OCT4 expression and vasculogenic mimicry formation positively correlate with poor prognosis in human breast cancer

International Journal of Molecular Sciences

Volumn 15, Issue 11, 2014, Pages 19634-19649

  Liu, Tieju ^a   Sun, Baocun ^a   Zhao, Xiulan ^a   Li, Yanlei ^a   Gu, Qiang ^a   Dong, Xueyi ^a   Liu, Fang ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; OCT4; Vasculogenic mimicry

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; CD31 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; OCTAMER TRANSCRIPTION FACTOR 4;

ADULT; ANGIOGENESIS; ARTICLE; BREAST CANCER; CANCER GRADING; CANCER PROGNOSIS; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FOLLOW UP; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MIDDLE AGED; NOTTINGHAM PROGNOSTIC INDICATOR; OVERALL SURVIVAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; AGED; BREAST TUMOR; FEMALE; GENETICS; METABOLISM; MORTALITY; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PROGNOSIS; RISK FACTOR; TUMOR VOLUME;

ADULT; AGED; BREAST NEOPLASMS; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM GRADING; NEOVASCULARIZATION, PATHOLOGIC; OCTAMER TRANSCRIPTION FACTOR-3; PROGNOSIS; RISK FACTORS; TUMOR BURDEN;

EID: 84921643084     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms151119634     Document Type: Article

References (35)

1. Niu, Y.; Liu, T.; Tse, G.M.; Sun, B.; Niu, R.; Li, H.M.; Wang, H.; Yang, Y.; Ye, X.; Wang, Y.; et al. Increased expression of centrosomal α, γ-tubulin in atypical ductal hyperplasia and carcinoma of the breast. Cancer Sci. 2009, 100, 580-587.
2. Loh, Y.H.; Wu, Q.; Chew, J.L.; Vega, V.B.; Zhang, W.; Chen, X.; Bourque, G.; George, J.; Leong, B.; Liu, J.; et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 2006, 38, 431-440.
3. Adjaye, J.; Huntriss, J.; Herwig, R.; BenKahla, A.; Brink, T.C.; Wierling, C.; Hultschig, C.; Groth, D.; Yaspo, M.L.; Picton, H.M.; et al. Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells. Stem Cells 2005, 23, 1514-1525.
4. Babaie, Y.; Herwig, R.; Greber, B.; Brink, T.C.; Wruck, W.; Groth, D.; Lehrach, H.; Burdon, T.; Adjaye, J. Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells 2007, 25, 500-510.
5. Takahashi, K.; Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126, 663-676.
6. Gidekel, S.; Pizov, G.; Bergman, Y.; Pikarsky, E. Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell 2003, 4, 361-370.
7. Zhou, X.; Huang, G.R.; Hu, P. Over-expression of Oct4 in human esophageal squamous cell carcinoma. Mol. Cells 2011, 32, 39-45.
8. Luo, F.; Yang, K.; Liu, R.L.; Meng, C.; Dang, R.F.; Xu, Y. Formation of vasculogenic mimicry in bone metastasis of prostate cancer: Correlation with cell apoptosis and senescence regulation pathways. Pathol. Res. Pract. 2014, 210, 291-295.
9. Kim, J.B.; Greber, B.; Arauzo-Bravo, M.J.; Meyer, J.; Park, K.I.; Zaehres, H.; Scholer, H.R. Direct reprogramming of human neural stem cells by OCT4. Nature 2009, 461, 649-643.
10. Hu, T.; Liu, S.; Breiter, D.R.; Wang, F.; Tang, Y.; Sun, S. Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. Cancer Res. 2008, 68, 6533-6540.
11. Chang, C.C.; Shieh, G.S.; Wu, P.; Lin, C.C.; Shiau, A.L.; Wu, C.L. Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells. Cancer Res. 2008, 68, 6281-6291.
12. Maniotis, A.J.; Folberg, R.; Hess, A.; Seftor, E.A.; Gardner, L.M.; Pe’er, J.; Trent, J.M.; Meltzer, P.S.; Hendrix, M.J. Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry. Am. J. Pathol. 1999, 155, 739-752.
13. Kirschmann, D.A.; Seftor, E.A.; Hardy, K.M.; Seftor, R.E.; Hendrix, M.J. Molecular pathways: Vasculogenic mimicry in tumor cells: Diagnostic and therapeutic implications. Clin. Cancer Res. 2012, 18, 2726-2732.
14. Yao, X.H.; Ping, Y.F.; Bian, X.W. Contribution of cancer stem cells to tumor vasculogenic mimicry. Protein Cell 2011, 2, 266-272.
15. Liu, T.J.; Sun, B.C.; Zhao, X.L.; Zhao, X.M.; Sun, T.; Gu, Q.; Yao, Z.; Dong, X.Y.; Zhao, N.; Liu, N. CD133+ cells with cancer stem cell characteristics associates with vasculogenic mimicry in triple-negative breast cancer. Oncogene 2013, 32, 544-553.
16. He, W.; Li, K.; Wang, F.; Qin, Y.R.; Fan, Q.X. Expression of OCT4 in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis. World J. Gastroenterol. 2012, 18, 712-719.
17. Wang, L.; Guo, Z.Y.; Zhang, R.; Xin, B.; Chen, R.; Zhao, J.; Wang, T.; Wen, W.H.; Jia, L.T.; Yao, L.B.; et al. Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma. Carcinogenesis 2013, 34, 1773-1781.
18. Albergaria, A.; Ricardo, S.; Milanezi, F.; Carneiro, V.; Amendoeira, I.; Vieira, D.; Cameselle-Teijeiro, J.; Schmitt, F. Nottingham Prognostic Index in triple-negative breast cancer: A reliable prognostic tool? BMC Cancer 2011, 11, 299.
19. Liu, N.; Yu, Q.; Liu, T.J.; Gebreamlak, E.P.; Wang, S.L.; Zhang, R.J.; Zhang, J.; Niu, Y. P-cadherin expression and basal-like subtype in breast cancers. Med. Oncol. 2012, 29, 2606-2612.
20. Liu, T.; Sun, B.; Zhao, X.; Gu, Q.; Dong, X.; Yao, Z.; Zhao, N.; Chi, J.; Liu, N.; Sun, R.; Ma, Y. HER2/neu expression correlates with vasculogenic mimicry in invasive breast carcinoma. J. Cell Mol. Med. 2013, 17, 116-122.
21. Seftor, R.E.; Hess, A.R.; Seftor, E.A.; Kirschmann, D.A.; Hardy, K.M.; Margaryan, N.V.; Hendrix, M.J. Tumor cell vasculogenic mimicry: From controversy to therapeutic promise. Am. J. Pathol. 2012, 181, 1115-1125.
22. De Resende, M.F.; Chinen, L.T.; Vieira, S.; Jampietro, J.; da Fonseca, F.P.; Vassallo, J.; Campos, L.C.; Guimaraes, G.C.; Soares, F.A.; Rocha, R.M. Prognostication of OCT4 isoform expression in prostate cancer. Tumour Biol. 2013, 34, 2665-2673.
23. Sun, T.; Sun, B.C.; Zhao, X.L.; Zhao, N.; Dong, X.Y.; Che, N.; Yao, Z.; Ma, Y.M.; Gu, Q.; Zong, W.K.; et al. Promotion of tumor cell metastasis and vasculogenic mimicry by way of transcription coactivation by Bcl-2 and Twist1: A study of hepatocellular carcinoma. Hepatology 2011, 54, 1690-1706.
24. Iki, K.; Pour, P.M. Expression of Oct4, a stem cell marker, in the hamster pancreatic cancer model. Pancreatology 2006, 6, 406-413.
25. Ezeh, U.I.; Turek, P.J.; Reijo, R.A.; Clark, A.T. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 2005, 104, 2255-2265.
26. Chang, C.J.; Chien, Y.; Lu, K.H.; Chang, S.C.; Chou, Y.C.; Huang, Y.T. Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells. Biochem. Biophys. Res. Commun. 2011, 415, 245-251.
27. Saigusa, S.; Tanaka, K.; Toiyama, Y.; Yokoe, T.; Okugawa, Y.; Ioue, Y.; Miki, C.; Kusunoki, M. Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. Ann. Surg. Oncol. 2009, 16, 3488-3498.
28. Wang, Y.D.; Cai, N.; Wu, X.L.; Cao, H.Z.; Xie, L.L.; Zheng, P.S. OCT4 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells by miR-125b/BAK1 pathway. Cell Death Dis. 2013, 4, e760.
29. Tsai, L.L.; Hu, F.W.; Lee, S.S.; Yu, C.H.; Yu, C.C.; Chang, Y.C. OCT4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition. PLoS One 2014, 9, e87207.
30. Kim, R.J.; Nam, J.S. OCT4 expression enhances features of cancer stem cells in a mouse model of breast cancer. Lab. Anim. Res. 2011, 27, 147-152.
31. Dai, X.; Ge, J.; Wang, X.; Qian, X.; Zhang, C.; Li, X. OCT4 regulates epithelial-mesenchymal transition and its knockdown inhibits colorectal cancer cell migration and invasion. Oncol. Rep. 2013, 29, 155-160.
32. Wang, W.; Lin, P.; Han, C.; Cai, W.; Zhao, X.; Sun, B. Vasculogenic mimicry contributes to lymph node metastasis of laryngeal squamous cell carcinoma. J. Exp. Clin. Cancer Res. 2010, 29, 60.
33. Shirakawa, K.; Wakasugi, H.; Heike, Y.; Watanabe, I.; Yamada, S.; Saito, K.; Konishi, F. Vasculogenic mimicry and pseudo-comedo formation in breast cancer. Int. J. Cancer 2002, 99, 821-828.
34. Kong, B.H.; Park, N.R.; Shim, J.K.; Kim, B.K.; Shin, H.J.; Lee, J.H.; Huh, Y.M.; Lee, S.J.; Kim, S.H.; Kim, E.H.; et al. Isolation of glioma cancer stem cells in relation to histological grades in glioma specimens. Childs Nerv. Syst. 2013, 29, 217-229.
35. Sun, B.; Zhang, S.; Zhang, D.; Du, J.; Guo, H.; Zhao, X.; Zhang, W.; Hao, X. Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinoma. Oncol. Rep. 2006, 16, 693-698.