RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression

Molecular Cancer

Volumn 14, Issue 1, 2015, Pages

  Cohen Solal, Karine A ^a   Boregowda, Rajeev K ^a   Lasfar, Ahmed ^b,c  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Invasion; Migration; Phosphatidylinositol 3 kinase (PI3K); Protein Kinase B (PKB AKT); RUNX2; Transcription factor

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR RUNX2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BINDING; PROTEIN KINASE B; RAS PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

BINDING AFFINITY; BREAST CANCER; CANCER CELL; CANCER GROWTH; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; MELANOMA; METASTASIS; OSTEOSARCOMA; PROSTATE CANCER; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVIEW; THYROID CANCER; TUMOR INVASION; TUMOR VOLUME; ANIMAL; CELL TRANSFORMATION; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RAS PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84937805075     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/s12943-015-0404-3     Document Type: Review

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