Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression leading to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma

Journal of Biological Chemistry

Volumn 287, Issue 39, 2012, Pages 32800-32824

  Bourguignon, Lilly Y W ^a   Wong, Gabriel ^a   Earle, Christine ^a   Chen, Liqun ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER STEM CELLS; CELL MARKERS; CELL POPULATIONS; CHROMATIN IMMUNOPRECIPITATION ASSAY; CIS-PLATIN; COMPLEX FORMATIONS; DOWN-REGULATION; HEAD-AND-NECK CANCER; HEAD-AND-NECK SQUAMOUS CELL CARCINOMA; HUMAN HEAD; HYALURONAN; MALIGNANT CANCERS; NUCLEAR TRANSLOCATIONS; PROTEIN ACTIVATION; TARGET FUNCTIONS; TUMOR CELLS; UP-REGULATION;

ALDEHYDES; CELL CULTURE; CELL PROLIFERATION; CHEMOTHERAPY; PLATINUM COMPOUNDS; RNA; STEM CELLS; TRANSCRIPTION FACTORS;

DISEASES;

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; CD44V ANTIGEN; CD44V3 ANTIGEN; CISPLATIN; DNA METHYLTRANSFERASE 1; HYALURONIC ACID; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; MICRORNA; MICRORNA 302; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN AOF1; PROTEIN AOF2; REGULATOR PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CANCER STEM CELL; CELL POPULATION; CELL RENEWAL; CHROMATIN IMMUNOPRECIPITATION; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC TRANSFECTION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INTERACTION; UPREGULATION;

ANTIGENS, CD44; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; CELL SURVIVAL; CISPLATIN; DRUG RESISTANCE, NEOPLASM; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; HYALURONIC ACID; ISOENZYMES; MICRORNAS; MOUTH NEOPLASMS; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; RETINAL DEHYDROGENASE; RNA, NEOPLASM; SIGNAL TRANSDUCTION; SOXB1 TRANSCRIPTION FACTORS;

EID: 84866559462     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.308528     Document Type: Article

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