Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions

Journal of Biological Chemistry

Volumn 286, Issue 18, 2011, Pages 16218-16228

  Zhang, Yanhong ^a   Yan, Wensheng ^a   Chen, Xinbin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CELL ADHESION MOLECULES; CELL POLARITY; CELL SURVIVAL; CYTOSKELETAL; DNA DAMAGES; E-CADHERINS; ECTOPIC EXPRESSIONS; EXPRESSION PATTERNS; EXTRACELLULAR MATRIX PROTEIN; GAIN-OF FUNCTION; IN-VIVO; LAMININ; MORPHOLOGICAL CHANGES; MUTANT ALLELES; NULL ALLELES; P53 GENE; THREE-DIMENSIONAL CULTURE; THREE-DIMENSIONAL MODEL; TIGHT JUNCTIONS; TUMOR CELLS; TUMOR SUPPRESSION; WILD TYPES;

ADHESION; CELL ADHESION; CELL DEATH; GENES; MORPHOLOGY; THREE DIMENSIONAL; TUMORS;

CELL CULTURE;

BETA CATENIN; KALININ; MUTANT PROTEIN; PROTEIN P53; PROTEIN ZO1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UVOMORULIN;

ACINAR CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL IMMORTALIZATION; CELL LINE; CELL POLARITY; CELL STRAIN MCF 10A; CONTROLLED STUDY; CULTURE TECHNIQUE; EPITHELIAL MESENCHYMAL TRANSITION; GAIN OF FUNCTION MUTATION; GENE MUTATION; GENE SILENCING; MORPHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THREE DIMENSIONAL CULTURE; TUMOR SPHEROID; WILD TYPE;

ALLELES; AMINO ACID SUBSTITUTION; ANIMALS; BETA CATENIN; CADHERINS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL POLARITY; CELL SURVIVAL; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; PHOSPHOPROTEINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; TWIST TRANSCRIPTION FACTOR;

GASTROPODA; MUS;

EID: 79955532880     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.214585     Document Type: Article

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