PI3K blockade by Ad-PTEN inhibits invasion and induces apoptosis in radial growth phase and metastatic melanoma cells

Molecular Medicine

Volumn 8, Issue 8, 2002, Pages 451-461

  Stewart, Alexis L ^a   Mhashilkar, Abner M ^a   Yang, Xiaohong Helena ^a   Ekmekcioglu, Suhendan ^b   Saito, Yuji ^b   Sieger, Kerry ^a   Schrock, Robert ^a   Onishi, Eric ^a   Swanson, Xin ^a   Mumm, John B ^b   Zumstein, Lou ^a   Watson, Graham J ^c   Snary, David ^c   Roth, Jack A ^b   Grimm, Elizabeth A ^b   Ramesh, Rajagopal ^b   Chada, Sunil ^a,b  

^a Introgen Therapeutics Inc   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PTEN PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ALLELE; ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CELL ASSAY; CELL INVASION; CELL MEMBRANE; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; ENZYME INHIBITION; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENE THERAPY; GENETIC CODE; GENETIC TRANSDUCTION; GLIOBLASTOMA; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG CANCER; MELANOMA; METASTASIS; PRIORITY JOURNAL; PROSTATE; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; TUMOR CELL DESTRUCTION; VIRAL GENE DELIVERY SYSTEM; ADENOVIRUS; APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; DRUG ANTAGONISM; ENDOTHELIUM; GENE TRANSFER; GENE VECTOR; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; ENDOTHELIUM; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; MELANOMA; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; TRANSGENES; TUMOR SUPPRESSOR PROTEINS;

EID: 0036690393     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03402025     Document Type: Article

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