-
1
-
-
56349158387
-
Type 2 diabetes: New genes, new understanding
-
Prokopenko I, McCarthy MI, Lindgren CM: Type 2 diabetes: new genes, new understanding. Trends Genet 24:613-621, 2008
-
(2008)
Trends Genet
, vol.24
, pp. 613-621
-
-
Prokopenko, I.1
McCarthy, M.I.2
Lindgren, C.M.3
-
2
-
-
47649086098
-
Genetics: How the UKPDS contributed to determining the genetic landscape of type 2 diabetes
-
Gloyn AL, McCarthy MI: Genetics: how the UKPDS contributed to determining the genetic landscape of type 2 diabetes. Diabet Med 25 (Suppl 2):35-40, 2008
-
(2008)
Diabet Med
, vol.25
, Issue.SUPPL. 2
, pp. 35-40
-
-
Gloyn, A.L.1
McCarthy, M.I.2
-
3
-
-
56349096931
-
-
Lango H, the U.K. Type 2 Diabetes Genetics Consortium, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN: Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 57:3129-3135, 2008
-
Lango H, the U.K. Type 2 Diabetes Genetics Consortium, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN: Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 57:3129-3135, 2008
-
-
-
-
4
-
-
50449085998
-
-
Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, So WY, Chan JC, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40:1039-1040, 2008
-
Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, So WY, Chan JC, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40:1039-1040, 2008
-
-
-
-
5
-
-
32544451924
-
-
Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkars- dottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gud- mundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thor- steinsdottir U, Gulcher JR, Kong A, Stefansson K: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet38:320-323, 2006
-
Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkars- dottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gud- mundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thor- steinsdottir U, Gulcher JR, Kong A, Stefansson K: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet38:320-323, 2006
-
-
-
-
6
-
-
33750602980
-
Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk
-
Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M, Wiltshire S, Hattersley AT, McCarthy MI: Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 55:2640-2644, 2006
-
(2006)
Diabetes
, vol.55
, pp. 2640-2644
-
-
Groves, C.J.1
Zeggini, E.2
Minton, J.3
Frayling, T.M.4
Weedon, M.N.5
Rayner, N.W.6
Hitman, G.A.7
Walker, M.8
Wiltshire, S.9
Hattersley, A.T.10
McCarthy, M.I.11
-
7
-
-
33845534950
-
TCF7L2 variation predicts hyperglycemia incidence in a French general population: The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study
-
Cauchi S, Meyre D, Choquet H, Dina C, Born C, Marre M, Balkau B, Froguel P: TCF7L2 variation predicts hyperglycemia incidence in a French general population: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Diabetes 55:3189-3192, 2006
-
(2006)
Diabetes
, vol.55
, pp. 3189-3192
-
-
Cauchi, S.1
Meyre, D.2
Choquet, H.3
Dina, C.4
Born, C.5
Marre, M.6
Balkau, B.7
Froguel, P.8
-
8
-
-
33750584981
-
Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: Replication and evidence for a role in both insulin secretion and insulin resistance
-
Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD, Mitchell BD, Shuldiner AR: Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 55:2654-2659, 2006
-
(2006)
Diabetes
, vol.55
, pp. 2654-2659
-
-
Damcott, C.M.1
Pollin, T.I.2
Reinhart, L.J.3
Ott, S.H.4
Shen, H.5
Silver, K.D.6
Mitchell, B.D.7
Shuldiner, A.R.8
-
9
-
-
34548790660
-
The importance of TCF7L2
-
Weedon MN: The importance of TCF7L2. Diabet Med 24:1062-1066, 2007
-
(2007)
Diabet Med
, vol.24
, pp. 1062-1066
-
-
Weedon, M.N.1
-
10
-
-
40949141938
-
Transcription factor 7-like 2 regulates p-cell survival and function in human pancreatic islets
-
Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K: Transcription factor 7-like 2 regulates p-cell survival and function in human pancreatic islets. Diabetes 57:645-653, 2008
-
(2008)
Diabetes
, vol.57
, pp. 645-653
-
-
Shu, L.1
Sauter, N.S.2
Schulthess, F.T.3
Matveyenko, A.V.4
Oberholzer, J.5
Maedler, K.6
-
11
-
-
0042879951
-
Insulin granule dynamics in pancreatic beta cells
-
Rorsman P, Renstrom E: Insulin granule dynamics in pancreatic beta cells. Diabetologia 46:1029-1045, 2003
-
(2003)
Diabetologia
, vol.46
, pp. 1029-1045
-
-
Rorsman, P.1
Renstrom, E.2
-
12
-
-
64649105053
-
TCF7L2 regulates late events in insulin secretion from pancreatic islet β-cells
-
da Silva Xavier G, Loder MK, McDonald A, Tarasov AI, Carzaniga R, Kronenberger K, Barg S, Rutter GA: TCF7L2 regulates late events in insulin secretion from pancreatic islet β-cells. Diabetes 58:894-905, 2009
-
(2009)
Diabetes
, vol.58
, pp. 894-905
-
-
da Silva Xavier, G.1
Loder, M.K.2
McDonald, A.3
Tarasov, A.I.4
Carzaniga, R.5
Kronenberger, K.6
Barg, S.7
Rutter, G.A.8
-
13
-
-
41849102063
-
Munc 18-1 and granuphilin collaborate during insulin granule exocytosis
-
Tomas A, Meda P, Regazzi R, Pessin JE, Halban PA: Munc 18-1 and granuphilin collaborate during insulin granule exocytosis. Traffic 9:813832, 2008
-
(2008)
Traffic
, vol.9
, pp. 813832
-
-
Tomas, A.1
Meda, P.2
Regazzi, R.3
Pessin, J.E.4
Halban, P.A.5
-
14
-
-
0019063270
-
Calcium action potentials and potassium permeability activation in pancreatic beta-cells
-
Ribalet B, Beigelman PM: Calcium action potentials and potassium permeability activation in pancreatic beta-cells. Am J Physiol 239:C124-C133,1980
-
(1980)
Am J Physiol
, vol.239
-
-
Ribalet, B.1
Beigelman, P.M.2
-
15
-
-
0035201145
-
Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells
-
Barg S, Ma X, Eliasson L, Galvanovskis J, Gopel SO, Obermuller S, Platzer J, Renstrom E, Trus M, Atlas D, Striessnig J, Rorsman P: Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells. Biophys J 81:3308-3323, 2001
-
(2001)
Biophys J
, vol.81
, pp. 3308-3323
-
-
Barg, S.1
Ma, X.2
Eliasson, L.3
Galvanovskis, J.4
Gopel, S.O.5
Obermuller, S.6
Platzer, J.7
Renstrom, E.8
Trus, M.9
Atlas, D.10
Striessnig, J.11
Rorsman, P.12
-
16
-
-
55049106032
-
The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus
-
Jin T, Liu L: The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus. Mol Endocrinol 22:2383-2392, 2008
-
(2008)
Mol Endocrinol
, vol.22
, pp. 2383-2392
-
-
Jin, T.1
Liu, L.2
-
17
-
-
34547702501
-
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
-
Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjogren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L: Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155-2163, 2007
-
(2007)
J Clin Invest
, vol.117
, pp. 2155-2163
-
-
Lyssenko, V.1
Lupi, R.2
Marchetti, P.3
Del Guerra, S.4
Orho-Melander, M.5
Almgren, P.6
Sjogren, M.7
Ling, C.8
Eriksson, K.F.9
Lethagen, A.L.10
Mancarella, R.11
Berglund, G.12
Tuomi, T.13
Nilsson, P.14
Del Prato, S.15
Groop, L.16
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