-
1
-
-
0030992837
-
Signalling through the lipid products of phosphoinositide-3-OH kinase
-
Toker A, Cantley LC. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 1997; 387:673-6.
-
(1997)
Nature
, vol.387
, pp. 673-676
-
-
Toker, A.1
Cantley, L.C.2
-
2
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide-3-kinase/AKT pathway
-
Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide-3-kinase/AKT pathway. Proc Natl Acad Sci USA 1999; 96:4240-5.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
3
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 1997; 7:261-9.
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
-
4
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
New York, NY
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (New York, NY) 2005; 307:1098-101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
5
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007; 129:1261-74.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
6
-
-
0036085555
-
Upregulation of renal BSC1 and TSC in prenatally programmed hypertension
-
Manning J, Beutler K, Knepper MA, Vehaskari VM. Upregulation of renal BSC1 and TSC in prenatally programmed hypertension. Am J Physiol 2002; 283:202-6.
-
(2002)
Am J Physiol
, vol.283
, pp. 202-206
-
-
Manning, J.1
Beutler, K.2
Knepper, M.A.3
Vehaskari, V.M.4
-
7
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002; 4:648-57.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
8
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115:577-90.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
9
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 2004; 18:1533-8.
-
(2004)
Genes Dev
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
DePinho, R.A.4
Guan, K.L.5
-
10
-
-
51849111556
-
PI3K pathway alterations in cancer: Variations on a theme
-
Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene 2008; 27:5497-510.
-
(2008)
Oncogene
, vol.27
, pp. 5497-5510
-
-
Yuan, T.L.1
Cantley, L.C.2
-
11
-
-
75149112667
-
Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer
-
Myatt SS, Wang J, Monteiro LJ, Christian M, Ho KK, Fusi L, et al. Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer. Cancer Res 70:367-77.
-
Cancer Res
, vol.70
, pp. 367-377
-
-
Myatt, S.S.1
Wang, J.2
Monteiro, L.J.3
Christian, M.4
Ho, K.K.5
Fusi, L.6
-
12
-
-
33746930170
-
FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer
-
Dong XY, Chen C, Sun X, Guo P, Vessella RL, Wang RX, et al. FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer. Cancer Res 2006; 66:6998-7006.
-
(2006)
Cancer Res
, vol.66
, pp. 6998-7006
-
-
Dong, X.Y.1
Chen, C.2
Sun, X.3
Guo, P.4
Vessella, R.L.5
Wang, R.X.6
-
13
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008; 455:1061-8.
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
14
-
-
1542267804
-
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
-
Hosaka T, Biggs WH, 3rd, Tieu D, Boyer AD, Varki NM, Cavenee WK, et al. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci USA 2004; 101:2975-80.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2975-2980
-
-
Hosaka, T.1
Biggs III, W.H.2
Tieu, D.3
Boyer, A.D.4
Varki, N.M.5
Cavenee, W.K.6
-
15
-
-
0038152845
-
Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
-
Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 2003; 301:215-8.
-
(2003)
Science
, vol.301
, pp. 215-218
-
-
Castrillon, D.H.1
Miao, L.2
Kollipara, R.3
Horner, J.W.4
DePinho, R.A.5
-
16
-
-
33846295218
-
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 2007; 128:309-23.
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
Kollipara, R.2
Chu, G.3
Ji, H.4
Xiao, Y.5
Ding, Z.6
-
17
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96:857-68.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
-
18
-
-
0034661826
-
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
-
Furuyama T, Nakazawa T, Nakano I, Mori N. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J 2000; 349:629-34.
-
(2000)
Biochem J
, vol.349
, pp. 629-634
-
-
Furuyama, T.1
Nakazawa, T.2
Nakano, I.3
Mori, N.4
-
19
-
-
0036651790
-
A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
-
Ramaswamy S, Nakamura N, Sansal I, Bergeron L, Sellers WR. A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2002; 2:81-91.
-
(2002)
Cancer Cell
, vol.2
, pp. 81-91
-
-
Ramaswamy, S.1
Nakamura, N.2
Sansal, I.3
Bergeron, L.4
Sellers, W.R.5
-
20
-
-
41849086320
-
FOXO-binding partners: It takes two to tango
-
van der Vos KE, Coffer PJ. FOXO-binding partners: it takes two to tango. Oncogene 2008; 27:2289-99.
-
(2008)
Oncogene
, vol.27
, pp. 2289-2299
-
-
Van Der Vos, K.E.1
Coffer, P.J.2
-
21
-
-
2942726155
-
The ins and outs of FoxO shuttling: Mechanisms of FoxO translocation and transcriptional regulation
-
Van Der Heide LP, Hoekman MF, Smidt MP. The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J 2004; 380:297-309.
-
(2004)
Biochem J
, vol.380
, pp. 297-309
-
-
Van Der Heide, L.P.1
Hoekman, M.F.2
Smidt, M.P.3
-
23
-
-
11144357466
-
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
-
Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004; 117:225-37.
-
(2004)
Cell
, vol.117
, pp. 225-237
-
-
Hu, M.C.1
Lee, D.F.2
Xia, W.3
Golfman, L.S.4
Ou-Yang, F.5
Yang, J.Y.6
-
24
-
-
33748075143
-
A FoxO-Smad synexpression group in human keratinocytes
-
Gomis RR, Alarcon C, He W, Wang Q, Seoane J, Lash A, et al. A FoxO-Smad synexpression group in human keratinocytes. Proc Natl Acad Sci USA 2006; 103:12747-52.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 12747-12752
-
-
Gomis, R.R.1
Alarcon, C.2
He, W.3
Wang, Q.4
Seoane, J.5
Lash, A.6
-
25
-
-
1642332084
-
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
-
Seoane J, Le HV, Shen L, Anderson SA, Massague J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 2004; 117:211-23.
-
(2004)
Cell
, vol.117
, pp. 211-223
-
-
Seoane, J.1
Le, H.V.2
Shen, L.3
Anderson, S.A.4
Massague, J.5
-
26
-
-
0027184681
-
Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation
-
Corral J, Forster A, Thompson S, Lampert F, Kaneko Y, Slater R, et al. Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation. Proc Natl Acad Sci USA 1993; 90:8538-42.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 8538-8542
-
-
Corral, J.1
Forster, A.2
Thompson, S.3
Lampert, F.4
Kaneko, Y.5
Slater, R.6
-
27
-
-
0027224048
-
The gene for PAX7, a member of the paired-box-containing genes, is localized on human chromosome arm 1p36
-
Shapiro DN, Sublett JE, Li B, Valentine MB, Morris SW, Noll M. The gene for PAX7, a member of the paired-box-containing genes, is localized on human chromosome arm 1p36. Genomics 1993; 17:767-9.
-
(1993)
Genomics
, vol.17
, pp. 767-769
-
-
Shapiro, D.N.1
Sublett, J.E.2
Li, B.3
Valentine, M.B.4
Morris, S.W.5
Noll, M.6
-
28
-
-
0027959091
-
Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family
-
Parry P, Wei Y, Evans G. Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family. Genes Chromosomes Canc 1994; 11:79-84.
-
(1994)
Genes Chromosomes Canc
, vol.11
, pp. 79-84
-
-
Parry, P.1
Wei, Y.2
Evans, G.3
-
29
-
-
0030869789
-
AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily
-
Hillion J, Le Coniat M, Jonveaux P, Berger R, Bernard OA. AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. Blood 1997; 90:3714-9.
-
(1997)
Blood
, vol.90
, pp. 3714-3719
-
-
Hillion, J.1
Le Coniat, M.2
Jonveaux, P.3
Berger, R.4
Bernard, O.A.5
-
30
-
-
0036787919
-
Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors
-
Lagutina I, Conway SJ, Sublett J, Grosveld GC. Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors. Mol Cell Biol 2002; 22:7204-16.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7204-7216
-
-
Lagutina, I.1
Conway, S.J.2
Sublett, J.3
Grosveld, G.C.4
-
31
-
-
2342496712
-
FoxOs at the crossroads of cellular metabolism, differentiation and transformation
-
Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation and transformation. Cell 2004; 117:421-6.
-
(2004)
Cell
, vol.117
, pp. 421-426
-
-
Accili, D.1
Arden, K.C.2
-
32
-
-
0141481091
-
FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics
-
Jacobs FM, van der Heide LP, Wijchers PJ, Burbach JP, Hoekman MF, Smidt MP. FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J Biol Chem 2003; 278:35959-67.
-
(2003)
J Biol Chem
, vol.278
, pp. 35959-35967
-
-
Jacobs, F.M.1
Van Der Heide, L.P.2
Wijchers, P.J.3
Burbach, J.P.4
Hoekman, M.F.5
Smidt, M.P.6
-
33
-
-
0037178789
-
FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress
-
Furukawa-Hibi Y, Yoshida-Araki K, Ohta T, Ikeda K, Motoyama N. FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. J Biol Chem 2002; 277:26729-32.
-
(2002)
J Biol Chem
, vol.277
, pp. 26729-26732
-
-
Furukawa-Hibi, Y.1
Yoshida-Araki, K.2
Ohta, T.3
Ikeda, K.4
Motoyama, N.5
-
34
-
-
2342653278
-
Control of cyclin G2 mRNA expression by forkhead transcription factors: Novel mechanism for cell cycle control by phosphoinositide-3-kinase and forkhead
-
2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide-3-kinase and forkhead. Mol Cell Biol 2004; 24:2181-9.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 2181-2189
-
-
Martinez-Gac, L.1
Marques, M.2
Garcia, Z.3
Campanero, M.R.4
Carrera, A.C.5
-
35
-
-
0036120725
-
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors
-
Kops GJ, Medema RH, Glassford J, Essers MA, Dijkers PF, Coffer PJ, et al. Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol Cell Biol 2002; 22:2025-36.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2025-2036
-
-
Kops, G.J.1
Medema, R.H.2
Glassford, J.3
Essers, M.A.4
Dijkers, P.F.5
Coffer, P.J.6
-
37
-
-
0036839685
-
Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D
-
Schmidt M, Fernandez de Mattos S, van der Horst A, Klompmaker R, Kops GJ, Lam EW, et al. Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol 2002; 22:7842-52.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7842-7852
-
-
Schmidt, M.1
Fernandez De Mattos, S.2
Van Der Horst, A.3
Klompmaker, R.4
Kops, G.J.5
Lam, E.W.6
-
38
-
-
41449088342
-
Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors
-
Evans-Anderson HJ, Alfieri CM, Yutzey KE. Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors. Circ Res 2008; 102:686-94.
-
(2008)
Circ Res
, vol.102
, pp. 686-694
-
-
Evans-Anderson, H.J.1
Alfieri, C.M.2
Yutzey, K.E.3
-
39
-
-
40749084491
-
FOXO transcription factor-dependent p15(INK4b) and p19(INK4d) expression
-
Katayama K, Nakamura A, Sugimoto Y, Tsuruo T, Fujita N. FOXO transcription factor-dependent p15(INK4b) and p19(INK4d) expression. Oncogene 2008; 27:1677-86.
-
(2008)
Oncogene
, vol.27
, pp. 1677-1686
-
-
Katayama, K.1
Nakamura, A.2
Sugimoto, Y.3
Tsuruo, T.4
Fujita, N.5
-
40
-
-
0037134040
-
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
-
Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, DiStefano PS, et al. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 2002; 296:530-4.
-
(2002)
Science
, vol.296
, pp. 530-534
-
-
Tran, H.1
Brunet, A.2
Grenier, J.M.3
Datta, S.R.4
Fornace Jr., A.J.5
DiStefano, P.S.6
-
41
-
-
0034733584
-
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
-
Siegel RM, Frederiksen JK, Zacharias DA, Chan FK, Johnson M, Lynch D, et al. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science 2000; 288:2354-7.
-
(2000)
Science
, vol.288
, pp. 2354-2357
-
-
Siegel, R.M.1
Frederiksen, J.K.2
Zacharias, D.A.3
Chan, F.K.4
Johnson, M.5
Lynch, D.6
-
42
-
-
0035909313
-
Forkhead transcription factors contribute to execution of the mitotic programme in mammals
-
Alvarez B, Martinez AC, Burgering BM, Carrera AC. Forkhead transcription factors contribute to execution of the mitotic programme in mammals. Nature 2001; 413:744-7.
-
(2001)
Nature
, vol.413
, pp. 744-747
-
-
Alvarez, B.1
Martinez, A.C.2
Burgering, B.M.3
Carrera, A.C.4
-
43
-
-
0034609737
-
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
-
Dijkers PF, Medema RH, Lammers JW, Koenderman L, Coffer PJ. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 2000; 10:1201-4.
-
(2000)
Curr Biol
, vol.10
, pp. 1201-1204
-
-
Dijkers, P.F.1
Medema, R.H.2
Lammers, J.W.3
Koenderman, L.4
Coffer, P.J.5
-
44
-
-
0037017396
-
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: Protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity
-
Dijkers PF, Birkenkamp KU, Lam EW, Thomas NS, Lammers JW, Koenderman L, et al. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol 2002; 156:531-42.
-
(2002)
J Cell Biol
, vol.156
, pp. 531-542
-
-
Dijkers, P.F.1
Birkenkamp, K.U.2
Lam, E.W.3
Thomas, N.S.4
Lammers, J.W.5
Koenderman, L.6
-
46
-
-
0037033005
-
FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer
-
Modur V, Nagarajan R, Evers BM, Milbrandt J. FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J Biol Chem 2002; 277:47928-37.
-
(2002)
J Biol Chem
, vol.277
, pp. 47928-47937
-
-
Modur, V.1
Nagarajan, R.2
Evers, B.M.3
Milbrandt, J.4
-
47
-
-
0037134491
-
The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor
-
Tang TT, Dowbenko D, Jackson A, Toney L, Lewin DA, Dent AL, et al. The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. J Biol Chem 2002; 277:14255-65.
-
(2002)
J Biol Chem
, vol.277
, pp. 14255-14265
-
-
Tang, T.T.1
Dowbenko, D.2
Jackson, A.3
Toney, L.4
Lewin, D.A.5
Dent, A.L.6
-
48
-
-
49849100725
-
Mdm2 induces monoubiquitination of FOXO4
-
Brenkman AB, de Keizer PL, van den Broek NJ, Jochemsen AG, Burgering BM. Mdm2 induces monoubiquitination of FOXO4. PloS One 2008; 3:2819.
-
(2008)
PloS One
, vol.3
, pp. 2819
-
-
Brenkman, A.B.1
De Keizer, P.L.2
Van Den Broek, N.J.3
Jochemsen, A.G.4
Burgering, B.M.5
-
49
-
-
0037115539
-
Tissue-specific induction of p53 targets in vivo
-
Fei P, Bernhard EJ, El-Deiry WS. Tissue-specific induction of p53 targets in vivo. Cancer Res 2002; 62:7316-27.
-
(2002)
Cancer Res
, vol.62
, pp. 7316-7327
-
-
Fei, P.1
Bernhard, E.J.2
El-Deiry, W.S.3
-
50
-
-
0012668180
-
Transactivation of repair genes by BRCA1
-
El-Deiry WS. Transactivation of repair genes by BRCA1. Cancer Biol Ther 2002; 1:490-1.
-
(2002)
Cancer Biol Ther
, vol.1
, pp. 490-491
-
-
El-Deiry, W.S.1
-
51
-
-
35948946514
-
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf
-
Bouchard C, Lee S, Paulus-Hock V, Loddenkemper C, Eilers M, Schmitt CA. FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. Genes Dev 2007; 21:2775-87.
-
(2007)
Genes Dev
, vol.21
, pp. 2775-2787
-
-
Bouchard, C.1
Lee, S.2
Paulus-Hock, V.3
Loddenkemper, C.4
Eilers, M.5
Schmitt, C.A.6
-
52
-
-
79960715027
-
The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor
-
Renault VM, Thekkat PU, Hoang KL, White JL, Brady CA, Kenzelmann Broz D, et al. The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor. Oncogene 2011; 30:3207-2.
-
(2011)
Oncogene
, vol.30
, pp. 3207-3212
-
-
Renault, V.M.1
Thekkat, P.U.2
Hoang, K.L.3
White, J.L.4
Brady, C.A.5
Kenzelmann Broz, D.6
-
53
-
-
22844438667
-
Crosstalk between p53 and FOXO transcription factors
-
You H, Mak TW. Crosstalk between p53 and FOXO transcription factors. Cell Cycle 2005; 4:37-8.
-
(2005)
Cell Cycle
, vol.4
, pp. 37-38
-
-
You, H.1
Mak, T.W.2
-
54
-
-
36549026878
-
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
-
Lee CH, Inoki K, Karbowniczek M, Petroulakis E, Sonenberg N, Henske EP, et al. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J 2007; 26:4812-23.
-
(2007)
EMBO J
, vol.26
, pp. 4812-4823
-
-
Lee, C.H.1
Inoki, K.2
Karbowniczek, M.3
Petroulakis, E.4
Sonenberg, N.5
Henske, E.P.6
-
55
-
-
34548820978
-
Dissecting the Akt/mammalian target of rapamycin signaling network: Emerging results from the head and neck cancer tissue array initiative
-
Molinolo AA, Hewitt SM, Amornphimoltham P, Keelawat S, Rangdaeng S, Meneses Garcia A, et al. Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res 2007; 13:4964-73.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4964-4973
-
-
Molinolo, A.A.1
Hewitt, S.M.2
Amornphimoltham, P.3
Keelawat, S.4
Rangdaeng, S.5
Meneses Garcia, A.6
-
56
-
-
32044435126
-
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
-
Levine AJ, Feng Z, Mak TW, You H, Jin S. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev 2006; 20:267-75.
-
(2006)
Genes Dev
, vol.20
, pp. 267-275
-
-
Levine, A.J.1
Feng, Z.2
Mak, T.W.3
You, H.4
Jin, S.5
-
57
-
-
48449101433
-
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
-
Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 2008; 134:451-60.
-
(2008)
Cell
, vol.134
, pp. 451-460
-
-
Budanov, A.V.1
Karin, M.2
-
58
-
-
33750298090
-
PTEN in the haematopoietic system and its therapeutic indications
-
Cheung AM, Mak TW. PTEN in the haematopoietic system and its therapeutic indications. Trends Mol Med 2006; 12:503-5.
-
(2006)
Trends Mol Med
, vol.12
, pp. 503-505
-
-
Cheung, A.M.1
Mak, T.W.2
-
59
-
-
77951911593
-
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor
-
Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, et al. FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Dev Cell 18:592-604.
-
Dev Cell
, vol.18
, pp. 592-604
-
-
Chen, C.C.1
Jeon, S.M.2
Bhaskar, P.T.3
Nogueira, V.4
Sundararajan, D.5
Tonic, I.6
-
60
-
-
77749264562
-
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
-
Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, et al. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 2010; 327:1223-8.
-
(2010)
Science
, vol.327
, pp. 1223-1228
-
-
Lee, J.H.1
Budanov, A.V.2
Park, E.J.3
Birse, R.4
Kim, T.E.5
Perkins, G.A.6
-
61
-
-
23744516268
-
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2
-
Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC. Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev 2005; 19:1773-8.
-
(2005)
Genes Dev
, vol.19
, pp. 1773-1778
-
-
Manning, B.D.1
Logsdon, M.N.2
Lipovsky, A.I.3
Abbott, D.4
Kwiatkowski, D.J.5
Cantley, L.C.6
-
62
-
-
78249255491
-
FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis
-
Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, et al. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18:472-84.
-
Cancer Cell
, vol.18
, pp. 472-484
-
-
Gan, B.1
Lim, C.2
Chu, G.3
Hua, S.4
Ding, Z.5
Collins, M.6
-
63
-
-
29244485921
-
The senescent side of tumor suppression
-
Collado M, Serrano M. The senescent side of tumor suppression. Cell Cycle 2005; 4:1722-4.
-
(2005)
Cell Cycle
, vol.4
, pp. 1722-1724
-
-
Collado, M.1
Serrano, M.2
-
64
-
-
23244452684
-
Suppressing cancer: The importance of being senescent
-
Campisi J. Suppressing cancer: the importance of being senescent. Science 2005; 309:886-7.
-
(2005)
Science
, vol.309
, pp. 886-887
-
-
Campisi, J.1
-
66
-
-
0842263745
-
Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
-
Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, Komuro I. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J 2004; 23:212-20.
-
(2004)
EMBO J
, vol.23
, pp. 212-220
-
-
Miyauchi, H.1
Minamino, T.2
Tateno, K.3
Kunieda, T.4
Toko, H.5
Komuro, I.6
-
67
-
-
79957880743
-
Cell cycle arrest is not senescence
-
Blagosklonny MV. Cell cycle arrest is not senescence. Aging 3:94-101.
-
Aging
, vol.3
, pp. 94-101
-
-
Blagosklonny, M.V.1
-
68
-
-
77949737971
-
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
-
Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, et al. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest 120:681-93.
-
J Clin Invest
, vol.120
, pp. 681-693
-
-
Alimonti, A.1
Nardella, C.2
Chen, Z.3
Clohessy, J.G.4
Carracedo, A.5
Trotman, L.C.6
-
69
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29:625-34.
-
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
70
-
-
40649089427
-
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a)
-
Emerling BM, Weinberg F, Liu JL, Mak TW, Chandel NS. PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci USA 2008; 105:2622-7.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2622-2627
-
-
Emerling, B.M.1
Weinberg, F.2
Liu, J.L.3
Mak, T.W.4
Chandel, N.S.5
-
71
-
-
0042029755
-
The forkhead transcription factor FOXO4 induces the downregulation of hypoxia- Inducible factor 1alpha by a von Hippel-Lindau protein-independent mechanism
-
Tang TT, Lasky LA. The forkhead transcription factor FOXO4 induces the downregulation of hypoxia- inducible factor 1alpha by a von Hippel-Lindau protein-independent mechanism. J Biol Chem 2003; 278:30125-35.
-
(2003)
J Biol Chem
, vol.278
, pp. 30125-30135
-
-
Tang, T.T.1
Lasky, L.A.2
-
72
-
-
37349025432
-
FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2
-
Bakker WJ, Harris IS, Mak TW. FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol Cell 2007; 28:941-53.
-
(2007)
Mol Cell
, vol.28
, pp. 941-953
-
-
Bakker, W.J.1
Harris, I.S.2
Mak, T.W.3
-
73
-
-
77952476474
-
Transcriptional role of FOXO1 in drug resistance through antioxidant defense systems
-
Goto T, Takano M. Transcriptional role of FOXO1 in drug resistance through antioxidant defense systems. Adv Exp Med Biol 2009; 665:171-9.
-
(2009)
Adv Exp Med Biol
, vol.665
, pp. 171-179
-
-
Goto, T.1
Takano, M.2
-
74
-
-
41649101414
-
Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells
-
Hui RC, Francis RE, Guest SK, Costa JR, Gomes AR, Myatt SS, et al. Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells. Mol Cancer Ther 2008; 7:670-8.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 670-678
-
-
Hui, R.C.1
Francis, R.E.2
Guest, S.K.3
Costa, J.R.4
Gomes, A.R.5
Myatt, S.S.6
-
75
-
-
52649115891
-
The forkhead transcription factor FOXO3a increases phosphoinositide-3- kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression
-
Hui RC, Gomes AR, Constantinidou D, Costa JR, Karadedou CT, Fernandez de Mattos S, et al. The forkhead transcription factor FOXO3a increases phosphoinositide-3-kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Mol Cell Biol 2008; 28:5886-98.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 5886-5898
-
-
Hui, R.C.1
Gomes, A.R.2
Constantinidou, D.3
Costa, J.R.4
Karadedou, C.T.5
Fernandez De Mattos, S.6
-
76
-
-
51849147067
-
Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells
-
Han CY, Cho KB, Choi HS, Han HK, Kang KW. Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells. Carcinogenesis 2008; 29:1837-44.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1837-1844
-
-
Han, C.Y.1
Cho, K.B.2
Choi, H.S.3
Han, H.K.4
Kang, K.W.5
-
77
-
-
76249087423
-
TGFbeta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
-
Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y, et al. TGFbeta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 2010; 463:676-80.
-
(2010)
Nature
, vol.463
, pp. 676-680
-
-
Naka, K.1
Hoshii, T.2
Muraguchi, T.3
Tadokoro, Y.4
Ooshio, T.5
Kondo, Y.6
-
78
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007; 128:325-39.
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
Lee, B.H.4
Castrillon, D.H.5
Cullen, D.E.6
-
79
-
-
70350497348
-
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
-
Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 2009; 5:540-53.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 540-553
-
-
Paik, J.H.1
Ding, Z.2
Narurkar, R.3
Ramkissoon, S.4
Muller, F.5
Kamoun, W.S.6
-
80
-
-
70350506802
-
FoxO3 regulates neural stem cell homeostasis
-
Renault VM, Rafalski VA, Morgan AA, Salih DA, Brett JO, Webb AE, et al. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell 2009; 5:527-39.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 527-539
-
-
Renault, V.M.1
Rafalski, V.A.2
Morgan, A.A.3
Salih, D.A.4
Brett, J.O.5
Webb, A.E.6
-
81
-
-
43749107299
-
FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts
-
Chiribau CB, Cheng L, Cucoranu IC, Yu YS, Clempus RE, Sorescu D. FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts. J Biol Chem 2008; 283:8211-7.
-
(2008)
J Biol Chem
, vol.283
, pp. 8211-8217
-
-
Chiribau, C.B.1
Cheng, L.2
Cucoranu, I.C.3
Yu, Y.S.4
Clempus, R.E.5
Sorescu, D.6
-
82
-
-
64749093574
-
Association of reactive oxygen species levels and radioresistance in cancer stem cells
-
Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009; 458:780-3.
-
(2009)
Nature
, vol.458
, pp. 780-783
-
-
Diehn, M.1
Cho, R.W.2
Lobo, N.A.3
Kalisky, T.4
Dorie, M.J.5
Kulp, A.N.6
-
83
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444:756-60.
-
(2006)
Nature
, vol.444
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
Hao, Y.4
Shi, Q.5
Hjelmeland, A.B.6
-
84
-
-
43149111604
-
Functional interaction between FOXO3a and ATM regulates DNA damage response
-
Tsai WB, Chung YM, Takahashi Y, Xu Z, Hu MC. Functional interaction between FOXO3a and ATM regulates DNA damage response. Nat Cell Biol 2008; 10:460-7.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 460-467
-
-
Tsai, W.B.1
Chung, Y.M.2
Takahashi, Y.3
Xu, Z.4
Hu, M.C.5
-
85
-
-
54449092731
-
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells
-
Yalcin S, Zhang X, Luciano JP, Mungamuri SK, Marinkovic D, Vercherat C, et al. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem 2008; 283:25692-705.
-
(2008)
J Biol Chem
, vol.283
, pp. 25692-25705
-
-
Yalcin, S.1
Zhang, X.2
Luciano, J.P.3
Mungamuri, S.K.4
Marinkovic, D.5
Vercherat, C.6
-
86
-
-
38049148308
-
FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases
-
Ni YG, Wang N, Cao DJ, Sachan N, Morris DJ, Gerard RD, et al. FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci USA 2007; 104:20517-22.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 20517-20522
-
-
Ni, Y.G.1
Wang, N.2
Cao, D.J.3
Sachan, N.4
Morris, D.J.5
Gerard, R.D.6
-
87
-
-
78651458656
-
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
-
Chandarlapaty S, Sawai A, Scaltriti M, Rodrik-Outmezguine V, Grbovic-Huezo O, Serra V, et al. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell 2011; 19:58-71.
-
(2011)
Cancer Cell
, vol.19
, pp. 58-71
-
-
Chandarlapaty, S.1
Sawai, A.2
Scaltriti, M.3
Rodrik-Outmezguine, V.4
Grbovic-Huezo, O.5
Serra, V.6
-
88
-
-
36448968532
-
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
-
Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, et al. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 2007; 6:472-83.
-
(2007)
Cell Metab
, vol.6
, pp. 472-483
-
-
Zhao, J.1
Brault, J.J.2
Schild, A.3
Cao, P.4
Sandri, M.5
Schiaffino, S.6
-
89
-
-
55949087699
-
Role of the metabolic stress responses of apoptosis and autophagy in tumor suppression
-
White E. Role of the metabolic stress responses of apoptosis and autophagy in tumor suppression. Ernst Schering Found Symp Proc 2007; 23-34.
-
(2007)
Ernst Schering Found Symp Proc
, pp. 23-34
-
-
White, E.1
-
90
-
-
79952228407
-
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 2011; 25:460-70.
-
(2011)
Genes Dev
, vol.25
, pp. 460-470
-
-
Guo, J.Y.1
Chen, H.Y.2
Mathew, R.3
Fan, J.4
Strohecker, A.M.5
Karsli-Uzunbas, G.6
-
91
-
-
79952229430
-
Pancreatic cancers require autophagy for tumor growth
-
Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev 2011; 25:717-29.
-
(2011)
Genes Dev
, vol.25
, pp. 717-729
-
-
Yang, S.1
Wang, X.2
Contino, G.3
Liesa, M.4
Sahin, E.5
Ying, H.6
|