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Volumn 14, Issue 1, 2014, Pages

Estrogen receptor α-coupled Bmi1 regulation pathway in breast cancer and its clinical implications

Author keywords

Bmi1; Breast cancer; Cyclin D1; Estrogen receptor ; p16INK4a

Indexed keywords

BMI1 PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; KI 67 ANTIGEN; PROGESTERONE RECEPTOR; RETINOBLASTOMA PROTEIN; BMI1 PROTEIN, HUMAN; ESTROGEN RECEPTOR ALPHA, HUMAN;

EID: 84896723950     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-122     Document Type: Article
Times cited : (12)

References (45)
  • 1
    • 79960980007 scopus 로고    scopus 로고
    • Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St Gallen international expert consensus on the primary therapy of early breast cancer 2011
    • 10.1093/annonc/mdr304, 3144634, 21709140
    • Goldhirsch A, Wood W, Coates A, Gelber R, Thürlimann B, Senn HJ. Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St Gallen international expert consensus on the primary therapy of early breast cancer 2011. Ann Oncol 2011, 22(8):1736-1747. 10.1093/annonc/mdr304, 3144634, 21709140.
    • (2011) Ann Oncol , vol.22 , Issue.8 , pp. 1736-1747
    • Goldhirsch, A.1    Wood, W.2    Coates, A.3    Gelber, R.4    Thürlimann, B.5    Senn, H.J.6
  • 2
    • 54849434450 scopus 로고    scopus 로고
    • Current research topics in endocrine therapy for breast cancer
    • 10.1007/s10147-008-0818-7, 18946747
    • Yamashita H. Current research topics in endocrine therapy for breast cancer. Int J Clin Oncol 2008, 13(5):380-383. 10.1007/s10147-008-0818-7, 18946747.
    • (2008) Int J Clin Oncol , vol.13 , Issue.5 , pp. 380-383
    • Yamashita, H.1
  • 3
    • 69249137029 scopus 로고    scopus 로고
    • Biological determinants of endocrine resistance in breast cancer
    • 10.1038/nrc2713, 19701242
    • Musgrove EA, Sutherland RL. Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer 2009, 9(9):631-643. 10.1038/nrc2713, 19701242.
    • (2009) Nat Rev Cancer , vol.9 , Issue.9 , pp. 631-643
    • Musgrove, E.A.1    Sutherland, R.L.2
  • 4
    • 78649335764 scopus 로고    scopus 로고
    • Selectively targeting estrogen receptors for cancer treatment
    • 10.1016/j.addr.2010.08.001, 2991615, 20708050
    • Shanle EK, Xu W. Selectively targeting estrogen receptors for cancer treatment. Adv Drug Deliv Rev 2010, 62(13):1265-1276. 10.1016/j.addr.2010.08.001, 2991615, 20708050.
    • (2010) Adv Drug Deliv Rev , vol.62 , Issue.13 , pp. 1265-1276
    • Shanle, E.K.1    Xu, W.2
  • 5
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
    • CTSU RI. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005, 365:1687-1717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
    • CTSU, R.I.1
  • 6
    • 25844509783 scopus 로고    scopus 로고
    • Steroid hormone receptor signaling in tumorigenesis
    • 10.1002/jcb.20566, 16092128
    • Singh RR, Kumar R. Steroid hormone receptor signaling in tumorigenesis. J Cell Biochem 2005, 96(3):490-505. 10.1002/jcb.20566, 16092128.
    • (2005) J Cell Biochem , vol.96 , Issue.3 , pp. 490-505
    • Singh, R.R.1    Kumar, R.2
  • 7
    • 77951746652 scopus 로고    scopus 로고
    • Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-{alpha}
    • 10.1091/mbc.E09-08-0724, 2861619, 20219974
    • Medunjanin S, Weinert S, Schmeisser A, Mayer D, Braun-Dullaeus RC. Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-{alpha}. Mol Biol Cell 2010, 21(9):1620-1628. 10.1091/mbc.E09-08-0724, 2861619, 20219974.
    • (2010) Mol Biol Cell , vol.21 , Issue.9 , pp. 1620-1628
    • Medunjanin, S.1    Weinert, S.2    Schmeisser, A.3    Mayer, D.4    Braun-Dullaeus, R.C.5
  • 8
    • 49349088733 scopus 로고    scopus 로고
    • Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer
    • 10.1093/carcin/bgn115, 2899848, 18499701
    • Rodriguez BA, Cheng AS, Yan PS, Potter D, Agosto-Perez FJ, Shapiro CL, Huang TH. Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer. Carcinogenesis 2008, 29(7):1459-1465. 10.1093/carcin/bgn115, 2899848, 18499701.
    • (2008) Carcinogenesis , vol.29 , Issue.7 , pp. 1459-1465
    • Rodriguez, B.A.1    Cheng, A.S.2    Yan, P.S.3    Potter, D.4    Agosto-Perez, F.J.5    Shapiro, C.L.6    Huang, T.H.7
  • 9
    • 38549141939 scopus 로고    scopus 로고
    • Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer
    • 10.1016/j.ccr.2008.01.001, 18242510
    • Iorns E, Turner NC, Elliott R, Syed N, Garrone O, Gasco M, Tutt AN, Crook T, Lord CJ, Ashworth A. Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer. Cancer Cell 2008, 13(2):91-104. 10.1016/j.ccr.2008.01.001, 18242510.
    • (2008) Cancer Cell , vol.13 , Issue.2 , pp. 91-104
    • Iorns, E.1    Turner, N.C.2    Elliott, R.3    Syed, N.4    Garrone, O.5    Gasco, M.6    Tutt, A.N.7    Crook, T.8    Lord, C.J.9    Ashworth, A.10
  • 10
    • 0025727771 scopus 로고
    • Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E [mu]-myc transgenic mice
    • 10.1016/0092-8674(91)90383-A, 1904009
    • Haupt Y, Alexander WS, Barri G, Peter Klinken S, Adams JM. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E [mu]-myc transgenic mice. Cell 1991, 65(5):753-763. 10.1016/0092-8674(91)90383-A, 1904009.
    • (1991) Cell , vol.65 , Issue.5 , pp. 753-763
    • Haupt, Y.1    Alexander, W.S.2    Barri, G.3    Peter Klinken, S.4    Adams, J.M.5
  • 11
    • 0033538578 scopus 로고    scopus 로고
    • Stabilization of chromatin structure by PRC1, a Polycomb complex
    • 10.1016/S0092-8674(00)80604-2, 10412979
    • Shao Z, Raible F, Mollaaghababa R, Guyon JR, Wu C, Bender W, Kingston RE. Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell 1999, 98(1):37-46. 10.1016/S0092-8674(00)80604-2, 10412979.
    • (1999) Cell , vol.98 , Issue.1 , pp. 37-46
    • Shao, Z.1    Raible, F.2    Mollaaghababa, R.3    Guyon, J.R.4    Wu, C.5    Bender, W.6    Kingston, R.E.7
  • 12
    • 33846148370 scopus 로고    scopus 로고
    • PRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4a tumor suppressor gene
    • 10.1101/gad.1499407, 1759899, 17210787
    • Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y. pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4a tumor suppressor gene. Gene Dev 2007, 21(1):49-54. 10.1101/gad.1499407, 1759899, 17210787.
    • (2007) Gene Dev , vol.21 , Issue.1 , pp. 49-54
    • Kotake, Y.1    Cao, R.2    Viatour, P.3    Sage, J.4    Zhang, Y.5    Xiong, Y.6
  • 13
    • 33846850149 scopus 로고    scopus 로고
    • Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi1 and c-Myc oncoproteins
    • 1783768, 17151361
    • Guo WJ, Datta S, Band V, Dimri GP. Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi1 and c-Myc oncoproteins. Mol Biol Cell 2007, 18(2):536-546. 1783768, 17151361.
    • (2007) Mol Biol Cell , vol.18 , Issue.2 , pp. 536-546
    • Guo, W.J.1    Datta, S.2    Band, V.3    Dimri, G.P.4
  • 14
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi1 regulate self-renewal of normal and malignant human mammary stem cells
    • 10.1158/0008-5472.CAN-06-0054, 16778178
    • Liu S, Dontu G, Mantle ID, Patel S, Ahn N, Jackson KW, Suri P, Wicha MS. Hedgehog signaling and Bmi1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006, 66(12):6063-6071. 10.1158/0008-5472.CAN-06-0054, 16778178.
    • (2006) Cancer Res , vol.66 , Issue.12 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3    Patel, S.4    Ahn, N.5    Jackson, K.W.6    Suri, P.7    Wicha, M.S.8
  • 15
    • 0141670822 scopus 로고    scopus 로고
    • Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi1
    • 10.1016/S1471-4906(03)00241-2, 14552834
    • Raaphorst FM. Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi1. Trends Immunol 2003, 24(10):522-524. 10.1016/S1471-4906(03)00241-2, 14552834.
    • (2003) Trends Immunol , vol.24 , Issue.10 , pp. 522-524
    • Raaphorst, F.M.1
  • 16
    • 0035906853 scopus 로고    scopus 로고
    • The bmi1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression
    • 10.1054/bjoc.2001.1791, 2363629, 11355949
    • Vonlanthen S, Heighway J, Altermatt H, Gugger M, Kappeler A, Borner M, van Lohuizen M, Betticher D. The bmi1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression. Br J Cancer 2001, 84(10):1372-1376. 10.1054/bjoc.2001.1791, 2363629, 11355949.
    • (2001) Br J Cancer , vol.84 , Issue.10 , pp. 1372-1376
    • Vonlanthen, S.1    Heighway, J.2    Altermatt, H.3    Gugger, M.4    Kappeler, A.5    Borner, M.6    van Lohuizen, M.7    Betticher, D.8
  • 18
    • 43649106221 scopus 로고    scopus 로고
    • Low Bmi1 expression is associated with an activated Bmi1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma
    • 10.1038/sj.bjc.6604360, 2391115, 18475299
    • Engelsen I, Mannelqvist M, Stefansson I, Carter S, Beroukhim R, Øyan A, Otte A, Kalland K, Akslen L, Salvesen H. Low Bmi1 expression is associated with an activated Bmi1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma. Br J Cancer 2008, 98(10):1662-1669. 10.1038/sj.bjc.6604360, 2391115, 18475299.
    • (2008) Br J Cancer , vol.98 , Issue.10 , pp. 1662-1669
    • Engelsen, I.1    Mannelqvist, M.2    Stefansson, I.3    Carter, S.4    Beroukhim, R.5    Øyan, A.6    Otte, A.7    Kalland, K.8    Akslen, L.9    Salvesen, H.10
  • 19
    • 78651376364 scopus 로고    scopus 로고
    • Knockdown of the Bmi1 oncogene inhibits cell proliferation and induces cell apoptosis and is involved in the decrease of Akt phosphorylation in the human breast carcinoma cell line MCF-7
    • Xu Z, Liu H, Lv X, Liu Y, Li S, Li H. Knockdown of the Bmi1 oncogene inhibits cell proliferation and induces cell apoptosis and is involved in the decrease of Akt phosphorylation in the human breast carcinoma cell line MCF-7. Oncol Rep 2011, 25(2):409-418.
    • (2011) Oncol Rep , vol.25 , Issue.2 , pp. 409-418
    • Xu, Z.1    Liu, H.2    Lv, X.3    Liu, Y.4    Li, S.5    Li, H.6
  • 20
    • 69449096782 scopus 로고    scopus 로고
    • Bmi1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases
    • 10.1038/onc.2009.165, 2733922, 19543317
    • Hoenerhoff MJ, Chu I, Barkan D, Liu ZY, Datta S, Dimri GP, Green JE. Bmi1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases. Oncogene 2009, 28(34):3022-3032. 10.1038/onc.2009.165, 2733922, 19543317.
    • (2009) Oncogene , vol.28 , Issue.34 , pp. 3022-3032
    • Hoenerhoff, M.J.1    Chu, I.2    Barkan, D.3    Liu, Z.Y.4    Datta, S.5    Dimri, G.P.6    Green, J.E.7
  • 22
    • 79251589918 scopus 로고    scopus 로고
    • Bmi1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer
    • 10.1186/1476-4598-10-10, 3038148, 21276221
    • Guo BH, Feng Y, Zhang R, Xu LH, Li MZ, Kung HF, Song LB, Zeng MS. Bmi1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer 2011, 10(1):10-33. 10.1186/1476-4598-10-10, 3038148, 21276221.
    • (2011) Mol Cancer , vol.10 , Issue.1 , pp. 10-33
    • Guo, B.H.1    Feng, Y.2    Zhang, R.3    Xu, L.H.4    Li, M.Z.5    Kung, H.F.6    Song, L.B.7    Zeng, M.S.8
  • 25
    • 81555208345 scopus 로고    scopus 로고
    • Assessment of Ki-67 in breast cancer: recommendations from the international Ki-67 in breast cancer working group
    • 10.1093/jnci/djr393, 3216967, 21960707
    • Dowsett M, Nielsen TO, A'Hern R, Bartlett J, Coombes RC, Cuzick J, Ellis M, Henry NL, Hugh JC, Lively T. Assessment of Ki-67 in breast cancer: recommendations from the international Ki-67 in breast cancer working group. J Natl Cancer Inst 2011, 103(22):1656-1664. 10.1093/jnci/djr393, 3216967, 21960707.
    • (2011) J Natl Cancer Inst , vol.103 , Issue.22 , pp. 1656-1664
    • Dowsett, M.1    Nielsen, T.O.2    A'Hern, R.3    Bartlett, J.4    Coombes, R.C.5    Cuzick, J.6    Ellis, M.7    Henry, N.L.8    Hugh, J.C.9    Lively, T.10
  • 26
    • 59849114016 scopus 로고    scopus 로고
    • Studying the subcellular localization and DNA-binding activity of FoxO transcription factors, downstream effectors of PI3K/Akt
    • Essafi A, Gomes AR, Pomeranz KM, Zwolinska AK, Varshochi R, McGovern UB, Lam EW. Studying the subcellular localization and DNA-binding activity of FoxO transcription factors, downstream effectors of PI3K/Akt. Methods Mol Biol 2009, 462:201-211.
    • (2009) Methods Mol Biol , vol.462 , pp. 201-211
    • Essafi, A.1    Gomes, A.R.2    Pomeranz, K.M.3    Zwolinska, A.K.4    Varshochi, R.5    McGovern, U.B.6    Lam, E.W.7
  • 27
    • 47749108741 scopus 로고    scopus 로고
    • FoxM1c counteracts oxidative stress-induced senescence and stimulates Bmi1 expression
    • 10.1074/jbc.M709604200, 2423239, 18408007
    • Li SK, Smith DK, Leung WY, Cheung AM, Lam EW, Dimri GP, Yao K-M. FoxM1c counteracts oxidative stress-induced senescence and stimulates Bmi1 expression. J Biol Chem 2008, 283(24):16545-16553. 10.1074/jbc.M709604200, 2423239, 18408007.
    • (2008) J Biol Chem , vol.283 , Issue.24 , pp. 16545-16553
    • Li, S.K.1    Smith, D.K.2    Leung, W.Y.3    Cheung, A.M.4    Lam, E.W.5    Dimri, G.P.6    Yao, K.-M.7
  • 29
    • 3543002856 scopus 로고    scopus 로고
    • Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter
    • 10.1128/MCB.24.16.7260-7274.2004, 479712, 15282324
    • Cicatiello L, Addeo R, Sasso A, Altucci L, Petrizzi VB, Borgo R, Cancemi M, Caporali S, Caristi S, Scafoglio C. Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter. Mol Cell Biol 2004, 24(16):7260-7274. 10.1128/MCB.24.16.7260-7274.2004, 479712, 15282324.
    • (2004) Mol Cell Biol , vol.24 , Issue.16 , pp. 7260-7274
    • Cicatiello, L.1    Addeo, R.2    Sasso, A.3    Altucci, L.4    Petrizzi, V.B.5    Borgo, R.6    Cancemi, M.7    Caporali, S.8    Caristi, S.9    Scafoglio, C.10
  • 30
    • 0033613085 scopus 로고    scopus 로고
    • Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element
    • 10.1073/pnas.96.20.11217, 18014, 10500157
    • Sabbah M, Courilleau D, Mester J, Redeuilh G. Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element. Proc Natl Acad Sci USA 1999, 96(20):11217-11222. 10.1073/pnas.96.20.11217, 18014, 10500157.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.20 , pp. 11217-11222
    • Sabbah, M.1    Courilleau, D.2    Mester, J.3    Redeuilh, G.4
  • 35
    • 84867520893 scopus 로고    scopus 로고
    • Relationship between B-Cell-specific moloney murine leukemia virus integration site 1 (Bmi1) and homologous recombination regulatory genes in invasive ductal breast carcinomas
    • da Silveira GG, Oliveira-Costa JP, Soave DF, Zanetti JS, Soares FA, Ribeiro-Silva A. Relationship between B-Cell-specific moloney murine leukemia virus integration site 1 (Bmi1) and homologous recombination regulatory genes in invasive ductal breast carcinomas. Histol Histopathol 2012, 27(10):1353-1359.
    • (2012) Histol Histopathol , vol.27 , Issue.10 , pp. 1353-1359
    • da Silveira, G.G.1    Oliveira-Costa, J.P.2    Soave, D.F.3    Zanetti, J.S.4    Soares, F.A.5    Ribeiro-Silva, A.6
  • 36
    • 3543119043 scopus 로고    scopus 로고
    • Genomic targets of nuclear estrogen receptors
    • 10.1210/me.2003-0044, 15031323
    • O'Lone R, Frith MC, Karlsson EK, Hansen U. Genomic targets of nuclear estrogen receptors. Mol Endocrinol 2004, 18(8):1859-1875. 10.1210/me.2003-0044, 15031323.
    • (2004) Mol Endocrinol , vol.18 , Issue.8 , pp. 1859-1875
    • O'Lone, R.1    Frith, M.C.2    Karlsson, E.K.3    Hansen, U.4
  • 39
    • 0032548965 scopus 로고    scopus 로고
    • Retinoblastoma and p16INK4a proteins in mammary carcinoma: their relationship to cyclin D1 and histopathological parameters
    • 10.1002/(SICI)1097-0215(19980220)79:1<71::AID-IJC14>3.0.CO;2-K, 9495362
    • Dublin EA, Patel NK, Gillett CE, Smith P, Peters G, Barnes DM. Retinoblastoma and p16INK4a proteins in mammary carcinoma: their relationship to cyclin D1 and histopathological parameters. Int J Cancer 1998, 79(1):71-75. 10.1002/(SICI)1097-0215(19980220)79:1<71::AID-IJC14>3.0.CO;2-K, 9495362.
    • (1998) Int J Cancer , vol.79 , Issue.1 , pp. 71-75
    • Dublin, E.A.1    Patel, N.K.2    Gillett, C.E.3    Smith, P.4    Peters, G.5    Barnes, D.M.6
  • 40
    • 23044508946 scopus 로고    scopus 로고
    • Cyclin D1 in breast cancer pathogenesis
    • 10.1200/JCO.2005.05.064, 15961768
    • Arnold A, Papanikolaou A. Cyclin D1 in breast cancer pathogenesis. J Clin Oncol 2005, 23(18):4215-4224. 10.1200/JCO.2005.05.064, 15961768.
    • (2005) J Clin Oncol , vol.23 , Issue.18 , pp. 4215-4224
    • Arnold, A.1    Papanikolaou, A.2
  • 41
    • 34547223720 scopus 로고    scopus 로고
    • INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
    • 10.1080/15216540701488358, 17654117
    • Cánepa ET, Scassa ME, Ceruti JM, Marazita MC, Carcagno AL, Sirkin PF, Ogara MF. INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions. IUBMB Life 2007, 59(7):419-426. 10.1080/15216540701488358, 17654117.
    • (2007) IUBMB Life , vol.59 , Issue.7 , pp. 419-426
    • Cánepa, E.T.1    Scassa, M.E.2    Ceruti, J.M.3    Marazita, M.C.4    Carcagno, A.L.5    Sirkin, P.F.6    Ogara, M.F.7
  • 42
    • 33644939223 scopus 로고    scopus 로고
    • P16INK4a expression in the female genital tract and its value in diagnosis
    • 10.1097/01.pap.0000201828.92719.f3, 16462152
    • O'Neill CJ, McCluggage WG. p16INK4a expression in the female genital tract and its value in diagnosis. Adv Anat Pathol 2006, 13(1):8-15. 10.1097/01.pap.0000201828.92719.f3, 16462152.
    • (2006) Adv Anat Pathol , vol.13 , Issue.1 , pp. 8-15
    • O'Neill, C.J.1    McCluggage, W.G.2
  • 43
    • 33748128513 scopus 로고    scopus 로고
    • P16INK4a immunoexpression: surrogate marker of high-risk HPV and high-grade cervical intraepithelial neoplasia
    • 10.1097/00125480-200607000-00006, 16858153
    • Kalof AN, Cooper K. p16INK4a immunoexpression: surrogate marker of high-risk HPV and high-grade cervical intraepithelial neoplasia. Adv Anat Pathol 2006, 13(4):190-194. 10.1097/00125480-200607000-00006, 16858153.
    • (2006) Adv Anat Pathol , vol.13 , Issue.4 , pp. 190-194
    • Kalof, A.N.1    Cooper, K.2
  • 44
    • 77958475314 scopus 로고    scopus 로고
    • Identification and characterization of Bmi1-responding element within the human p16INK4a promoter
    • 10.1074/jbc.M110.133686, 2963359, 20551323
    • Meng S, Luo M, Sun H, Yu X, Shen M, Zhang Q, Zhou R, Ju X, Tao W, Liu D. Identification and characterization of Bmi1-responding element within the human p16INK4a promoter. J Biol Chem 2010, 285(43):33219-33229. 10.1074/jbc.M110.133686, 2963359, 20551323.
    • (2010) J Biol Chem , vol.285 , Issue.43 , pp. 33219-33229
    • Meng, S.1    Luo, M.2    Sun, H.3    Yu, X.4    Shen, M.5    Zhang, Q.6    Zhou, R.7    Ju, X.8    Tao, W.9    Liu, D.10
  • 45
    • 47049090497 scopus 로고    scopus 로고
    • Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium
    • 10.1016/j.cub.2008.06.070, 18635350
    • Pietersen AM, Evers B, Prasad AA, Tanger E, Cornelissen-Steijger P, Jonkers J, van Lohuizen M. Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium. Curr Biol 2008, 18(14):1094-1099. 10.1016/j.cub.2008.06.070, 18635350.
    • (2008) Curr Biol , vol.18 , Issue.14 , pp. 1094-1099
    • Pietersen, A.M.1    Evers, B.2    Prasad, A.A.3    Tanger, E.4    Cornelissen-Steijger, P.5    Jonkers, J.6    van Lohuizen, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.