Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis

Journal of Clinical Investigation

Volumn 125, Issue 8, 2015, Pages 2935-2951

  Kramann, Rafael ^a,b   Fleig, Susanne V ^a,c   Schneider, Rebekka K ^a   Fabian, Steven L ^a   DiRocco, Derek P ^a   Maarouf, Omar ^a   Wongboonsin, Janewit ^a   Ikeda, Yoichiro ^a   Heckl, Dirk ^a   Chang, Steven L ^a   Rennke, Helmut G ^a   Waikar, Sushrut S ^a   Humphreys, Benjamin D ^a,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA GALACTOSIDE; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA 1; DARINAPARSIN; FIBRONECTIN; GLUTATHIONE; SMALL INTERFERING RNA; TAMOXIFEN; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; UNCLASSIFIED DRUG; GANT 61; GLI PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; ORGANOARSENIC DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL LYSATE; CELL PROLIFERATION; CONTROLLED STUDY; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HAIR FOLLICLE; IN VITRO STUDY; KIDNEY FIBROSIS; KIDNEY INJURY; MALE; MESENCHYMAL STEM CELL; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SKIN GRAFT; UPREGULATION; URETER OBSTRUCTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE CHECKPOINT; CELL LINE; DRUG EFFECTS; FIBROSIS; GENETICS; HUMAN; KIDNEY; KIDNEY DISEASES; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; ARSENICALS; CELL CYCLE CHECKPOINTS; CELL LINE; FIBROSIS; GLUTATHIONE; HUMANS; KIDNEY; KIDNEY DISEASES; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, KNOCKOUT; MYOFIBROBLASTS; PYRIDINES; PYRIMIDINES;

EID: 84939240157     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI74929     Document Type: Article

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