Isolation and characterization of human breast cancer cells with SOX2 promoter activity

Biochemical and Biophysical Research Communications

Volumn 437, Issue 2, 2013, Pages 205-211

  Liang, Shanshan ^a   Furuhashi, Masako ^a   Nakane, Rie ^a   Nakazawa, Seitaro ^a   Goudarzi, Houman ^a   Hamada, Jun ichi ^a   Iizasa, Hisashi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Cancer stem cells; SOX2 promoter; Stemness; Transcription factor reporter

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR SOX2;

ABCB1 GENE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER STEM CELL; CD24 GENE; CD44 GENE; CELL POPULATION; CONTROLLED STUDY; GENE; GENE ACTIVITY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE ISOLATION; HUMAN; HUMAN CELL; NANOG GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; SEX DETERMINING REGION Y BOX 2 GENE; TWIST1 GENE;

CANCER STEM CELLS; SOX2 PROMOTER; STEMNESS; TRANSCRIPTION FACTOR REPORTER;

BASE SEQUENCE; BREAST NEOPLASMS; DNA PRIMERS; FEMALE; HUMANS; MCF-7 CELLS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SOXB1 TRANSCRIPTION FACTORS;

EID: 84880717598     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.06.038     Document Type: Article

References (20)

1. Sarkar A., Hochedlinger K. The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. Cell Stem Cell 2013, 12:15-30.
2. Li X.L., Eishi Y., Bai Y.Q., Sakai H., Akiyama Y., Tani M., Takizawa T., Koike M., Yuasa Y. Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma. Int. J. Oncol. 2004, 24:257-263.
3. Rudin C.M., Durinck S., Stawiski E.W., Poirier J.T., Modrusan Z., Shames D.S., Bergbower E.A., Guan Y., Shin J., Guillory J., Rivers C.S., Foo C.K., Bhatt D., Stinson J., Gnad F., Haverty P.M., Gentleman R., Chaudhuri S., Janakiraman V., Jaiswal B.S., Parikh C., Yuan W., Zhang Z., Koeppen H., Wu T.D., Stern H.M., Yauch R.L., Huffman K.E., Paskulin D.D., Illei P.B., Varella-Garcia M., Gazdar A.F., de Sauvage F.J., Bourgon R., Minna J.D., Brock M.V., Seshagiri S. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat. Genet. 2012, 44:1111-1116.
4. Girouard S.D., Laga A.C., Mihm M.C., Scolyer R.A., Thompson J.F., Zhan Q., Widlund H.R., Lee C.W., Murphy G.F. SOX2 contributes to melanoma cell invasion. Lab. Invest. 2012, 92:362-370.
5. Bass A.J., Watanabe H., Mermel C.H., Yu S., Perner S., Verhaak R.G., Kim S.Y., Wardwell L., Tamayo P., Gat-Viks I., Ramos A.H., Woo M.S., Weir B.A., Getz G., Beroukhim R., O'Kelly M., Dutt A., Rozenblatt-Rosen O., Dziunycz P., Komisarof J., Chirieac L.R., Lafargue C.J., Scheble V., Wilbertz T., Ma C., Rao S., Nakagawa H., Stairs D.B., Lin L., Giordano T.J., Wagner P., Minna J.D., Gazdar A.F., Zhu C.Q., Brose M.S., Cecconello I., Jr U.R., Marie S.K., Dahl O., Shivdasani R.A., Tsao M.S., Rubin M.A., Wong K.K., Regev A., Hahn W.C., Beer D.G., Rustgi A.K., Meyerson M. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat. Genet. 2009, 41:1238-1242.
6. Rodriguez-Pinilla S.M., Sarrio D., Moreno-Bueno G., Rodriguez-Gil Y., Martinez M.A., Hernandez L., Hardisson D., Reis-Filho J.S., Palacios J. Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer. Mod. Pathol. 2007, 20:474-481.
7. Alonso M.M., Diez-Valle R., Manterola L., Rubio A., Liu D., Cortes-Santiago N., Urquiza L., Jauregi P., Lopez de Munain A., Sampron N., Aramburu A., Tejada-Solis S., Vicente C., Odero M.D., Bandres E., Garcia-Foncillas J., Idoate M.A., Lang F.F., Fueyo J., Gomez-Manzano C. Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas. PLoS One 2011, 6:e26740.
8. Li A.S., Siu M.K., Zhang H., Wong E.S., Chan K.Y., Ngan H.Y., Cheung A.N. Hypermethylation of SOX2 gene in hydatidiform mole and choriocarcinoma. Reprod. Sci. 2008, 15:735-744.
9. Stolzenburg S., Rots M.G., Beltran A.S., Rivenbark A.G., Yuan X., Qian H., Strahl B.D., Blancafort P. Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer. Nucleic Acids Res. 2012, 40:6725-6740.
10. Tomioka M., Nishimoto M., Miyagi S., Katayanagi T., Fukui N., Niwa H., Muramatsu M., Okuda A. Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex. Nucleic Acids Res. 2002, 30:3202-3213.
11. Sikorska M., Sandhu J.K., Deb-Rinker P., Jezierski A., Leblanc J., Charlebois C., Ribecco-Lutkiewicz M., Bani-Yaghoub M., Walker P.R. Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation. J. Neurosci. Res. 2008, 86:1680-1693.
12. Katoh K., Misawa K., Kuma K., Miyata T. MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Res. 2002, 30:3059-3066.
13. Katoh K., Kuma K., Toh H., Miyata T. MAFFT version 5: improvement in accuracy of multiple sequence alignment. Nucleic Acids Res. 2005, 33:511-518.
14. Katoh Y., Katoh M. Comparative genomics on SOX2 orthologs. Oncol. Rep. 2005, 14:797-800.
15. Ponti D., Costa A., Zaffaroni N., Pratesi G., Petrangolini G., Coradini D., Pilotti S., Pierotti M.A., Daidone M.G. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 2005, 65:5506-5511.
16. Patrawala L., Calhoun T., Schneider-Broussard R., Zhou J., Claypool K., Tang D.G. Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic. Cancer Res. 2005, 65:6207-6219.
17. Jung J.W., Park S.B., Lee S.J., Seo M.S., Trosko J.E., Kang K.S. Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression. PLoS One 2011, 6:e28068.
18. Yu F., Li J., Chen H., Fu J., Ray S., Huang S., Zheng H., Ai W. Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene 2011, 30:2161-2172.
19. Chen Y., Shi L., Zhang L., Li R., Liang J., Yu W., Sun L., Yang X., Wang Y., Zhang Y., Shang Y. The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J. Biol. Chem. 2008, 283:17969-17978.
20. Wu F., Zhang J., Wang P., Ye X., Jung K., Bone K.M., Pearson J.D., Ingham R.J., McMullen T.P., Ma Y., Lai R. Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity. Cell. Signal. 2012, 24:1989-1998.