Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian sikhs

Obesity

Volumn 18, Issue 2, 2010, Pages 425-429

  Been, Latonya F ^a   Nath, Swapan K ^b   Ralhan, Sarju K ^c   Wander, Gurpreet S ^c   Mehra, Narinder K ^d   Singh, Jairup ^e   Mulvihill, John J ^a   Sanghera, Dharambir K ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^c DAYANAND MEDICAL COLLEGE AND HOSPITAL   (India)

^d ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^e GURU NANAK DEV UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; MC4R PROTEIN, HUMAN; MELANOCORTIN 4 RECEPTOR; MLXIPL PROTEIN, HUMAN;

ADULT; ARTICLE; ASIAN; BODY MASS; BODY WEIGHT; CASE CONTROL STUDY; ETHNOLOGY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; HUMAN; INDIA; INSULIN RESISTANCE; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOPHYSIOLOGY; PHENOTYPE; QUANTITATIVE TRAIT; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST CIRCUMFERENCE;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BODY MASS INDEX; BODY WEIGHT; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INDIA; INSULIN RESISTANCE; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; OBESITY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; RECEPTOR, MELANOCORTIN, TYPE 4; RISK ASSESSMENT; RISK FACTORS; WAIST CIRCUMFERENCE;

EID: 75749112078     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2009.254     Document Type: Article

References (16)

1. Farooqi IS, Keogh, JM, Yeo GS et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 2003;348: 1085-1095.
2. Chambers JC, Elliott P, Zabaneh D et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 2008;40: 716-718.
3. Kooner JS, Chambers JC, Aguilar-Salinas CA et al. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet 2008;40: 149-151.
4. Sanghera DK, Bhatti JS, Bhatti GK et al. The Khatri Sikh Diabetes Study (SDS): study design, methodology, sample collection, and initial results. Hum Biol 2006;78: 43-63.
5. Diagnosis and classification of diabetes mellitus. Diabetes Care 2004;27(Suppl 1):S5-S10.
6. Sanghera DK, Ortega L, Han S et al. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet 2008;9: 59.
7. Sanghera DK, Nath SK, Ortega L et al. TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels. Ann Hum Genet 2008;72: 499-509.
8. WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004;363: 157-163.
9. Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28: 412-419.
10. Purcell S, Cherny SS, Sham PC. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003;19: 149-150.
11. Aulchenko YS, Ripatti S, Lindqvist I et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 2009;41: 47-55.
12. Kathiresan S, Voight BF, Purcell S et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 2009;41: 334-341.
13. Loos RJ, Lindgren CM, Li S et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008;40: 768-775.
14. Thorleifsson G, Walters GB, Gudbjartsson DF et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009;41: 18-24.
15. Willer CJ, Speliotes EK, Loos RJ et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41: 25-34.
16. Meyre D, Delplanque J, Chèvre JC et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 2009;41: 157-159.