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Volumn 7, Issue , 2015, Pages 303-319

The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer

Author keywords

Epithelial to mesenchymal transition; Mesenchymal to epithelial transition; Stem cells

Indexed keywords

ESTROGEN RECEPTOR; KI 67 ANTIGEN; MESSENGER RNA; PROGESTERONE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 84941285503     PISSN: None     EISSN: 11791314     Source Type: Journal    
DOI: 10.2147/BCTT.S71163     Document Type: Article
Times cited : (29)

References (168)
  • 1
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sørlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A. 2001;98(19):10869–10874.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.19 , pp. 10869-10874
    • Sørlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 2
    • 77954740501 scopus 로고    scopus 로고
    • Metastatic behavior of breast cancer subtypes
    • Kennecke H, Yerushalmi R, Woods R, et al. Metastatic behavior of breast cancer subtypes. J Clin Oncol. 2010;28(20):3271–3277.
    • (2010) J Clin Oncol , vol.28 , Issue.20 , pp. 3271-3277
    • Kennecke, H.1    Yerushalmi, R.2    Woods, R.3
  • 3
    • 33847063053 scopus 로고    scopus 로고
    • The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes
    • Carey LA, Dees EC, Sawyer L, et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res. 2007;13(8):2329–2334.
    • (2007) Clin Cancer Res , vol.13 , Issue.8 , pp. 2329-2334
    • Carey, L.A.1    Dees, E.C.2    Sawyer, L.3
  • 4
    • 84868123650 scopus 로고    scopus 로고
    • Concordance among gene expression-based predictors for ER-positive breast cancer treated with adjuvant tamoxifen
    • Prat A, Parker JS, Fan C, et al. Concordance among gene expression-based predictors for ER-positive breast cancer treated with adjuvant tamoxifen. Ann Oncol. 2012;23(11):2866–2873.
    • (2012) Ann Oncol , vol.23 , Issue.11 , pp. 2866-2873
    • Prat, A.1    Parker, J.S.2    Fan, C.3
  • 5
    • 79958263078 scopus 로고    scopus 로고
    • Strategies for homeostatic stem cell self-renewal in adult tissues
    • Simons BD, Clevers H. Strategies for homeostatic stem cell self-renewal in adult tissues. Cell. 2011;145(6):851–862.
    • (2011) Cell , vol.145 , Issue.6 , pp. 851-862
    • Simons, B.D.1    Clevers, H.2
  • 6
    • 34247117277 scopus 로고    scopus 로고
    • Evidence for a stem cell hierarchy in the adult human breast
    • Villadsen R, Fridriksdottir AJ, Rønnov-Jessen L, et al. Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol. 2007;177(1): 87–101.
    • (2007) J Cell Biol , vol.177 , Issue.1 , pp. 87-101
    • Villadsen, R.1    Fridriksdottir, A.J.2    Rønnov-Jessen, L.3
  • 8
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C, Hur MH, Charafe-Jauffret E, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell. 2007;15(1):555–567.
    • (2007) Cell Stem Cell , vol.15 , Issue.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3
  • 9
    • 34547566701 scopus 로고    scopus 로고
    • Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes
    • Ince TA, Richardson AL, Bell GW, et al. Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell. 2007;12(2):160–170.
    • (2007) Cancer Cell , vol.12 , Issue.2 , pp. 160-170
    • Ince, T.A.1    Richardson, A.L.2    Bell, G.W.3
  • 10
    • 55749104730 scopus 로고    scopus 로고
    • The CD44+/CD24- phenotype is enriched in basal-like breast tumors
    • Honeth G, Bendahl PO, Ringnér M, et al. The CD44+/CD24- phenotype is enriched in basal-like breast tumors. Breast Cancer Res. 2008;10:R53.
    • (2008) Breast Cancer Res , vol.10
    • Honeth, G.1    Bendahl, P.O.2    Ringnér, M.3
  • 11
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 12
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663–676.
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 13
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007; 318(5858):1917–1920.
    • (2007) Science , vol.318 , Issue.5858 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 14
    • 48449084118 scopus 로고    scopus 로고
    • Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
    • Marson A, Levine SS, Cole MF, et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 2008;134(3):521–533.
    • (2008) Cell , vol.134 , Issue.3 , pp. 521-533
    • Marson, A.1    Levine, S.S.2    Cole, M.F.3
  • 15
    • 77954860342 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression
    • Micalizzi DS, Farabaugh SM, Ford HL. Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia. 2010;15(2):117–134.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , Issue.2 , pp. 117-134
    • Micalizzi, D.S.1    Farabaugh, S.M.2    Ford, H.L.3
  • 16
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition gen­erates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, et al. The epithelial-mesenchymal transition gen­erates cells with properties of stem cells. Cell. 2008;133(4):704–715.
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 17
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel AP, Lièvre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One. 2008;3(8):e2888.
    • (2008) Plos One , vol.3 , Issue.8
    • Morel, A.P.1    Lièvre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 18
    • 79953881831 scopus 로고    scopus 로고
    • Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency
    • Anokye-Danso F, Trivedi CM, Juhr D, et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell. 2011;8(4):376–388.
    • (2011) Cell Stem Cell , vol.8 , Issue.4 , pp. 376-388
    • Anokye-Danso, F.1    Trivedi, C.M.2    Juhr, D.3
  • 19
    • 0032582513 scopus 로고    scopus 로고
    • Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    • Nichols J, Zevnik B, Anastassiadis K, et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 1998;95(3):379–391.
    • (1998) Cell , vol.95 , Issue.3 , pp. 379-391
    • Nichols, J.1    Zevnik, B.2    Anastassiadis, K.3
  • 20
    • 77951812598 scopus 로고    scopus 로고
    • [The dual role of OCT4]
    • French
    • Stefanovic S, Pucéat M. [The dual role of OCT4]. Med Sci (Paris). 2010;26(4):411–416. French.
    • (2010) Med Sci (Paris) , vol.26 , Issue.4 , pp. 411-416
    • Stefanovic, S.1    Pucéat, M.2
  • 21
    • 10044285191 scopus 로고    scopus 로고
    • Oct4 is required for primordial germ cell survival
    • Kehler J, Tolkunova E, Koschorz B, et al. Oct4 is required for primordial germ cell survival. EMBO Rep. 2004;5(11):1078–1083.
    • (2004) EMBO Rep , vol.5 , Issue.11 , pp. 1078-1083
    • Kehler, J.1    Tolkunova, E.2    Koschorz, B.3
  • 22
    • 69949118280 scopus 로고    scopus 로고
    • Interplay of Oct4 with Sox2 and Sox17: A molecular switch from stem cell pluripotency to specifying a cardiac fate
    • Stefanovic S, Abboud N, Désilets S, Nury D, Cowan C, Pucéat M. Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol. 2009; 186(5):665–673.
    • (2009) J Cell Biol , vol.186 , Issue.5 , pp. 665-673
    • Stefanovic, S.1    Abboud, N.2    Désilets, S.3    Nury, D.4    Cowan, C.5    Pucéat, M.6
  • 23
    • 14844324977 scopus 로고    scopus 로고
    • Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation
    • Deb-Rinker P, Ly D, Jezierski A, Sikorska M, Walker PR. Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. J Biol Chem. 2005;280(8): 6257–6260.
    • (2005) J Biol Chem , vol.280 , Issue.8 , pp. 6257-6260
    • Deb-Rinker, P.1    Ly, D.2    Jezierski, A.3    Sikorska, M.4    Walker, P.R.5
  • 24
    • 84870388822 scopus 로고    scopus 로고
    • Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells
    • Lin Y, Yang Y, Li W, et al. Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. Mol Cell. 2012;48(4):627–640.
    • (2012) Mol Cell , vol.48 , Issue.4 , pp. 627-640
    • Lin, Y.1    Yang, Y.2    Li, W.3
  • 25
    • 84890634153 scopus 로고    scopus 로고
    • Expression of the pluri­potency transcription factor OCT4 in the normal and aberrant mammary gland
    • Hassiotou F, Hepworth AR, Beltran AS, et al. Expression of the pluri­potency transcription factor OCT4 in the normal and aberrant mammary gland. Front Oncol. 2013;3:79.
    • (2013) Front Oncol , vol.3
    • Hassiotou, F.1    Hepworth, A.R.2    Beltran, A.S.3
  • 26
    • 84872046078 scopus 로고    scopus 로고
    • The sox family of transcription factors: Versatile regulators of stem and progenitor cell fate
    • Sarkar A, Hochedlinger K. The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. Cell Stem Cell. 2013;12(1):15–30.
    • (2013) Cell Stem Cell , vol.12 , Issue.1 , pp. 15-30
    • Sarkar, A.1    Hochedlinger, K.2
  • 27
    • 84875240866 scopus 로고    scopus 로고
    • The multiple roles for Sox2 in stem cell maintenance and tumorigenesis
    • Liu K, Lin B, Zhao M, et al. The multiple roles for Sox2 in stem cell maintenance and tumorigenesis. Cell Signal. 2013;25(5):1264–1271.
    • (2013) Cell Signal , vol.25 , Issue.5 , pp. 1264-1271
    • Liu, K.1    Lin, B.2    Zhao, M.3
  • 28
    • 84921776917 scopus 로고    scopus 로고
    • SOX2 and cancer: Current research and its implica­tions in the clinic
    • Weina K, Utikal J. SOX2 and cancer: current research and its implica­tions in the clinic. Clin Transl Med. 2014;3:19.
    • (2014) Clin Transl Med , vol.3
    • Weina, K.1    Utikal, J.2
  • 29
    • 84877102425 scopus 로고    scopus 로고
    • Concise review: The Sox2-Oct4 connection: Critical players in a much larger interdependent network integrated at multiple levels
    • Rizzino A. Concise review: the Sox2-Oct4 connection: critical players in a much larger interdependent network integrated at multiple levels. Stem Cells. 2013;31(6):1033–1039.
    • (2013) Stem Cells , vol.31 , Issue.6 , pp. 1033-1039
    • Rizzino, A.1
  • 30
    • 25144525014 scopus 로고    scopus 로고
    • Core transcriptional regulatory circuitry in human embryonic stem cells
    • Boyer LA, Lee TI, Cole MF, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947–956.
    • (2005) Cell , vol.122 , Issue.6 , pp. 947-956
    • Boyer, L.A.1    Lee, T.I.2    Cole, M.F.3
  • 31
    • 44649117905 scopus 로고    scopus 로고
    • Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
    • Chen X, Xu H, Yuan P, et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell. 2008;133(6):1106–1117.
    • (2008) Cell , vol.133 , Issue.6 , pp. 1106-1117
    • Chen, X.1    Xu, H.2    Yuan, P.3
  • 32
    • 84880717598 scopus 로고    scopus 로고
    • Isolation and characterization of human breast cancer cells with SOX2 promoter activity
    • Liang S, Furuhashi M, Nakane R, et al. Isolation and characterization of human breast cancer cells with SOX2 promoter activity. Biochem Biophys Res Commun. 2013;437(2):205–211.
    • (2013) Biochem Biophys Res Commun , vol.437 , Issue.2 , pp. 205-211
    • Liang, S.1    Furuhashi, M.2    Nakane, R.3
  • 33
    • 84858341630 scopus 로고    scopus 로고
    • Sox2 expression in breast tumours and activation in breast cancer stem cells
    • Leis O, Eguiara A, Lopez-Arribillaga E, et al. Sox2 expression in breast tumours and activation in breast cancer stem cells. Oncogene. 2012; 31(11):1354–1365.
    • (2012) Oncogene , vol.31 , Issue.11 , pp. 1354-1365
    • Leis, O.1    Eguiara, A.2    Lopez-Arribillaga, E.3
  • 34
    • 79251564420 scopus 로고    scopus 로고
    • Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma
    • Lengerke C, Fehm T, Kurth R, et al. Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma. BMC Cancer. 2011;11:42.
    • (2011) BMC Cancer , vol.11
    • Lengerke, C.1    Fehm, T.2    Kurth, R.3
  • 35
    • 79960069606 scopus 로고    scopus 로고
    • Switching on pluripotency: A perspective on the biological requirement of Nanog
    • Theunissen TW, Silva JC. Switching on pluripotency: a perspective on the biological requirement of Nanog. Philos Trans R Soc Lond B Biol Sci. 2011;366(1575):2222–2229.
    • (2011) Philos Trans R Soc Lond B Biol Sci , vol.366 , Issue.1575 , pp. 2222-2229
    • Theunissen, T.W.1    Silva, J.C.2
  • 36
    • 84884163527 scopus 로고    scopus 로고
    • Targeting cancer stem cells: Emerging role of Nanog transcription factor
    • Wang ML, Chiou SH, Wu CW. Targeting cancer stem cells: emerging role of Nanog transcription factor. Onco Targets Ther. 2013;6:1207–1220.
    • (2013) Onco Targets Ther , vol.6 , pp. 1207-1220
    • Wang, M.L.1    Chiou, S.H.2    Wu, C.W.3
  • 37
    • 68749110887 scopus 로고    scopus 로고
    • Nanog is the gateway to the pluripotent ground state
    • Silva J, Nichols J, Theunissen TW, et al. Nanog is the gateway to the pluripotent ground state. Cell. 2009;138(4):722–737.
    • (2009) Cell , vol.138 , Issue.4 , pp. 722-737
    • Silva, J.1    Nichols, J.2    Theunissen, T.W.3
  • 38
    • 67349263454 scopus 로고    scopus 로고
    • When X-inactivation meets pluripotency: An intimate rendezvous
    • Navarro P, Avner P. When X-inactivation meets pluripotency: an intimate rendezvous. FEBS Lett. 2009;583(11):1721–1727.
    • (2009) FEBS Lett , vol.583 , Issue.11 , pp. 1721-1727
    • Navarro, P.1    Avner, P.2
  • 39
    • 79959883334 scopus 로고    scopus 로고
    • Role of Oct4 in maintaining and regaining stem cell pluripotency
    • Shi G, Jin Y. Role of Oct4 in maintaining and regaining stem cell pluripotency. Stem Cell Res Ther. 2010;1(5):39.
    • (2010) Stem Cell Res Ther , vol.1 , Issue.5
    • Shi, G.1    Jin, Y.2
  • 40
    • 84901190709 scopus 로고    scopus 로고
    • The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis
    • Lu X, Mazur SJ, Lin T, Appella E, Xu Y. The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis. Oncogene. 2014;33(20):2655–2664.
    • (2014) Oncogene , vol.33 , Issue.20 , pp. 2655-2664
    • Lu, X.1    Mazur, S.J.2    Lin, T.3    Appella, E.4    Xu, Y.5
  • 41
    • 84877290864 scopus 로고    scopus 로고
    • Cyclohexylmethyl flavonoids suppress propagation of breast cancer stem cells via downregulation of NANOG
    • Liao WY, Liaw CC, Huang YC, et al. Cyclohexylmethyl flavonoids suppress propagation of breast cancer stem cells via downregulation of NANOG. Evid Based Complement Alternat Med. 2013;2013:170261.
    • (2013) Evid Based Complement Alternat Med , vol.2013
    • Liao, W.Y.1    Liaw, C.C.2    Huang, Y.C.3
  • 42
    • 84867243788 scopus 로고    scopus 로고
    • Expression of the pluripo­tency markers Oct3/4, Nanog and Sox2 in human breast cancer cell lines
    • Ling GQ, Chen DB, Wang BQ, Zhang LS. Expression of the pluripo­tency markers Oct3/4, Nanog and Sox2 in human breast cancer cell lines. Oncol Lett. 2012;4(6):1264–1268.
    • (2012) Oncol Lett , vol.4 , Issue.6 , pp. 1264-1268
    • Ling, G.Q.1    Chen, D.B.2    Wang, B.Q.3    Zhang, L.S.4
  • 43
    • 66149167315 scopus 로고    scopus 로고
    • Functional evidence that the self-renewal gene NANOG regulates human tumor development
    • Jeter CR, Badeaux M, Choy G, et al. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells. 2009;27(5):993–1005.
    • (2009) Stem Cells , vol.27 , Issue.5 , pp. 993-1005
    • Jeter, C.R.1    Badeaux, M.2    Choy, G.3
  • 44
    • 27644473695 scopus 로고    scopus 로고
    • Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma
    • Ezeh UI, Turek PJ, Reijo RA, Clark AT. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer. 2005;104(10):2255–2265.
    • (2005) Cancer , vol.104 , Issue.10 , pp. 2255-2265
    • Ezeh, U.I.1    Turek, P.J.2    Reijo, R.A.3    Clark, A.T.4
  • 45
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang CV. MYC on the path to cancer. Cell. 2012;149(1):22–35.
    • (2012) Cell , vol.149 , Issue.1 , pp. 22-35
    • Dang, C.V.1
  • 46
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131(5):861–872.
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 47
    • 37549005086 scopus 로고    scopus 로고
    • Why myc? An unexpected ingredient in the stem cell cocktail
    • Knoepfler PS. Why myc? An unexpected ingredient in the stem cell cocktail. Cell Stem Cell. 2008;2(1):18–21.
    • (2008) Cell Stem Cell , vol.2 , Issue.1 , pp. 18-21
    • Knoepfler, P.S.1
  • 48
    • 70349832928 scopus 로고    scopus 로고
    • Nursing some sense out of Myc
    • Sodir NM, Evan GI. Nursing some sense out of Myc. J Biol. 2009;8:77.
    • (2009) J Biol , vol.8
    • Sodir, N.M.1    Evan, G.I.2
  • 49
    • 70349836305 scopus 로고    scopus 로고
    • Hynes NE. C-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mam­mary gland
    • Stoelzle T, Schwarb P, Trumpp A, Hynes NE. c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mam­mary gland. BMC Biol. 2009;7:63.
    • (2009) BMC Biol , vol.7
    • Stoelzle, T.1    Schwarb, P.2    Trumpp, A.3
  • 50
    • 79952841250 scopus 로고    scopus 로고
    • MYC and breast cancer
    • Xu J, Chen Y, Olopade OI. MYC and breast cancer. Genes Cancer. 2010;1(6):629–640.
    • (2010) Genes Cancer , vol.1 , Issue.6 , pp. 629-640
    • Xu, J.1    Chen, Y.2    Olopade, O.I.3
  • 51
    • 34447530928 scopus 로고    scopus 로고
    • Cole MD. C-Myc transforms human mammary epithelial cells through repression of the Wnt inhibi­tors DKK1 and SFRP1
    • Cowling VH, D’Cruz CM, Chodosh LA, Cole MD. c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibi­tors DKK1 and SFRP1. Mol Cell Biol. 2007;27(14):5135–5146.
    • (2007) Mol Cell Biol , vol.27 , Issue.14 , pp. 5135-5146
    • Cowling, V.H.1    D’Cruz, C.M.2    Chodosh, L.A.3
  • 52
    • 27644453600 scopus 로고    scopus 로고
    • Salhab M, et al. HTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer
    • Elkak AE, Meligonis G, Salhab M, et al. hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer. J Carcinog. 2005;4:17.
    • (2005) J Carcinog , vol.4
    • Elkak, A.E.1    Meligonis, G.2
  • 53
    • 84886423250 scopus 로고    scopus 로고
    • Impact of c-MYC protein expression on outcome of patients with early-stage HER2+ breast cancer treated with adjuvant trastuzumab NCCTG (Alliance) N9831
    • Dueck AC, Reinholz MM, Geiger XJ, et al. Impact of c-MYC protein expression on outcome of patients with early-stage HER2+ breast cancer treated with adjuvant trastuzumab NCCTG (alliance) N9831. Clin Cancer Res. 2013;19(20):5798–5807.
    • (2013) Clin Cancer Res , vol.19 , Issue.20 , pp. 5798-5807
    • Dueck, A.C.1    Reinholz, M.M.2    Geiger, X.J.3
  • 54
    • 62049086099 scopus 로고    scopus 로고
    • The pathobiology of Krüppel-like factors in colorectal cancer
    • Ghaleb AM, Yang VW. The pathobiology of Krüppel-like factors in colorectal cancer. Curr Colorectal Cancer Rep. 2008;4(2):59–64.
    • (2008) Curr Colorectal Cancer Rep , vol.4 , Issue.2 , pp. 59-64
    • Ghaleb, A.M.1    Yang, V.W.2
  • 55
    • 79955608022 scopus 로고    scopus 로고
    • Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion
    • Yu F, Li J, Chen H, et al. Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene. 2011;30(18):2161–2172.
    • (2011) Oncogene , vol.30 , Issue.18 , pp. 2161-2172
    • Yu, F.1    Li, J.2    Chen, H.3
  • 56
    • 84885624626 scopus 로고    scopus 로고
    • Deficiency of Kruppel-like factor KLF4 in mammary tumor cells inhibits tumor growth and pul­monary metastasis and is accompanied by compromised recruitment of myeloid-derived suppressor cells
    • Yu F, Shi Y, Wang J, Li J, Fan D, Ai W. Deficiency of Kruppel-like factor KLF4 in mammary tumor cells inhibits tumor growth and pul­monary metastasis and is accompanied by compromised recruitment of myeloid-derived suppressor cells. Int J Cancer. 2013;133(12):2872–2883.
    • (2013) Int J Cancer , vol.133 , Issue.12 , pp. 2872-2883
    • Yu, F.1    Shi, Y.2    Wang, J.3    Li, J.4    Fan, D.5    Ai, W.6
  • 57
    • 84865589321 scopus 로고    scopus 로고
    • How does Lin28 let-7 control development and disease?
    • Thornton JE, Gregory RI. How does Lin28 let-7 control development and disease? Trends Cell Biol. 2012;22(9):474–482.
    • (2012) Trends Cell Biol , vol.22 , Issue.9 , pp. 474-482
    • Thornton, J.E.1    Gregory, R.I.2
  • 58
    • 20044395613 scopus 로고    scopus 로고
    • RAS is regulated by the let-7 microRNA family
    • Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell. 2005;120(5):635–647.
    • (2005) Cell , vol.120 , Issue.5 , pp. 635-647
    • Johnson, S.M.1    Grosshans, H.2    Shingara, J.3
  • 59
    • 84880670678 scopus 로고    scopus 로고
    • The Wnt-β-catenin pathway represses let-7 microRNA expression through transactivation of Lin28 to aug­ment breast cancer stem cell expansion
    • Cai WY, Wei TZ, Luo QC, et al. The Wnt-β-catenin pathway represses let-7 microRNA expression through transactivation of Lin28 to aug­ment breast cancer stem cell expansion. J Cell Sci. 2013;126(Pt 13): 2877–2889.
    • (2013) J Cell Sci , vol.126 , pp. 2877-2889
    • Cai, W.Y.1    Wei, T.Z.2    Luo, Q.C.3
  • 60
    • 81855183636 scopus 로고    scopus 로고
    • Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms
    • Piskounova E, Polytarchou C, Thornton JE, et al. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell. 2011; 147(5):1066–1079.
    • (2011) Cell , vol.147 , Issue.5 , pp. 1066-1079
    • Piskounova, E.1    Polytarchou, C.2    Thornton, J.E.3
  • 61
    • 77955052917 scopus 로고    scopus 로고
    • The role of miRNAs and endogenous siRNAs in maternal-to-zygotic reprogramming and the establishment of pluripotency
    • Svoboda P, Flemr M. The role of miRNAs and endogenous siRNAs in maternal-to-zygotic reprogramming and the establishment of pluripotency. EMBO Rep. 2010;11(8):590–597.
    • (2010) EMBO Rep , vol.11 , Issue.8 , pp. 590-597
    • Svoboda, P.1    Flemr, M.2
  • 62
    • 79951578160 scopus 로고    scopus 로고
    • Oct4 regulates the miR-302 cluster in P19 mouse embryonic carcinoma cells
    • Liu H, Deng S, Zhao Z, et al. Oct4 regulates the miR-302 cluster in P19 mouse embryonic carcinoma cells. Mol Biol Rep. 2011;38(3): 2155–2160.
    • (2011) Mol Biol Rep , vol.38 , Issue.3 , pp. 2155-2160
    • Liu, H.1    Deng, S.2    Zhao, Z.3
  • 63
    • 66149160608 scopus 로고    scopus 로고
    • Embryonic stem cell-specific microRNAs promote induced pluripotency
    • Judson RL, Babiarz J, Venere M, Blelloch R. Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol. 2009;27(5):459–461.
    • (2009) Nat Biotechnol , vol.27 , Issue.5 , pp. 459-461
    • Judson, R.L.1    Babiarz, J.2    Venere, M.3    Blelloch, R.4
  • 64
    • 84876491657 scopus 로고    scopus 로고
    • MicroRNA-302 replacement therapy sensitizes breast cancer cells to ionizing radiation
    • Liang Z, Ahn J, Guo D, Votaw JR, Shim H. MicroRNA-302 replacement therapy sensitizes breast cancer cells to ionizing radiation. Pharm Res. 2013;30(4):1008–1016.
    • (2013) Pharm Res , vol.30 , Issue.4 , pp. 1008-1016
    • Liang, Z.1    Ahn, J.2    Guo, D.3    Votaw, J.R.4    Shim, H.5
  • 65
    • 84866559462 scopus 로고    scopus 로고
    • Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression lead­ing to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma
    • Bourguignon LY, Wong G, Earle C, Chen L. Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression lead­ing to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma. J Biol Chem. 2012;287(39):32800–32824.
    • (2012) J Biol Chem , vol.287 , Issue.39 , pp. 32800-32824
    • Bourguignon, L.Y.1    Wong, G.2    Earle, C.3    Chen, L.4
  • 67
    • 84887605316 scopus 로고    scopus 로고
    • The miR-17/92 cluster: A comprehensive update on its genomics, genetics, functions and increasingly impor­tant and numerous roles in health and disease
    • Mogilyansky E, Rigoutsos I. The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly impor­tant and numerous roles in health and disease. Cell Death Differ. 2013;20(12):1603–1614.
    • (2013) Cell Death Differ , vol.20 , Issue.12 , pp. 1603-1614
    • Mogilyansky, E.1    Rigoutsos, I.2
  • 68
    • 84871246002 scopus 로고    scopus 로고
    • The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initi­ating cell characteristics downstream of Six1 in human breast cancer
    • Smith AL, Iwanaga R, Drasin DJ, et al. The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initi­ating cell characteristics downstream of Six1 in human breast cancer. Oncogene. 2012;31(50):5162–5171.
    • (2012) Oncogene , vol.31 , Issue.50 , pp. 5162-5171
    • Smith, A.L.1    Iwanaga, R.2    Drasin, D.J.3
  • 69
    • 79959913677 scopus 로고    scopus 로고
    • MicroRNA sequence and expression analysis in breast tumors by deep sequencing
    • Farazi TA, Horlings HM, Ten Hoeve JJ, et al. MicroRNA sequence and expression analysis in breast tumors by deep sequencing. Cancer Res. 2011;71(13):4443–4453.
    • (2011) Cancer Res , vol.71 , Issue.13 , pp. 4443-4453
    • Farazi, T.A.1    Horlings, H.M.2    Ten Hoeve, J.J.3
  • 70
    • 70449124423 scopus 로고    scopus 로고
    • Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines
    • Leivonen SK, Mäkelä R, Ostling P, et al. Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines. Oncogene. 2009;28(44):3926–3936.
    • (2009) Oncogene , vol.28 , Issue.44 , pp. 3926-3936
    • Leivonen, S.K.1    Mäkelä, R.2    Ostling, P.3
  • 71
    • 0034028901 scopus 로고    scopus 로고
    • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    • Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet. 2000;24(4):372–376.
    • (2000) Nat Genet , vol.24 , Issue.4 , pp. 372-376
    • Niwa, H.1    Miyazaki, J.2    Smith, A.G.3
  • 72
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 2006;7(2):131–142.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , Issue.2 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 73
    • 84864996678 scopus 로고    scopus 로고
    • The ubiquitin-proteasome system and signal transduc­tion pathways regulating epithelial mesenchymal transition of cancer
    • Voutsadakis IA. The ubiquitin-proteasome system and signal transduc­tion pathways regulating epithelial mesenchymal transition of cancer. J Biomed Sci. 2012;19:67.
    • (2012) J Biomed Sci , vol.19
    • Voutsadakis, I.A.1
  • 74
    • 67650996754 scopus 로고    scopus 로고
    • Neilson EG. Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest. 2009;119(6):1429–1437.
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1429-1437
    • Zeisberg, M.1
  • 75
    • 84898030144 scopus 로고    scopus 로고
    • Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions
    • Guo F, Parker Kerrigan BC, Yang D, et al. Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions. J Hematol Oncol. 2014;7:19.
    • (2014) J Hematol Oncol , vol.7
    • Guo, F.1    Parker Kerrigan, B.C.2    Yang, D.3
  • 76
    • 77954862083 scopus 로고    scopus 로고
    • The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells
    • Taylor MA, Parvani JG, Schiemann WP. The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia. 2010;15(2):169–190.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , Issue.2 , pp. 169-190
    • Taylor, M.A.1    Parvani, J.G.2    Schiemann, W.P.3
  • 77
    • 80054784515 scopus 로고    scopus 로고
    • The transcrip­tion factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer
    • Dhasarathy A, Phadke D, Mav D, Shah RR, Wade PA. The transcrip­tion factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer. PLoS One. 2011;6(10):e26514.
    • (2011) Plos One , vol.6 , Issue.10
    • Dhasarathy, A.1    Phadke, D.2    Mav, D.3    Shah, R.R.4    Wade, P.A.5
  • 78
    • 84878983107 scopus 로고    scopus 로고
    • Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming
    • Tiwari N, Tiwari VK, Waldmeier L, et al. Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming. Cancer Cell. 2013;23(6):768–783.
    • (2013) Cancer Cell , vol.23 , Issue.6 , pp. 768-783
    • Tiwari, N.1    Tiwari, V.K.2    Waldmeier, L.3
  • 79
    • 84055216937 scopus 로고    scopus 로고
    • Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence
    • Tran DD, Corsa CA, Biswas H, Aft RL, Longmore GD. Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence. Mol Cancer Res. 2011;9(12):1644–1657.
    • (2011) Mol Cancer Res , vol.9 , Issue.12 , pp. 1644-1657
    • Tran, D.D.1    Corsa, C.A.2    Biswas, H.3    Aft, R.L.4    Longmore, G.D.5
  • 80
    • 77954854837 scopus 로고    scopus 로고
    • Snail family regula­tion and epithelial mesenchymal transitions in breast cancer progression
    • de Herreros AG, Peiró S, Nassour M, Savagner P. Snail family regula­tion and epithelial mesenchymal transitions in breast cancer progression. J Mammary Gland Biol Neoplasia. 2010;15(2):135–147.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , Issue.2 , pp. 135-147
    • De Herreros, A.G.1    Peiró, S.2    Nassour, M.3    Savagner, P.4
  • 81
    • 79551614327 scopus 로고    scopus 로고
    • Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate
    • Proia TA, Keller PJ, Gupta PB, et al. Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell. 2011;8(2):149–163.
    • (2011) Cell Stem Cell , vol.8 , Issue.2 , pp. 149-163
    • Proia, T.A.1    Keller, P.J.2    Gupta, P.B.3
  • 82
    • 78149485367 scopus 로고    scopus 로고
    • Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malig­nant breast cancer progression
    • Foubert E, De Craene B, Berx G. Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malig­nant breast cancer progression. Breast Cancer Res. 2010;12:206.
    • (2010) Breast Cancer Res , vol.12
    • Foubert, E.1    De Craene, B.2    Berx, G.3
  • 83
    • 79960072564 scopus 로고    scopus 로고
    • Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis
    • Lee KA, Gjorevski N, Boghaert E, Radisky DC, Nelson CM. Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis. EMBO J. 2011;30(13):2662–2674.
    • (2011) EMBO J , vol.30 , Issue.13 , pp. 2662-2674
    • Lee, K.A.1    Gjorevski, N.2    Boghaert, E.3    Radisky, D.C.4    Nelson, C.M.5
  • 84
    • 84898605112 scopus 로고    scopus 로고
    • Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells
    • Gras B, Jacqueroud L, Wierinckx A, et al. Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells. PLoS One. 2014;9(3):e92254.
    • (2014) Plos One , vol.9 , Issue.3
    • Gras, B.1    Jacqueroud, L.2    Wierinckx, A.3
  • 85
    • 84879477550 scopus 로고    scopus 로고
    • Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibit­ing the activity of RhoA GTPase
    • Zhang A, Wang Q, Han Z, et al. Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibit­ing the activity of RhoA GTPase. Oncol Lett. 2013;6(2):339–346.
    • (2013) Oncol Lett , vol.6 , Issue.2 , pp. 339-346
    • Zhang, A.1    Wang, Q.2    Han, Z.3
  • 86
    • 0035866376 scopus 로고    scopus 로고
    • Down-regulation of promoter 1 3 activity of the human aromatase gene in breast tissue by zinc-finger protein, Snail (SnaH)
    • Okubo T, Truong TK, Yu B, et al. Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, Snail (SnaH). Cancer Res. 2001;61(4):1338–1346.
    • (2001) Cancer Res , vol.61 , Issue.4 , pp. 1338-1346
    • Okubo, T.1    Truong, T.K.2    Yu, B.3
  • 87
    • 21244437500 scopus 로고    scopus 로고
    • Expression of the transcrip­tion factors snail, slug, and twist and their clinical significance in human breast cancer
    • Martin TA, Goyal A, Watkins G, Jiang WG. Expression of the transcrip­tion factors snail, slug, and twist and their clinical significance in human breast cancer. Ann Surg Oncol. 2005;12(6):488–496.
    • (2005) Ann Surg Oncol , vol.12 , Issue.6 , pp. 488-496
    • Martin, T.A.1    Goyal, A.2    Watkins, G.3    Jiang, W.G.4
  • 88
    • 84890421264 scopus 로고    scopus 로고
    • Nuclear expression of snail is an independent negative prognostic factor in human breast cancer
    • Muenst S, Däster S, Obermann EC, et al. Nuclear expression of snail is an independent negative prognostic factor in human breast cancer. Dis Markers. 2013;35(5):337–344.
    • (2013) Dis Markers , vol.35 , Issue.5 , pp. 337-344
    • Muenst, S.1    Däster, S.2    Obermann, E.C.3
  • 89
    • 84871385387 scopus 로고    scopus 로고
    • ZEB/miR-200 feedback loop: At the crossroads of signal transduction in cancer
    • Hill L, Browne G, Tulchinsky E. ZEB/miR-200 feedback loop: at the crossroads of signal transduction in cancer. Int J Cancer. 2013;132(4): 745–754.
    • (2013) Int J Cancer , vol.132 , Issue.4 , pp. 745-754
    • Hill, L.1    Browne, G.2    Tulchinsky, E.3
  • 90
    • 84874225673 scopus 로고    scopus 로고
    • Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation
    • Wang G, Guo X, Hong W, et al. Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. Proc Natl Acad Sci U S A. 2013;110(8):2858–2863.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.8 , pp. 2858-2863
    • Wang, G.1    Guo, X.2    Hong, W.3
  • 91
    • 80052470207 scopus 로고    scopus 로고
    • Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
    • Korpal M, Ell BJ, Buffa FM, et al. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med. 2012;17(9):1101–1108.
    • (2012) Nat Med , vol.17 , Issue.9 , pp. 1101-1108
    • Korpal, M.1    Ell, B.J.2    Buffa, F.M.3
  • 92
    • 84855987633 scopus 로고    scopus 로고
    • Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells
    • Kasimir-Bauer S, Hoffmann O, Wallwiener D, Kimmig R, Fehm T. Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells. Breast Cancer Res. 2012;14:R15.
    • (2012) Breast Cancer Res , vol.14
    • Kasimir-Bauer, S.1    Hoffmann, O.2    Wallwiener, D.3    Kimmig, R.4    Fehm, T.5
  • 93
    • 84860337922 scopus 로고    scopus 로고
    • Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients
    • van Nes JG, de Kruijf EM, Putter H, et al. Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients. Breast Cancer Res Treat. 2012;133(1):49–59.
    • (2012) Breast Cancer Res Treat , vol.133 , Issue.1 , pp. 49-59
    • Van Nes, J.G.1    De Kruijf, E.M.2    Putter, H.3
  • 94
    • 84875435474 scopus 로고    scopus 로고
    • E47 and Id1 interplay in epithelial-mesenchymal transition
    • Cubillo E, Diaz-Lopez A, Cuevas EP, et al. E47 and Id1 interplay in epithelial-mesenchymal transition. PLoS One. 2013;8(3):e59948.
    • (2013) Plos One , vol.8 , Issue.3
    • Cubillo, E.1    Diaz-Lopez, A.2    Cuevas, E.P.3
  • 95
    • 33845325353 scopus 로고    scopus 로고
    • Reassessment of id1 protein expression in human mammary, prostate, and bladder cancers using a monospecific rabbit monoclonal anti-id1 antibody
    • Perk J, Gil-Bazo I, Chin Y, et al. Reassessment of id1 protein expression in human mammary, prostate, and bladder cancers using a monospecific rabbit monoclonal anti-id1 antibody. Cancer Res. 2006;66(22):10870–10877.
    • (2006) Cancer Res , vol.66 , Issue.22 , pp. 10870-10877
    • Perk, J.1    Gil-Bazo, I.2    Chin, Y.3
  • 96
    • 84871648551 scopus 로고    scopus 로고
    • Slug controls stem/progeni­tor cell growth dynamics during mammary gland morphogenesis
    • Nassour M, Idoux-Gillet Y, Selmi A, et al. Slug controls stem/progeni­tor cell growth dynamics during mammary gland morphogenesis. PLoS One. 2012;7(12):e53498.
    • (2012) Plos One , vol.7 , Issue.12
    • Nassour, M.1    Idoux-Gillet, Y.2    Selmi, A.3
  • 97
    • 81855182066 scopus 로고    scopus 로고
    • Twist2 contributes to breast cancer progres­sion by promoting an epithelial-mesenchymal transition and stem-like cell self-renewal
    • Fang X, Cai Y, Liu J, et al. Twist2 contributes to breast cancer progres­sion by promoting an epithelial-mesenchymal transition and stem-like cell self-renewal. Oncogene. 2011;30(47):4707–4720.
    • (2011) Oncogene , vol.30 , Issue.47 , pp. 4707-4720
    • Fang, X.1    Cai, Y.2    Liu, J.3
  • 98
    • 72949104153 scopus 로고    scopus 로고
    • Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression
    • Vesuna F, Lisok A, Kimble B, Raman V. Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression. Neoplasia. 2009;11(12):1318–1328.
    • (2009) Neoplasia , vol.11 , Issue.12 , pp. 1318-1328
    • Vesuna, F.1    Lisok, A.2    Kimble, B.3    Raman, V.4
  • 99
    • 77957583439 scopus 로고    scopus 로고
    • Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition
    • Yang MH, Hsu DS, Wang HW, et al. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol. 2010; 12(10):982–992.
    • (2010) Nat Cell Biol , vol.12 , Issue.10 , pp. 982-992
    • Yang, M.H.1    Hsu, D.S.2    Wang, H.W.3
  • 100
    • 84916928394 scopus 로고    scopus 로고
    • Oct-4 and Nanog promote the epithelial-mesenchymal transition of breast cancer stem cells and are associated with poor prognosis in breast cancer patients
    • Wang D, Lu P, Zhang H, et al. Oct-4 and Nanog promote the epithelial-mesenchymal transition of breast cancer stem cells and are associated with poor prognosis in breast cancer patients. Oncotarget. 2014; 5(21):10803–10815.
    • (2014) Oncotarget , vol.5 , Issue.21 , pp. 10803-10815
    • Wang, D.1    Lu, P.2    Zhang, H.3
  • 101
    • 77957551870 scopus 로고    scopus 로고
    • A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
    • Li R, Liang J, Ni S, et al. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell. 2010;7(1):51–63.
    • (2010) Cell Stem Cell , vol.7 , Issue.1 , pp. 51-63
    • Li, R.1    Liang, J.2    Ni, S.3
  • 102
    • 38849139125 scopus 로고    scopus 로고
    • ABCG2 expression and side population abundance regulated by a transforming growth factor beta-directed epithelial-mesenchymal transition
    • Yin L, Castagnino P, Assoian RK. ABCG2 expression and side population abundance regulated by a transforming growth factor beta-directed epithelial-mesenchymal transition. Cancer Res. 2008; 68(3):800–807.
    • (2008) Cancer Res , vol.68 , Issue.3 , pp. 800-807
    • Yin, L.1    Castagnino, P.2    Assoian, R.K.3
  • 103
    • 84892839751 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance
    • Mallini P, Lennard T, Kirby J, Meeson A. Epithelial-to-mesenchymal transition: what is the impact on breast cancer stem cells and drug resistance. Cancer Treat Rev. 2014;40:341–348.
    • (2014) Cancer Treat Rev , vol.40 , pp. 341-348
    • Mallini, P.1    Lennard, T.2    Kirby, J.3    Meeson, A.4
  • 104
    • 34548706039 scopus 로고    scopus 로고
    • Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model
    • Tang B, Yoo N, Vu M, et al. Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model. Cancer Res. 2007;67(18):8643–8652.
    • (2007) Cancer Res , vol.67 , Issue.18 , pp. 8643-8652
    • Tang, B.1    Yoo, N.2    Vu, M.3
  • 105
    • 77952768290 scopus 로고    scopus 로고
    • Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regula­tion of E-cadherin gene expression
    • Yori JL, Johnson E, Zhou G, Jain MK, Keri RA. Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regula­tion of E-cadherin gene expression. J Biol Chem. 2010;285(22): 16854–16863.
    • (2010) J Biol Chem , vol.285 , Issue.22 , pp. 16854-16863
    • Yori, J.L.1    Johnson, E.2    Zhou, G.3    Jain, M.K.4    Keri, R.A.5
  • 107
    • 68949093614 scopus 로고    scopus 로고
    • KLF4 suppresses estrogen-dependent breast cancer growth by inhibiting the transcriptional activ­ity of ERalpha
    • Akaogi K, Nakajima Y, Ito I, et al. KLF4 suppresses estrogen-dependent breast cancer growth by inhibiting the transcriptional activ­ity of ERalpha. Oncogene. 2009;28(32):2894–2902.
    • (2009) Oncogene , vol.28 , Issue.32 , pp. 2894-2902
    • Akaogi, K.1    Nakajima, Y.2    Ito, I.3
  • 108
    • 84859954415 scopus 로고    scopus 로고
    • Novel insight into KLF4 proteolytic regulation in estrogen receptor signaling and breast carcinogenesis
    • Hu D, Zhou Z, Davidson NE, Huang Y, Wan Y. Novel insight into KLF4 proteolytic regulation in estrogen receptor signaling and breast carcinogenesis. J Biol Chem. 2012;287(17):13584–13597.
    • (2012) J Biol Chem , vol.287 , Issue.17 , pp. 13584-13597
    • Hu, D.1    Zhou, Z.2    Davidson, N.E.3    Huang, Y.4    Wan, Y.5
  • 109
    • 84892610740 scopus 로고    scopus 로고
    • Lin28 induces epithelial-to-mesenchymal transition and stemness via downregulation of let-7a in breast cancer cells
    • Liu Y, Li H, Feng J, et al. Lin28 induces epithelial-to-mesenchymal transition and stemness via downregulation of let-7a in breast cancer cells. PLoS One. 2013;8(12):e83083.
    • (2013) Plos One , vol.8 , Issue.12
    • Liu, Y.1    Li, H.2    Feng, J.3
  • 110
    • 79955755007 scopus 로고    scopus 로고
    • MicroRNA cluster 302–367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition
    • Liao B, Bao X, Liu L, et al. MicroRNA cluster 302–367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. J Biol Chem. 2011;286(19):17359–17364.
    • (2011) J Biol Chem , vol.286 , Issue.19 , pp. 17359-17364
    • Liao, B.1    Bao, X.2    Liu, L.3
  • 111
    • 79955780736 scopus 로고    scopus 로고
    • Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
    • Subramanyam D, Lamouille S, Judson RL, et al. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011;29(5):443–448.
    • (2011) Nat Biotechnol , vol.29 , Issue.5 , pp. 443-448
    • Subramanyam, D.1    Lamouille, S.2    Judson, R.L.3
  • 112
    • 34547141894 scopus 로고    scopus 로고
    • Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    • Mani SA, Yang J, Brooks M, et al. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A. 2007;104(24): 10069–10074.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.24 , pp. 10069-10074
    • Mani, S.A.1    Yang, J.2    Brooks, M.3
  • 113
    • 84875473628 scopus 로고    scopus 로고
    • FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer
    • Hollier BG, Tinnirello AA, Werden SJ, et al. FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer. Cancer Res. 2013;73(6):1981–1992.
    • (2013) Cancer Res , vol.73 , Issue.6 , pp. 1981-1992
    • Hollier, B.G.1    Tinnirello, A.A.2    Werden, S.J.3
  • 114
    • 83055168263 scopus 로고    scopus 로고
    • Regulation of breast cancer metastasis by Runx2 and estrogen signaling: The role of SNAI2
    • Chimge NO, Baniwal SK, Little GH, et al. Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2. Breast Cancer Res. 2011;13:R127.
    • (2011) Breast Cancer Res , vol.13
    • Chimge, N.O.1    Baniwal, S.K.2    Little, G.H.3
  • 115
    • 14544283318 scopus 로고    scopus 로고
    • Expression of estrogen receptor-alpha and -beta, glucocorticoid receptor, and progesterone receptor genes in human embryonic stem cells and embryoid bodies
    • Hong SH, Nah HY, Lee YJ, et al. Expression of estrogen receptor-alpha and -beta, glucocorticoid receptor, and progesterone receptor genes in human embryonic stem cells and embryoid bodies. Mol Cells. 2004;18(3):320–325.
    • (2004) Mol Cells , vol.18 , Issue.3 , pp. 320-325
    • Hong, S.H.1    Nah, H.Y.2    Lee, Y.J.3
  • 116
    • 44449142900 scopus 로고    scopus 로고
    • Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts
    • Horwitz KB, Dye WW, Harrell JC, Kabos P, Sartorius CA. Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts. Proc Natl Acad Sci U S A. 2008;105(15):5774–5779.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.15 , pp. 5774-5779
    • Horwitz, K.B.1    Dye, W.W.2    Harrell, J.C.3    Kabos, P.4    Sartorius, C.A.5
  • 117
    • 79959213451 scopus 로고    scopus 로고
    • Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant subpopu­lation in luminal breast cancers
    • Kabos P, Haughian JM, Wang X, et al. Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant subpopu­lation in luminal breast cancers. Breast Cancer Res Treat. 2011; 128(1):45–55.
    • (2011) Breast Cancer Res Treat , vol.128 , Issue.1 , pp. 45-55
    • Kabos, P.1    Haughian, J.M.2    Wang, X.3
  • 118
    • 84903764777 scopus 로고    scopus 로고
    • The transcriptional regulation of SOX2 on FOXA1 gene and its application in diagnosis of human breast and lung cancers
    • Li X, Chen S, Sun T, et al. The transcriptional regulation of SOX2 on FOXA1 gene and its application in diagnosis of human breast and lung cancers. Clin Lab. 2014;60(6):909–918.
    • (2014) Clin Lab , vol.60 , Issue.6 , pp. 909-918
    • Li, X.1    Chen, S.2    Sun, T.3
  • 119
    • 84856937196 scopus 로고    scopus 로고
    • FOXA1: A transcription factor with parallel func­tions in development and cancer
    • Bernardo GM, Keri RA. FOXA1: a transcription factor with parallel func­tions in development and cancer. Biosci Rep. 2012;32(2):113–130.
    • (2012) Biosci Rep , vol.32 , Issue.2 , pp. 113-130
    • Bernardo, G.M.1    Keri, R.A.2
  • 120
    • 32844465287 scopus 로고    scopus 로고
    • Regulatory mechanisms controlling human E-cadherin gene expression
    • Liu YN, Lee WW, Wang CY, Chao TH, Chen Y, Chen JH. Regulatory mechanisms controlling human E-cadherin gene expression. Oncogene. 2005;24(56):8277–8290.
    • (2005) Oncogene , vol.24 , Issue.56 , pp. 8277-8290
    • Liu, Y.N.1    Lee, W.W.2    Wang, C.Y.3    Chao, T.H.4    Chen, Y.5    Chen, J.H.6
  • 121
    • 81755184076 scopus 로고    scopus 로고
    • Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression
    • Jung JW, Park SB, Lee SJ, Seo MS, Trosko JE, Kang KS. Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression. PLoS One. 2011;6(11):e28068.
    • (2011) Plos One , vol.6 , Issue.11
    • Jung, J.W.1    Park, S.B.2    Lee, S.J.3    Seo, M.S.4    Trosko, J.E.5    Kang, K.S.6
  • 122
    • 79960844882 scopus 로고    scopus 로고
    • Effects of estrogen on the pro­portion of stem cells in the breast
    • Simões BM, Piva M, Iriondo O, et al. Effects of estrogen on the pro­portion of stem cells in the breast. Breast Cancer Res Treat. 2011; 129(1):23–35.
    • (2011) Breast Cancer Res Treat , vol.129 , Issue.1 , pp. 23-35
    • Simões, B.M.1    Piva, M.2    Iriondo, O.3
  • 123
    • 78650732630 scopus 로고    scopus 로고
    • Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling
    • Fillmore CM, Gupta PB, Rudnick JA, et al. Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010;107(50):21737–21742.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.50 , pp. 21737-21742
    • Fillmore, C.M.1    Gupta, P.B.2    Rudnick, J.A.3
  • 124
    • 28844494352 scopus 로고    scopus 로고
    • Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modula­tion of beta-catenin phosphorylation
    • Hiscox S, Jiang WG, Obermeier K, et al. Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modula­tion of beta-catenin phosphorylation. Int J Cancer. 2006;118(2):290–301.
    • (2006) Int J Cancer , vol.118 , Issue.2 , pp. 290-301
    • Hiscox, S.1    Jiang, W.G.2    Obermeier, K.3
  • 125
    • 77953384898 scopus 로고    scopus 로고
    • Control of mam­mary stem cell function by steroid hormone signalling
    • Asselin-Labat ML, Vaillant F, Sheridan JM, et al. Control of mam­mary stem cell function by steroid hormone signalling. Nature. 2010; 465(7299):798–802.
    • (2010) Nature , vol.465 , Issue.7299 , pp. 798-802
    • Asselin-Labat, M.L.1    Vaillant, F.2    Sheridan, J.M.3
  • 126
    • 77953388315 scopus 로고    scopus 로고
    • Progesterone induces adult mammary stem cell expansion
    • Joshi PA, Jackson HW, Beristain AG, et al. Progesterone induces adult mammary stem cell expansion. Nature. 2010;465(7299):803–807.
    • (2010) Nature , vol.465 , Issue.7299 , pp. 803-807
    • Joshi, P.A.1    Jackson, H.W.2    Beristain, A.G.3
  • 127
    • 79959344615 scopus 로고    scopus 로고
    • Estrogen receptor silencing induces epithelial to mesenchymal transition in human breast cancer cells
    • Al Saleh S, Al Mulla F, Luqmani YA. Estrogen receptor silencing induces epithelial to mesenchymal transition in human breast cancer cells. PLoS One. 2011;6(6):e20610.
    • (2011) Plos One , vol.6 , Issue.6
    • Al Saleh, S.1    Al Mulla, F.2    Luqmani, Y.A.3
  • 128
    • 0023676353 scopus 로고
    • Transforming growth factor beta: Potential autocrine growth inhibitor of estro­gen receptor-negative human breast cancer cells
    • Arteaga CL, Tandon AK, Von Hoff DD, Osborne CK. Transforming growth factor beta: potential autocrine growth inhibitor of estro­gen receptor-negative human breast cancer cells. Cancer Res. 1988;48:3898–3904.
    • (1988) Cancer Res , vol.48 , pp. 3898-3904
    • Arteaga, C.L.1    Tandon, A.K.2    Von Hoff, D.D.3    Osborne, C.K.4
  • 129
    • 33847419142 scopus 로고    scopus 로고
    • Molecular definition of breast tumor heterogeneity
    • Shipitsin M, Campbell LL, Argani P, et al. Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007;11:259–273.
    • (2007) Cancer Cell , vol.11 , pp. 259-273
    • Shipitsin, M.1    Campbell, L.L.2    Argani, P.3
  • 130
    • 84863725383 scopus 로고    scopus 로고
    • Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α
    • Vesuna F, Lisok A, Kimble B, et al. Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α. Oncogene. 2012;31(27):32223–3234.
    • (2012) Oncogene , vol.31 , Issue.27 , pp. 32223-33234
    • Vesuna, F.1    Lisok, A.2    Kimble, B.3
  • 131
    • 0029934262 scopus 로고    scopus 로고
    • Methylation of estro­gen receptor gene 5′ CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors
    • Lapidus RG, Ferguson AT, Ottaviano YL, et al. Methylation of estro­gen receptor gene 5′ CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors. Clin Cancer Res. 1996;2(5):805–810.
    • (1996) Clin Cancer Res , vol.2 , Issue.5 , pp. 805-810
    • Lapidus, R.G.1    Ferguson, A.T.2    Ottaviano, Y.L.3
  • 132
    • 84902545803 scopus 로고    scopus 로고
    • Estrogen promotes stemness and inva­siveness of ER-positive breast cancer cells through Gli1 activation
    • Sun Y, Wang Y, Fan C, et al. Estrogen promotes stemness and inva­siveness of ER-positive breast cancer cells through Gli1 activation. Mol Cancer. 2014;13:137.
    • (2014) Mol Cancer , vol.13
    • Sun, Y.1    Wang, Y.2    Fan, C.3
  • 133
    • 4544326176 scopus 로고    scopus 로고
    • Evidence for the notch signaling pathway on the role of estrogen in angiogenesis
    • Soares R, Balogh G, Guo S, Gärtner F, Russo J, Schmitt F. Evidence for the notch signaling pathway on the role of estrogen in angiogenesis. Mol Endocrinol. 2004;18:2333–2343.
    • (2004) Mol Endocrinol , vol.18 , pp. 2333-2343
    • Soares, R.1    Balogh, G.2    Guo, S.3    Gärtner, F.4    Russo, J.5    Schmitt, F.6
  • 134
    • 84931410524 scopus 로고    scopus 로고
    • Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity
    • D’Angelo RC, Ouzounova M, Davis A, et al. Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity. Mol Cancer Ther. 2015;14(3):779–787.
    • (2015) Mol Cancer Ther , vol.14 , Issue.3 , pp. 779-787
    • D’Angelo, R.C.1    Ouzounova, M.2    Davis, A.3
  • 135
    • 84896723950 scopus 로고    scopus 로고
    • Estrogen receptor α-coupled Bmi1 regu­lation pathway in breast cancer and its clinical implications
    • Wang H, Liu H, Li X, et al. Estrogen receptor α-coupled Bmi1 regu­lation pathway in breast cancer and its clinical implications. BMC Cancer. 2014;14:122.
    • (2014) BMC Cancer , vol.14
    • Wang, H.1    Liu, H.2    Li, X.3
  • 136
    • 67349149082 scopus 로고    scopus 로고
    • MicroR­NA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
    • Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS. MicroR­NA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell. 2009;137(4):647–658.
    • (2009) Cell , vol.137 , Issue.4 , pp. 647-658
    • Xu, N.1    Papagiannakopoulos, T.2    Pan, G.3    Thomson, J.A.4    Kosik, K.S.5
  • 137
    • 46149089421 scopus 로고    scopus 로고
    • Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression
    • Godar S, Ince TA, Bell GW, et al. Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell. 2008;134(1):62–73.
    • (2008) Cell , vol.134 , Issue.1 , pp. 62-73
    • Godar, S.1    Ince, T.A.2    Bell, G.W.3
  • 138
    • 84866423871 scopus 로고    scopus 로고
    • MicroRNAs in thep53 network: Micromanagement of tumour suppression
    • Hermeking H. MicroRNAs in thep53 network: micromanagement of tumour suppression. Nat Rev Cancer. 2012;12(9):613–626.
    • (2012) Nat Rev Cancer , vol.12 , Issue.9 , pp. 613-626
    • Hermeking, H.1
  • 139
    • 84895557855 scopus 로고    scopus 로고
    • Strasberg-Rieber M. P53 inactivation decreases dependence on estrogen/ERK signalling for proliferation but promotes EMT and susceptibility to 3-bromopyruvate in ERα+ breast cancer MCF-7 cells
    • Rieber M, Strasberg-Rieber M. p53 inactivation decreases dependence on estrogen/ERK signalling for proliferation but promotes EMT and susceptibility to 3-bromopyruvate in ERα+ breast cancer MCF-7 cells. Biochem Pharmacol. 2014;88(2):169–177.
    • (2014) Biochem Pharmacol , vol.88 , Issue.2 , pp. 169-177
    • Rieber, M.1
  • 140
    • 79955532880 scopus 로고    scopus 로고
    • Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions
    • Zhang Y, Yan W, Chen X. Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions. J Biol Chem. 2011;286(18):16218–16228.
    • (2011) J Biol Chem , vol.286 , Issue.18 , pp. 16218-16228
    • Zhang, Y.1    Yan, W.2    Chen, X.3
  • 141
    • 34047263449 scopus 로고    scopus 로고
    • Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells
    • Weisz L, Damalas A, Liontos M, et al. Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells. Cancer Res. 2007;67(6):2396–2401.
    • (2007) Cancer Res , vol.67 , Issue.6 , pp. 2396-2401
    • Weisz, L.1    Damalas, A.2    Liontos, M.3
  • 142
    • 78149284013 scopus 로고    scopus 로고
    • Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
    • Schramek D, Leibbrandt A, Sigl V, et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 2010;468(7320):98–102.
    • (2010) Nature , vol.468 , Issue.7320 , pp. 98-102
    • Schramek, D.1    Leibbrandt, A.2    Sigl, V.3
  • 143
    • 78650369893 scopus 로고    scopus 로고
    • The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion
    • Liu M, Sakamaki T, Casimiro MC, et al. The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion. Cancer Res. 2010;70(24):10464–10473.
    • (2010) Cancer Res , vol.70 , Issue.24 , pp. 10464-10473
    • Liu, M.1    Sakamaki, T.2    Casimiro, M.C.3
  • 144
    • 84883447180 scopus 로고    scopus 로고
    • Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines
    • Tsubaki M, Komai M, Fujimoto S, et al. Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines. J Exp Clin Cancer Res. 2013;32:62.
    • (2013) J Exp Clin Cancer Res , vol.32
    • Tsubaki, M.1    Komai, M.2    Fujimoto, S.3
  • 145
    • 84884716320 scopus 로고    scopus 로고
    • P53 in breast cancer subtypes and new insights into response to chemotherapy
    • Bertheau P, Lehmann-Che J, Varna M, et al. p53 in breast cancer subtypes and new insights into response to chemotherapy. Breast. 2013;22 Suppl 2:S27–S29.
    • (2013) Breast , vol.22
    • Bertheau, P.1    Lehmann-Che, J.2    Varna, M.3
  • 146
    • 78049302116 scopus 로고    scopus 로고
    • P53 post-translational modification: Deregulated in tumorigenesis
    • Dai C, Gu W. p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med. 2010;16(11):528–535.
    • (2010) Trends Mol Med , vol.16 , Issue.11 , pp. 528-535
    • Dai, C.1    Gu, W.2
  • 147
    • 84883795806 scopus 로고    scopus 로고
    • DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail
    • Mimoto R, Taira N, Takahashi H, et al. DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail. Cancer Lett. 2013;339(2):214–225.
    • (2013) Cancer Lett , vol.339 , Issue.2 , pp. 214-225
    • Mimoto, R.1    Taira, N.2    Takahashi, H.3
  • 148
    • 84921643084 scopus 로고    scopus 로고
    • OCT4 expression and vasculogenic mimicry formation positively correlate with poor prognosis in human breast cancer
    • Liu T, Sun B, Zhao X, et al. OCT4 expression and vasculogenic mimicry formation positively correlate with poor prognosis in human breast cancer. Int J Mol Sci. 2014;15(11):19634–19649.
    • (2014) Int J Mol Sci , vol.15 , Issue.11 , pp. 19634-19649
    • Liu, T.1    Sun, B.2    Zhao, X.3
  • 149
    • 84891904837 scopus 로고    scopus 로고
    • Sox2 promotes tamoxifen resistance in breast cancer cells
    • Piva M, Domenici G, Iriondo O, et al. Sox2 promotes tamoxifen resistance in breast cancer cells. EMBO Mol Med. 2014;6(1):66–79.
    • (2014) EMBO Mol Med , vol.6 , Issue.1 , pp. 66-79
    • Piva, M.1    Domenici, G.2    Iriondo, O.3
  • 150
    • 84922425839 scopus 로고    scopus 로고
    • Expression of stemness genes in primary breast cancer tissues: The role of SOX2 as a prog­nostic marker for detection of early recurrence
    • Finicelli M, Benedetti G, Squillaro T, et al. Expression of stemness genes in primary breast cancer tissues: the role of SOX2 as a prog­nostic marker for detection of early recurrence. Oncotarget. 2014; 5(20):9678–9688.
    • (2014) Oncotarget , vol.5 , Issue.20 , pp. 9678-9688
    • Finicelli, M.1    Benedetti, G.2    Squillaro, T.3
  • 151
    • 84895067522 scopus 로고    scopus 로고
    • Increased SOX2 expression in less differentiated breast carcinomas and their lymph node metastases
    • Huang YH, Luo MH, Ni YB, et al. Increased SOX2 expression in less differentiated breast carcinomas and their lymph node metastases. Histopathology. 2014;64(4):494–503.
    • (2014) Histopathology , vol.64 , Issue.4 , pp. 494-503
    • Huang, Y.H.1    Luo, M.H.2    Ni, Y.B.3
  • 152
    • 84891556597 scopus 로고    scopus 로고
    • Prognostic significance of NANOG and KLF4 for breast cancer
    • Nagata T, Shimada Y, Sekine S, et al. Prognostic significance of NANOG and KLF4 for breast cancer. Breast Cancer. 2014; 21(1):96–101.
    • (2014) Breast Cancer , vol.21 , Issue.1 , pp. 96-101
    • Nagata, T.1    Shimada, Y.2    Sekine, S.3
  • 153
    • 11144358328 scopus 로고    scopus 로고
    • Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer
    • Pandya AY, Talley LI, Frost AR, et al. Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer. Clin Cancer Res. 2004;10(8):2709–2719.
    • (2004) Clin Cancer Res , vol.10 , Issue.8 , pp. 2709-2719
    • Pandya, A.Y.1    Talley, L.I.2    Frost, A.R.3
  • 154
    • 0029076002 scopus 로고
    • Expression of c-myc proteins in breast cancer as related to established prognostic factors and survival
    • Pietiläinen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma VM, Syrjänen K. Expression of c-myc proteins in breast cancer as related to established prognostic factors and survival. Anticancer Res. 1995;15(3):959–964.
    • (1995) Anticancer Res , vol.15 , Issue.3 , pp. 959-964
    • Pietiläinen, T.1    Lipponen, P.2    Aaltomaa, S.3    Eskelinen, M.4    Kosma, V.M.5    Syrjänen, K.6
  • 155
    • 84886423250 scopus 로고    scopus 로고
    • Impact of c-MYC protein expression on outcome of patients with early-stage HER2+ breast cancer treated with adjuvant trastuzumab NCCTG (Alliance) N9831
    • Dueck AC, Reinholz MM, Geiger XJ, et al. Impact of c-MYC protein expression on outcome of patients with early-stage HER2+ breast cancer treated with adjuvant trastuzumab NCCTG (alliance) N9831. Clin Cancer Res. 2013;19(20):5798–5807.
    • (2013) Clin Cancer Res , vol.19 , Issue.20 , pp. 5798-5807
    • Dueck, A.C.1    Reinholz, M.M.2    Geiger, X.J.3
  • 156
    • 84891484479 scopus 로고    scopus 로고
    • MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency
    • Ren J, Jin F, Yu Z, et al. MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency. Tumour Biol. 2013; 34(6):3945–3958.
    • (2013) Tumour Biol , vol.34 , Issue.6 , pp. 3945-3958
    • Ren, J.1    Jin, F.2    Yu, Z.3
  • 157
    • 0038024096 scopus 로고    scopus 로고
    • C-myc, not HER-2/neu, can predict recurrence and mortality of patients with node-negative breast cancer
    • Schlotter CM, Vogt U, Bosse U, Mersch B, Wassmann K. C-myc, not HER-2/neu, can predict recurrence and mortality of patients with node-negative breast cancer. Breast Cancer Res. 2003;5(2):R30–R36.
    • (2003) Breast Cancer Res , vol.5 , Issue.2
    • Schlotter, C.M.1    Vogt, U.2    Bosse, U.3    Mersch, B.4    Wassmann, K.5
  • 158
    • 34548833289 scopus 로고    scopus 로고
    • MYC amplifica­tion in breast cancer: A chromogenic in situ hybridisation study
    • Rodriguez-Pinilla SM, Jones RL, Lambros MB, et al. MYC amplifica­tion in breast cancer: a chromogenic in situ hybridisation study. J Clin Pathol. 2007;60(9):1017–1023.
    • (2007) J Clin Pathol , vol.60 , Issue.9 , pp. 1017-1023
    • Rodriguez-Pinilla, S.M.1    Jones, R.L.2    Lambros, M.B.3
  • 159
    • 84863808561 scopus 로고    scopus 로고
    • Lin28 regulates HER2 and pro­motes malignancy through multiple mechanisms
    • Feng C, Neumeister V, Ma W, et al. Lin28 regulates HER2 and pro­motes malignancy through multiple mechanisms. Cell Cycle. 2012; 11(13):2486–2494.
    • (2012) Cell Cycle , vol.11 , Issue.13 , pp. 2486-2494
    • Feng, C.1    Neumeister, V.2    Ma, W.3
  • 160
    • 84902168532 scopus 로고    scopus 로고
    • Lin28B expression correlates with aggressive clinicopathological characteristics in breast invasive ductal carcinoma
    • Xie R, Wang Y, Nie W, et al. Lin28B expression correlates with aggressive clinicopathological characteristics in breast invasive ductal carcinoma. Cancer Biother Radiopharm. 2014;29(5):215–220.
    • (2014) Cancer Biother Radiopharm , vol.29 , Issue.5 , pp. 215-220
    • Xie, R.1    Wang, Y.2    Nie, W.3
  • 161
    • 24944450362 scopus 로고    scopus 로고
    • The transcriptional repressor Snail promotes mammary tumor recurrence
    • Moody SE, Perez D, Pan TC, et al. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell. 2005;8(3):197–209.
    • (2005) Cancer Cell , vol.8 , Issue.3 , pp. 197-209
    • Moody, S.E.1    Perez, D.2    Pan, T.C.3
  • 162
    • 84857817163 scopus 로고    scopus 로고
    • Slug and Sox9 coop­eratively determine the mammary stem cell state
    • Guo W, Keckesova Z, Donaher JL, et al. Slug and Sox9 coop­eratively determine the mammary stem cell state. Cell. 2012;148(5): 1015–1028.
    • (2012) Cell , vol.148 , Issue.5 , pp. 1015-1028
    • Guo, W.1    Keckesova, Z.2    Donaher, J.L.3
  • 163
    • 84865997778 scopus 로고    scopus 로고
    • High TWIST1 mRNA expres­sion is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genes
    • Riaz M, Sieuwerts AM, Look MP, et al. High TWIST1 mRNA expres­sion is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genes. Breast Cancer Res. 2012;14:R123.
    • (2012) Breast Cancer Res , vol.14
    • Riaz, M.1    Sieuwerts, A.M.2    Look, M.P.3
  • 164
    • 84869122494 scopus 로고    scopus 로고
    • Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer
    • Markiewicz A, Ahrends T, Welnicka-Jaśkiewicz M, et al. Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer. J Transl Med. 2012;10:226.
    • (2012) J Transl Med , vol.10
    • Markiewicz, A.1    Ahrends, T.2    Welnicka-Jaśkiewicz, M.3
  • 165
    • 84866324123 scopus 로고    scopus 로고
    • Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links
    • Scheel C, Weinberg RA. Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol. 2012;22(5–6):396–403.
    • (2012) Semin Cancer Biol , vol.22 , Issue.5-6 , pp. 396-403
    • Scheel, C.1    Weinberg, R.A.2
  • 166
    • 84860389952 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and cancer stem cells: A danger­ously dynamic duo in breast cancer progression
    • May CD, Sphyris N, Evans KW, Werden SJ, Guo W, Mani SA. Epithelial-mesenchymal transition and cancer stem cells: a danger­ously dynamic duo in breast cancer progression. Breast Cancer Res. 2011;13:202.
    • (2011) Breast Cancer Res , vol.13
    • May, C.D.1    Sphyris, N.2    Evans, K.W.3    Werden, S.J.4    Guo, W.5    Mani, S.A.6
  • 167
    • 84906927974 scopus 로고    scopus 로고
    • Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer
    • Papadaki MA, Kallergi G, Zafeiriou Z, et al. Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer. BMC Cancer. 2014;14:651.
    • (2014) BMC Cancer , vol.14
    • Papadaki, M.A.1    Kallergi, G.2    Zafeiriou, Z.3
  • 168
    • 84884180105 scopus 로고    scopus 로고
    • SurvExpress: An online biomarker validation tool and database for cancer gene expression data using survival analysis
    • Aguirre-Gamboa R, Gomez-Rueda H, Martinez-Ledesma E, et al. SurvExpress: an online biomarker validation tool and database for cancer gene expression data using survival analysis. PLoS One. 2013;8(9):e74250.
    • (2013) Plos One , vol.8 , Issue.9
    • Aguirre-Gamboa, R.1    Gomez-Rueda, H.2    Martinez-Ledesma, E.3


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