) The association of pericardial fat with calcified coronary plaque. Obesity (Silver Spring) 16: 1914-1919.
18. Mahabadi AA, Massaro JM, Rosito GA, Levy D, Murabito JM, et al. (2009) Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study. Eur Heart J 30: 850-856.
19. Fox CS, Gona P, Hoffmann U, Porter SA, Salton CJ, et al. (2009) Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study. Circulation 119: 1586-1591.
20. Soliman EZ, Ding J, Hsu FC, Carr JJ, Polak JF, et al. (2010) Association between carotid intima-media thickness and pericardial fat in the Multi-Ethnic Study of Atherosclerosis (MESA). J Stroke Cerebrovasc Dis 19: 58-65.
21. Walden TB, Hansen IR, Timmons JA, Cannon B, Nedergaard J, (2011) Recruited versus nonrecruited molecular signatures of brown, "brite" and white adipose tissues. Am J Physiol Endocrinol Metab.
22. Kikuchi K, Gupta V, Wang J, Holdway JE, Wills AA, et al. (2011) tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development 138: 2895-2902.
23. Grandinetti KB, Stevens TA, Ha S, Salamone RJ, Walker JR, et al. (2011) Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPalpha. Oncogene 30: 3328-3335.
24. Naiki T, Saijou E, Miyaoka Y, Sekine K, Miyajima A, (2007) TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta. J Biol Chem 282: 24075-24082.
25. Dedhia PH, Keeshan K, Uljon S, Xu L, Vega ME, et al. (2010) Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood 116: 1321-1328.
26. Eder K, Guan H, Sung HY, Ward J, Angyal A, et al. (2008) Tribbles-2 is a novel regulator of inflammatory activation of monocytes. Int Immunol 20: 1543-1550.
27. Ostertag A, Jones A, Rose AJ, Liebert M, Kleinsorg S, et al. (2010) Control of adipose tissue inflammation through TRB1. Diabetes 59: 1991-2000.
28. Bi XP, Tan HW, Xing SS, Wang ZH, Tang MX, et al. (2008) Overexpression of TRB3 gene in adipose tissue of rats with high fructose-induced metabolic syndrome. Endocr J 55: 747-752.
29. Phan J, Reue K, (2005) Lipin, a lipodystrophy and obesity gene. Cell Metab 1: 73-83.
30. Fawcett KA, Grimsey N, Loos RJ, Wheeler E, Daly A, et al. (2008) Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations. Diabetes 57: 2527-2533.
31. Almasy L, Blangero J, (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62: 1198-1211.
32. Willer CJ, Li Y, Abecasis GR, (2010) METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26: 2190-2191.
33. Pe'er I, Yelensky R, Altshuler D, Daly MJ, (2008) Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol 32: 381-385.
34. Storey JD, Tibshirani R, (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 100: 9440-9445.
35. Goring HH, Curran JE, Johnson MP, Dyer TD, Charlesworth J, et al. (2007) Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet 39: 1208-1216.
36. Idaghdour Y, Czika W, Shianna KV, Lee SH, Visscher PM, et al. (2010) Geographical genomics of human leukocyte gene expression variation in southern Morocco. Nat Genet 42: 62-67.
37. Heap GA, Trynka G, Jansen RC, Bruinenberg M, Swertz MA, et al. (2009) Complex nature of SNP genotype effects on gene expression in primary human leucocytes. BMC Med Genomics 2: 1.
38. Dixon AL, Liang L, Moffatt MF, Chen W, Heath S, et al. (2007) A genome-wide association study of global gene expression. Nat Genet 39: 1202-1207.
39. Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, et al. (2007) Population genomics of human gene expression. Nat Genet 39: 1217-1224.
40. Kwan T, Benovoy D, Dias C, Gurd S, Provencher C, et al. (2008) Genome-wide analysis of transcript isoform variation in humans. Nat Genet 40: 225-231.
41. Heinzen EL, Ge D, Cronin KD, Maia JM, Shianna KV, et al. (2008) Tissue-specific genetic control of splicing: implications for the study of complex traits. PLoS Biol 6: e1 doi:10.1371/journal.pbio.0060001.
42. Zeller T, Wild P, Szymczak S, Rotival M, Schillert A, et al. (2010) Genetics and beyond-the transcriptome of human monocytes and disease susceptibility. PLoS ONE 5: e10693 doi:10.1371/journal.pone.0010693.
43. Emilsson V, Thorleifsson G, Zhang B, Leonardson AS, Zink F, et al. (2008) Genetics of gene expression and its effect on disease. Nature 452: 423-428.
44. Greenawalt DM, Dobrin R, Chudin E, Hatoum IJ, Suver C, et al. (2011) A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Res 21: 1008-1016.
45. Webster JA, Gibbs JR, Clarke J, Ray M, Zhang W, et al. (2009) Genetic control of human brain transcript expression in Alzheimer disease. Am J Hum Genet 84: 445-458.
46. Schadt EE, Molony C, Chudin E, Hao K, Yang X, et al. (2008) Mapping the genetic architecture of gene expression in human liver. PLoS Biol 6: e107 doi:10.1371/journal.pbio.0060107.
47. Grundberg E, Kwan T, Ge B, Lam KC, Koka V, et al. (2009) Population genomics in a disease targeted primary cell model. Genome Res 19: 1942-1952.
48. Ding J, Gudjonsson JE, Liang L, Stuart PE, Li Y, et al. (2010) Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals. Am J Hum Genet 87: 779-789.
49. Dimas AS, Deutsch S, Stranger BE, Montgomery SB, Borel C, et al. (2009) Common regulatory variation impacts gene expression in a cell type-dependent manner. Science 325: 1246-1250.
50. Dawber TR, Meadors GF, Moore FE, (1951) Epidemiologic approaches to heart disease: the Framingham study. Am J Publich Health 41: 279-286.
51. Splansky GL, Corey D, Yang Q, Atwood LD, Cupples LA, et al. (2007) The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol 165: 1328-1335.
52. Maurovich-Horvat P, Massaro J, Fox CS, Moselewski F, O'Donnell CJ, et al. (2007) Comparison of anthropometric, area- and volume-based assessment of abdominal subcutaneous and visceral adipose tissue volumes using multi-detector computed tomography. Int J Obes (Lond) 31: 500-506.
53. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38: 904-909.
54. Bild DE, Bluemke DA, Burke GL, Detrano R, Roux AV, et al. (2002) Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol 156: 871-881.
55. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, et al. (2008) Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med 358: 1336-1345.
56. Sharrett AR, Ding J, Criqui MH, Saad MF, Liu K, et al. (2006) Smoking, diabetes, and blood cholesterol differ in their associations with subclinical atherosclerosis: the Multiethnic Study of Atherosclerosis (MESA). Atherosclerosis 186: 441-447.
57. Howie BN, Donnelly P, Marchini J, (2009) A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet 5: e1000529 doi:10.1371/journal.pgen.1000529.