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Volumn 21, Issue 4, 2015, Pages 356-371

Hedgehog: Multiple paths for multiple roles in shaping the brain and spinal cord

Author keywords

axonal guidance; Boc; congenital diseases; neural stem cells; primary cilium; Smoothened

Indexed keywords

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

EID: 84937574914     PISSN: 10738584     EISSN: 10894098     Source Type: Journal    
DOI: 10.1177/1073858414531457     Document Type: Review
Times cited : (21)

References (126)
  • 1
    • 84867649476 scopus 로고    scopus 로고
    • Analysis of human samples reveals imparired SHH-dependent cerebellar development in Joubert syndrome/Meckel syndrome
    • others
    • Aguilar A, Meunier A, Martinovic J, Bonniere M, Attie-Bitach, Encha-Razavi F, and others. 2012. Analysis of human samples reveals imparired SHH-dependent cerebellar development in Joubert syndrome/Meckel syndrome. Proc Natl Acad Sci USA 109 (42): 16951-6.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.42 , pp. 16951-16956
    • Aguilar, A.1    Meunier, A.2    Martinovic, J.3    Bonniere, M.4    Attie-Bitach5    Encha-Razavi, F.6
  • 2
    • 27144487469 scopus 로고    scopus 로고
    • In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
    • Ahn S, Joyner AL,. 2005. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 437 (7060): 894-7.
    • (2005) Nature , vol.437 , Issue.7060 , pp. 894-897
    • Ahn, S.1    Joyner, A.L.2
  • 3
    • 84855996276 scopus 로고    scopus 로고
    • Sonic hedgehog lineage in the mouse hypothalamus: From progenitor domains to hypothalamic regions
    • Alvarez-Bolado G, Paul FA, Blaess S,. 2012. Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions. Neural Dev 7: 4.
    • (2012) Neural Dev , vol.7 , pp. 4
    • Alvarez-Bolado, G.1    Paul, F.A.2    Blaess, S.3
  • 4
    • 84455205524 scopus 로고    scopus 로고
    • The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
    • others
    • Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, and others. 2011. The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science 334 (6063): 1727-31.
    • (2011) Science , vol.334 , Issue.6063 , pp. 1727-1731
    • Alvarez, J.I.1    Dodelet-Devillers, A.2    Kebir, H.3    Ifergan, I.4    Fabre, P.J.5    Terouz, S.6
  • 5
    • 52649162719 scopus 로고    scopus 로고
    • Chemoattractive activity of sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb
    • Angot E, Loulier K, Nguyen-Ba-Charvet KT, Gadeau AP, Ruat M, Traiffort E,. 2008. Chemoattractive activity of sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb. Stem Cells 26 (9): 2311-20.
    • (2008) Stem Cells , vol.26 , Issue.9 , pp. 2311-2320
    • Angot, E.1    Loulier, K.2    Nguyen-Ba-Charvet, K.T.3    Gadeau, A.P.4    Ruat, M.5    Traiffort, E.6
  • 6
    • 84856094426 scopus 로고    scopus 로고
    • Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube
    • others
    • Balaskas N, Ribeiro A, Panovska J, Dessaud E, Sasai N, Page KM, and others. 2012. Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. Cell 148 (1-2): 273-84.
    • (2012) Cell , vol.148 , Issue.1-2 , pp. 273-284
    • Balaskas, N.1    Ribeiro, A.2    Panovska, J.3    Dessaud, E.4    Sasai, N.5    Page, K.M.6
  • 7
    • 37549049804 scopus 로고    scopus 로고
    • Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal
    • Balordi F, Fishell G,. 2007. Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal. J Neurosci 27 (52): 14248-59.
    • (2007) J Neurosci , vol.27 , Issue.52 , pp. 14248-14259
    • Balordi, F.1    Fishell, G.2
  • 8
    • 84883487161 scopus 로고    scopus 로고
    • Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling
    • others
    • Barakat B, Yu L, Lo C, Vu D, De Luca E, Cain JE, and others. 2013a. Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling. EMBO Rep 14 (9): 837-44.
    • (2013) EMBO Rep , vol.14 , Issue.9 , pp. 837-844
    • Barakat, B.1    Yu, L.2    Lo, C.3    Vu, D.4    De Luca, E.5    Cain, J.E.6
  • 9
    • 77955420936 scopus 로고    scopus 로고
    • Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer
    • Barakat MT, Humke EW, Scott MP,. 2010. Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med 16 (8): 337-48.
    • (2010) Trends Mol Med , vol.16 , Issue.8 , pp. 337-348
    • Barakat, M.T.1    Humke, E.W.2    Scott, M.P.3
  • 10
    • 84879004103 scopus 로고    scopus 로고
    • Kif3a is necessary for initiation and maintenance of medulloblastoma
    • Barakat MT, Humke EW, Scott MP,. 2013b. Kif3a is necessary for initiation and maintenance of medulloblastoma. Carcinogenesis 34 (6): 1382-92.
    • (2013) Carcinogenesis , vol.34 , Issue.6 , pp. 1382-1392
    • Barakat, M.T.1    Humke, E.W.2    Scott, M.P.3
  • 11
    • 84871453762 scopus 로고    scopus 로고
    • Tangentially migrating neurons assemble a primary cilium that promotes their reorientation to the cortical plate
    • others
    • Baudoin JP, Viou L, Launay PS, Luccardini C, Espeso Gil S, Kiyasova V, and others. 2012. Tangentially migrating neurons assemble a primary cilium that promotes their reorientation to the cortical plate. Neuron 76 (6): 1108-22.
    • (2012) Neuron , vol.76 , Issue.6 , pp. 1108-1122
    • Baudoin, J.P.1    Viou, L.2    Launay, P.S.3    Luccardini, C.4    Espeso Gil, S.5    Kiyasova, V.6
  • 12
    • 79952733097 scopus 로고    scopus 로고
    • Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord
    • Belgacem YH, Borodinsky LN,. 2011. Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. Proc Natl Acad Sci U S A 108 (11): 4482-7.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.11 , pp. 4482-4487
    • Belgacem, Y.H.1    Borodinsky, L.N.2
  • 13
    • 79951850782 scopus 로고    scopus 로고
    • Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons
    • Beug ST, Parks RJ, McBride HM, Wallace VA,. 2011. Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons. Mol Cell Neurosci 46 (3): 583-96.
    • (2011) Mol Cell Neurosci , vol.46 , Issue.3 , pp. 583-596
    • Beug, S.T.1    Parks, R.J.2    McBride, H.M.3    Wallace, V.A.4
  • 14
    • 84865306296 scopus 로고    scopus 로고
    • Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium
    • Bijlsma MF, Damhofer H, Roelink H,. 2012. Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium. Sci Signal 5 (238): ra60.
    • (2012) Sci Signal , vol.5 , Issue.238 , pp. ra60
    • Bijlsma, M.F.1    Damhofer, H.2    Roelink, H.3
  • 15
    • 14544271857 scopus 로고    scopus 로고
    • Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord
    • others
    • Bourikas D, Pekarik V, Baeriswyl T, Grunditz A, Sadhu R, Nardo M, and others. 2005. Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord. Nat Neurosci 8 (3): 297-304.
    • (2005) Nat Neurosci , vol.8 , Issue.3 , pp. 297-304
    • Bourikas, D.1    Pekarik, V.2    Baeriswyl, T.3    Grunditz, A.4    Sadhu, R.5    Nardo, M.6
  • 16
    • 84869132784 scopus 로고    scopus 로고
    • Purkinje cell maturation participates in the control of oligodendrocyte differentiation: Role of sonic hedgehog and vitronectin
    • others
    • Bouslama-Oueghlani L, Wehrle R, Doulazmi M, Chen XR, Jaudon F, Lemaigre-Dubreuil Y, and others. 2012. Purkinje cell maturation participates in the control of oligodendrocyte differentiation: role of sonic hedgehog and vitronectin. PLoS One 7 (11): e49015.
    • (2012) PLoS One , vol.7 , Issue.11 , pp. e49015
    • Bouslama-Oueghlani, L.1    Wehrle, R.2    Doulazmi, M.3    Chen, X.R.4    Jaudon, F.5    Lemaigre-Dubreuil, Y.6
  • 17
    • 84879414522 scopus 로고    scopus 로고
    • The mechanisms of Hedgehog signalling and its roles in development and disease
    • Briscoe J, Thérond PP,. 2013. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol 14 (7): 416-29.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , Issue.7 , pp. 416-429
    • Briscoe, J.1    Thérond, P.P.2
  • 18
    • 77952715761 scopus 로고    scopus 로고
    • Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala
    • others
    • Carney RS, Mangin JM, Hayes L, Mansfield K, Sousa VH, Fishell G, and others. 2010. Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala. Neural Dev 5: 14.
    • (2010) Neural Dev , vol.5 , pp. 14
    • Carney, R.S.1    Mangin, J.M.2    Hayes, L.3    Mansfield, K.4    Sousa, V.H.5    Fishell, G.6
  • 19
    • 42549109108 scopus 로고    scopus 로고
    • Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning
    • Chamberlain CE, Jeong J, Guo C, Allen BL, McMahon AP,. 2008. Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development 135 (6): 1097-106.
    • (2008) Development , vol.135 , Issue.6 , pp. 1097-1106
    • Chamberlain, C.E.1    Jeong, J.2    Guo, C.3    Allen, B.L.4    McMahon, A.P.5
  • 20
    • 0035860538 scopus 로고    scopus 로고
    • Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
    • others
    • Chamoun Z, Mann RK, Nellen D, von Kessler DP, Bellotto M, Beachy PA, and others. 2001. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 293 (5537): 2080-4.
    • (2001) Science , vol.293 , Issue.5537 , pp. 2080-2084
    • Chamoun, Z.1    Mann, R.K.2    Nellen, D.3    Von Kessler, D.P.4    Bellotto, M.5    Beachy, P.A.6
  • 21
    • 0037418830 scopus 로고    scopus 로고
    • The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance
    • Charron F, Stein E, Jeong J, McMahon AP, Tessier-Lavigne M,. 2003. The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113 (1): 11-23.
    • (2003) Cell , vol.113 , Issue.1 , pp. 11-23
    • Charron, F.1    Stein, E.2    Jeong, J.3    McMahon, A.P.4    Tessier-Lavigne, M.5
  • 22
    • 84873735792 scopus 로고    scopus 로고
    • Decoding the phosphorylation code in Hedgehog signal transduction
    • Chen Y, Jiang J,. 2013. Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res 23 (2): 186-200.
    • (2013) Cell Res , vol.23 , Issue.2 , pp. 186-200
    • Chen, Y.1    Jiang, J.2
  • 23
    • 0037314331 scopus 로고    scopus 로고
    • Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung
    • Chuang PT, Kawcak T, McMahon AP,. 2003. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev 17 (3): 342-7.
    • (2003) Genes Dev , vol.17 , Issue.3 , pp. 342-347
    • Chuang, P.T.1    Kawcak, T.2    McMahon, A.P.3
  • 24
    • 84872737413 scopus 로고    scopus 로고
    • Indian hedgehog B function is required for the specification of oligodendrocyte progenitor cells in the zebrafish CNS
    • others
    • Chung AY, Kim S, Kim E, Kim D, Jeong I, Cha YR, and others. 2013. Indian hedgehog B function is required for the specification of oligodendrocyte progenitor cells in the zebrafish CNS. J Neurosci 33 (4): 1728-33.
    • (2013) J Neurosci , vol.33 , Issue.4 , pp. 1728-1733
    • Chung, A.Y.1    Kim, S.2    Kim, E.3    Kim, D.4    Jeong, I.5    Cha, Y.R.6
  • 25
    • 84883457798 scopus 로고    scopus 로고
    • Morphogen interpretation: The transcriptional logic of neural tube patterning
    • Cohen M, Briscoe J, Blassberg R,. 2013. Morphogen interpretation: the transcriptional logic of neural tube patterning. Curr Opin Genet Dev 23 (4): 423-8.
    • (2013) Curr Opin Genet Dev , vol.23 , Issue.4 , pp. 423-428
    • Cohen, M.1    Briscoe, J.2    Blassberg, R.3
  • 26
    • 77955287417 scopus 로고    scopus 로고
    • Hedgehog signaling update
    • Cohen MM Jr,. 2010. Hedgehog signaling update. Am J Med Genet A 152A (8): 1875-914.
    • (2010) Am J Med Genet A , vol.152 , Issue.8 , pp. 1875-1914
    • Cohen, M.M.1    Jr2
  • 27
    • 84872564445 scopus 로고    scopus 로고
    • Gli2 mutations as a cause of hypopituitarism
    • Cohen LE,. 2012. Gli2 mutations as a cause of hypopituitarism. Pediatr Endocrinol Rev 9 (4): 706-9.
    • (2012) Pediatr Endocrinol Rev , vol.9 , Issue.4 , pp. 706-709
    • Cohen, L.E.1
  • 28
    • 0344953585 scopus 로고    scopus 로고
    • A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis
    • others
    • Cooper MK, Wassif CA, Krakowiak PA, Taipale J, Gong R, Kelley RI, and others. 2003. A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet 33 (4): 508-13.
    • (2003) Nat Genet , vol.33 , Issue.4 , pp. 508-513
    • Cooper, M.K.1    Wassif, C.A.2    Krakowiak, P.A.3    Taipale, J.4    Gong, R.5    Kelley, R.I.6
  • 29
    • 84887137194 scopus 로고    scopus 로고
    • Emilin3 is required for notochord sheath integrity and interacts with Scube2 to regulate notochord-derived Hedgehog signals
    • Corallo D, Schiavinato A, Trapani V, Moro E, Argenton F, Bonaldo P,. 2013. Emilin3 is required for notochord sheath integrity and interacts with Scube2 to regulate notochord-derived Hedgehog signals. Development 140 (22): 4594-601.
    • (2013) Development , vol.140 , Issue.22 , pp. 4594-4601
    • Corallo, D.1    Schiavinato, A.2    Trapani, V.3    Moro, E.4    Argenton, F.5    Bonaldo, P.6
  • 30
    • 84860337278 scopus 로고    scopus 로고
    • A Sonic hedgehog (Shh) response deficit in trisomic cells
    • be a common denominator for multiple features of Down syndrome
    • Currier DG, Polk RC, Reeves RH,. 2012. A Sonic hedgehog (Shh) response deficit in trisomic cells. be a common denominator for multiple features of Down syndrome. Prog Brain Res 197: 223-36.
    • (2012) Prog Brain Res , vol.197 , pp. 223-236
    • Currier, D.G.1    Polk, R.C.2    Reeves, R.H.3
  • 31
    • 84884145737 scopus 로고    scopus 로고
    • Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model
    • others
    • Das I, Park JM, Shin JH, Jeon SK, Lorenzi H, Linden DJ, and others. 2013. Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. Sci Transl Med 5 (201): 201ra120.
    • (2013) Sci Transl Med , vol.5 , Issue.201 , pp. 201ra120
    • Das, I.1    Park, J.M.2    Shin, J.H.3    Jeon, S.K.4    Lorenzi, H.5    Linden, D.J.6
  • 32
    • 79951915546 scopus 로고    scopus 로고
    • Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors
    • others
    • Dave RK, Ellis T, Toumpas MC, Robson JP, Julian E, Adolphe C, and others. 2011. Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS One 6 (2): e14680.
    • (2011) PLoS One , vol.6 , Issue.2 , pp. e14680
    • Dave, R.K.1    Ellis, T.2    Toumpas, M.C.3    Robson, J.P.4    Julian, E.5    Adolphe, C.6
  • 34
    • 84883157273 scopus 로고    scopus 로고
    • Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity
    • others
    • Delloye-Bourgeois C, Gibert B, Rama N, Delcros JG, Gadot N, Scoazec JY, and others. 2013. Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity. PLoS Biol 11 (8): e1001623.
    • (2013) PLoS Biol , vol.11 , Issue.8 , pp. e1001623
    • Delloye-Bourgeois, C.1    Gibert, B.2    Rama, N.3    Delcros, J.G.4    Gadot, N.5    Scoazec, J.Y.6
  • 35
    • 44349159118 scopus 로고    scopus 로고
    • Multiple roles for lipids in the Hedgehog signalling pathway
    • Eaton S,. 2008. Multiple roles for lipids in the Hedgehog signalling pathway. Nat Rev Mol Cell Biol 9 (6): 437-45.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , Issue.6 , pp. 437-445
    • Eaton, S.1
  • 36
    • 84862214862 scopus 로고    scopus 로고
    • Regulation of thalamic development by sonic hedgehog
    • Epstein DJ,. 2012. Regulation of thalamic development by sonic hedgehog. Front Neurosci 6: 57.
    • (2012) Front Neurosci , vol.6 , pp. 57
    • Epstein, D.J.1
  • 37
    • 74849100633 scopus 로고    scopus 로고
    • Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc
    • Fabre P, Shimogori T, Charron F,. 2010. Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc. J Neurosci 30 (1): 266-75.
    • (2010) J Neurosci , vol.30 , Issue.1 , pp. 266-275
    • Fabre, P.1    Shimogori, T.2    Charron, F.3
  • 38
    • 84880584133 scopus 로고    scopus 로고
    • Investigation of the proteolipid protein promoter activity during demyelination and repair
    • Ferent J, Ruat M, Traiffort E,. 2013a. Investigation of the proteolipid protein promoter activity during demyelination and repair. Differentiation 85 (4-5): 182-9.
    • (2013) Differentiation , vol.85 , Issue.4-5 , pp. 182-189
    • Ferent, J.1    Ruat, M.2    Traiffort, E.3
  • 39
    • 84873027567 scopus 로고    scopus 로고
    • Sonic hedgehog signaling is a positive oligodendrocyte regulator during demyelination
    • Ferent J, Zimmer C, Durbec P, Ruat M, Traiffort E,. 2013b. Sonic hedgehog signaling is a positive oligodendrocyte regulator during demyelination. J Neurosci 33 (5): 1759-72.
    • (2013) J Neurosci , vol.33 , Issue.5 , pp. 1759-1772
    • Ferent, J.1    Zimmer, C.2    Durbec, P.3    Ruat, M.4    Traiffort, E.5
  • 40
    • 84874833350 scopus 로고    scopus 로고
    • Functional characterization of a heterozygous GLI2 missense mutation in patients with multiple pituitary hormone deficiency
    • others
    • Flemming GM, Klammt J, Ambler G, Bao Y, Blum WF, Cowell C, and others. 2013. Functional characterization of a heterozygous GLI2 missense mutation in patients with multiple pituitary hormone deficiency. J Clin Endocrinol Metab 98 (3): E567-75.
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.3 , pp. E567-E575
    • Flemming, G.M.1    Klammt, J.2    Ambler, G.3    Bao, Y.4    Blum, W.F.5    Cowell, C.6
  • 41
    • 33748951151 scopus 로고    scopus 로고
    • Morphogen to mitogen: The multiple roles of hedgehog signalling in vertebrate neural development
    • Fuccillo M, Joyner AL, Fishell G,. 2006. Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development. Nat Rev Neurosci 7 (10): 772-83.
    • (2006) Nat Rev Neurosci , vol.7 , Issue.10 , pp. 772-783
    • Fuccillo, M.1    Joyner, A.L.2    Fishell, G.3
  • 42
    • 77958065240 scopus 로고    scopus 로고
    • Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain
    • Garcia AD, Petrova R, Eng L, Joyner AL,. 2010. Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain. J Neurosci 30 (41): 13597-608.
    • (2010) J Neurosci , vol.30 , Issue.41 , pp. 13597-13608
    • Garcia, A.D.1    Petrova, R.2    Eng, L.3    Joyner, A.L.4
  • 43
    • 84864307761 scopus 로고    scopus 로고
    • Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit
    • others
    • Gonzalez-Reyes LE, Verbitsky M, Blesa J, Jackson-Lewis V, Paredes D, Tillack K, and others. 2012. Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit. Neuron 75 (2): 306-19.
    • (2012) Neuron , vol.75 , Issue.2 , pp. 306-319
    • Gonzalez-Reyes, L.E.1    Verbitsky, M.2    Blesa, J.3    Jackson-Lewis, V.4    Paredes, D.5    Tillack, K.6
  • 44
    • 84887473986 scopus 로고    scopus 로고
    • Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: New therapeutic opportunities
    • others
    • Gruber Filbin M, Dabral SK, Pazyra-Murphy MF, Ramkissoon S, Kung AL, Pak E, and others. 2013. Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities. Nat Med 19 (11): 1518-23.
    • (2013) Nat Med , vol.19 , Issue.11 , pp. 1518-1523
    • Gruber Filbin, M.1    Dabral, S.K.2    Pazyra-Murphy, M.F.3    Ramkissoon, S.4    Kung, A.L.5    Pak, E.6
  • 45
    • 84860613389 scopus 로고    scopus 로고
    • Protein kinase C-α and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog
    • Guo D, Standley C, Bellve K, Fogarty K, Bao ZZ,. 2012. Protein kinase C-α and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. Mol Cell Neurosci 50 (1): 82-92.
    • (2012) Mol Cell Neurosci , vol.50 , Issue.1 , pp. 82-92
    • Guo, D.1    Standley, C.2    Bellve, K.3    Fogarty, K.4    Bao, Z.Z.5
  • 47
    • 70349631211 scopus 로고    scopus 로고
    • Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons
    • Hammond R, Blaess S, Abeliovich A,. 2009. Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons. PLoS One 4 (9): e7007.
    • (2009) PLoS One , vol.4 , Issue.9 , pp. e7007
    • Hammond, R.1    Blaess, S.2    Abeliovich, A.3
  • 49
    • 84858638527 scopus 로고    scopus 로고
    • Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation
    • others
    • Harwell CC, Parker PR, Gee SM, Okada A, McConnell SK, Kreitzer AC, and others. 2012. Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation. Neuron 73 (6): 1116-26.
    • (2012) Neuron , vol.73 , Issue.6 , pp. 1116-1126
    • Harwell, C.C.1    Parker, P.R.2    Gee, S.M.3    Okada, A.4    McConnell, S.K.5    Kreitzer, A.C.6
  • 50
    • 84872370843 scopus 로고    scopus 로고
    • Duration of Shh signaling contributes to mDA neuron diversity
    • Hayes L, Ralls S, Wang H, Ahn S,. 2013. Duration of Shh signaling contributes to mDA neuron diversity. Dev Biol 374 (1): 115-26.
    • (2013) Dev Biol , vol.374 , Issue.1 , pp. 115-126
    • Hayes, L.1    Ralls, S.2    Wang, H.3    Ahn, S.4
  • 51
    • 84887279104 scopus 로고    scopus 로고
    • Astrocyte-derived sonic hedgehog contributes to angiogenesis in brain microvascular endothelial cells via RhoA/ROCK pathway after oxygen-glucose deprivation
    • others
    • He QW, Xia YP, Chen SC, Wang Y, Huang M, Huang Y, and others. 2013. Astrocyte-derived sonic hedgehog contributes to angiogenesis in brain microvascular endothelial cells via RhoA/ROCK pathway after oxygen-glucose deprivation. Mol Neurobiol 47 (3): 976-87.
    • (2013) Mol Neurobiol , vol.47 , Issue.3 , pp. 976-987
    • He, Q.W.1    Xia, Y.P.2    Chen, S.C.3    Wang, Y.4    Huang, M.5    Huang, Y.6
  • 52
    • 84880934981 scopus 로고    scopus 로고
    • Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning
    • others
    • Holtz AM, Peterson KA, Nishi Y, Morin S, Song JY, Charron F, and others. 2013. Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development 140 (16): 3423-34.
    • (2013) Development , vol.140 , Issue.16 , pp. 3423-3434
    • Holtz, A.M.1    Peterson, K.A.2    Nishi, Y.3    Morin, S.4    Song, J.Y.5    Charron, F.6
  • 53
    • 84868088488 scopus 로고    scopus 로고
    • Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice
    • Hong M, Krauss RS,. 2012. Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice. PLoS Genet 8 (10): e1002999.
    • (2012) PLoS Genet , vol.8 , Issue.10 , pp. e1002999
    • Hong, M.1    Krauss, R.S.2
  • 54
    • 84889044006 scopus 로고    scopus 로고
    • Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover
    • others
    • Huang S, Zhang Z, Zhang C, Lv X, Zheng X, Chen Z, and others. 2013. Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. PLoS Biol 11 (11): e1001721.
    • (2013) PLoS Biol , vol.11 , Issue.11 , pp. e1001721
    • Huang, S.1    Zhang, Z.2    Zhang, C.3    Lv, X.4    Zheng, X.5    Chen, Z.6
  • 55
    • 77952389933 scopus 로고    scopus 로고
    • Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development
    • others
    • Huang X, Liu J, Ketova T, Fleming JT, Grover VK, Cooper MK, and others. 2010. Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proc Natl Acad Sci U S A 107 (18): 8422-7.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.18 , pp. 8422-8427
    • Huang, X.1    Liu, J.2    Ketova, T.3    Fleming, J.T.4    Grover, V.K.5    Cooper, M.K.6
  • 56
    • 0242581681 scopus 로고    scopus 로고
    • Hedgehog signalling in the mouse requires intraflagellar transport proteins
    • Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV,. 2003. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426 (6962): 83-7.
    • (2003) Nature , vol.426 , Issue.6962 , pp. 83-87
    • Huangfu, D.1    Liu, A.2    Rakeman, A.S.3    Murcia, N.S.4    Niswander, L.5    Anderson, K.V.6
  • 57
    • 79960623943 scopus 로고    scopus 로고
    • Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity
    • others
    • Ihrie RA, Shah JK, Harwell CC, Levine JH, Guinto CD, Lezameta M, and others. 2011. Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity. Neuron 71 (2): 250-62.
    • (2011) Neuron , vol.71 , Issue.2 , pp. 250-262
    • Ihrie, R.A.1    Shah, J.K.2    Harwell, C.C.3    Levine, J.H.4    Guinto, C.D.5    Lezameta, M.6
  • 58
    • 79958210024 scopus 로고    scopus 로고
    • Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation
    • others
    • Izzi L, Levesque M, Morin S, Laniel D, Wilkes BC, Mille F, and others. 2011. Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell 20 (6): 788-801.
    • (2011) Dev Cell , vol.20 , Issue.6 , pp. 788-801
    • Izzi, L.1    Levesque, M.2    Morin, S.3    Laniel, D.4    Wilkes, B.C.5    Mille, F.6
  • 59
    • 46449127054 scopus 로고    scopus 로고
    • β-arrestin-mediated localization of Smoothened to the primary cilium
    • others
    • Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, and others. 2008. β-arrestin-mediated localization of Smoothened to the primary cilium. Science 320 (5884): 1777-81.
    • (2008) Science , vol.320 , Issue.5884 , pp. 1777-1781
    • Kovacs, J.J.1    Whalen, E.J.2    Liu, R.3    Xiao, K.4    Kim, J.5    Chen, M.6
  • 60
    • 82655189981 scopus 로고    scopus 로고
    • Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins
    • Larkins CE, Aviles GD, East MP, Kahn RA, Caspary T,. 2011. Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins. Mol Biol Cell 22 (23): 4694-703.
    • (2011) Mol Biol Cell , vol.22 , Issue.23 , pp. 4694-4703
    • Larkins, C.E.1    Aviles, G.D.2    East, M.P.3    Kahn, R.A.4    Caspary, T.5
  • 61
    • 84878453549 scopus 로고    scopus 로고
    • The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus
    • Li G, Fang L, Fernandez G, Pleasure SJ,. 2013a. The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus. Neuron 78 (4): 658-72.
    • (2013) Neuron , vol.78 , Issue.4 , pp. 658-672
    • Li, G.1    Fang, L.2    Fernandez, G.3    Pleasure, S.J.4
  • 62
    • 84888330535 scopus 로고    scopus 로고
    • A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity
    • others
    • Li P, Du F, Yuelling LW, Lin T, Muradimova RE, Tricarico R, and others. 2013b. A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity. Nat Neurosci 16 (12): 1737-44.
    • (2013) Nat Neurosci , vol.16 , Issue.12 , pp. 1737-1744
    • Li, P.1    Du, F.2    Yuelling, L.W.3    Lin, T.4    Muradimova, R.E.5    Tricarico, R.6
  • 63
    • 67649118749 scopus 로고    scopus 로고
    • Turning cancer stem cells inside out: An exploration of glioma stem cell signaling pathways
    • Li Z, Wang H, Eyler CE, Hjelmeland AB, Rich JN,. 2009. Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. J Biol Chem 284 (25): 16705-9.
    • (2009) J Biol Chem , vol.284 , Issue.25 , pp. 16705-16709
    • Li, Z.1    Wang, H.2    Eyler, C.E.3    Hjelmeland, A.B.4    Rich, J.N.5
  • 64
    • 10744230965 scopus 로고    scopus 로고
    • Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches
    • others
    • Machold R, Hayashi S, Rutlin M, Muzumdar MD, Nery S, Corbin JG, and others. 2003. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 39 (6): 937-50.
    • (2003) Neuron , vol.39 , Issue.6 , pp. 937-950
    • Machold, R.1    Hayashi, S.2    Rutlin, M.3    Muzumdar, M.D.4    Nery, S.5    Corbin, J.G.6
  • 65
    • 77958058043 scopus 로고    scopus 로고
    • The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence
    • Magnani D, Hasenpusch-Theil K, Jacobs EC, Campagnoni AT, Price DJ, Theil T,. 2010. The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence. J Neurosci 30 (41): 13883-94.
    • (2010) J Neurosci , vol.30 , Issue.41 , pp. 13883-13894
    • Magnani, D.1    Hasenpusch-Theil, K.2    Jacobs, E.C.3    Campagnoni, A.T.4    Price, D.J.5    Theil, T.6
  • 66
    • 84885359219 scopus 로고    scopus 로고
    • Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor
    • others
    • Marazziti D, Di Pietro C, Golini E, Mandillo S, La Sala G, Matteoni R, and others. 2013. Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor. Proc Natl Acad Sci U S A 110 (41): 16486-91.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.41 , pp. 16486-16491
    • Marazziti, D.1    Di Pietro, C.2    Golini, E.3    Mandillo, S.4    La Sala, G.5    Matteoni, R.6
  • 67
    • 84881529800 scopus 로고    scopus 로고
    • The cytoskeletal protein Zyxin inhibits Shh signaling during the CNS patterning in Xenopus laevis through interaction with the transcription factor Gli1
    • others
    • Martynova NY, Ermolina LV, Ermakova GV, Eroshkin FM, Gyoeva FK, Baturina NS, and others. 2013. The cytoskeletal protein Zyxin inhibits Shh signaling during the CNS patterning in Xenopus laevis through interaction with the transcription factor Gli1. Dev Biol 380 (1): 37-48.
    • (2013) Dev Biol , vol.380 , Issue.1 , pp. 37-48
    • Martynova, N.Y.1    Ermolina, L.V.2    Ermakova, G.V.3    Eroshkin, F.M.4    Gyoeva, F.K.5    Baturina, N.S.6
  • 69
    • 84885954184 scopus 로고    scopus 로고
    • Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression
    • others
    • Milla LA, Arros A, Espinoza N, Remke M, Kool M, Taylor MD, and others. 2014. Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression. Int J Cancer 134 (1): 21-31.
    • (2014) Int J Cancer , vol.134 , Issue.1 , pp. 21-31
    • Milla, L.A.1    Arros, A.2    Espinoza, N.3    Remke, M.4    Kool, M.5    Taylor, M.D.6
  • 70
    • 84880587825 scopus 로고    scopus 로고
    • Transgenic overexpression of Sox17 promotes oligodendrocyte development and attenuates demyelination
    • Ming X, Chew LJ, Gallo V,. 2013. Transgenic overexpression of Sox17 promotes oligodendrocyte development and attenuates demyelination. J Neurosci 33 (30): 12528-42.
    • (2013) J Neurosci , vol.33 , Issue.30 , pp. 12528-12542
    • Ming, X.1    Chew, L.J.2    Gallo, V.3
  • 71
    • 84872200443 scopus 로고    scopus 로고
    • Sonic hedgehog regulates presynaptic terminal size, ultrastructure and function in hippocampal neurons
    • others
    • Mitchell N, Petralia RS, Currier DG, Wang YX, Kim A, Mattson MP, and others. 2012. Sonic hedgehog regulates presynaptic terminal size, ultrastructure and function in hippocampal neurons. J Cell Sci 125 (Pt 18): 4207-13.
    • (2012) J Cell Sci , vol.125 , pp. 4207-4213
    • Mitchell, N.1    Petralia, R.S.2    Currier, D.G.3    Wang, Y.X.4    Kim, A.5    Mattson, M.P.6
  • 73
    • 84872508509 scopus 로고    scopus 로고
    • The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
    • others
    • Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, and others. 2013. The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Cell 152 (1-2): 210-23.
    • (2013) Cell , vol.152 , Issue.1-2 , pp. 210-223
    • Mukhopadhyay, S.1    Wen, X.2    Ratti, N.3    Loktev, A.4    Rangell, L.5    Scales, S.J.6
  • 74
    • 80955181031 scopus 로고    scopus 로고
    • The Hedgehog's tale: Developing strategies for targeting cancer
    • Ng JM, Curran T,. 2011. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer 11 (7): 493-501.
    • (2011) Nat Rev Cancer , vol.11 , Issue.7 , pp. 493-501
    • Ng, J.M.1    Curran, T.2
  • 75
    • 77951208479 scopus 로고    scopus 로고
    • Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus
    • Nielsen CM, Dymecki SM,. 2010. Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev Biol 340 (2): 430-7.
    • (2010) Dev Biol , vol.340 , Issue.2 , pp. 430-437
    • Nielsen, C.M.1    Dymecki, S.M.2
  • 76
    • 84882676538 scopus 로고    scopus 로고
    • Interaction of PACAP with Sonic hedgehog reveals complex regulation of the hedgehog pathway by PKA
    • Niewiadomski P, Zhujiang A, Youssef M, Waschek JA,. 2013. Interaction of PACAP with Sonic hedgehog reveals complex regulation of the hedgehog pathway by PKA. Cell Signal 25 (11): 2222-30.
    • (2013) Cell Signal , vol.25 , Issue.11 , pp. 2222-2230
    • Niewiadomski, P.1    Zhujiang, A.2    Youssef, M.3    Waschek, J.A.4
  • 77
    • 84882251212 scopus 로고    scopus 로고
    • Nato3 integrates with the Shh-Foxa2 transcriptional network regulating the differentiation of midbrain dopaminergic neurons
    • Nissim-Eliraz E, Zisman S, Schatz O, Ben-Arie N,. 2013. Nato3 integrates with the Shh-Foxa2 transcriptional network regulating the differentiation of midbrain dopaminergic neurons. J Mol Neurosci 51 (1): 13-27.
    • (2013) J Mol Neurosci , vol.51 , Issue.1 , pp. 13-27
    • Nissim-Eliraz, E.1    Zisman, S.2    Schatz, O.3    Ben-Arie, N.4
  • 79
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard C, Wieschaus E,. 1980. Mutations affecting segment number and polarity in Drosophila. Nature 287 (5785): 795-801.
    • (1980) Nature , vol.287 , Issue.5785 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 80
    • 33751078546 scopus 로고    scopus 로고
    • Boc is a receptor for sonic hedgehog in the guidance of commissural axons
    • others
    • Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre PJ, and others. 2006. Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature 444 (7117): 369-73.
    • (2006) Nature , vol.444 , Issue.7117 , pp. 369-373
    • Okada, A.1    Charron, F.2    Morin, S.3    Shin, D.S.4    Wong, K.5    Fabre, P.J.6
  • 81
    • 84890449899 scopus 로고    scopus 로고
    • Sonic hedgehog promotes generation and maintenance of human forebrain Olig2 progenitors
    • Ortega JA, Radonjic NV, Zecevic N,. 2013. Sonic hedgehog promotes generation and maintenance of human forebrain Olig2 progenitors. Front Cell Neurosci 7: 254.
    • (2013) Front Cell Neurosci , vol.7 , pp. 254
    • Ortega, J.A.1    Radonjic, N.V.2    Zecevic, N.3
  • 82
    • 84875452685 scopus 로고    scopus 로고
    • Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals
    • Palm W, Swierczynska MM, Kumari V, Ehrhart-Bornstein M, Bornstein SR, Eaton S,. 2013. Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. PLoS Biol 11 (3): e1001505.
    • (2013) PLoS Biol , vol.11 , Issue.3 , pp. e1001505
    • Palm, W.1    Swierczynska, M.M.2    Kumari, V.3    Ehrhart-Bornstein, M.4    Bornstein, S.R.5    Eaton, S.6
  • 83
    • 84885661260 scopus 로고    scopus 로고
    • Functional interaction between autophagy and ciliogenesis
    • others
    • Pampliega O, Orhon I, Patel B, Sridhar S, Diaz-Carretero A, Beau I, and others. 2013. Functional interaction between autophagy and ciliogenesis. Nature 502 (7470): 194-200.
    • (2013) Nature , vol.502 , Issue.7470 , pp. 194-200
    • Pampliega, O.1    Orhon, I.2    Patel, B.3    Sridhar, S.4    Diaz-Carretero, A.5    Beau, I.6
  • 84
    • 84859709125 scopus 로고    scopus 로고
    • Sonic hedgehog is cytoprotective against oxidative challenge in a cellular model of amyotrophic lateral sclerosis
    • Peterson R, Turnbull J,. 2012. Sonic hedgehog is cytoprotective against oxidative challenge in a cellular model of amyotrophic lateral sclerosis. J Mol Neurosci 47 (1): 31-41.
    • (2012) J Mol Neurosci , vol.47 , Issue.1 , pp. 31-41
    • Peterson, R.1    Turnbull, J.2
  • 85
    • 84866446340 scopus 로고    scopus 로고
    • Sonic hedgehog distribution within mature hippocampal neurons
    • Petralia RS, Wang YX, Mattson MP, Yao PJ,. 2011. Sonic hedgehog distribution within mature hippocampal neurons. Commun Integr Biol 4 (6): 775-7.
    • (2011) Commun Integr Biol , vol.4 , Issue.6 , pp. 775-777
    • Petralia, R.S.1    Wang, Y.X.2    Mattson, M.P.3    Yao, P.J.4
  • 86
    • 85027939713 scopus 로고    scopus 로고
    • Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma
    • Epub Jan 27. doi:
    • Petrova E, Matevossian A, Resh MD,. 2014. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. Epub Jan 27. doi: 10.1038/onc.2013.575.
    • (2014) Oncogene
    • Petrova, E.1    Matevossian, A.2    Resh, M.D.3
  • 87
    • 84886691865 scopus 로고    scopus 로고
    • Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions
    • Petrova R, Garcia AD, Joyner AL,. 2013. Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions. J Neurosci 33 (44): 17490-505.
    • (2013) J Neurosci , vol.33 , Issue.44 , pp. 17490-17505
    • Petrova, R.1    Garcia, A.D.2    Joyner, A.L.3
  • 88
    • 0029844192 scopus 로고    scopus 로고
    • Cholesterol modification of hedgehog signaling proteins in animal development
    • Porter JA, Young KE, Beachy PA,. 1996. Cholesterol modification of hedgehog signaling proteins in animal development. Science 274 (5285): 255-9.
    • (1996) Science , vol.274 , Issue.5285 , pp. 255-259
    • Porter, J.A.1    Young, K.E.2    Beachy, P.A.3
  • 89
    • 78650734598 scopus 로고    scopus 로고
    • Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression
    • Pozniak CD, Langseth AJ, Dijkgraaf GJ, Choe Y, Werb Z, Pleasure SJ,. 2010. Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression. Proc Natl Acad Sci U S A 107 (50): 21795-800.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.50 , pp. 21795-21800
    • Pozniak, C.D.1    Langseth, A.J.2    Dijkgraaf, G.J.3    Choe, Y.4    Werb, Z.5    Pleasure, S.J.6
  • 90
    • 79957618775 scopus 로고    scopus 로고
    • KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes
    • others
    • Putoux A, Thomas S, Coene KL, Davis EE, Alalnay Y, Ogur G, and others. 2011. KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes. Nat Genet 43 (6): 601-6.
    • (2011) Nat Genet , vol.43 , Issue.6 , pp. 601-606
    • Putoux, A.1    Thomas, S.2    Coene, K.L.3    Davis, E.E.4    Alalnay, Y.5    Ogur, G.6
  • 91
    • 84885089031 scopus 로고    scopus 로고
    • Sonic Hedgehog modulates EGFR dependent proliferation of neural stem cells during late mouse embryogenesis through EGFR transactivation
    • others
    • Reinchisi G, Parada M, Lois P, Oyanadel C, Shaughnessy R, Gonzalez A, and others. 2013. Sonic Hedgehog modulates EGFR dependent proliferation of neural stem cells during late mouse embryogenesis through EGFR transactivation. Front Cell Neurosci 7: 166.
    • (2013) Front Cell Neurosci , vol.7 , pp. 166
    • Reinchisi, G.1    Parada, M.2    Lois, P.3    Oyanadel, C.4    Shaughnessy, R.5    Gonzalez, A.6
  • 92
    • 84867799739 scopus 로고    scopus 로고
    • The Hedgehog signal transduction network
    • Robbins DJ, Fei DL, Riobo NA,. 2012. The Hedgehog signal transduction network. Sci Signal 5 (246): re6.
    • (2012) Sci Signal , vol.5 , Issue.246 , pp. re6
    • Robbins, D.J.1    Fei, D.L.2    Riobo, N.A.3
  • 93
    • 76149133124 scopus 로고    scopus 로고
    • The molecular genetics of holoprosencephaly
    • Roessler E, Muenke M,. 2010. The molecular genetics of holoprosencephaly. Am J Med Genet C Semin Med Genet 154C (1): 56-61.
    • (2010) Am J Med Genet C Semin Med Genet , vol.154 , Issue.1 , pp. 56-61
    • Roessler, E.1    Muenke, M.2
  • 94
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott MP,. 2007. Patched1 regulates hedgehog signaling at the primary cilium. Science 317 (5836): 372-6.
    • (2007) Science , vol.317 , Issue.5836 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 95
    • 84877731532 scopus 로고    scopus 로고
    • Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina
    • others
    • Sanchez-Arrones L, Nieto-Lopez F, Sanchez-Camacho C, Carreres MI, Herrera E, Okada A, and others. 2013. Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina. J Neurosci 33 (20): 8596-607.
    • (2013) J Neurosci , vol.33 , Issue.20 , pp. 8596-8607
    • Sanchez-Arrones, L.1    Nieto-Lopez, F.2    Sanchez-Camacho, C.3    Carreres, M.I.4    Herrera, E.5    Okada, A.6
  • 96
    • 84878392551 scopus 로고    scopus 로고
    • Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning
    • Sanders TA, Llagostera E, Barna M,. 2013. Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning. Nature 497 (7451): 628-32.
    • (2013) Nature , vol.497 , Issue.7451 , pp. 628-632
    • Sanders, T.A.1    Llagostera, E.2    Barna, M.3
  • 97
    • 78650844253 scopus 로고    scopus 로고
    • Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages
    • others
    • Shikata Y, Okada T, Hashimoto M, Ellis T, Matsumaru D, Shiroishi T, and others. 2011. Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages. Dev Biol 349 (2): 147-59.
    • (2011) Dev Biol , vol.349 , Issue.2 , pp. 147-159
    • Shikata, Y.1    Okada, T.2    Hashimoto, M.3    Ellis, T.4    Matsumaru, D.5    Shiroishi, T.6
  • 98
    • 84875946599 scopus 로고    scopus 로고
    • Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]
    • others
    • Sirko S, Behrendt G, Johansson PA, Tripathi P, Costa M, Bek S, and others. 2013. Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]. Cell Stem Cell 12 (4): 426-39.
    • (2013) Cell Stem Cell , vol.12 , Issue.4 , pp. 426-439
    • Sirko, S.1    Behrendt, G.2    Johansson, P.A.3    Tripathi, P.4    Costa, M.5    Bek, S.6
  • 99
    • 77954955134 scopus 로고    scopus 로고
    • Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
    • Sousa VH, Fishell G,. 2010. Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain. Curr Opin Genet Dev 20 (4): 391-9.
    • (2010) Curr Opin Genet Dev , vol.20 , Issue.4 , pp. 391-399
    • Sousa, V.H.1    Fishell, G.2
  • 100
    • 42649103998 scopus 로고    scopus 로고
    • Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool
    • others
    • Spassky N, Han YG, Aguilar A, Strehl L, Besse L, Laclef C, and others. 2008. Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool. Dev Biol. 317 (1): 246-59.
    • (2008) Dev Biol , vol.317 , Issue.1 , pp. 246-259
    • Spassky, N.1    Han, Y.G.2    Aguilar, A.3    Strehl, L.4    Besse, L.5    Laclef, C.6
  • 101
    • 84867269642 scopus 로고    scopus 로고
    • Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time
    • Su CY, Bay SN, Mariani LE, Hillman MJ, Caspary T,. 2012. Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time. Development 139 (21): 4062-71.
    • (2012) Development , vol.139 , Issue.21 , pp. 4062-4071
    • Su, C.Y.1    Bay, S.N.2    Mariani, L.E.3    Hillman, M.J.4    Caspary, T.5
  • 102
    • 84876691602 scopus 로고    scopus 로고
    • Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development
    • Tang M, Luo SX, Tang V, Huang EJ,. 2013. Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development. Neural Dev 8: 8.
    • (2013) Neural Dev , vol.8 , pp. 8
    • Tang, M.1    Luo, S.X.2    Tang, V.3    Huang, E.J.4
  • 103
    • 84859177990 scopus 로고    scopus 로고
    • Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway
    • Taniguchi K, Anderson AE, Sutherland AE, Wotton D,. 2012. Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway. PLoS Genet 8 (2): e1002524.
    • (2012) PLoS Genet , vol.8 , Issue.2 , pp. e1002524
    • Taniguchi, K.1    Anderson, A.E.2    Sutherland, A.E.3    Wotton, D.4
  • 104
    • 84884399058 scopus 로고    scopus 로고
    • RIO kinase 3 acts as a SUFU-dependent positive regulator of Hedgehog signaling
    • others
    • Tariki M, Wieczorek SA, Schneider P, Banfer S, Veitinger S, Jacob R, and others. 2013. RIO kinase 3 acts as a SUFU-dependent positive regulator of Hedgehog signaling. Cell Signal 25 (12): 2668-75.
    • (2013) Cell Signal , vol.25 , Issue.12 , pp. 2668-2675
    • Tariki, M.1    Wieczorek, S.A.2    Schneider, P.3    Banfer, S.4    Veitinger, S.5    Jacob, R.6
  • 106
    • 84870978645 scopus 로고    scopus 로고
    • Sulfatase 1 promotes the motor neuron-to-oligodendrocyte fate switch by activating Shh signaling in Olig2 progenitors of the embryonic ventral spinal cord
    • Touahri Y, Escalas N, Benazeraf B, Cochard P, Danesin C, Soula C,. 2012. Sulfatase 1 promotes the motor neuron-to-oligodendrocyte fate switch by activating Shh signaling in Olig2 progenitors of the embryonic ventral spinal cord. J Neurosci 32 (50): 18018-34.
    • (2012) J Neurosci , vol.32 , Issue.50 , pp. 18018-18034
    • Touahri, Y.1    Escalas, N.2    Benazeraf, B.3    Cochard, P.4    Danesin, C.5    Soula, C.6
  • 107
    • 77950664245 scopus 로고    scopus 로고
    • Sonic Hedgehog signaling in the mammalian brain
    • Traiffort E, Angot E, Ruat M,. 2010. Sonic Hedgehog signaling in the mammalian brain. J Neurochem 113 (3): 576-90.
    • (2010) J Neurochem , vol.113 , Issue.3 , pp. 576-590
    • Traiffort, E.1    Angot, E.2    Ruat, M.3
  • 108
    • 34547408924 scopus 로고    scopus 로고
    • High expression and anterograde axonal transport of aminoterminal sonic hedgehog in the adult hamster brain
    • Traiffort E, Moya KL, Faure H, Hassig R, Ruat M,. 2001. High expression and anterograde axonal transport of aminoterminal sonic hedgehog in the adult hamster brain. Eur J Neurosci 14 (5): 839-50.
    • (2001) Eur J Neurosci , vol.14 , Issue.5 , pp. 839-850
    • Traiffort, E.1    Moya, K.L.2    Faure, H.3    Hassig, R.4    Ruat, M.5
  • 109
    • 84880528267 scopus 로고    scopus 로고
    • The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome
    • Trazzi S, Fuchs C, Valli E, Perini G, Bartesaghi R, Ciani E,. 2013. The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome. J Biol Chem 288 (29): 20817-29.
    • (2013) J Biol Chem , vol.288 , Issue.29 , pp. 20817-20829
    • Trazzi, S.1    Fuchs, C.2    Valli, E.3    Perini, G.4    Bartesaghi, R.5    Ciani, E.6
  • 110
    • 0034755395 scopus 로고    scopus 로고
    • Control of retinal ganglion cell axon growth: A new role for Sonic hedgehog
    • Trousse F, Marti E, Gruss P, Torres M, Bovolenta P,. 2001. Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog. Development 128 (20): 3927-36.
    • (2001) Development , vol.128 , Issue.20 , pp. 3927-3936
    • Trousse, F.1    Marti, E.2    Gruss, P.3    Torres, M.4    Bovolenta, P.5
  • 111
    • 84863568816 scopus 로고    scopus 로고
    • Temporally- and spatially regulated generation of distinct descendants by sonic hedgehog-expressing progenitors in the forebrain
    • Wada Y, Yamauchi K, Murakami F, Tanabe Y,. 2012. Temporally- and spatially regulated generation of distinct descendants by sonic hedgehog-expressing progenitors in the forebrain. Dev Neurobiol 72 (8): 1099-113.
    • (2012) Dev Neurobiol , vol.72 , Issue.8 , pp. 1099-1113
    • Wada, Y.1    Yamauchi, K.2    Murakami, F.3    Tanabe, Y.4
  • 112
    • 84878112106 scopus 로고    scopus 로고
    • Structure of the human smoothened receptor bound to an antitumour agent
    • others
    • Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, and others. 2013. Structure of the human smoothened receptor bound to an antitumour agent. Nature 497 (7449): 338-43.
    • (2013) Nature , vol.497 , Issue.7449 , pp. 338-343
    • Wang, C.1    Wu, H.2    Katritch, V.3    Han, G.W.4    Huang, X.P.5    Liu, W.6
  • 113
    • 78349305842 scopus 로고    scopus 로고
    • Direct and indirect requirements of Shh/Gli signaling in early pituitary development
    • Wang Y, Martin JF, Bai CB,. 2010. Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev Biol 348 (2): 199-209.
    • (2010) Dev Biol , vol.348 , Issue.2 , pp. 199-209
    • Wang, Y.1    Martin, J.F.2    Bai, C.B.3
  • 114
    • 84881499818 scopus 로고    scopus 로고
    • Sonic hedgehog regulates its own receptor on postcrossing commissural axons in a glypican1-dependent manner
    • Wilson NH, Stoeckli ET,. 2013. Sonic hedgehog regulates its own receptor on postcrossing commissural axons in a glypican1-dependent manner. Neuron 79 (3): 478-91.
    • (2013) Neuron , vol.79 , Issue.3 , pp. 478-491
    • Wilson, N.H.1    Stoeckli, E.T.2
  • 115
    • 84883722622 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycans containing a glypican 5 core and 2- O -sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation
    • others
    • Witt RM, Hecht ML, Pazyra-Murphy MF, Cohen SM, Noti C, van Kuppevelt TH, and others. 2013. Heparan sulfate proteoglycans containing a glypican 5 core and 2- O -sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation. J Biol Chem 288 (36): 26275-88.
    • (2013) J Biol Chem , vol.288 , Issue.36 , pp. 26275-26288
    • Witt, R.M.1    Hecht, M.L.2    Pazyra-Murphy, M.F.3    Cohen, S.M.4    Noti, C.5    Van Kuppevelt, T.H.6
  • 116
    • 84860669184 scopus 로고    scopus 로고
    • Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation
    • others
    • Wu M, Hernandez M, Shen S, Sabo JK, Kelkar D, Wang J, and others. 2012. Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation. J Neurosci 32 (19): 6651-64.
    • (2012) J Neurosci , vol.32 , Issue.19 , pp. 6651-6664
    • Wu, M.1    Hernandez, M.2    Shen, S.3    Sabo, J.K.4    Kelkar, D.5    Wang, J.6
  • 117
    • 84876939667 scopus 로고    scopus 로고
    • Specified neural progenitors sort to form sharp domains after noisy Shh signaling
    • others
    • Xiong F, Tentner AR, Huang P, Gelas A, Mosaliganti KR, Souhait L, and others. 2013. Specified neural progenitors sort to form sharp domains after noisy Shh signaling. Cell 153 (3): 550-61.
    • (2013) Cell , vol.153 , Issue.3 , pp. 550-561
    • Xiong, F.1    Tentner, A.R.2    Huang, P.3    Gelas, A.4    Mosaliganti, K.R.5    Souhait, L.6
  • 118
    • 84887412399 scopus 로고    scopus 로고
    • Signaling mechanisms of non-conventional axon guidance cues: The Shh, BMP and Wnt morphogens
    • Yam PT, Charron F,. 2013. Signaling mechanisms of non-conventional axon guidance cues: the Shh, BMP and Wnt morphogens. Curr Opin Neurobiol 23 (6): 965-73.
    • (2013) Curr Opin Neurobiol , vol.23 , Issue.6 , pp. 965-973
    • Yam, P.T.1    Charron, F.2
  • 119
    • 84869840135 scopus 로고    scopus 로고
    • 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing
    • others
    • Yam PT, Kent CB, Morin S, Farmer WT, Alchini R, Lepelletier L, and others. 2012. 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing. Neuron 76 (4): 735-49.
    • (2012) Neuron , vol.76 , Issue.4 , pp. 735-749
    • Yam, P.T.1    Kent, C.B.2    Morin, S.3    Farmer, W.T.4    Alchini, R.5    Lepelletier, L.6
  • 120
    • 65549101582 scopus 로고    scopus 로고
    • Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway
    • Yam PT, Langlois SD, Morin S, Charron F,. 2009. Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway. Neuron 62 (3): 349-62.
    • (2009) Neuron , vol.62 , Issue.3 , pp. 349-362
    • Yam, P.T.1    Langlois, S.D.2    Morin, S.3    Charron, F.4
  • 121
    • 84875074444 scopus 로고    scopus 로고
    • Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord
    • Yu K, McGlynn S, Matise MP,. 2013. Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development 140 (7): 1594-604.
    • (2013) Development , vol.140 , Issue.7 , pp. 1594-1604
    • Yu, K.1    McGlynn, S.2    Matise, M.P.3
  • 123
    • 84887702556 scopus 로고    scopus 로고
    • Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci
    • others
    • Zhang Y, Fu L, Qi X, Zhang Z, Xia Y, Jia J, and others. 2013b. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun 4: 2608.
    • (2013) Nat Commun , vol.4 , pp. 2608
    • Zhang, Y.1    Fu, L.2    Qi, X.3    Zhang, Z.4    Xia, Y.5    Jia, J.6
  • 124
    • 84863393632 scopus 로고    scopus 로고
    • Disruption of SoxB1-dependent Sonic Hedgehog expression in the hypothalamus causes septo-optic dysplasia
    • Zhao L, Zevallos SE, Rizzoti K, Jeong Y, Lovell-Badge R, Epstein DJ,. 2012. Disruption of SoxB1-dependent Sonic Hedgehog expression in the hypothalamus causes septo-optic dysplasia. Dev Cell 22 (3): 585-96.
    • (2012) Dev Cell , vol.22 , Issue.3 , pp. 585-596
    • Zhao, L.1    Zevallos, S.E.2    Rizzoti, K.3    Jeong, Y.4    Lovell-Badge, R.5    Epstein, D.J.6
  • 125
    • 36049033946 scopus 로고    scopus 로고
    • Hedgehog regulates smoothened activity by inducing a conformational switch
    • Zhao Y, Tong C, Jiang J,. 2007. Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 450 (7167): 252-8.
    • (2007) Nature , vol.450 , Issue.7167 , pp. 252-258
    • Zhao, Y.1    Tong, C.2    Jiang, J.3
  • 126
    • 84870320094 scopus 로고    scopus 로고
    • MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling
    • others
    • Zhou H, Spaeth JM, Kim NH, Xu X, Friez MJ, Schwartz CE, and others. 2012. MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling. Proc Natl Acad Sci U S A 109 (48): 19763-8.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.48 , pp. 19763-19768
    • Zhou, H.1    Spaeth, J.M.2    Kim, N.H.3    Xu, X.4    Friez, M.J.5    Schwartz, C.E.6


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