A novel mutation involving the carboxy terminal region of the fgfr3 gene in a multiple myeloma patient with t(4;14)

Leukemia

Volumn 16, Issue 6, 2002, Pages 1201-1202

  Intini, D ^a   Baldini, L ^a   Lombardi, L ^a   Neri, A ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FIBROBLAST GROWTH FACTOR 3;

AGED; CANCER STAGING; CARBOXY TERMINAL SEQUENCE; CASE REPORT; CAUSE OF DEATH; CHROMOSOME 14Q; CHROMOSOME 4P; CHROMOSOME TRANSLOCATION 14; CHROMOSOME TRANSLOCATION 4; COMORBIDITY; DNA SEQUENCE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; LETTER; MISSENSE MUTATION; MULTIPLE MYELOMA; PLASMA CELL LEUKEMIA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 85047699266     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402502     Document Type: Letter

References (11)

1. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
2. A novel chromosomal translocation t(4;14)(p16.3;q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
3. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
4. Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by double-color fluorescent in situ hybridization
5. Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts
6. FGFR activation in skeletal disorders: Too much of a good thing
7. Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14)
8. FGFR3 gene mutations associated with human skeletal disorders occur rarely in multiple myeloma
9. Isolation of an additional member of the fibroblast growth factor receptor family, FGFR3
10. Stop codon FGFR3 mutations in thanatophoric dwarfism type 1
11. Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma