The wnt-β-catenin pathway represses let-7 microrna expression through transactivation of Lin28 to augment breast cancer stem cell expansion

Journal of Cell Science

Volumn 126, Issue 13, 2013, Pages 2877-2889

  Cai, Wang Yu ^a   Wei, Tong Zhen ^a   Luo, Qi Cong ^b   Wu, Qiu Wan ^b   Liu, Qing Feng ^a   Yang, Meng ^a   Ye, Guo Dong ^a   Wu, Jia Fa ^a   Chen, Yuan Yuan ^a   Sun, Guang Bin ^a   Liu, Yun Jia ^a   Zhao, Wen Xiu ^c   Zhang, Zhi Ming ^b   Li, Bo An ^a  

^a XIAMEN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^c ZHONGSHAN HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

Breast cancer; Let 7; Lin28; Stem cell; Wnt catenin pathway

Indexed keywords

BETA CATENIN; LET 7 PROTEIN; LIN28 PROTEIN; MICRORNA; PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WNT PROTEIN;

ARTICLE; BREAST CANCER; CANCER MODEL; CANCER STEM CELL; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; GENETIC IDENTIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; MICROARRAY ANALYSIS; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA PROCESSING; STEM CELL EXPANSION; TRANSACTIVATION; UPREGULATION;

BREAST CANCER; LET-7; LIN28; STEM CELL; WNT-Β-CATENIN PATHWAY;

ANIMALS; BETA CATENIN; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; LUCIFERASES; MAMMARY GLANDS, ANIMAL; MICE; MICE, KNOCKOUT; MICRORNAS; NEOPLASTIC STEM CELLS; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; WNT1 PROTEIN;

EID: 84880670678     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.123810     Document Type: Article

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