-
1
-
-
0034611791
-
Obesity as a medical problem
-
Kopelman, P.G. Obesity as a medical problem. Nature 404, 635-643 (2000). (Pubitemid 30205068)
-
(2000)
Nature
, vol.404
, Issue.6778
, pp. 635-643
-
-
Kopelman, P.G.1
-
2
-
-
0030843960
-
Genetic and environmental factors in relative body weight and human adiposity
-
DOI 10.1023/A:1025635913927
-
Maes, H.H., Neale, M.C. & Eaves, L.J. Genetic and environmental factors in relative body weight and human adiposity. Behav. Genet. 27, 325-351 (1997). (Pubitemid 27415169)
-
(1997)
Behavior Genetics
, vol.27
, Issue.4
, pp. 325-351
-
-
Maes, H.H.M.1
Neale, M.C.2
Eaves, L.J.3
-
3
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
DOI 10.1126/science.1141634
-
Frayling, T.M. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889-894 (2007). (Pubitemid 46764279)
-
(2007)
Science
, vol.316
, Issue.5826
, pp. 889-894
-
-
Frayling, T.M.1
Timpson, N.J.2
Weedon, M.N.3
Zeggini, E.4
Freathy, R.M.5
Lindgren, C.M.6
Perry, J.R.B.7
Elliott, K.S.8
Lango, H.9
Rayner, N.W.10
Shields, B.11
Harries, L.W.12
Barrett, J.C.13
Ellard, S.14
Groves, C.J.15
Knight, B.16
Patch, A.-M.17
Ness, A.R.18
Ebrahim, S.19
Lawlor, D.A.20
Ring, S.M.21
Ben-Shlomo, Y.22
Jarvelin, M.-R.23
Sovio, U.24
Bennett, A.J.25
Melzer, D.26
Ferrucci, L.27
Loos, R.J.F.28
Barroso, I.29
Wareham, N.J.30
Karpe, F.31
Owen, K.R.32
Cardon, L.R.33
Walker, M.34
Hitman, G.A.35
Palmer, C.N.A.36
Doney, A.S.F.37
Morris, A.D.38
Smith, G.D.39
Hattersley, A.T.40
McCarthy, M.I.41
more..
-
4
-
-
44849086097
-
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
-
Liu, Y.J. et al. Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum. Mol. Genet. 17, 1803-1813 (2008).
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 1803-1813
-
-
Liu, Y.J.1
-
5
-
-
44349166252
-
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
-
DOI 10.1038/ng.156, PII NG156
-
Chambers, J.C. et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat. Genet. 40, 716-718 (2008). (Pubitemid 351748872)
-
(2008)
Nature Genetics
, vol.40
, Issue.6
, pp. 716-718
-
-
Chambers, J.C.1
Elliott, P.2
Zabaneh, D.3
Zhang, W.4
Li, Y.5
Froguel, P.6
Balding, D.7
Scott, J.8
Kooner, J.S.9
-
6
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
DOI 10.1038/ng.140, PII NG140
-
Loos, R.J. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat. Genet. 40, 768-775 (2008). (Pubitemid 351748863)
-
(2008)
Nature Genetics
, vol.40
, Issue.6
, pp. 768-775
-
-
Loos, R.J.F.1
Lindgren, C.M.2
Li, S.3
Wheeler, E.4
Zhao, J.H.5
Prokopenko, I.6
Inouye, M.7
Freathy, R.M.8
Attwood, A.P.9
Beckmann, J.S.10
Berndt, S.I.11
Jacobs, K.B.12
Chanock, S.J.13
Hayes, R.B.14
Bergmann, S.15
Bennett, A.J.16
Bingham, S.A.17
Bochud, M.18
Brown, M.19
Cauchi, S.20
Connell, J.M.21
Cooper, C.22
Smith, G.D.23
Day, I.24
Dina, C.25
De, S.26
Dermitzakis, E.T.27
Doney, A.S.F.28
Elliott, K.S.29
Elliott, P.30
Evans, D.M.31
Sadaf Farooqi, I.32
Froguel, P.33
Ghori, J.34
Groves, C.J.35
Gwilliam, R.36
Hadley, D.37
Hall, A.S.38
Hattersley, A.T.39
Hebebrand, J.40
Heid, I.M.41
Lamina, C.42
Gieger, C.43
Illig, T.44
Meitinger, T.45
Wichmann, H.-E.46
Herrera, B.47
Hinney, A.48
Hunt, S.E.49
Jarvelin, M.-R.50
Johnson, T.51
Jolley, J.D.M.52
Karpe, F.53
Keniry, A.54
Khaw, K.-T.55
Luben, R.N.56
Mangino, M.57
Marchini, J.58
McArdle, W.L.59
McGinnis, R.60
Meyre, D.61
Munroe, P.B.62
Morris, A.D.63
Ness, A.R.64
Neville, M.J.65
Nica, A.C.66
Ong, K.K.67
O'Rahilly, S.68
Owen, K.R.69
Palmer, C.N.A.70
Papadakis, K.71
Potter, S.72
Pouta, A.73
more..
-
7
-
-
58149163141
-
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
-
Thorleifsson, G. et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat. Genet. 41, 18-24 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 18-24
-
-
Thorleifsson, G.1
-
8
-
-
58149163142
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
Willer, C.J. et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25-34 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 25-34
-
-
Willer, C.J.1
-
9
-
-
59149097625
-
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
-
Meyre, D. et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat. Genet. 41, 157-159 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 157-159
-
-
Meyre, D.1
-
10
-
-
61849137254
-
Genome-wide association and replication studies identified TRHR as an important gene for lean body mass
-
Liu, X.G. et al. Genome-wide association and replication studies identified TRHR as an important gene for lean body mass. Am. J. Hum. Genet. 84, 418-423 (2009).
-
(2009)
Am. J. Hum. Genet.
, vol.84
, pp. 418-423
-
-
Liu, X.G.1
-
11
-
-
67349188883
-
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
-
Cho, Y.S. et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat. Genet. 41, 527-534 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 527-534
-
-
Cho, Y.S.1
-
12
-
-
78049337953
-
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
-
Speliotes, E.K. et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937-948 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 937-948
-
-
Speliotes, E.K.1
-
13
-
-
0035990614
-
Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship
-
DOI 10.1046/j.1467-789X.2002.00065.x
-
Deurenberg, P., Deurenberg-Yap, M. & Guricci, S. Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship. Obes. Rev. 3, 141-146 (2002). (Pubitemid 34815232)
-
(2002)
Obesity Reviews
, vol.3
, Issue.3
, pp. 141-146
-
-
Deurenberg, P.1
Deurenberg-Yap, M.2
Guricci, S.3
-
15
-
-
79952019307
-
Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus
-
Okada, Y. et al. Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. Hum. Mol. Genet. 20, 1224-1231 (2011).
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 1224-1231
-
-
Okada, Y.1
-
16
-
-
12144285594
-
Assessing the impact of population stratification on genetic association studies
-
DOI 10.1038/ng1333
-
Freedman, M.L. et al. Assessing the impact of population stratification on genetic association studies. Nat. Genet. 36, 388-393 (2004). (Pubitemid 38437262)
-
(2004)
Nature Genetics
, vol.36
, Issue.4
, pp. 388-393
-
-
Freedman, M.L.1
Reich, D.2
Penney, K.L.3
McDonald, G.J.4
Mignault, A.A.5
Patterson, N.6
Gabriel, S.B.7
Topol, E.J.8
Smoller, J.W.9
Pato, C.N.10
Pato, M.T.11
Petryshen, T.L.12
Kolonel, L.N.13
Lander, E.S.14
Sklar, P.15
Henderson, B.16
Hirschhorn, J.N.17
Altshuler, D.18
-
17
-
-
84862777036
-
Meta-analysis identifies common variants associated with body mass index in east Asians
-
Advance online publication (12 February), doi:10.1038/ng.1086
-
Wen, W. et al. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat. Genet. Advance online publication (12 February 2012), doi:10.1038/ng.1086.
-
(2012)
Nat. Genet.
-
-
Wen, W.1
-
18
-
-
64549160686
-
Variation in the gene encoding Kruppel-like factor 7 influences body fat: Studies of 14,818 Danes
-
Zobel, D.P. et al. Variation in the gene encoding Kruppel-like factor 7 influences body fat: studies of 14,818 Danes. Eur. J. Endocrinol. 160, 603-609 (2009).
-
(2009)
Eur. J. Endocrinol.
, vol.160
, pp. 603-609
-
-
Zobel, D.P.1
-
19
-
-
77950858297
-
From monogenic to polygenic obesity: Recent advances
-
Hinney, A., Vogel, C.I. & Hebebrand, J. From monogenic to polygenic obesity: recent advances. Eur. Child Adolesc. Psychiatry 19, 297-310 (2010).
-
(2010)
Eur. Child Adolesc. Psychiatry
, vol.19
, pp. 297-310
-
-
Hinney, A.1
Vogel, C.I.2
Hebebrand, J.3
-
20
-
-
67349166946
-
Detecting gene-gene interactions that underlie human diseases
-
Cordell, H.J. Detecting gene-gene interactions that underlie human diseases. Nat. Rev. Genet. 10, 392-404 (2009).
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 392-404
-
-
Cordell, H.J.1
-
21
-
-
77955382146
-
BMI at age 8 years is influenced by the type 2 diabetes susceptibility genes HHEX-IDE and CDKAL1
-
Winkler, C. et al. BMI at age 8 years is influenced by the type 2 diabetes susceptibility genes HHEX-IDE and CDKAL1. Diabetes 59, 2063-2067 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 2063-2067
-
-
Winkler, C.1
-
22
-
-
77955558577
-
Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight
-
Andersson, E.A. et al. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. Diabetologia 53, 1908-1916 (2010).
-
(2010)
Diabetologia
, vol.53
, pp. 1908-1916
-
-
Andersson, E.A.1
-
23
-
-
34249828965
-
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
-
DOI 10.1038/ng2043, PII NG2043
-
Steinthorsdottir, V. et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat. Genet. 39, 770-775 (2007). (Pubitemid 46848592)
-
(2007)
Nature Genetics
, vol.39
, Issue.6
, pp. 770-775
-
-
Steinthorsdottir, V.1
Thorleifsson, G.2
Reynisdottir, I.3
Benediktsson, R.4
Jonsdottir, T.5
Walters, G.B.6
Styrkarsdottir, U.7
Gretarsdottir, S.8
Emilsson, V.9
Ghosh, S.10
Baker, A.11
Snorradottir, S.12
Bjarnason, H.13
Ng, M.C.Y.14
Hansen, T.15
Bagger, Y.16
Wilensky, R.L.17
Reilly, M.P.18
Adeyemo, A.19
Chen, Y.20
Zhou, J.21
Gudnason, V.22
Chen, G.23
Huang, H.24
Lashley, K.25
Doumatey, A.26
So, W.-Y.27
Ma, R.C.Y.28
Andersen, G.29
Borch-Johnsen, K.30
Jorgensen, T.31
Van Vliet-Ostaptchouk, J.V.32
Hofker, M.H.33
Wijmenga, C.34
Christiansen, C.35
Rader, D.J.36
Rotimi, C.37
Gurney, M.38
Chan, J.C.N.39
Pedersen, O.40
Sigurdsson, G.41
Gulcher, J.R.42
Thorsteinsdottir, U.43
Kong, A.44
Stefansson, K.45
more..
-
24
-
-
77957553197
-
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
-
Yamauchi, T. et al. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat. Genet. 42, 864-868 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 864-868
-
-
Yamauchi, T.1
-
25
-
-
75749091912
-
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
-
Saxena, R. et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat. Genet. 42, 142-148 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 142-148
-
-
Saxena, R.1
-
26
-
-
78651306412
-
Kruppel-like factor KLF9 regulates PPARγ transactivation at the middle stage of adipogenesis
-
Pei, H., Yao, Y., Yang, Y., Liao, K. & Wu, J.R. Kruppel-like factor KLF9 regulates PPARγ transactivation at the middle stage of adipogenesis. Cell Death Differ. 18, 315-327 (2011).
-
(2011)
Cell Death Differ.
, vol.18
, pp. 315-327
-
-
Pei, H.1
Yao, Y.2
Yang, Y.3
Liao, K.4
Wu, J.R.5
-
27
-
-
18844432308
-
Adiponectin and adiponectin receptors
-
DOI 10.1210/er.2005-0005
-
Kadowaki, T. & Yamauchi, T. Adiponectin and adiponectin receptors. Endocr. Rev. 26, 439-451 (2005). (Pubitemid 40686653)
-
(2005)
Endocrine Reviews
, vol.26
, Issue.3
, pp. 439-451
-
-
Kadowaki, T.1
Yamauchi, T.2
-
28
-
-
20144389501
-
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation
-
DOI 10.1016/j.cmet.2004.11.005, PII S1550413104000063
-
Oishi, Y. et al. Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab. 1, 27-39 (2005). (Pubitemid 43960584)
-
(2005)
Cell Metabolism
, vol.1
, Issue.1
, pp. 27-39
-
-
Oishi, Y.1
Manabe, I.2
Tobe, K.3
Tsushima, K.4
Shindo, T.5
Fujiu, K.6
Nishimura, G.7
Maemura, K.8
Yamauchi, T.9
Kubota, N.10
Suzuki, R.11
Kitamura, T.12
Akira, S.13
Kadowaki, T.14
Nagai, R.15
-
29
-
-
77649198629
-
Myostatin (GDF-8) as a key factor linking muscle mass and bone structure
-
Elkasrawy, M.N. & Hamrick, M.W. Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J. Musculoskelet. Neuronal Interact. 10, 56-63 (2010).
-
(2010)
J. Musculoskelet. Neuronal Interact.
, vol.10
, pp. 56-63
-
-
Elkasrawy, M.N.1
Hamrick, M.W.2
-
30
-
-
2942735123
-
Myostatin mutation associated with gross muscle hypertrophy in a child
-
DOI 10.1056/NEJMoa040933
-
Schuelke, M. et al. Myostatin mutation associated with gross muscle hypertrophy in a child. N. Engl. J. Med. 350, 2682-2688 (2004). (Pubitemid 38788003)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.26
, pp. 2682-2688
-
-
Schuelke, M.1
Wagner, K.R.2
Stolz, L.E.3
Hubner, C.4
Riebel, T.5
Komen, W.6
Braun, T.7
Tobin, J.F.8
Lee, S.-J.9
-
31
-
-
76449086120
-
An evolutionarily conserved Myostatin proximal promoter/enhancer confers basal levels of transcription and spatial specificity in vivo
-
Grade, C.V., Salerno, M.S., Schubert, F.R., Dietrich, S. & Alvares, L.E. An evolutionarily conserved Myostatin proximal promoter/enhancer confers basal levels of transcription and spatial specificity in vivo. Dev. Genes Evol. 219, 497-508 (2009).
-
(2009)
Dev. Genes Evol.
, vol.219
, pp. 497-508
-
-
Grade, C.V.1
Salerno, M.S.2
Schubert, F.R.3
Dietrich, S.4
Alvares, L.E.5
-
32
-
-
23944489344
-
Validity of self-reported height and weight in a Japanese workplace population
-
DOI 10.1038/sj.ijo.0803012
-
Wada, K. et al. Validity of self-reported height and weight in a Japanese workplace population. Int. J. Obes. (Lond) 29, 1093-1099 (2005). (Pubitemid 41192217)
-
(2005)
International Journal of Obesity
, vol.29
, Issue.9
, pp. 1093-1099
-
-
Wada, K.1
Tamakoshi, K.2
Tsunekawa, T.3
Otsuka, R.4
Zhang, H.5
Murata, C.6
Nagasawa, N.7
Matsushita, K.8
Sugiura, K.9
Yatsuya, H.10
Toyoshima, H.11
-
33
-
-
0032847510
-
Reliability of self-reported body height and weight of adult Japanese women
-
DOI 10.1017/S0021932099005556
-
Nakamura, K., Hoshino, Y., Kodama, K. & Yamamoto, M. Reliability of self-reported body height and weight of adult Japanese women. J. Biosoc. Sci. 31, 555-558 (1999). (Pubitemid 29488415)
-
(1999)
Journal of Biosocial Science
, vol.31
, Issue.4
, pp. 555-558
-
-
Nakamura, K.1
Hoshino, Y.2
Kodama, K.3
Yamamoto, M.4
-
34
-
-
79959503826
-
-
The International HapMap Consortium. The International HapMap Project
-
The International HapMap Consortium. The International HapMap Project. Nature 426, 789-796 (2003).
-
(2003)
Nature
, vol.426
, pp. 789-796
-
-
-
35
-
-
0032714352
-
Genomic control for association studies
-
Devlin, B. & Roeder, K. Genomic control for association studies. Biometrics 55, 997-1004 (1999).
-
(1999)
Biometrics
, vol.55
, pp. 997-1004
-
-
Devlin, B.1
Roeder, K.2
-
36
-
-
53049090475
-
Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: Effects on population-based association studies
-
Yamaguchi-Kabata, Y. et al. Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies. Am. J. Hum. Genet. 83, 445-456 (2008).
-
(2008)
Am. J. Hum. Genet.
, vol.83
, pp. 445-456
-
-
Yamaguchi-Kabata, Y.1
-
37
-
-
34548738566
-
Population genomics of human gene expression
-
DOI 10.1038/ng2142, PII NG2142
-
Stranger, B.E. et al. Population genomics of human gene expression. Nat. Genet. 39, 1217-1224 (2007). (Pubitemid 47482691)
-
(2007)
Nature Genetics
, vol.39
, Issue.10
, pp. 1217-1224
-
-
Stranger, B.E.1
Nica, A.C.2
Forrest, M.S.3
Dimas, A.4
Bird, C.P.5
Beazley, C.6
Ingle, C.E.7
Dunning, M.8
Flicek, P.9
Koller, D.10
Montgomery, S.11
Tavare, S.12
Deloukas, P.13
Dermitzakis, E.T.14
-
38
-
-
85066456886
-
Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies
-
W.H.O. Expert Consultation
-
W.H.O. Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363, 157-163 (2004).
-
(2004)
Lancet
, vol.363
, pp. 157-163
-
-
|