메뉴 건너뛰기




Volumn 92, Issue 8, 2012, Pages 1181-1190

Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomas

Author keywords

epithelial mesenchymal transition; immunohistochemistry; real time PCR; Runx2; thyroid carcinoma

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANGIOGENIC FACTOR; GELATINASE A; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR TWIST; VASCULOTROPIN A; VASCULOTROPIN C;

EID: 84864428355     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.84     Document Type: Article
Times cited : (96)

References (34)
  • 1
    • 33645307434 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in thyroid follicular-cell neoplasia
    • Kondo T, Ezzat S, Asa SL. Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat Rev Cancer 2006;6:292-306.
    • (2006) Nat Rev Cancer , vol.6 , pp. 292-306
    • Kondo, T.1    Ezzat, S.2    Asa, S.L.3
  • 3
    • 22644447278 scopus 로고    scopus 로고
    • Regulation of skeletal development by the runx family of transcription factors
    • Komori T. Regulation of skeletal development by the Runx family of transcription factors. J Cell Biochem 2005;95:445-453.
    • (2005) J Cell Biochem , vol.95 , pp. 445-453
    • Komori, T.1
  • 4
    • 54949084641 scopus 로고    scopus 로고
    • Role of the runx1-evi1 fusion gene in leukemogenesis
    • Maki K, Yamagata T, Mitani K. Role of the RUNX1-EVI1 fusion gene in leukemogenesis. Cancer Sci 2008;99:1878-1883.
    • (2008) Cancer Sci , vol.99 , pp. 1878-1883
    • Maki, K.1    Yamagata, T.2    Mitani, K.3
  • 5
    • 35348831090 scopus 로고    scopus 로고
    • Regulation and functional role of the runt-related transcription factor-2 in pancreatic cancer
    • Kayed H, Jiang X, Keleg S, et al. Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancer. Br J Cancer 2007;97:1106-1115.
    • (2007) Br J Cancer , vol.97 , pp. 1106-1115
    • Kayed, H.1    Jiang, X.2    Keleg, S.3
  • 6
    • 33846034921 scopus 로고    scopus 로고
    • Regulatory roles of runx2 in metastatic tumor and cancer cell interactions with bone
    • Pratap J, Lian JB, Javed A, et al. Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone. Cancer Metastasis Rev 2006;25:589-600.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 589-600
    • Pratap, J.1    Lian, J.B.2    Javed, A.3
  • 7
    • 79251620636 scopus 로고    scopus 로고
    • Control of runx3 by histone methyltransferases
    • Lee YM. Control of RUNX3 by histone methyltransferases. J Cell Biochem 2011;112:394-400.
    • (2011) J Cell Biochem , vol.112 , pp. 394-400
    • Lee, Y.M.1
  • 8
    • 76849112495 scopus 로고    scopus 로고
    • Runx2 association with progression of prostate cancer in patients: Mechanisms mediating bone osteolysis and osteoblastic metastatic lesions
    • Akech J, Wixted JJ, Bedard K, et al. Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions. Oncogene 2010;29:811-821.
    • (2010) Oncogene , vol.29 , pp. 811-821
    • Akech, J.1    Wixted, J.J.2    Bedard, K.3
  • 9
    • 69249155244 scopus 로고    scopus 로고
    • Hdac4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating runx2 activity
    • Sun X, Wei L, Chen Q, et al. HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity. J Biol Chem 2009;284:21881-21890.
    • (2009) J Biol Chem , vol.284 , pp. 21881-21890
    • Sun, X.1    Wei, L.2    Chen, Q.3
  • 10
    • 28844448789 scopus 로고    scopus 로고
    • The mapkap-1/-runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF
    • Papachristou DJ, Papachristou GI, Papaefthimiou OA, et al. The MAPKAP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF. Histopathology 2005;47:565-574.
    • (2005) Histopathology , vol.47 , pp. 565-574
    • Papachristou, D.J.1    Papachristou, G.I.2    Papaefthimiou, O.A.3
  • 11
    • 77956880700 scopus 로고    scopus 로고
    • Runx2 transcriptome of prostate cancer cells: Insights into invasiveness and bone metastasis
    • Baniwal SK, Khalid O, Gabet Y, et al. Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis. Mol Cancer 2010;9:258.
    • (2010) Mol Cancer , vol.9 , pp. 258
    • Baniwal, S.K.1    Khalid, O.2    Gabet, Y.3
  • 12
    • 49649097767 scopus 로고    scopus 로고
    • TWIST modulates prostate cancer cell-mediated bone cell activity and is upregulated by osteogenic induction
    • Yuen HF, Kwok WK, Chan KK, et al. TWIST modulates prostate cancer cell-mediated bone cell activity and is upregulated by osteogenic induction. Carcinogenesis 2008;29:1509-1518.
    • (2008) Carcinogenesis , vol.29 , pp. 1509-1518
    • Yuen, H.F.1    Kwok, W.K.2    Chan, K.K.3
  • 13
    • 33847298591 scopus 로고    scopus 로고
    • Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion
    • Vasko V, Espinosa AV, Scouten W, et al. Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion. Proc Natl Acad Sci USA 2007;104:2803-2808.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2803-2808
    • Vasko, V.1    Espinosa, A.V.2    Scouten, W.3
  • 15
    • 36549090007 scopus 로고    scopus 로고
    • Enhanced b-raf protein expression is independent of v600e mutant status in thyroid carcinomas
    • Kondo T, Nakazawa T, Murata S, et al. Enhanced B-Raf protein expression is independent of V600E mutant status in thyroid carcinomas. Hum Pathol 2007;38:1810-1818.
    • (2007) Hum Pathol , vol.38 , pp. 1810-1818
    • Kondo, T.1    Nakazawa, T.2    Murata, S.3
  • 16
    • 0034105756 scopus 로고    scopus 로고
    • Expression of thyroid transcription factor-1 (TTF-1) in human C cells and medullary thyroid carcinomas
    • Katoh R, Miyagi E, Nakamura N, et al. Expression of thyroid transcription factor-1 (TTF-1) in human C cells and medullary thyroid carcinomas. Hum Pathol 2000;31:386-393.
    • (2000) Hum Pathol , vol.31 , pp. 386-393
    • Katoh, R.1    Miyagi, E.2    Nakamura, N.3
  • 17
    • 0037311506 scopus 로고    scopus 로고
    • Expression of human pendrin in diseased thyroids
    • Kondo T, Nakamura N, Suzuki K, et al. Expression of human pendrin in diseased thyroids. J Histochem Cytochem 2003;51:167-173.
    • (2003) J Histochem Cytochem , vol.51 , pp. 167-173
    • Kondo, T.1    Nakamura, N.2    Suzuki, K.3
  • 18
    • 77957968437 scopus 로고    scopus 로고
    • Hypoxia-inducible adenosine a2b receptor modulates proliferation of colon carcinoma cells
    • Ma DF, Kondo T, Nakazawa T, et al. Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells. Hum Pathol 2010;41:1550-1557.
    • (2010) Hum Pathol , vol.41 , pp. 1550-1557
    • Ma, D.F.1    Kondo, T.2    Nakazawa, T.3
  • 19
    • 79751526399 scopus 로고    scopus 로고
    • 8-Prenylkaempferol accelerates osteoblast maturation through bone morphogenetic protein-2/p38 pathway to activate runx2 transcription
    • Chiou WF, Lee CH, Liao JF, et al. 8-Prenylkaempferol accelerates osteoblast maturation through bone morphogenetic protein-2/p38 pathway to activate Runx2 transcription. Life Sci 2011;88:335-342.
    • (2011) Life Sci , vol.88 , pp. 335-342
    • Chiou, W.F.1    Lee, C.H.2    Liao, J.F.3
  • 20
    • 77955271025 scopus 로고    scopus 로고
    • Runx2 in normal tissues and cancer cells: A developing story
    • Blyth K, Vaillant F, Jenkins A, et al. Runx2 in normal tissues and cancer cells: a developing story. Blood Cells Mol Dis 2010;45:117-123.
    • (2010) Blood Cells Mol Dis , vol.45 , pp. 117-123
    • Blyth, K.1    Vaillant, F.2    Jenkins, A.3
  • 21
    • 33645396217 scopus 로고    scopus 로고
    • Expression of cd73 and its ecto-50-nucleotidase activity are elevated in papillary thyroid carcinomas
    • Kondo T, Nakazawa T, Murata SI, et al. Expression of CD73 and its ecto-50-nucleotidase activity are elevated in papillary thyroid carcinomas. Histopathology 2006;48:612-614.
    • (2006) Histopathology , vol.48 , pp. 612-614
    • Kondo, T.1    Nakazawa, T.2    Murata, S.I.3
  • 22
    • 77954822074 scopus 로고    scopus 로고
    • Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidism
    • Endo T, Kobayashi T. Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidism. Mol Endocrinol 2010;24:1267-1273.
    • (2010) Mol Endocrinol , vol.24 , pp. 1267-1273
    • Endo, T.1    Kobayashi, T.2
  • 23
    • 78449307996 scopus 로고    scopus 로고
    • Runx2 in human breast carcinoma: Its potential roles in cancer progression
    • Onodera Y, Miki Y, Suzuki T, et al. Runx2 in human breast carcinoma: its potential roles in cancer progression. Cancer Sci 2010;101:2670-2675.
    • (2010) Cancer Sci , vol.101 , pp. 2670-2675
    • Onodera, Y.1    Miki, Y.2    Suzuki, T.3
  • 24
    • 67650369580 scopus 로고    scopus 로고
    • Suppression of androgenindependent prostate cancer cell aggressiveness by fty720: Validating runx2 as a potential antimetastatic drug screening platform
    • Chua CW, Chiu YT, Yuen HF, et al. Suppression of androgenindependent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform. Clin Cancer Res 2009;15:4322-4335.
    • (2009) Clin Cancer Res , vol.15 , pp. 4322-4335
    • Chua, C.W.1    Chiu, Y.T.2    Yuen, H.F.3
  • 25
    • 33646130414 scopus 로고    scopus 로고
    • Gene expression signatures and biomarkers of noninvasive and invasive breast cancer cells: Comprehensive profiles by representational difference analysis, microarrays and proteomics
    • Nagaraja GM, Othman M, Fox BP, et al. Gene expression signatures and biomarkers of noninvasive and invasive breast cancer cells: comprehensive profiles by representational difference analysis, microarrays and proteomics. Oncogene 2006;25:2328-2338.
    • (2006) Oncogene , vol.25 , pp. 2328-2338
    • Nagaraja, G.M.1    Othman, M.2    Fox, B.P.3
  • 26
    • 75949085815 scopus 로고    scopus 로고
    • Runx2 regulates survivin expression in prostate cancer cells
    • Lim M, Zhong C, Yang S, et al. Runx2 regulates survivin expression in prostate cancer cells. Lab Invest 2010;90:222-233.
    • (2010) Lab Invest , vol.90 , pp. 222-233
    • Lim, M.1    Zhong, C.2    Yang, S.3
  • 27
    • 63449096647 scopus 로고    scopus 로고
    • Runx1 and runx2 upregulate galectin-3 expression in human pituitary tumors
    • Zhang H-Y, Jin L, Stilling GA, et al. RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors. Endocrine 2009;35:101-111.
    • (2009) Endocrine , vol.35 , pp. 101-111
    • Zhang, H.-Y.1    Jin, L.2    Stilling, G.A.3
  • 28
    • 40149103478 scopus 로고    scopus 로고
    • Application of immunohistochemistry to thyroid neoplasms
    • Fischer S, Asa SL. Application of immunohistochemistry to thyroid neoplasms. Arch Pathol Lab Med 2008;132:359-372.
    • (2008) Arch Pathol Lab Med , vol.132 , pp. 359-372
    • Fischer, S.1    Asa, S.L.2
  • 29
    • 25444473106 scopus 로고    scopus 로고
    • The runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion
    • Pratap J, Javed A, Languino LR, et al. The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol 2005;25:8581-8591.
    • (2005) Mol Cell Biol , vol.25 , pp. 8581-8591
    • Pratap, J.1    Javed, A.2    Languino, L.R.3
  • 30
    • 13444306168 scopus 로고    scopus 로고
    • Impaired intranuclear trafficking of runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo
    • Javed A, Barnes GL, Pratap J, et al. Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Proc Natl Acad Sci USA 2005;102:1454-1459.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1454-1459
    • Javed, A.1    Barnes, G.L.2    Pratap, J.3
  • 31
    • 77953571622 scopus 로고    scopus 로고
    • Snail: More than EMT
    • Wu Y, Zhou BP. Snail: more than EMT. Cell Adh Migr 2010;4:199-203.
    • (2010) Cell Adh Migr , vol.4 , pp. 199-203
    • Wu, Y.1    Zhou, B.P.2
  • 32
    • 78651401992 scopus 로고    scopus 로고
    • Snail2 is an essential mediator of twist1-induced epithelial mesenchymal transition and metastasis
    • Casas E, Kim J, Bendesky A, et al. Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res 2011;71:245-254.
    • (2011) Cancer Res , vol.71 , pp. 245-254
    • Casas, E.1    Kim, J.2    Bendesky, A.3
  • 33
    • 15544386594 scopus 로고    scopus 로고
    • Extracellular nucleotides activate runx2 in the osteoblast-like HOBIT cell line: A possible molecular link between mechanical stress and osteoblasts' response
    • Costessi A, Pines A, D'Andrea P, et al. Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response. Bone 2005;36:418-432.
    • (2005) Bone , vol.36 , pp. 418-432
    • Costessi, A.1    Pines, A.2    D'Andrea, P.3
  • 34
    • 0037441529 scopus 로고    scopus 로고
    • Regulation of the osteoblast-specific transcription factor, runx2: Responsiveness to multiple signal transduction pathways
    • Franceschi RT, Xiao G. Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways. J Cell Biochem 2003;88:446-454.
    • (2003) J Cell Biochem , vol.88 , pp. 446-454
    • Franceschi, R.T.1    Xiao, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.