The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer

Oncogene

Volumn 31, Issue 50, 2012, Pages 5162-5171

  Smith, A L ^a   Iwanaga, R ^a   Drasin, D J ^a   Micalizzi, D S ^a   Vartuli, R L ^a   Tan, A C ^b   Ford, H L ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

epithelial to mesenchymal transition; miRNA; Six1; TGF b; tumor initiating cell

Indexed keywords

MICRORNA; MICRORNA 106B 25; PROTEIN P21; SMAD7 PROTEIN; TRANSCRIPTION FACTOR SIX1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; GENE CLUSTER; HUMAN; HUMAN TISSUE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; MCF-7 CELLS; MICRORNAS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84871246002     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.11     Document Type: Article

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