메뉴 건너뛰기




Volumn 26, Issue 4, 2015, Pages 425-449

Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations

Author keywords

Development; Fibroblast Growth Factor Receptor; Myeloproliferative syndrome; Rhabdomyosarcoma; Translocation

Indexed keywords

1 TERT BUTYL 3 [6 (3,5 DIMETHOXYPHENYL) 2 (4 DIETHYLAMINOBUTYLAMINO)PYRIDO[2,3 D]PYRIMIDIN 7 YL]UREA; ANTINEOPLASTIC AGENT; AZD 4547; AZD 8010; BCR FGFR1 FUSION PROTEIN; CEP110 FGFR1 FUSION PROTEIN; CYSTEINE; DOVITINIB; ERLOTINIB; FGFR1 FUSION PROTEIN; FGFR1OP FGFR1 FUSION PROTEIN; FGFR2 AHCYL1 FUSION PROTEIN; FGFR2 FUSION PROTEIN; FGFR3 BAIAP2L1 FUSION PROTEIN; FGFR3 TACC3 FUSION PROTEIN; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FIBROBLAST GROWTH FACTOR RECEPTOR 4; GEFITINIB; HYBRID PROTEIN; IMATINIB; PAZOPANIB; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TIF1 FGFR1 FUSION PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZNF198 FGFR1 FUSION PROTEIN;

EID: 84938286765     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2015.03.003     Document Type: Short Survey
Times cited : (114)

References (209)
  • 1
    • 0034213931 scopus 로고    scopus 로고
    • RTK mutations and human syndromes: when good receptors turn bad
    • Robertson S.C., Tynan J., Donoghue D.J. RTK mutations and human syndromes: when good receptors turn bad. Trends Genet 2000, 16:368.
    • (2000) Trends Genet , vol.16 , pp. 368
    • Robertson, S.C.1    Tynan, J.2    Donoghue, D.J.3
  • 2
    • 17844402791 scopus 로고    scopus 로고
    • Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations
    • Wilkie A.O. Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations. Cytokine Growth Factor Rev 2005, 16:187-203.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 187-203
    • Wilkie, A.O.1
  • 5
    • 75149170979 scopus 로고    scopus 로고
    • Fibroblast growth factor signalling: from development to cancer
    • Turner N., Grose R. Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer 2010, 10:116-129.
    • (2010) Nat Rev Cancer , vol.10 , pp. 116-129
    • Turner, N.1    Grose, R.2
  • 6
    • 84857433085 scopus 로고    scopus 로고
    • Mechanisms of FGFR-mediated carcinogenesis
    • Ahmad I., Iwata T., Leung H.Y. Mechanisms of FGFR-mediated carcinogenesis. Biochim Biophys Acta 2012, 1823:850-860.
    • (2012) Biochim Biophys Acta , vol.1823 , pp. 850-860
    • Ahmad, I.1    Iwata, T.2    Leung, H.Y.3
  • 7
    • 0032515975 scopus 로고    scopus 로고
    • Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain
    • Robertson S.C., Meyer A.N., Hart K.C., Galvin B.D., Webster M.K., Donoghue D.J. Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain. Proc Natl Acad Sci U S A 1998, 95:4567-4572.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 4567-4572
    • Robertson, S.C.1    Meyer, A.N.2    Hart, K.C.3    Galvin, B.D.4    Webster, M.K.5    Donoghue, D.J.6
  • 8
    • 84902631616 scopus 로고    scopus 로고
    • Crouzon's syndrome: a review of literature and case report
    • Padmanabhan V., Hegde A.M., Rai K. Crouzon's syndrome: a review of literature and case report. Contemp Clin Dent 2011, 2:211-214.
    • (2011) Contemp Clin Dent , vol.2 , pp. 211-214
    • Padmanabhan, V.1    Hegde, A.M.2    Rai, K.3
  • 9
    • 70350646899 scopus 로고    scopus 로고
    • Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors
    • Goriely A., Hansen R.M., Taylor I.B., Olesen I.A., Jacobsen G.K., McGowan S.J., et al. Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors. Nat Genet 2009, 41:1247-1252.
    • (2009) Nat Genet , vol.41 , pp. 1247-1252
    • Goriely, A.1    Hansen, R.M.2    Taylor, I.B.3    Olesen, I.A.4    Jacobsen, G.K.5    McGowan, S.J.6
  • 11
    • 0029816813 scopus 로고    scopus 로고
    • Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras
    • Galvin B.D., Hart K.C., Meyer A.N., Webster M.K., Donoghue D.J. Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras. Proc Natl Acad Sci U S A 1996, 93:7894-7899.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 7894-7899
    • Galvin, B.D.1    Hart, K.C.2    Meyer, A.N.3    Webster, M.K.4    Donoghue, D.J.5
  • 14
    • 0031985174 scopus 로고    scopus 로고
    • Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
    • d'Avis P.Y., Robertson S.C., Meyer A.N., Bardwell W.M., Webster M.K., Donoghue D.J. Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I. Cell Growth Differ 1998, 9:71-78.
    • (1998) Cell Growth Differ , vol.9 , pp. 71-78
    • d'Avis, P.Y.1    Robertson, S.C.2    Meyer, A.N.3    Bardwell, W.M.4    Webster, M.K.5    Donoghue, D.J.6
  • 15
    • 0028046606 scopus 로고
    • A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome
    • Muenke M., Schell U., Hehr A., Robin N.H., Losken H.W., Schinzel A., et al. A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Nat Genet 1994, 8:269-274.
    • (1994) Nat Genet , vol.8 , pp. 269-274
    • Muenke, M.1    Schell, U.2    Hehr, A.3    Robin, N.H.4    Losken, H.W.5    Schinzel, A.6
  • 17
    • 79952698205 scopus 로고    scopus 로고
    • The primary site of the acrocephalic feature in Apert Syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling
    • Nagata M., Nuckolls G.H., Wang X., Shum L., Seki Y., Kawase T., et al. The primary site of the acrocephalic feature in Apert Syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling. Bone 2011, 48:847-856.
    • (2011) Bone , vol.48 , pp. 847-856
    • Nagata, M.1    Nuckolls, G.H.2    Wang, X.3    Shum, L.4    Seki, Y.5    Kawase, T.6
  • 18
    • 0031005778 scopus 로고    scopus 로고
    • FGFR activation in skeletal disorders: too much of a good thing
    • Webster M.K., Donoghue D.J. FGFR activation in skeletal disorders: too much of a good thing. Trends Genet 1997, 13:178-182.
    • (1997) Trends Genet , vol.13 , pp. 178-182
    • Webster, M.K.1    Donoghue, D.J.2
  • 19
    • 46249129455 scopus 로고    scopus 로고
    • Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling
    • Ahmed Z., Schuller A.C., Suhling K., Tregidgo C., Ladbury J.E. Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling. Biochem J 2008, 413:37-49.
    • (2008) Biochem J , vol.413 , pp. 37-49
    • Ahmed, Z.1    Schuller, A.C.2    Suhling, K.3    Tregidgo, C.4    Ladbury, J.E.5
  • 20
    • 0028798546 scopus 로고
    • Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome
    • Wilkie A.O., Slaney S.F., Oldridge M., Poole M.D., Ashworth G.J., Hockley A.D., et al. Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome. Nat Genet 1995, 9:165-172.
    • (1995) Nat Genet , vol.9 , pp. 165-172
    • Wilkie, A.O.1    Slaney, S.F.2    Oldridge, M.3    Poole, M.D.4    Ashworth, G.J.5    Hockley, A.D.6
  • 22
    • 84900305191 scopus 로고    scopus 로고
    • A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation
    • Chen P., Zhang L., Weng T., Zhang S., Sun S., Chang M., et al. A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation. PLOS ONE 2014, 9:e87311.
    • (2014) PLOS ONE , vol.9 , pp. e87311
    • Chen, P.1    Zhang, L.2    Weng, T.3    Zhang, S.4    Sun, S.5    Chang, M.6
  • 24
    • 0033786730 scopus 로고    scopus 로고
    • Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase
    • Bell C.A., Tynan J.A., Hart K.C., Meyer A.N., Robertson S.C., Donoghue D.J. Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase. Mol Biol Cell 2000, 11:3589-3599.
    • (2000) Mol Biol Cell , vol.11 , pp. 3589-3599
    • Bell, C.A.1    Tynan, J.A.2    Hart, K.C.3    Meyer, A.N.4    Robertson, S.C.5    Donoghue, D.J.6
  • 25
    • 84933041582 scopus 로고    scopus 로고
    • FGFR3 unliganded dimer stabilization by the juxtamembrane domain
    • Sarabipour S., Hristova K. FGFR3 unliganded dimer stabilization by the juxtamembrane domain. J Mol Biol 2015.
    • (2015) J Mol Biol
    • Sarabipour, S.1    Hristova, K.2
  • 27
    • 84925698748 scopus 로고    scopus 로고
    • Beare-Stevenson syndrome: two new patients, including a novel finding of tracheal cartilaginous sleeve
    • Wenger T.L., Bhoj E.J., Wetmore R.F., Mennuti M.T., Bartlet S.P., Mollen T.J., et al. Beare-Stevenson syndrome: two new patients, including a novel finding of tracheal cartilaginous sleeve. Am J Med Genet A 2015, 167:852-857.
    • (2015) Am J Med Genet A , vol.167 , pp. 852-857
    • Wenger, T.L.1    Bhoj, E.J.2    Wetmore, R.F.3    Mennuti, M.T.4    Bartlet, S.P.5    Mollen, T.J.6
  • 28
    • 0030064347 scopus 로고    scopus 로고
    • Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia
    • Webster M.K., Donoghue D.J. Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia. Embo J 1996, 15:520-527.
    • (1996) Embo J , vol.15 , pp. 520-527
    • Webster, M.K.1    Donoghue, D.J.2
  • 29
    • 0028872752 scopus 로고
    • Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3
    • Tavormina P.L., Shiang R., Thompson L.M., Zhu Y.Z., Wilkin D.J., Lachman R.S., et al. Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3. Nat Genet 1995, 9:321-328.
    • (1995) Nat Genet , vol.9 , pp. 321-328
    • Tavormina, P.L.1    Shiang, R.2    Thompson, L.M.3    Zhu, Y.Z.4    Wilkin, D.J.5    Lachman, R.S.6
  • 30
    • 0027964261 scopus 로고
    • Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia
    • Shiang R., Thompson L.M., Zhu Y.Z., Church D.M., Fielder T.J., Bocian M., et al. Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 1994, 78:335-342.
    • (1994) Cell , vol.78 , pp. 335-342
    • Shiang, R.1    Thompson, L.M.2    Zhu, Y.Z.3    Church, D.M.4    Fielder, T.J.5    Bocian, M.6
  • 31
    • 0028093135 scopus 로고
    • Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia
    • Rousseau F., Bonaventure J., Legeai-Mallet L., Pelet A., Rozet J.M., Maroteaux P., et al. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature 1994, 371:252-254.
    • (1994) Nature , vol.371 , pp. 252-254
    • Rousseau, F.1    Bonaventure, J.2    Legeai-Mallet, L.3    Pelet, A.4    Rozet, J.M.5    Maroteaux, P.6
  • 32
    • 34250829395 scopus 로고    scopus 로고
    • Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
    • Pollock P.M., Gartside M.G., Dejeza L.C., Powell M.A., Mallon M.A., Davies H., et al. Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Oncogene 2007, 26:7158-7162.
    • (2007) Oncogene , vol.26 , pp. 7158-7162
    • Pollock, P.M.1    Gartside, M.G.2    Dejeza, L.C.3    Powell, M.A.4    Mallon, M.A.5    Davies, H.6
  • 33
    • 0030941036 scopus 로고    scopus 로고
    • Activation of FGF receptors by mutations in the transmembrane domain
    • Li Y., Mangasarian K., Mansukhani A., Basilico C. Activation of FGF receptors by mutations in the transmembrane domain. Oncogene 1997, 14:1397-1406.
    • (1997) Oncogene , vol.14 , pp. 1397-1406
    • Li, Y.1    Mangasarian, K.2    Mansukhani, A.3    Basilico, C.4
  • 34
    • 37049003993 scopus 로고    scopus 로고
    • Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines
    • Ruhe J.E., Streit S., Hart S., Wong C.H., Spech K., Knyazev P., et al. Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines. Cancer Res 2007, 67:11368-11376.
    • (2007) Cancer Res , vol.67 , pp. 11368-11376
    • Ruhe, J.E.1    Streit, S.2    Hart, S.3    Wong, C.H.4    Spech, K.5    Knyazev, P.6
  • 35
    • 78650211213 scopus 로고    scopus 로고
    • Loss of heterozygosity and DNA methylation affect germline fibroblast growth factor receptor 4 polymorphism to direct allelic selection in breast cancer
    • Zhu X., Zheng L., Asa S.L., Ezzat S. Loss of heterozygosity and DNA methylation affect germline fibroblast growth factor receptor 4 polymorphism to direct allelic selection in breast cancer. Am J Pathol 2010, 177:2860-2869.
    • (2010) Am J Pathol , vol.177 , pp. 2860-2869
    • Zhu, X.1    Zheng, L.2    Asa, S.L.3    Ezzat, S.4
  • 36
    • 0036468871 scopus 로고    scopus 로고
    • Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele
    • Bange J., Prechtl D., Cheburkin Y., Specht K., Harbeck N., Schmitt M., et al. Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. Cancer Res 2002, 62:840-847.
    • (2002) Cancer Res , vol.62 , pp. 840-847
    • Bange, J.1    Prechtl, D.2    Cheburkin, Y.3    Specht, K.4    Harbeck, N.5    Schmitt, M.6
  • 37
    • 33747363496 scopus 로고    scopus 로고
    • FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer
    • Thussbas C., Nahrig J., Streit S., Bange J., Kriner M., Kates R., et al. FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer. J Clin Oncol 2006, 24:3747-3755.
    • (2006) J Clin Oncol , vol.24 , pp. 3747-3755
    • Thussbas, C.1    Nahrig, J.2    Streit, S.3    Bange, J.4    Kriner, M.5    Kates, R.6
  • 39
    • 4644223140 scopus 로고    scopus 로고
    • The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression
    • Wang J., Stockton D.W., Ittmann M. The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression. Clin Cancer Res 2004, 10:6169-6178.
    • (2004) Clin Cancer Res , vol.10 , pp. 6169-6178
    • Wang, J.1    Stockton, D.W.2    Ittmann, M.3
  • 40
    • 84855290115 scopus 로고    scopus 로고
    • The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis
    • Tateno T., Asa S.L., Zheng L., Mayr T., Ullrich A., Ezzat S. The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis. PLoS Genet 2011, 7:e1002400.
    • (2011) PLoS Genet , vol.7 , pp. e1002400
    • Tateno, T.1    Asa, S.L.2    Zheng, L.3    Mayr, T.4    Ullrich, A.5    Ezzat, S.6
  • 41
    • 0029945085 scopus 로고    scopus 로고
    • Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II
    • Webster M.K., D'Avis P.Y., Robertson S.C., Donoghue D.J. Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II. Mol Cell Biol 1996, 16:4081-4087.
    • (1996) Mol Cell Biol , vol.16 , pp. 4081-4087
    • Webster, M.K.1    D'Avis, P.Y.2    Robertson, S.C.3    Donoghue, D.J.4
  • 42
    • 84890796808 scopus 로고    scopus 로고
    • Suppression of severe achondroplasia with developmental delay and acanthosis nigricans by the p.Thr651Pro mutation
    • Manickam K., Donoghue D.J., Meyer A.N., Snyder P.J., Prior T.W. Suppression of severe achondroplasia with developmental delay and acanthosis nigricans by the p.Thr651Pro mutation. Am J Med Genet A 2014, 164A:243-250.
    • (2014) Am J Med Genet A , vol.164A , pp. 243-250
    • Manickam, K.1    Donoghue, D.J.2    Meyer, A.N.3    Snyder, P.J.4    Prior, T.W.5
  • 43
    • 0035254612 scopus 로고    scopus 로고
    • Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
    • Chesi M., Brents L.A., Ely S.A., Bais C., Robbiani D.F., Mesri E.A., et al. Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma. Blood 2001, 97:729-736.
    • (2001) Blood , vol.97 , pp. 729-736
    • Chesi, M.1    Brents, L.A.2    Ely, S.A.3    Bais, C.4    Robbiani, D.F.5    Mesri, E.A.6
  • 44
    • 0029935895 scopus 로고    scopus 로고
    • Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia
    • Naski M.C., Wang Q., Xu J., Ornitz D.M. Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet 1996, 13:233-237.
    • (1996) Nat Genet , vol.13 , pp. 233-237
    • Naski, M.C.1    Wang, Q.2    Xu, J.3    Ornitz, D.M.4
  • 45
    • 0033516620 scopus 로고    scopus 로고
    • Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3
    • Bellus G.A., Bamshad M.J., Przylepa K.A., Dorst J., Lee R.R., Hurko O., et al. Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3. Am J Med Genet 1999, 85:53-65.
    • (1999) Am J Med Genet , vol.85 , pp. 53-65
    • Bellus, G.A.1    Bamshad, M.J.2    Przylepa, K.A.3    Dorst, J.4    Lee, R.R.5    Hurko, O.6
  • 46
    • 5644241730 scopus 로고    scopus 로고
    • The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling
    • Lievens P.M., Mutinelli C., Baynes D., Liboi E. The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling. J Biol Chem 2004, 279:43254-43260.
    • (2004) J Biol Chem , vol.279 , pp. 43254-43260
    • Lievens, P.M.1    Mutinelli, C.2    Baynes, D.3    Liboi, E.4
  • 47
    • 33947331068 scopus 로고    scopus 로고
    • FGFR3 intracellular mutations induce tyrosine phosphorylation in the Golgi and defective glycosylation
    • Gibbs L., Legeai-Mallet L. FGFR3 intracellular mutations induce tyrosine phosphorylation in the Golgi and defective glycosylation. Biochim Biophys Acta 2007, 1773:502-512.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 502-512
    • Gibbs, L.1    Legeai-Mallet, L.2
  • 48
    • 54749158107 scopus 로고    scopus 로고
    • Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells
    • Meyer A.N., McAndrew C.W., Donoghue D.J. Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells. Cancer Res 2008, 68:7362-7370.
    • (2008) Cancer Res , vol.68 , pp. 7362-7370
    • Meyer, A.N.1    McAndrew, C.W.2    Donoghue, D.J.3
  • 50
    • 0035866380 scopus 로고    scopus 로고
    • The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate
    • van Rhijn B.W., Lurkin I., Radvanyi F., Kirkels W.J., van der Kwast T.H., Zwarthoff E.C. The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate. Cancer Res 2001, 61:1265-1268.
    • (2001) Cancer Res , vol.61 , pp. 1265-1268
    • van Rhijn, B.W.1    Lurkin, I.2    Radvanyi, F.3    Kirkels, W.J.4    van der Kwast, T.H.5    Zwarthoff, E.C.6
  • 51
    • 79959643392 scopus 로고    scopus 로고
    • K-Ras and beta-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder
    • Ahmad I., Singh L.B., Foth M., Morris C.A., Taketo M.M., Wu X.R., et al. K-Ras and beta-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Dis Model Mech 2011, 4:548-555.
    • (2011) Dis Model Mech , vol.4 , pp. 548-555
    • Ahmad, I.1    Singh, L.B.2    Foth, M.3    Morris, C.A.4    Taketo, M.M.5    Wu, X.R.6
  • 52
    • 84900833911 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice
    • Foth M., Ahmad I., van Rhijn B.W., van der Kwast T., Bergman A.M., King L., et al. Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice. J Pathol 2014, 233:148-158.
    • (2014) J Pathol , vol.233 , pp. 148-158
    • Foth, M.1    Ahmad, I.2    van Rhijn, B.W.3    van der Kwast, T.4    Bergman, A.M.5    King, L.6
  • 53
    • 84866499993 scopus 로고    scopus 로고
    • Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer
    • Juanpere N., Agell L., Lorenzo M., de Muga S., Lopez-Vilaro L., Murillo R., et al. Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer. Hum Pathol 2012, 43:1573-1582.
    • (2012) Hum Pathol , vol.43 , pp. 1573-1582
    • Juanpere, N.1    Agell, L.2    Lorenzo, M.3    de Muga, S.4    Lopez-Vilaro, L.5    Murillo, R.6
  • 54
    • 0029032394 scopus 로고
    • A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia
    • Bellus G.A., McIntosh I., Smith E.A., Aylsworth A.S., Kaitila I., Horton W.A., et al. A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia. Nat Genet 1995, 10:357-359.
    • (1995) Nat Genet , vol.10 , pp. 357-359
    • Bellus, G.A.1    McIntosh, I.2    Smith, E.A.3    Aylsworth, A.S.4    Kaitila, I.5    Horton, W.A.6
  • 55
    • 0030969251 scopus 로고    scopus 로고
    • Transmembrane domain sequence requirements for activation of the p185c-neu receptor tyrosine kinase
    • Chen L.I., Webster M.K., Meyer A.N., Donoghue D.J. Transmembrane domain sequence requirements for activation of the p185c-neu receptor tyrosine kinase. J Cell Biol 1997, 137:619-631.
    • (1997) J Cell Biol , vol.137 , pp. 619-631
    • Chen, L.I.1    Webster, M.K.2    Meyer, A.N.3    Donoghue, D.J.4
  • 56
    • 34548250374 scopus 로고    scopus 로고
    • A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases
    • Chen H., Ma J., Li W., Eliseenkova A.V., Xu C., Neubert T.A., et al. A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol Cell 2007, 27:717-730.
    • (2007) Mol Cell , vol.27 , pp. 717-730
    • Chen, H.1    Ma, J.2    Li, W.3    Eliseenkova, A.V.4    Xu, C.5    Neubert, T.A.6
  • 57
    • 84872796862 scopus 로고    scopus 로고
    • KIDs rule: regulatory phosphorylation of RTKs
    • Locascio L.E., Donoghue D.J. KIDs rule: regulatory phosphorylation of RTKs. Trends Biochem Sci 2013, 38:75-84.
    • (2013) Trends Biochem Sci , vol.38 , pp. 75-84
    • Locascio, L.E.1    Donoghue, D.J.2
  • 58
    • 84924939973 scopus 로고    scopus 로고
    • Comprehensive analysis of targetable oncogenic mutations in Chinese cervical cancers
    • Xiang L., Li J., Jiang W., Shen X., Yang W., Wu X., et al. Comprehensive analysis of targetable oncogenic mutations in Chinese cervical cancers. Oncotarget 2015, 6:4968-4975.
    • (2015) Oncotarget , vol.6 , pp. 4968-4975
    • Xiang, L.1    Li, J.2    Jiang, W.3    Shen, X.4    Yang, W.5    Wu, X.6
  • 59
    • 0031009711 scopus 로고    scopus 로고
    • Amino acid residues which distinguish the mitogenic potentials of two FGF receptors
    • Wang J.K., Goldfarb M. Amino acid residues which distinguish the mitogenic potentials of two FGF receptors. Oncogene 1997, 14:1767-1778.
    • (1997) Oncogene , vol.14 , pp. 1767-1778
    • Wang, J.K.1    Goldfarb, M.2
  • 60
    • 84880983541 scopus 로고    scopus 로고
    • Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
    • Jones D.T., Hutter B., Jager N., Korshuno A., Kool M., Warnatz H.J., et al. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet 2013, 45:927-932.
    • (2013) Nat Genet , vol.45 , pp. 927-932
    • Jones, D.T.1    Hutter, B.2    Jager, N.3    Korshuno, A.4    Kool, M.5    Warnatz, H.J.6
  • 61
    • 55349107544 scopus 로고    scopus 로고
    • Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    • Jones D.T., Kocialkowski S., Liu L., Pearson D.M., Backlund L.M., Ichimura K., et al. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res 2008, 68:8673-8677.
    • (2008) Cancer Res , vol.68 , pp. 8673-8677
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3    Pearson, D.M.4    Backlund, L.M.5    Ichimura, K.6
  • 62
    • 67349219657 scopus 로고    scopus 로고
    • Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
    • Jones D.T., Kocialkowski S., Liu L., Pearson D.M., Ichimura K., Collins V.P. Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Oncogene 2009, 28:2119-2123.
    • (2009) Oncogene , vol.28 , pp. 2119-2123
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3    Pearson, D.M.4    Ichimura, K.5    Collins, V.P.6
  • 65
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455:1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 66
    • 0036491040 scopus 로고    scopus 로고
    • Molecular pathogenesis of rhabdomyosarcoma
    • Xia S.J., Pressey J.G., Barr F.G. Molecular pathogenesis of rhabdomyosarcoma. Cancer Biol Ther 2002, 1:97-104.
    • (2002) Cancer Biol Ther , vol.1 , pp. 97-104
    • Xia, S.J.1    Pressey, J.G.2    Barr, F.G.3
  • 67
    • 84865645637 scopus 로고    scopus 로고
    • Current state-of-the-art systemic therapy for pediatric soft tissue sarcomas
    • Ray A., Huh W.W. Current state-of-the-art systemic therapy for pediatric soft tissue sarcomas. Curr Oncol Rep 2012, 14:311-319.
    • (2012) Curr Oncol Rep , vol.14 , pp. 311-319
    • Ray, A.1    Huh, W.W.2
  • 68
    • 70449450426 scopus 로고    scopus 로고
    • Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
    • Taylor J.G.T., Cheuk A.T., Tsang P.S., Chung J.Y., Song Y.K., Desai K., et al. Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J Clin Invest 2009, 119:3395-3407.
    • (2009) J Clin Invest , vol.119 , pp. 3395-3407
    • Taylor, J.G.T.1    Cheuk, A.T.2    Tsang, P.S.3    Chung, J.Y.4    Song, Y.K.5    Desai, K.6
  • 69
    • 84885029891 scopus 로고    scopus 로고
    • Targeting wild-type and mutationally activated FGFR4 in rhabdomyosarcoma with the inhibitor ponatinib (AP24534)
    • Li S.Q., Cheuk A.T., Shern J.F., Song Y.K., Hurd L., Liao H., et al. Targeting wild-type and mutationally activated FGFR4 in rhabdomyosarcoma with the inhibitor ponatinib (AP24534). PLoS ONE 2013, 8:e76551.
    • (2013) PLoS ONE , vol.8 , pp. e76551
    • Li, S.Q.1    Cheuk, A.T.2    Shern, J.F.3    Song, Y.K.4    Hurd, L.5    Liao, H.6
  • 70
    • 84961289657 scopus 로고    scopus 로고
    • Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas
    • Seiwert T.Y., Zuo Z., Keck M.K., Khattri A., Pedamallu C.S., Stricker T.P., et al. Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Clin Cancer Res 2015, 21:632-641.
    • (2015) Clin Cancer Res , vol.21 , pp. 632-641
    • Seiwert, T.Y.1    Zuo, Z.2    Keck, M.K.3    Khattri, A.4    Pedamallu, C.S.5    Stricker, T.P.6
  • 71
    • 84896691170 scopus 로고    scopus 로고
    • Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors
    • Shern J.F., Chen L., Chmielecki J., Wei J.S., Patidar R., Rosenberg M., et al. Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Cancer Discov 2014, 4:216-231.
    • (2014) Cancer Discov , vol.4 , pp. 216-231
    • Shern, J.F.1    Chen, L.2    Chmielecki, J.3    Wei, J.S.4    Patidar, R.5    Rosenberg, M.6
  • 72
    • 84908080486 scopus 로고    scopus 로고
    • Structural analysis of the human fibroblast growth factor receptor 4 kinase
    • Lesca E., Lammens A., Huber R., Augustin M. Structural analysis of the human fibroblast growth factor receptor 4 kinase. J Mol Biol 2014, 426:3744-3756.
    • (2014) J Mol Biol , vol.426 , pp. 3744-3756
    • Lesca, E.1    Lammens, A.2    Huber, R.3    Augustin, M.4
  • 73
    • 77955739897 scopus 로고    scopus 로고
    • Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer
    • Cao L., Yu Y., Bilke S., Walker R.L., Mayeenuddin L.H., Azorsa D.O., et al. Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer. Cancer Res 2010, 70:6497-6508.
    • (2010) Cancer Res , vol.70 , pp. 6497-6508
    • Cao, L.1    Yu, Y.2    Bilke, S.3    Walker, R.L.4    Mayeenuddin, L.H.5    Azorsa, D.O.6
  • 74
    • 84863954538 scopus 로고    scopus 로고
    • FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma
    • Crose L.E., Etheridge K.T., Chen C., Belyea B., Talbot L.J., Bentley R.C., et al. FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma. Clin Cancer Res 2012, 18:3780-3790.
    • (2012) Clin Cancer Res , vol.18 , pp. 3780-3790
    • Crose, L.E.1    Etheridge, K.T.2    Chen, C.3    Belyea, B.4    Talbot, L.J.5    Bentley, R.C.6
  • 76
    • 38049178481 scopus 로고    scopus 로고
    • Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation
    • Lew E.D., Bae J.H., Rohmann E., Wollnik B., Schlessinger J. Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation. Proc Natl Acad Sci U S A 2007, 104:19802-19807.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19802-19807
    • Lew, E.D.1    Bae, J.H.2    Rohmann, E.3    Wollnik, B.4    Schlessinger, J.5
  • 80
    • 84979857652 scopus 로고    scopus 로고
    • FGFR3 mutation frequency in 324 cases from the International Skeletal Dysplasia Registry
    • Xue Y., Sun A., Mekikian P.B., Martin J., Rimoin D.L., Lachman R.S., et al. FGFR3 mutation frequency in 324 cases from the International Skeletal Dysplasia Registry. Mol Genet Genomic Med 2014, 2:497-503.
    • (2014) Mol Genet Genomic Med , vol.2 , pp. 497-503
    • Xue, Y.1    Sun, A.2    Mekikian, P.B.3    Martin, J.4    Rimoin, D.L.5    Lachman, R.S.6
  • 81
    • 77950678272 scopus 로고    scopus 로고
    • Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy
    • Sierra J.R., Cepero V., Giordano S. Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy. Mol Cancer 2010, 9:75.
    • (2010) Mol Cancer , vol.9 , pp. 75
    • Sierra, J.R.1    Cepero, V.2    Giordano, S.3
  • 82
    • 40049099220 scopus 로고    scopus 로고
    • The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
    • Yun C.H., Mengwasser K.E., Toms A.V., Woo M.S., Greulich H., Wong K.K., et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A 2008, 105:2070-2075.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2070-2075
    • Yun, C.H.1    Mengwasser, K.E.2    Toms, A.V.3    Woo, M.S.4    Greulich, H.5    Wong, K.K.6
  • 83
    • 33750302365 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
    • Kosaka T., Yatabe Y., Endoh H., Yoshida K., Hida T., Tsuboi M., et al. Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res 2006, 12:5764-5769.
    • (2006) Clin Cancer Res , vol.12 , pp. 5764-5769
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3    Yoshida, K.4    Hida, T.5    Tsuboi, M.6
  • 84
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S., Rudzki Z., Walsh S., Grigg A., Arthur C., Taylor K., et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 2002, 99:3472-3475.
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Grigg, A.4    Arthur, C.5    Taylor, K.6
  • 86
    • 2642558897 scopus 로고    scopus 로고
    • Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors
    • Blencke S., Zech B., Engkvist O., Greff Z., Orfi L., Horvath Z., et al. Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors. Chem Biol 2004, 11:691-701.
    • (2004) Chem Biol , vol.11 , pp. 691-701
    • Blencke, S.1    Zech, B.2    Engkvist, O.3    Greff, Z.4    Orfi, L.5    Horvath, Z.6
  • 87
    • 60549084927 scopus 로고    scopus 로고
    • Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors
    • Renhowe P.A., Pecchi S., Shafer C.M., Machajewski T.D., Jazan E.M., Taylor C., et al. Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors. J Med Chem 2009, 52:278-292.
    • (2009) J Med Chem , vol.52 , pp. 278-292
    • Renhowe, P.A.1    Pecchi, S.2    Shafer, C.M.3    Machajewski, T.D.4    Jazan, E.M.5    Taylor, C.6
  • 88
    • 15944378835 scopus 로고    scopus 로고
    • CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma
    • Trudel S., Li Z.H., Wei E., Wiesmann M., Chang H., Chen C., et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood 2005, 105:2941-2948.
    • (2005) Blood , vol.105 , pp. 2941-2948
    • Trudel, S.1    Li, Z.H.2    Wei, E.3    Wiesmann, M.4    Chang, H.5    Chen, C.6
  • 89
    • 22344453138 scopus 로고    scopus 로고
    • CHIR-258: a potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia
    • Lopes de Menezes D.E., Peng J., Garrett E.N., Louie S.G., Lee S.H., Wiesmann M., et al. CHIR-258: a potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia. Clin Cancer Res 2005, 11:5281-5291.
    • (2005) Clin Cancer Res , vol.11 , pp. 5281-5291
    • Lopes de Menezes, D.E.1    Peng, J.2    Garrett, E.N.3    Louie, S.G.4    Lee, S.H.5    Wiesmann, M.6
  • 90
    • 33748349241 scopus 로고    scopus 로고
    • CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice
    • Xin X., Abrams T.J., Hollenbach P.W., Rendahl K.G., Tang Y., Oei Y.A., et al. CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice. Clin Cancer Res 2006, 12:4908-4915.
    • (2006) Clin Cancer Res , vol.12 , pp. 4908-4915
    • Xin, X.1    Abrams, T.J.2    Hollenbach, P.W.3    Rendahl, K.G.4    Tang, Y.5    Oei, Y.A.6
  • 91
    • 84881039897 scopus 로고    scopus 로고
    • The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, and ponatinib ATP-competitive inhibitors
    • Byron S.A., Chen H., Wortmann A., Loch D., Gartside M.G., Dehkhoda F., et al. The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, and ponatinib ATP-competitive inhibitors. Neoplasia 2013, 15:975-988.
    • (2013) Neoplasia , vol.15 , pp. 975-988
    • Byron, S.A.1    Chen, H.2    Wortmann, A.3    Loch, D.4    Gartside, M.G.5    Dehkhoda, F.6
  • 92
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Comprehensive molecular portraits of human breast tumours. Nature 2012, 490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 93
    • 79955667838 scopus 로고    scopus 로고
    • Targeting mutant fibroblast growth factor receptors in cancer
    • Greulich H., Pollock P.M. Targeting mutant fibroblast growth factor receptors in cancer. Trends Mol Med 2011, 17:283-292.
    • (2011) Trends Mol Med , vol.17 , pp. 283-292
    • Greulich, H.1    Pollock, P.M.2
  • 94
    • 84879417823 scopus 로고    scopus 로고
    • Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance
    • Chell V., Balmanno K., Little A.S., Wilson M., Andrews S., Blockley L., et al. Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance. Oncogene 2013, 32:3059-3070.
    • (2013) Oncogene , vol.32 , pp. 3059-3070
    • Chell, V.1    Balmanno, K.2    Little, A.S.3    Wilson, M.4    Andrews, S.5    Blockley, L.6
  • 95
  • 97
    • 84905508021 scopus 로고    scopus 로고
    • FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer
    • Wang R., Wang L., Li Y., Hu H., Shen L., Shen X., et al. FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer. Clin Cancer Res 2014, 20:4107-4114.
    • (2014) Clin Cancer Res , vol.20 , pp. 4107-4114
    • Wang, R.1    Wang, L.2    Li, Y.3    Hu, H.4    Shen, L.5    Shen, X.6
  • 98
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012, 489:519-525.
    • (2012) Nature , vol.489 , pp. 519-525
  • 99
    • 14944369975 scopus 로고    scopus 로고
    • Transforming property of TEL-FGFR3 mediated through PI3-K in a T-cell lymphoma that subsequently progressed to AML
    • Maeda T., Yagasaki F., Ishikawa M., Takahashi N., Bessho M. Transforming property of TEL-FGFR3 mediated through PI3-K in a T-cell lymphoma that subsequently progressed to AML. Blood 2005, 105:2115-2123.
    • (2005) Blood , vol.105 , pp. 2115-2123
    • Maeda, T.1    Yagasaki, F.2    Ishikawa, M.3    Takahashi, N.4    Bessho, M.5
  • 100
    • 84890019316 scopus 로고    scopus 로고
    • Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours
    • Parker B.C., Engels M., Annala M., Zhang W. Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours. J Pathol 2014, 232:4-15.
    • (2014) J Pathol , vol.232 , pp. 4-15
    • Parker, B.C.1    Engels, M.2    Annala, M.3    Zhang, W.4
  • 101
    • 84888380730 scopus 로고    scopus 로고
    • Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
    • Guo G., Sun X., Chen C., Wu S., Huang P., Li Z., et al. Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet 2013, 45:1459-1463.
    • (2013) Nat Genet , vol.45 , pp. 1459-1463
    • Guo, G.1    Sun, X.2    Chen, C.3    Wu, S.4    Huang, P.5    Li, Z.6
  • 102
    • 84873045850 scopus 로고    scopus 로고
    • Oncogenic FGFR3 gene fusions in bladder cancer
    • Williams S.V., Hurst C.D., Knowles M.A. Oncogenic FGFR3 gene fusions in bladder cancer. Hum Mol Genet 2013, 22:795-803.
    • (2013) Hum Mol Genet , vol.22 , pp. 795-803
    • Williams, S.V.1    Hurst, C.D.2    Knowles, M.A.3
  • 103
    • 84897018525 scopus 로고    scopus 로고
    • Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients
    • Kim Y., Hammerman P.S., Kim J., Yoon J.A., Lee Y., Sun J.M., et al. Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients. J Clin Oncol 2014, 32:121-128.
    • (2014) J Clin Oncol , vol.32 , pp. 121-128
    • Kim, Y.1    Hammerman, P.S.2    Kim, J.3    Yoon, J.A.4    Lee, Y.5    Sun, J.M.6
  • 104
    • 84878783802 scopus 로고    scopus 로고
    • Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing
    • Majewski I.J., Mittempergher L., Davidson N.M., Bosma A., Willems S.M., Horlings H.M., et al. Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing. J Pathol 2013, 230:270-276.
    • (2013) J Pathol , vol.230 , pp. 270-276
    • Majewski, I.J.1    Mittempergher, L.2    Davidson, N.M.3    Bosma, A.4    Willems, S.M.5    Horlings, H.M.6
  • 105
    • 84873347374 scopus 로고    scopus 로고
    • The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma
    • Parker B.C., Annala M.J., Cogdell D.E., Granberg K.J., Sun Y., Ji P., et al. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J Clin Invest 2013, 123:855-865.
    • (2013) J Clin Invest , vol.123 , pp. 855-865
    • Parker, B.C.1    Annala, M.J.2    Cogdell, D.E.3    Granberg, K.J.4    Sun, Y.5    Ji, P.6
  • 106
    • 84865805666 scopus 로고    scopus 로고
    • Transforming fusions of FGFR and TACC genes in human glioblastoma
    • Singh D., Chan J.M., Zoppoli P., Niola F., Sullivan R., Castano A., et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 2012, 337:1231-1235.
    • (2012) Science , vol.337 , pp. 1231-1235
    • Singh, D.1    Chan, J.M.2    Zoppoli, P.3    Niola, F.4    Sullivan, R.5    Castano, A.6
  • 107
    • 84896543721 scopus 로고    scopus 로고
    • Molecular characterization of gallbladder cancer using somatic mutation profiling
    • Javle M., Rashid A., Churi C., Kar S., Zuo M., Eterovic A.K., et al. Molecular characterization of gallbladder cancer using somatic mutation profiling. Hum Pathol 2014, 45:701-708.
    • (2014) Hum Pathol , vol.45 , pp. 701-708
    • Javle, M.1    Rashid, A.2    Churi, C.3    Kar, S.4    Zuo, M.5    Eterovic, A.K.6
  • 109
    • 84896492774 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma
    • Arai Y., Totoki Y., Hosoda F., Shirota T., Hama N., Nakamura H., et al. Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma. Hepatology 2014, 59:1427-1434.
    • (2014) Hepatology , vol.59 , pp. 1427-1434
    • Arai, Y.1    Totoki, Y.2    Hosoda, F.3    Shirota, T.4    Hama, N.5    Nakamura, H.6
  • 110
    • 84896457874 scopus 로고    scopus 로고
    • New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing
    • Ross J.S., Wang K., Gay L., Al-Rohil R., Rand J.V., Jones D.M., et al. New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. Oncologist 2014, 19:235-242.
    • (2014) Oncologist , vol.19 , pp. 235-242
    • Ross, J.S.1    Wang, K.2    Gay, L.3    Al-Rohil, R.4    Rand, J.V.5    Jones, D.M.6
  • 111
    • 84901742112 scopus 로고    scopus 로고
    • Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma
    • Borad M.J., Champion M.D., Egan J.B., Liang W.S., Fonseca R., Bryce A.H., et al. Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma. PLoS Genet 2014, 10:e1004135.
    • (2014) PLoS Genet , vol.10 , pp. e1004135
    • Borad, M.J.1    Champion, M.D.2    Egan, J.B.3    Liang, W.S.4    Fonseca, R.5    Bryce, A.H.6
  • 112
    • 67650070345 scopus 로고    scopus 로고
    • L2' loop is critical for caspase-7 active site formation
    • Witkowski W.A., Hardy J.A. L2' loop is critical for caspase-7 active site formation. Protein Sci 2009, 18:1459-1468.
    • (2009) Protein Sci , vol.18 , pp. 1459-1468
    • Witkowski, W.A.1    Hardy, J.A.2
  • 113
    • 84877300436 scopus 로고    scopus 로고
    • A case of acute myelogenous leukaemia characterised by the BCR-FGFR1 translocation
    • Matikas A., Tzannou I., Oikonomopoulou D., Bakiri M. A case of acute myelogenous leukaemia characterised by the BCR-FGFR1 translocation. BMJ Case Rep 2013, 2013.
    • (2013) BMJ Case Rep , pp. 2013
    • Matikas, A.1    Tzannou, I.2    Oikonomopoulou, D.3    Bakiri, M.4
  • 114
    • 79958051808 scopus 로고    scopus 로고
    • The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11)
    • Wasag B., Lierman E., Meeus P., Cools J., Vandenberghe P. The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11). Haematologica 2011, 96:922-926.
    • (2011) Haematologica , vol.96 , pp. 922-926
    • Wasag, B.1    Lierman, E.2    Meeus, P.3    Cools, J.4    Vandenberghe, P.5
  • 115
  • 116
    • 84868309107 scopus 로고    scopus 로고
    • The transcriptional landscape and mutational profile of lung adenocarcinoma
    • Seo J.S., Ju Y.S., Lee W.C., Shin J.Y., Lee J.K., Bleazard T., et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res 2012, 22:2109-2119.
    • (2012) Genome Res , vol.22 , pp. 2109-2119
    • Seo, J.S.1    Ju, Y.S.2    Lee, W.C.3    Shin, J.Y.4    Lee, J.K.5    Bleazard, T.6
  • 117
    • 84900410805 scopus 로고    scopus 로고
    • Personalized ovarian cancer disease surveillance and detection of candidate therapeutic drug target in circulating tumor DNA
    • Martignetti J.A., Camacho-Vanegas O., Priedigkeit N., Camacho C., Pereir E., Lin L., et al. Personalized ovarian cancer disease surveillance and detection of candidate therapeutic drug target in circulating tumor DNA. Neoplasia 2014, 16:97-103.
    • (2014) Neoplasia , vol.16 , pp. 97-103
    • Martignetti, J.A.1    Camacho-Vanegas, O.2    Priedigkeit, N.3    Camacho, C.4    Pereir, E.5    Lin, L.6
  • 118
    • 84929292324 scopus 로고    scopus 로고
    • Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
    • Sia D., Losic B., Moeini A., Cabellos L., Hao K., Revill K., et al. Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma. Nat Commun 2015, 6:6087.
    • (2015) Nat Commun , vol.6 , pp. 6087
    • Sia, D.1    Losic, B.2    Moeini, A.3    Cabellos, L.4    Hao, K.5    Revill, K.6
  • 119
    • 84863569032 scopus 로고    scopus 로고
    • Identification of a novel partner gene, TPR, fused to FGFR1 in 8p11 myeloproliferative syndrome
    • Li F., Zhai Y.P., Tang Y.M., Wang L.P., Wan P.J. Identification of a novel partner gene, TPR, fused to FGFR1 in 8p11 myeloproliferative syndrome. Genes Chromosomes Cancer 2012, 51:890-897.
    • (2012) Genes Chromosomes Cancer , vol.51 , pp. 890-897
    • Li, F.1    Zhai, Y.P.2    Tang, Y.M.3    Wang, L.P.4    Wan, P.J.5
  • 120
    • 0034661925 scopus 로고    scopus 로고
    • ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain
    • Xiao S., McCarthy J.G., Aster J.C., Fletcher J.A. ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain. Blood 2000, 96:699-704.
    • (2000) Blood , vol.96 , pp. 699-704
    • Xiao, S.1    McCarthy, J.G.2    Aster, J.C.3    Fletcher, J.A.4
  • 121
    • 0036020954 scopus 로고    scopus 로고
    • FLT3 in human hematologic malignancies
    • Kiyoi H., Naoe T. FLT3 in human hematologic malignancies. Leuk Lymphoma 2002, 43:1541-1547.
    • (2002) Leuk Lymphoma , vol.43 , pp. 1541-1547
    • Kiyoi, H.1    Naoe, T.2
  • 122
    • 84856323402 scopus 로고    scopus 로고
    • Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies
    • Medves S., Demoulin J.B. Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies. J Cell Mol Med 2012, 16:237-248.
    • (2012) J Cell Mol Med , vol.16 , pp. 237-248
    • Medves, S.1    Demoulin, J.B.2
  • 123
    • 0034161335 scopus 로고    scopus 로고
    • FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)
    • Guasch G., Mack G.J., Popovici C., Dastugue N., Birnbaum D., Rattner J.B., et al. FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33). Blood 2000, 95:1788-1796.
    • (2000) Blood , vol.95 , pp. 1788-1796
    • Guasch, G.1    Mack, G.J.2    Popovici, C.3    Dastugue, N.4    Birnbaum, D.5    Rattner, J.B.6
  • 124
    • 0034687657 scopus 로고    scopus 로고
    • The TACC domain identifies a family of centrosomal proteins that can interact with microtubules
    • Gergely F., Karlsson C., Still I., Cowell J., Kilmartin J., Raff J.W. The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. Proc Natl Acad Sci U S A 2000, 97:14352-14357.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 14352-14357
    • Gergely, F.1    Karlsson, C.2    Still, I.3    Cowell, J.4    Kilmartin, J.5    Raff, J.W.6
  • 125
    • 33748325741 scopus 로고    scopus 로고
    • Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER
    • Browman D.T., Resek M.E., Zajchowski L.D., Robbins S.M. Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER. J Cell Sci 2006, 119:3149-3160.
    • (2006) J Cell Sci , vol.119 , pp. 3149-3160
    • Browman, D.T.1    Resek, M.E.2    Zajchowski, L.D.3    Robbins, S.M.4
  • 126
    • 0035167404 scopus 로고    scopus 로고
    • 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
    • Guasch G., Ollendorff V., Borg J.P., Birnbaum D., Pebusque M.J. 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways. Mol Cell Biol 2001, 21:8129-8142.
    • (2001) Mol Cell Biol , vol.21 , pp. 8129-8142
    • Guasch, G.1    Ollendorff, V.2    Borg, J.P.3    Birnbaum, D.4    Pebusque, M.J.5
  • 127
    • 22044436906 scopus 로고    scopus 로고
    • Constitutively activated FGFR3 mutants signal through PLC{gamma}-dependent and -independent pathways for hematopoietic transformation
    • Chen J., Williams I.R., Lee B.H., Duclos N., Huntly B.J., Donoghue D.J., et al. Constitutively activated FGFR3 mutants signal through PLC{gamma}-dependent and -independent pathways for hematopoietic transformation. Blood 2005, 106:328-337.
    • (2005) Blood , vol.106 , pp. 328-337
    • Chen, J.1    Williams, I.R.2    Lee, B.H.3    Duclos, N.4    Huntly, B.J.5    Donoghue, D.J.6
  • 128
    • 84877622702 scopus 로고    scopus 로고
    • A translocation t(2;8)(q12;p11) fuses FGFR1 to a novel partner gene, RANBP2/NUP358, in a myeloproliferative/myelodysplastic neoplasm
    • Gervais C., Dano L., Perrusson N., Helias C., Jeandidier E., Galois A.C., et al. A translocation t(2;8)(q12;p11) fuses FGFR1 to a novel partner gene, RANBP2/NUP358, in a myeloproliferative/myelodysplastic neoplasm. Leukemia 2013, 27:1186-1188.
    • (2013) Leukemia , vol.27 , pp. 1186-1188
    • Gervais, C.1    Dano, L.2    Perrusson, N.3    Helias, C.4    Jeandidier, E.5    Galois, A.C.6
  • 129
    • 0037954576 scopus 로고    scopus 로고
    • Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)
    • Hiwatari M., Taki T., Taketani T., Taniwaki M., Sugita K., Okuya M., et al. Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23). Oncogene 2003, 22:2851-2855.
    • (2003) Oncogene , vol.22 , pp. 2851-2855
    • Hiwatari, M.1    Taki, T.2    Taketani, T.3    Taniwaki, M.4    Sugita, K.5    Okuya, M.6
  • 130
    • 0035895067 scopus 로고    scopus 로고
    • The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins
    • Demiroglu A., Steer E.J., Heath C., Taylor K., Bentley M., Allen S.L., et al. The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins. Blood 2001, 98:3778-3783.
    • (2001) Blood , vol.98 , pp. 3778-3783
    • Demiroglu, A.1    Steer, E.J.2    Heath, C.3    Taylor, K.4    Bentley, M.5    Allen, S.L.6
  • 131
    • 84904254200 scopus 로고    scopus 로고
    • FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism
    • Acquaviva J., He S., Zhang C., Jimenez J.P., Nagai M., Sang J., et al. FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism. Mol Cancer Res 2014, 12:1042-1054.
    • (2014) Mol Cancer Res , vol.12 , pp. 1042-1054
    • Acquaviva, J.1    He, S.2    Zhang, C.3    Jimenez, J.P.4    Nagai, M.5    Sang, J.6
  • 132
    • 36348943566 scopus 로고    scopus 로고
    • Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome
    • Chase A., Grand F.H., Cross N.C. Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome. Blood 2007, 110:3729-3734.
    • (2007) Blood , vol.110 , pp. 3729-3734
    • Chase, A.1    Grand, F.H.2    Cross, N.C.3
  • 133
    • 80051470769 scopus 로고    scopus 로고
    • Comparative pre-clinical evaluation of receptor tyrosine kinase inhibitors for the treatment of multiple myeloma
    • de Brito L.R., Batey M.A., Zhao Y., Squires M.S., Maitland H., Leung H.Y., et al. Comparative pre-clinical evaluation of receptor tyrosine kinase inhibitors for the treatment of multiple myeloma. Leuk Res 2011, 35:1233-1240.
    • (2011) Leuk Res , vol.35 , pp. 1233-1240
    • de Brito, L.R.1    Batey, M.A.2    Zhao, Y.3    Squires, M.S.4    Maitland, H.5    Leung, H.Y.6
  • 134
    • 77953787254 scopus 로고    scopus 로고
    • Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the immunophenotype of chronic lymphocytic leukemia
    • Bacher U., Haferlach T., Schnittger S., Weiss T., Burkhard O., Bechtel B., et al. Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the immunophenotype of chronic lymphocytic leukemia. Cancer Genet Cytogenet 2010, 200:170-174.
    • (2010) Cancer Genet Cytogenet , vol.200 , pp. 170-174
    • Bacher, U.1    Haferlach, T.2    Schnittger, S.3    Weiss, T.4    Burkhard, O.5    Bechtel, B.6
  • 135
    • 84883860863 scopus 로고    scopus 로고
    • Novel FGFR3 rearrangement t(4;22)(p16;q11.2) in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma
    • Cerny J., Yu H., Miron P.M. Novel FGFR3 rearrangement t(4;22)(p16;q11.2) in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma. Ann Hematol 2013, 92:1433-1435.
    • (2013) Ann Hematol , vol.92 , pp. 1433-1435
    • Cerny, J.1    Yu, H.2    Miron, P.M.3
  • 136
    • 80053560214 scopus 로고    scopus 로고
    • FOXO1-FGFR1 fusion and amplification in a solid variant of alveolar rhabdomyosarcoma
    • Liu J., Guzman M.A., Pezanowski D., Patel D., Hauptman J., Keisling M., et al. FOXO1-FGFR1 fusion and amplification in a solid variant of alveolar rhabdomyosarcoma. Mod Pathol 2011, 24:1327-1335.
    • (2011) Mod Pathol , vol.24 , pp. 1327-1335
    • Liu, J.1    Guzman, M.A.2    Pezanowski, D.3    Patel, D.4    Hauptman, J.5    Keisling, M.6
  • 137
    • 84922647170 scopus 로고    scopus 로고
    • Identification of a novel FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour
    • Lee J.C., Jeng Y.M., Su S.Y., Wu C.T., Tsai K.S., Lee C.H., et al. Identification of a novel FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour. J Pathol 2015, 235:539-545.
    • (2015) J Pathol , vol.235 , pp. 539-545
    • Lee, J.C.1    Jeng, Y.M.2    Su, S.Y.3    Wu, C.T.4    Tsai, K.S.5    Lee, C.H.6
  • 138
    • 84926517994 scopus 로고    scopus 로고
    • A novel fusion of SQSTM1 and FGFR1 in a patient with acute myelomonocytic leukemia with t(5;8)(q35;p11) translocation
    • Nakamura Y., Ito Y., Wakimoto N., Kakegawa E., Uchida Y., Bessho M. A novel fusion of SQSTM1 and FGFR1 in a patient with acute myelomonocytic leukemia with t(5;8)(q35;p11) translocation. Blood Cancer J 2014, 4:e265.
    • (2014) Blood Cancer J , vol.4 , pp. e265
    • Nakamura, Y.1    Ito, Y.2    Wakimoto, N.3    Kakegawa, E.4    Uchida, Y.5    Bessho, M.6
  • 139
    • 84907759689 scopus 로고    scopus 로고
    • Systemic mastocytosis with associated myeloproliferative neoplasm with t(8;19)(p12;q13.1) and abnormality of FGFR1: report of a unique case
    • Duckworth C.B., Zhang L., Li S. Systemic mastocytosis with associated myeloproliferative neoplasm with t(8;19)(p12;q13.1) and abnormality of FGFR1: report of a unique case. Int J Clin Exp Pathol 2014, 7:801-807.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 801-807
    • Duckworth, C.B.1    Zhang, L.2    Li, S.3
  • 140
    • 84866905219 scopus 로고    scopus 로고
    • Common fragile sites: genomic hotspots of DNA damage and carcinogenesis
    • Ma K., Qiu L., Mrasek K., Zhang J., Liehr T., Quintana L.G., et al. Common fragile sites: genomic hotspots of DNA damage and carcinogenesis. Int J Mol Sci 2012, 13:11974-11999.
    • (2012) Int J Mol Sci , vol.13 , pp. 11974-11999
    • Ma, K.1    Qiu, L.2    Mrasek, K.3    Zhang, J.4    Liehr, T.5    Quintana, L.G.6
  • 142
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012, 487:330-337.
    • (2012) Nature , vol.487 , pp. 330-337
  • 143
  • 144
    • 84878593111 scopus 로고    scopus 로고
    • Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
    • Dulak A.M., Stojanov P., Peng S., Lawrence M.S., Fox C., Stewart C., et al. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet 2013, 45:478-486.
    • (2013) Nat Genet , vol.45 , pp. 478-486
    • Dulak, A.M.1    Stojanov, P.2    Peng, S.3    Lawrence, M.S.4    Fox, C.5    Stewart, C.6
  • 145
    • 26444481568 scopus 로고    scopus 로고
    • Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
    • Rand V., Huang J., Stockwell T., Ferriera S., Buzko O., Levy S., et al. Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas. Proc Natl Acad Sci U S A 2005, 102:14344-14349.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 14344-14349
    • Rand, V.1    Huang, J.2    Stockwell, T.3    Ferriera, S.4    Buzko, O.5    Levy, S.6
  • 147
    • 24744453982 scopus 로고    scopus 로고
    • Somatic mutations of the protein kinase gene family in human lung cancer
    • Davies H., Hunter C., Smith R., Stephens P., Greenman C., Bignell G., et al. Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 2005, 65:7591-7595.
    • (2005) Cancer Res , vol.65 , pp. 7591-7595
    • Davies, H.1    Hunter, C.2    Smith, R.3    Stephens, P.4    Greenman, C.5    Bignell, G.6
  • 149
    • 84886376886 scopus 로고    scopus 로고
    • Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling
    • Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., et al. Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling. Mol Cancer Res 2013, 11:1166-1178.
    • (2013) Mol Cancer Res , vol.11 , pp. 1166-1178
    • Dahl, C.1    Christensen, C.2    Jonsson, G.3    Lorentzen, A.4    Skjodt, M.L.5    Borg, A.6
  • 151
    • 23944446080 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2, gain-of-function mutations, and tumourigenesis: investigating a potential link
    • Hansen R.M., Goriely A., Wall S.A., Roberts I.S., Wilkie A.O. Fibroblast growth factor receptor 2, gain-of-function mutations, and tumourigenesis: investigating a potential link. J Pathol 2005, 207:27-31.
    • (2005) J Pathol , vol.207 , pp. 27-31
    • Hansen, R.M.1    Goriely, A.2    Wall, S.A.3    Roberts, I.S.4    Wilkie, A.O.5
  • 152
    • 84857549430 scopus 로고    scopus 로고
    • FGFR2 point mutations in 466 endometrioid endometrial tumors: relationship with MSI, KRAS, PIK3CA, CTNNB1 mutations and clinicopathological features
    • Byron S.A., Gartside M., Powell M.A., Wellens C.L., Gao F., Mutch D.G., et al. FGFR2 point mutations in 466 endometrioid endometrial tumors: relationship with MSI, KRAS, PIK3CA, CTNNB1 mutations and clinicopathological features. PLoS ONE 2012, 7:e30801.
    • (2012) PLoS ONE , vol.7 , pp. e30801
    • Byron, S.A.1    Gartside, M.2    Powell, M.A.3    Wellens, C.L.4    Gao, F.5    Mutch, D.G.6
  • 153
    • 0035328856 scopus 로고    scopus 로고
    • Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers
    • Jang J.H., Shin K.H., Park J.G. Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. Cancer Res 2001, 61:3541-3543.
    • (2001) Cancer Res , vol.61 , pp. 3541-3543
    • Jang, J.H.1    Shin, K.H.2    Park, J.G.3
  • 154
    • 84907056979 scopus 로고    scopus 로고
    • Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC
    • Tchaicha J.H., Akbay E.A., Altabef A., Mikse O.R., Kikuchi E., Rhee K., et al. Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC. Cancer Res 2014, 74:4676-4684.
    • (2014) Cancer Res , vol.74 , pp. 4676-4684
    • Tchaicha, J.H.1    Akbay, E.A.2    Altabef, A.3    Mikse, O.R.4    Kikuchi, E.5    Rhee, K.6
  • 155
    • 84864419974 scopus 로고    scopus 로고
    • Dissecting the genomic complexity underlying medulloblastoma
    • Jones D.T., Jager N., Kool M., Zichner T., Hutter B., Sultan M., et al. Dissecting the genomic complexity underlying medulloblastoma. Nature 2012, 488:100-105.
    • (2012) Nature , vol.488 , pp. 100-105
    • Jones, D.T.1    Jager, N.2    Kool, M.3    Zichner, T.4    Hutter, B.5    Sultan, M.6
  • 156
    • 84880281635 scopus 로고    scopus 로고
    • Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers
    • Pickering C.R., Zhang J., Yoo S.Y., Bengtsson L., Moorthy S., Neskey D.M., et al. Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov 2013, 3:770-781.
    • (2013) Cancer Discov , vol.3 , pp. 770-781
    • Pickering, C.R.1    Zhang, J.2    Yoo, S.Y.3    Bengtsson, L.4    Moorthy, S.5    Neskey, D.M.6
  • 157
    • 84897022815 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of urothelial bladder carcinoma
    • Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 2014, 507:315-322.
    • (2014) Nature , vol.507 , pp. 315-322
  • 158
    • 78149483788 scopus 로고    scopus 로고
    • FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy
    • Kompier L.C., Lurkin I., van der Aa M.N., van Rhijn B.W., van der Kwast T.H., Zwarthoff E.C. FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy. PLoS ONE 2010, 5:e13821.
    • (2010) PLoS ONE , vol.5 , pp. e13821
    • Kompier, L.C.1    Lurkin, I.2    van der Aa, M.N.3    van Rhijn, B.W.4    van der Kwast, T.H.5    Zwarthoff, E.C.6
  • 161
    • 0036926992 scopus 로고    scopus 로고
    • Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders
    • Van Rhijn B.W., Van Tilborg A.A., Lurkin I., Bonaventure J., De Vries A., Thiery J.P., et al. Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders. Eur J Hum Genet 2002, 10:819-824.
    • (2002) Eur J Hum Genet , vol.10 , pp. 819-824
    • Van Rhijn, B.W.1    Van Tilborg, A.A.2    Lurkin, I.3    Bonaventure, J.4    De Vries, A.5    Thiery, J.P.6
  • 163
    • 33747873545 scopus 로고    scopus 로고
    • PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors
    • Lopez-Knowles E., Hernandez S., Malats N., Kogevinas M., Lloreta J., Carrato A., et al. PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. Cancer Res 2006, 66:7401-7404.
    • (2006) Cancer Res , vol.66 , pp. 7401-7404
    • Lopez-Knowles, E.1    Hernandez, S.2    Malats, N.3    Kogevinas, M.4    Lloreta, J.5    Carrato, A.6
  • 164
    • 33747079040 scopus 로고    scopus 로고
    • Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas
    • Hernandez S., Lopez-Knowles E., Lloreta J., Kogevinas M., Amoro A., Tardon A., et al. Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas. J Clin Oncol 2006, 24:3664-3671.
    • (2006) J Clin Oncol , vol.24 , pp. 3664-3671
    • Hernandez, S.1    Lopez-Knowles, E.2    Lloreta, J.3    Kogevinas, M.4    Amoro, A.5    Tardon, A.6
  • 165
    • 33646359953 scopus 로고    scopus 로고
    • Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q
    • Lindgren D., Liedberg F., Andersson A., Chebil G., Gudjonsson S., Borg A., et al. Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q. Oncogene 2006, 25:2685-2696.
    • (2006) Oncogene , vol.25 , pp. 2685-2696
    • Lindgren, D.1    Liedberg, F.2    Andersson, A.3    Chebil, G.4    Gudjonsson, S.5    Borg, A.6
  • 166
    • 0035825598 scopus 로고    scopus 로고
    • Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma
    • Sibley K., Cuthbert-Heavens D., Knowles M.A. Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma. Oncogene 2001, 20:686-691.
    • (2001) Oncogene , vol.20 , pp. 686-691
    • Sibley, K.1    Cuthbert-Heavens, D.2    Knowles, M.A.3
  • 167
    • 84899833582 scopus 로고    scopus 로고
    • Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden
    • Cazier J.B., Rao S.R., McLean C.M., Walker A.K., Wright B.J., Jaeger E.E., et al. Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden. Nat Commun 2014, 5:3756.
    • (2014) Nat Commun , vol.5 , pp. 3756
    • Cazier, J.B.1    Rao, S.R.2    McLean, C.M.3    Walker, A.K.4    Wright, B.J.5    Jaeger, E.E.6
  • 168
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons D.W., Jones S., Zhang X., Lin J.C., Leary R.J., Angenendt P., et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008, 321:1807-1812.
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3    Lin, J.C.4    Leary, R.J.5    Angenendt, P.6
  • 169
    • 84884996623 scopus 로고    scopus 로고
    • The integrated landscape of driver genomic alterations in glioblastoma
    • Frattini V., Trifonov V., Chan J.M., Castano A., Lia M., Abate F., et al. The integrated landscape of driver genomic alterations in glioblastoma. Nat Genet 2013, 45:1141-1149.
    • (2013) Nat Genet , vol.45 , pp. 1141-1149
    • Frattini, V.1    Trifonov, V.2    Chan, J.M.3    Castano, A.4    Lia, M.5    Abate, F.6
  • 170
    • 84890177607 scopus 로고    scopus 로고
    • Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups
    • Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups. Nat Commun 2013, 4:2873.
    • (2013) Nat Commun , vol.4 , pp. 2873
  • 173
    • 84908897459 scopus 로고    scopus 로고
    • Identification of actionable mutations in malignant pleural mesothelioma
    • Shukuya T., Serizawa M., Watanabe M., Akamatsu H., Abe M., Imai H., et al. Identification of actionable mutations in malignant pleural mesothelioma. Lung Cancer 2014, 86:35-40.
    • (2014) Lung Cancer , vol.86 , pp. 35-40
    • Shukuya, T.1    Serizawa, M.2    Watanabe, M.3    Akamatsu, H.4    Abe, M.5    Imai, H.6
  • 174
    • 34247627458 scopus 로고    scopus 로고
    • Expression and mutation status of candidate kinases in multiple myeloma
    • Claudio J.O., Zhan F., Zhuang L., Khaja R., Zhu Y.X., Sivananthan K., et al. Expression and mutation status of candidate kinases in multiple myeloma. Leukemia 2007, 21:1124-1127.
    • (2007) Leukemia , vol.21 , pp. 1124-1127
    • Claudio, J.O.1    Zhan, F.2    Zhuang, L.3    Khaja, R.4    Zhu, Y.X.5    Sivananthan, K.6
  • 175
    • 0038156100 scopus 로고    scopus 로고
    • Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients
    • Onwuazor O.N., Wen X.Y., Wang D.Y., Zhuang L., Masih-Khan E., Claudio J., et al. Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients. Blood 2003, 102:772-773.
    • (2003) Blood , vol.102 , pp. 772-773
    • Onwuazor, O.N.1    Wen, X.Y.2    Wang, D.Y.3    Zhuang, L.4    Masih-Khan, E.5    Claudio, J.6
  • 176
    • 0036799415 scopus 로고    scopus 로고
    • Novel mutation and RNA splice variant of fibroblast growth factor receptor 3 in multiple myeloma patients at diagnosis
    • Soverini S., Terragna C., Testoni N., Ruggeri D., Tosi P., Zamagni E., et al. Novel mutation and RNA splice variant of fibroblast growth factor receptor 3 in multiple myeloma patients at diagnosis. Haematologica 2002, 87:1036-1040.
    • (2002) Haematologica , vol.87 , pp. 1036-1040
    • Soverini, S.1    Terragna, C.2    Testoni, N.3    Ruggeri, D.4    Tosi, P.5    Zamagni, E.6
  • 177
  • 178
    • 0035858985 scopus 로고    scopus 로고
    • Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations
    • Ronchetti D., Greco A., Compasso S., Colombo G., Dell'Era P., Otsuki T., et al. Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations. Oncogene 2001, 20:3553-3562.
    • (2001) Oncogene , vol.20 , pp. 3553-3562
    • Ronchetti, D.1    Greco, A.2    Compasso, S.3    Colombo, G.4    Dell'Era, P.5    Otsuki, T.6
  • 179
    • 0032532626 scopus 로고    scopus 로고
    • FGFR3 gene mutations associated with human skeletal disorders occur rarely in multiple myeloma
    • Fracchiolla N.S., Luminari S., Baldini L., Lombardi L., Maiolo A.T., Neri A. FGFR3 gene mutations associated with human skeletal disorders occur rarely in multiple myeloma. Blood 1998, 92:2987-2989.
    • (1998) Blood , vol.92 , pp. 2987-2989
    • Fracchiolla, N.S.1    Luminari, S.2    Baldini, L.3    Lombardi, L.4    Maiolo, A.T.5    Neri, A.6
  • 180
    • 85047699266 scopus 로고    scopus 로고
    • A novel mutation involving the carboxy terminal region of the FGFR3 gene in a multiple myeloma patient with t(4;14)
    • Intini D., Baldini L., Lombardi L., Neri A. A novel mutation involving the carboxy terminal region of the FGFR3 gene in a multiple myeloma patient with t(4;14). Leukemia 2002, 16:1201-1202.
    • (2002) Leukemia , vol.16 , pp. 1201-1202
    • Intini, D.1    Baldini, L.2    Lombardi, L.3    Neri, A.4
  • 181
    • 24344468707 scopus 로고    scopus 로고
    • Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas
    • Zhang Y., Hiraishi Y., Wang H., Sumi K.S., Hayashido Y., Toratan S., et al. Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas. Int J Cancer 2005, 117:166-168.
    • (2005) Int J Cancer , vol.117 , pp. 166-168
    • Zhang, Y.1    Hiraishi, Y.2    Wang, H.3    Sumi, K.S.4    Hayashido, Y.5    Toratan, S.6
  • 183
    • 34547730818 scopus 로고    scopus 로고
    • Mutational analysis of EGFR and related signaling pathway genes in lung Adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4
    • Marks J.L., McLellan M.D., Zakowski M.F., Lash A.E., Kasai Y., Broderick S., et al. Mutational analysis of EGFR and related signaling pathway genes in lung Adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4. PLoS ONE 2007, 2:e426.
    • (2007) PLoS ONE , vol.2 , pp. e426
    • Marks, J.L.1    McLellan, M.D.2    Zakowski, M.F.3    Lash, A.E.4    Kasai, Y.5    Broderick, S.6
  • 184
    • 0029798614 scopus 로고    scopus 로고
    • Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes
    • Bellus G.A., Gaudenz K., Zackai E.H., Clarke L.A., Szabo J., Francomano C.A., et al. Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes. Nat Genet 1996, 14:174-176.
    • (1996) Nat Genet , vol.14 , pp. 174-176
    • Bellus, G.A.1    Gaudenz, K.2    Zackai, E.H.3    Clarke, L.A.4    Szabo, J.5    Francomano, C.A.6
  • 185
    • 0033361757 scopus 로고    scopus 로고
    • A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene
    • Tavormina P.L., Bellus G.A., Webster M.K., Bamshad M.J., Fraley A.E., McIntosh I., et al. A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene. Am J Hum Genet 1999, 64:722-731.
    • (1999) Am J Hum Genet , vol.64 , pp. 722-731
    • Tavormina, P.L.1    Bellus, G.A.2    Webster, M.K.3    Bamshad, M.J.4    Fraley, A.E.5    McIntosh, I.6
  • 186
    • 0028793472 scopus 로고
    • Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans
    • Meyers G.A., Orlow S.J., Munro I.R., Przylepa K.A., Jabs E.W. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Nat Genet 1995, 11:462-464.
    • (1995) Nat Genet , vol.11 , pp. 462-464
    • Meyers, G.A.1    Orlow, S.J.2    Munro, I.R.3    Przylepa, K.A.4    Jabs, E.W.5
  • 187
    • 0033659625 scopus 로고    scopus 로고
    • Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype
    • Bellus G.A., Spector E.B., Speiser P.W., Weaver C.A., Garber A.T., Bryke C.R., et al. Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype. Am J Hum Genet 2000, 67:1411-1421.
    • (2000) Am J Hum Genet , vol.67 , pp. 1411-1421
    • Bellus, G.A.1    Spector, E.B.2    Speiser, P.W.3    Weaver, C.A.4    Garber, A.T.5    Bryke, C.R.6
  • 188
    • 18244368758 scopus 로고    scopus 로고
    • Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis
    • Kan S.H., Elanko N., Johnson D., Cornejo-Roldan L., Cook J., Reich E.W., et al. Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis. Am J Hum Genet 2002, 70:472-486.
    • (2002) Am J Hum Genet , vol.70 , pp. 472-486
    • Kan, S.H.1    Elanko, N.2    Johnson, D.3    Cornejo-Roldan, L.4    Cook, J.5    Reich, E.W.6
  • 191
    • 84929247289 scopus 로고    scopus 로고
    • Mechanism of oncogenic signal activation by the novel fusion kinase FGFR3-BAIAP2L1
    • Nakanishi Y., Akiyama N., Tsukaguchi T., Fujii T., Satoh Y., Ishii N., et al. Mechanism of oncogenic signal activation by the novel fusion kinase FGFR3-BAIAP2L1. Mol Cancer Ther 2015, 14:704-712.
    • (2015) Mol Cancer Ther , vol.14 , pp. 704-712
    • Nakanishi, Y.1    Akiyama, N.2    Tsukaguchi, T.3    Fujii, T.4    Satoh, Y.5    Ishii, N.6
  • 192
    • 84927166354 scopus 로고    scopus 로고
    • RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas
    • Bao Z.S., Chen H.M., Yang M.Y., Zhang C.B., Yu K., Ye W.L., et al. RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas. Genome Res 2014, 24:1765-1773.
    • (2014) Genome Res , vol.24 , pp. 1765-1773
    • Bao, Z.S.1    Chen, H.M.2    Yang, M.Y.3    Zhang, C.B.4    Yu, K.5    Ye, W.L.6
  • 194
    • 84919724844 scopus 로고    scopus 로고
    • Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma
    • Capelletti M., Dodge M.E., Ercan D., Hammerman P.S., Park S.I., Kim J., et al. Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma. Clin Cancer Res 2014, 20:6551-6558.
    • (2014) Clin Cancer Res , vol.20 , pp. 6551-6558
    • Capelletti, M.1    Dodge, M.E.2    Ercan, D.3    Hammerman, P.S.4    Park, S.I.5    Kim, J.6
  • 195
    • 0035577690 scopus 로고    scopus 로고
    • Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation
    • Yagasaki F., Wakao D., Yokoyama Y., Uchida Y., Murohashi I., Kayano H., et al. Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation. Cancer Res 2001, 61:8371-8374.
    • (2001) Cancer Res , vol.61 , pp. 8371-8374
    • Yagasaki, F.1    Wakao, D.2    Yokoyama, Y.3    Uchida, Y.4    Murohashi, I.5    Kayano, H.6
  • 196
    • 79954575639 scopus 로고    scopus 로고
    • 8p11 Myeloproliferative syndrome with BCR-FGFR1 rearrangement presenting with T-lymphoblastic lymphoma and bone marrow stromal cell proliferation: a case report and review of the literature
    • Kim S.Y., Oh B., She C.J., Kim H.K., Jeon Y.K., Shin M.G., et al. 8p11 Myeloproliferative syndrome with BCR-FGFR1 rearrangement presenting with T-lymphoblastic lymphoma and bone marrow stromal cell proliferation: a case report and review of the literature. Leuk Res 2011, 35:e30-e34.
    • (2011) Leuk Res , vol.35 , pp. e30-e34
    • Kim, S.Y.1    Oh, B.2    She, C.J.3    Kim, H.K.4    Jeon, Y.K.5    Shin, M.G.6
  • 197
    • 22344446662 scopus 로고    scopus 로고
    • Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion
    • Murati A., Arnoulet C., Lafage-Pochitaloff M., Adelaide J., Derre M., Slama B., et al. Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion. Int J Oncol 2005, 26:1485-1492.
    • (2005) Int J Oncol , vol.26 , pp. 1485-1492
    • Murati, A.1    Arnoulet, C.2    Lafage-Pochitaloff, M.3    Adelaide, J.4    Derre, M.5    Slama, B.6
  • 198
    • 77955981092 scopus 로고    scopus 로고
    • B-cell acute lymphoblastic leukemia as evolution of a 8p11 myeloproliferative syndrome with t(8;22)(p11;q11) and BCR-FGFR1 fusion gene
    • Baldazzi C., Iacobucci I., Luatti S., Ottaviani E., Marzocchi G., Paolini S., et al. B-cell acute lymphoblastic leukemia as evolution of a 8p11 myeloproliferative syndrome with t(8;22)(p11;q11) and BCR-FGFR1 fusion gene. Leuk Res 2010, 34:e282-e285.
    • (2010) Leuk Res , vol.34 , pp. e282-e285
    • Baldazzi, C.1    Iacobucci, I.2    Luatti, S.3    Ottaviani, E.4    Marzocchi, G.5    Paolini, S.6
  • 199
    • 84861206616 scopus 로고    scopus 로고
    • Favorable outcome of allogeneic hematopoietic cell transplantation for 8p11 myeloproliferative syndrome associated with BCR-FGFR1 gene fusion
    • Dolan M., Cioc A., Cross N.C., Neglia J.P., Tolar J. Favorable outcome of allogeneic hematopoietic cell transplantation for 8p11 myeloproliferative syndrome associated with BCR-FGFR1 gene fusion. Pediatr Blood Cancer 2012, 59:194-196.
    • (2012) Pediatr Blood Cancer , vol.59 , pp. 194-196
    • Dolan, M.1    Cioc, A.2    Cross, N.C.3    Neglia, J.P.4    Tolar, J.5
  • 200
    • 84869233183 scopus 로고    scopus 로고
    • A case of 8p11 myeloproliferative syndrome with BCR-FGFR1 gene fusion presenting with trilineage acute leukemia/lymphoma, successfully treated by cord blood transplantation
    • Morishige S., Oku E., Takata Y., Kimura Y., Arakawa F., Seki R., et al. A case of 8p11 myeloproliferative syndrome with BCR-FGFR1 gene fusion presenting with trilineage acute leukemia/lymphoma, successfully treated by cord blood transplantation. Acta Haematol 2013, 129:83-89.
    • (2013) Acta Haematol , vol.129 , pp. 83-89
    • Morishige, S.1    Oku, E.2    Takata, Y.3    Kimura, Y.4    Arakawa, F.5    Seki, R.6
  • 201
    • 84872270776 scopus 로고    scopus 로고
    • Acute leukemia showing t(8;22)(p11;q11), myelodysplasia, CD13/CD33/CD19 expression and immunoglobulin heavy chain gene rearrangement
    • Shimanuki M., Sonoki T., Hosoi H., Watanuki J., Murata S., Mushino T., et al. Acute leukemia showing t(8;22)(p11;q11), myelodysplasia, CD13/CD33/CD19 expression and immunoglobulin heavy chain gene rearrangement. Acta Haematol 2013, 129:238-242.
    • (2013) Acta Haematol , vol.129 , pp. 238-242
    • Shimanuki, M.1    Sonoki, T.2    Hosoi, H.3    Watanuki, J.4    Murata, S.5    Mushino, T.6
  • 202
    • 53449099794 scopus 로고    scopus 로고
    • Rare translocations involving chromosome band 8p11 in myeloid neoplasms
    • Lee S.G., Park T.S., Lee S.T., Lee K.A., Song J., Kim J., et al. Rare translocations involving chromosome band 8p11 in myeloid neoplasms. Cancer Genet Cytogenet 2008, 186:127-129.
    • (2008) Cancer Genet Cytogenet , vol.186 , pp. 127-129
    • Lee, S.G.1    Park, T.S.2    Lee, S.T.3    Lee, K.A.4    Song, J.5    Kim, J.6
  • 203
    • 80051474782 scopus 로고    scopus 로고
    • T(8;22)/BCR-FGFR1 myeloproliferative disorder presenting as B-acute lymphoblastic leukemia: report of a case treated with sorafenib and review of the literature
    • Wakim J.J., Tirado C.A., Chen W., Collins R. t(8;22)/BCR-FGFR1 myeloproliferative disorder presenting as B-acute lymphoblastic leukemia: report of a case treated with sorafenib and review of the literature. Leuk Res 2011, 35:e151-e153.
    • (2011) Leuk Res , vol.35 , pp. e151-e153
    • Wakim, J.J.1    Tirado, C.A.2    Chen, W.3    Collins, R.4
  • 205
    • 33845501610 scopus 로고    scopus 로고
    • Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia
    • Gu T.L., Goss V.L., Reeves C., Popova L., Nardone J., Macneill J., et al. Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. Blood 2006, 108:4202-4204.
    • (2006) Blood , vol.108 , pp. 4202-4204
    • Gu, T.L.1    Goss, V.L.2    Reeves, C.3    Popova, L.4    Nardone, J.5    Macneill, J.6
  • 206
    • 0037216062 scopus 로고    scopus 로고
    • Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3)
    • Guasch G., Popovici C., Mugneret F., Chaffanet M., Pontarotti P., Birnbaum D., et al. Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3). Blood 2003, 101:286-288.
    • (2003) Blood , vol.101 , pp. 286-288
    • Guasch, G.1    Popovici, C.2    Mugneret, F.3    Chaffanet, M.4    Pontarotti, P.5    Birnbaum, D.6
  • 207
    • 84907684079 scopus 로고    scopus 로고
    • Molecular identification of a TPR-FGFR1 fusion transcript in an adult with myeloproliferative neoplasm, T-lymphoblastic lymphoma, and a t(1;8)(q25;p11.2)
    • Kim S.Y., Kim J.E., Park S., Kim H.K. Molecular identification of a TPR-FGFR1 fusion transcript in an adult with myeloproliferative neoplasm, T-lymphoblastic lymphoma, and a t(1;8)(q25;p11.2). Cancer Genet 2014, 207:258-262.
    • (2014) Cancer Genet , vol.207 , pp. 258-262
    • Kim, S.Y.1    Kim, J.E.2    Park, S.3    Kim, H.K.4
  • 208
    • 84925547563 scopus 로고    scopus 로고
    • 8p11 myeloproliferative syndrome with t(1;8)(q25;p11.2): a case report and review of the literature
    • Kim W.S., Park S.G., Park G., Jang S.J., Moon D.S., Kang S.H. 8p11 myeloproliferative syndrome with t(1;8)(q25;p11.2): a case report and review of the literature. Acta Haematol 2015, 133:101-105.
    • (2015) Acta Haematol , vol.133 , pp. 101-105
    • Kim, W.S.1    Park, S.G.2    Park, G.3    Jang, S.J.4    Moon, D.S.5    Kang, S.H.6
  • 209
    • 77955899481 scopus 로고    scopus 로고
    • Biphenotypic hematologic malignancy: a case report of the 8p11 myeloproliferative syndrome in a child
    • Chen X., Zhang Y., Li Y., Lei P., Zhai Y., Liu L. Biphenotypic hematologic malignancy: a case report of the 8p11 myeloproliferative syndrome in a child. J Pediatr Hematol Oncol 2010, 32:501-503.
    • (2010) J Pediatr Hematol Oncol , vol.32 , pp. 501-503
    • Chen, X.1    Zhang, Y.2    Li, Y.3    Lei, P.4    Zhai, Y.5    Liu, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.