메뉴 건너뛰기




Volumn 106, Issue 1, 2005, Pages 328-337

Constitutively activated FGFR3 mutants signal through PLCγ-dependent and -independent pathways for hematopoietic transformation

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 3; PHENYLALANINE; PHOSPHOLIPASE C GAMMA;

EID: 22044436906     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-09-3686     Document Type: Article
Times cited : (37)

References (37)
  • 2
    • 0035839841 scopus 로고    scopus 로고
    • Chromosome translocations in multiple myeloma
    • Bergsagel PL, Kuehl WM. Chromosome translocations in multiple myeloma. Oncogene. 2001;20: 5611-5622.
    • (2001) Oncogene , vol.20 , pp. 5611-5622
    • Bergsagel, P.L.1    Kuehl, W.M.2
  • 3
    • 0029978550 scopus 로고    scopus 로고
    • Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines
    • Chesi M, Bergsagel PL, Brents LA, Smith CM, Gerhard DS, Kuehl WM. Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines. Blood. 1996;88:674-681.
    • (1996) Blood , vol.88 , pp. 674-681
    • Chesi, M.1    Bergsagel, P.L.2    Brents, L.A.3    Smith, C.M.4    Gerhard, D.S.5    Kuehl, W.M.6
  • 4
    • 0031839633 scopus 로고    scopus 로고
    • Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma
    • Chesi M, Bergsagel PL, Shonukan OO, et al. Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma. Blood. 1998;91:4457-4463.
    • (1998) Blood , vol.91 , pp. 4457-4463
    • Chesi, M.1    Bergsagel, P.L.2    Shonukan, O.O.3
  • 5
    • 0030922231 scopus 로고    scopus 로고
    • Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
    • Chesi M, Nardini E, Brents LA, et al. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet. 1997;16: 260-264.
    • (1997) Nat Genet , vol.16 , pp. 260-264
    • Chesi, M.1    Nardini, E.2    Brents, L.A.3
  • 6
    • 0029928791 scopus 로고    scopus 로고
    • Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
    • Colvin JS, Bohne BA, Harding GW, McEwen DG, Ornitz DM. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet. 1996;12:390-397.
    • (1996) Nat Genet , vol.12 , pp. 390-397
    • Colvin, J.S.1    Bohne, B.A.2    Harding, G.W.3    McEwen, D.G.4    Ornitz, D.M.5
  • 7
    • 0029917507 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 is a negative regulator of bone growth
    • Deng C, Wynshaw-Boris A, Zhou F, Kuo A, Leder P. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell. 1996;84:911-921.
    • (1996) Cell , vol.84 , pp. 911-921
    • Deng, C.1    Wynshaw-Boris, A.2    Zhou, F.3    Kuo, A.4    Leder, P.5
  • 8
    • 1842557964 scopus 로고    scopus 로고
    • The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant
    • Chang H, Sloan S, Li D, et al. The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant. Br J Haematol. 2004;125:64-68.
    • (2004) Br J Haematol , vol.125 , pp. 64-68
    • Chang, H.1    Sloan, S.2    Li, D.3
  • 9
    • 0032212243 scopus 로고    scopus 로고
    • The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
    • Chesi M, Nardini E, Lim RS, Smith KD, Kuehl WM, Bergsagel PL. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood. 1998;92:3025-3034.
    • (1998) Blood , vol.92 , pp. 3025-3034
    • Chesi, M.1    Nardini, E.2    Lim, R.S.3    Smith, K.D.4    Kuehl, W.M.5    Bergsagel, P.L.6
  • 10
    • 0028872752 scopus 로고
    • Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptors
    • Tavormina PL, Shiang R, Thompson LM, et al. Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptors. Nat Genet. 1995;9:321-328.
    • (1995) Nat Genet , vol.9 , pp. 321-328
    • Tavormina, P.L.1    Shiang, R.2    Thompson, L.M.3
  • 11
    • 0027344852 scopus 로고
    • Structural and functional diversity in the FGF receptor multigene family
    • Johnson DE, Williams LT. Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res. 1993;60:1-41.
    • (1993) Adv Cancer Res , vol.60 , pp. 1-41
    • Johnson, D.E.1    Williams, L.T.2
  • 12
    • 0030064347 scopus 로고    scopus 로고
    • Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia
    • Webster MK, Donoghue DJ. Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia. EMBO J. 1996;15:520-527.
    • (1996) EMBO J , vol.15 , pp. 520-527
    • Webster, M.K.1    Donoghue, D.J.2
  • 13
    • 0035168141 scopus 로고    scopus 로고
    • Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation
    • Hart KC, Robertson SC, Donoghue DJ. Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol Biol Cell. 2001;12: 931-942.
    • (2001) Mol Biol Cell , vol.12 , pp. 931-942
    • Hart, K.C.1    Robertson, S.C.2    Donoghue, D.J.3
  • 14
    • 0034142212 scopus 로고    scopus 로고
    • Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis
    • Plowright EE, Li Z, Bergsagel PL, et al. Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis. Blood. 2000;95:992-998.
    • (2000) Blood , vol.95 , pp. 992-998
    • Plowright, E.E.1    Li, Z.2    Bergsagel, P.L.3
  • 15
    • 0035254612 scopus 로고    scopus 로고
    • Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
    • Chesi M, Brents LA, Ely SA, et al. Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma. Blood. 2001;97:729-736.
    • (2001) Blood , vol.97 , pp. 729-736
    • Chesi, M.1    Brents, L.A.2    Ely, S.A.3
  • 16
    • 0035871687 scopus 로고    scopus 로고
    • The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells
    • Li Z, Zhu YX, Plowright EE, et al. The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells. Blood. 2001;97:2413-2419.
    • (2001) Blood , vol.97 , pp. 2413-2419
    • Li, Z.1    Zhu, Y.X.2    Plowright, E.E.3
  • 17
    • 0030027488 scopus 로고    scopus 로고
    • Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
    • Mohammadi M, Dikic I, Sorokin A, Burgess WH, Jaye M, Schlessinger J. Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol Cell Biol. 1996;16:977-989.
    • (1996) Mol Cell Biol , vol.16 , pp. 977-989
    • Mohammadi, M.1    Dikic, I.2    Sorokin, A.3    Burgess, W.H.4    Jaye, M.5    Schlessinger, J.6
  • 18
    • 0025941527 scopus 로고
    • A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (FIg) is a binding site for the SH2 domain of phospholipase C-gamma 1
    • Mohammadi M, Honegger AM, Rotin D, et al. A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (FIg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol. 1991;11: 5068-5078.
    • (1991) Mol Cell Biol , vol.11 , pp. 5068-5078
    • Mohammadi, M.1    Honegger, A.M.2    Rotin, D.3
  • 19
    • 0037013284 scopus 로고    scopus 로고
    • Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B: A role in STAT5 activation
    • Kong M, Wang CS, Donoghue DJ. Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B: a role in STAT5 activation. J Biol Chem. 2002;277:15962-15970.
    • (2002) J Biol Chem , vol.277 , pp. 15962-15970
    • Kong, M.1    Wang, C.S.2    Donoghue, D.J.3
  • 20
    • 0035577690 scopus 로고    scopus 로고
    • Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with at(4;12)(p16; p13) chromosomal translocation
    • Yagasaki F, Wakao D, Yokoyama Y, et al. Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with at(4;12)(p16; p13) chromosomal translocation. Cancer Res. 2001;61:8371-8374.
    • (2001) Cancer Res , vol.61 , pp. 8371-8374
    • Yagasaki, F.1    Wakao, D.2    Yokoyama, Y.3
  • 21
    • 0034678609 scopus 로고    scopus 로고
    • Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia
    • Liu Q, Schwaller J, Kutok J, et al. Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia. EMBO J. 2000;19:1827-1838.
    • (2000) EMBO J , vol.19 , pp. 1827-1838
    • Liu, Q.1    Schwaller, J.2    Kutok, J.3
  • 22
    • 3142519560 scopus 로고    scopus 로고
    • Positive and negative regulatory roles of the WW-like domain in TEL-PDGF{beta}R transformation
    • Chen J, Williams IR, Kutok JL, et al. Positive and negative regulatory roles of the WW-like domain in TEL-PDGF{beta}R transformation. Blood. 2004;104:535-542.
    • (2004) Blood , vol.104 , pp. 535-542
    • Chen, J.1    Williams, I.R.2    Kutok, J.L.3
  • 23
    • 3042725365 scopus 로고    scopus 로고
    • Stable expression of small interfering RN a sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin
    • Chen J, Wall NR, Kocher K, et al. Stable expression of small interfering RN A sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin. J Clin Invest. 2004;113:1784-1791.
    • (2004) J Clin Invest , vol.113 , pp. 1784-1791
    • Chen, J.1    Wall, N.R.2    Kocher, K.3
  • 24
    • 0033639119 scopus 로고    scopus 로고
    • Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2
    • Schwaller J, Parganas E, Wang D, et al. Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. Mol Cell. 2000;6: 693-704.
    • (2000) Mol Cell , vol.6 , pp. 693-704
    • Schwaller, J.1    Parganas, E.2    Wang, D.3
  • 25
    • 0032530972 scopus 로고    scopus 로고
    • Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- And lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes
    • Schwaller J, Frantsve J, Aster J, et al. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes. EMBO J. 1998;17:5321-5333.
    • (1998) EMBO J , vol.17 , pp. 5321-5333
    • Schwaller, J.1    Frantsve, J.2    Aster, J.3
  • 26
    • 0029935895 scopus 로고    scopus 로고
    • Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia
    • Naski MC, Wang Q, Xu J, Omitz DM. Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet. 1996;13:233-237.
    • (1996) Nat Genet , vol.13 , pp. 233-237
    • Naski, M.C.1    Wang, Q.2    Xu, J.3    Omitz, D.M.4
  • 27
    • 0026502460 scopus 로고
    • Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells
    • Omitz DM, Yayon A, Flanagan JG, Svahn CM, Levi E, Leder P. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol Cell Biol. 1992;12:240-247.
    • (1992) Mol Cell Biol , vol.12 , pp. 240-247
    • Omitz, D.M.1    Yayon, A.2    Flanagan, J.G.3    Svahn, C.M.4    Levi, E.5    Leder, P.6
  • 28
    • 0037174151 scopus 로고    scopus 로고
    • FGF receptors ubiquitylation: Dependence on tyrosine kinase activity and role in downregulation
    • Monsonego-Ornan E, Adar R, Rom E, Yayon A. FGF receptors ubiquitylation: dependence on tyrosine kinase activity and role in downregulation. FEBS Lett. 2002;528:83-89.
    • (2002) FEBS Lett , vol.528 , pp. 83-89
    • Monsonego-Ornan, E.1    Adar, R.2    Rom, E.3    Yayon, A.4
  • 29
    • 0026641249 scopus 로고
    • Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
    • Mohammadi M, Dionrie CA, Li W, et al. Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature. 1992;358:681-684.
    • (1992) Nature , vol.358 , pp. 681-684
    • Mohammadi, M.1    Dionrie, C.A.2    Li, W.3
  • 30
    • 14944369975 scopus 로고    scopus 로고
    • Transforming property of TEL-FGFR3 mediated through PI3-K in a T-cell lymphoma that subsequently progressed to AML
    • Maeda T, Yagasaki F, Ishikawa M, Takahashi N, Bessho M. Transforming property of TEL-FGFR3 mediated through PI3-K in a T-cell lymphoma that subsequently progressed to AML. Blood. 2005; 105:2115-2123).
    • (2005) Blood , vol.105 , pp. 2115-2123
    • Maeda, T.1    Yagasaki, F.2    Ishikawa, M.3    Takahashi, N.4    Bessho, M.5
  • 31
    • 0030896404 scopus 로고    scopus 로고
    • Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
    • Su WC, Kitagawa M, Xue N, et al. Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature. 1997;386:288-292.
    • (1997) Nature , vol.386 , pp. 288-292
    • Su, W.C.1    Kitagawa, M.2    Xue, N.3
  • 32
    • 1842372689 scopus 로고    scopus 로고
    • Signal transduction pathway of human fibroblast growth factor receptor 3: Identification of a novel 66-kDa phosphoprotein
    • Kanai M, Goke M, Tsunekawa S, Podolsky DK. Signal transduction pathway of human fibroblast growth factor receptor 3: identification of a novel 66-kDa phosphoprotein. J Biol Chem. 1997;272: 6621-6628.
    • (1997) J Biol Chem , vol.272 , pp. 6621-6628
    • Kanai, M.1    Goke, M.2    Tsunekawa, S.3    Podolsky, D.K.4
  • 33
    • 0242490120 scopus 로고    scopus 로고
    • The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3
    • Agazie YM, Movilla N, Ischenko I, Hayman MJ. The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3. Oncogene. 2003;22:6909-6918.
    • (2003) Oncogene , vol.22 , pp. 6909-6918
    • Agazie, Y.M.1    Movilla, N.2    Ischenko, I.3    Hayman, M.J.4
  • 34
    • 0037408535 scopus 로고    scopus 로고
    • Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events
    • Quintanilla-Martinez L, Kremer M, Specht K, et al. Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events. Am J Pathol. 2003;162:1449-1461.
    • (2003) Am J Pathol , vol.162 , pp. 1449-1461
    • Quintanilla-Martinez, L.1    Kremer, M.2    Specht, K.3
  • 35
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. 1999;10:105-115.
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1    Landowski, T.H.2    Oshiro, M.M.3
  • 36
    • 5644241730 scopus 로고    scopus 로고
    • The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling
    • Lievens PM, Mutinelli C, Baynes D, Liboi E. The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling. J Biol Chem. 2004;279: 43254-43260.
    • (2004) J Biol Chem , vol.279 , pp. 43254-43260
    • Lievens, P.M.1    Mutinelli, C.2    Baynes, D.3    Liboi, E.4
  • 37
    • 0032841519 scopus 로고    scopus 로고
    • Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas
    • Cappellen D, De Oliveira C, Ricol D, et al. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nat Genet. 1999; 23:18-20.
    • (1999) Nat Genet , vol.23 , pp. 18-20
    • Cappellen, D.1    De Oliveira, C.2    Ricol, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.