Targeting the Hedgehog-Glioma-associated oncogene homolog pathway inhibits bleomycin-induced lung fibrosis in mice

American Journal of Respiratory Cell and Molecular Biology

Volumn 51, Issue 1, 2014, Pages 11-25

  Moshai, Elika Farrokhi ^a   Wémeau Stervinou, Lidwine ^a   Cigna, Natacha ^a   Brayer, Stephanie ^a   Sommé, Joëlle Marchal ^a   Crestani, Bruno ^a,b,c   Mailleux, Arnaud A ^a  

^a INSERM   (France)

^b ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Bleomycin; Lung fibrosis; Mouse model; Sonic Hedgehog pathway

Indexed keywords

ALPHA ACTIN; ALPHA SMOOTH MUSCLE ACTIN; BETA TUBULIN; BLEOMYCIN; CASPASE 3; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; INTERLEUKIN 1BETA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN A; VISMODEGIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LUNG HOMOGENATE; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

BLEOMYCIN; LUNG FIBROSIS; MOUSE MODEL; SONIC HEDGEHOG PATHWAY;

ANILIDES; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLEOMYCIN; BLOTTING, WESTERN; CELL PROLIFERATION; COLLAGEN; FLUORESCENT ANTIBODY TECHNIQUE; GLIOMA; HEDGEHOG PROTEINS; IMMUNOENZYME TECHNIQUES; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MICE; MICE, INBRED C57BL; PULMONARY FIBROSIS; PYRIDINES; PYRIMIDINES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 84903700343     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0154OC     Document Type: Article

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