Cdon Mutation and Fetal Ethanol Exposure Synergize to Produce Midline Signaling Defects and Holoprosencephaly Spectrum Disorders in Mice

PLoS Genetics

Volumn 8, Issue 10, 2012, Pages

  Hong, Mingi ^a   Krauss, Robert S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; FIBROBLAST GROWTH FACTOR 8; GOOSECOID PROTEIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR SIX3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CDON GENE; CELL PROLIFERATION; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DISEASE SEVERITY; EMBRYO; FEMALE; FETAL ALCOHOL SYNDROME; FETUS; FGF8 GENE; FOREBRAIN; GENE; GENE EXPRESSION; GENE FUNCTION; GENETIC SUSCEPTIBILITY; GENOTYPE ENVIRONMENT INTERACTION; GLI1 GENE; HOLOPROSENCEPHALY; LOSS OF FUNCTION MUTATION; MOUSE; NKX2.1 GENE; NONHUMAN; PHENOTYPE; PRENATAL EXPOSURE; PROTEIN EXPRESSION; PTCH1 GENE; RISK FACTOR; SIGNAL TRANSDUCTION; SOMITE;

ANIMALS; BRAIN; CELL ADHESION MOLECULES; CRANIOFACIAL ABNORMALITIES; DEVELOPMENTAL DISABILITIES; ETHANOL; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GOOSECOID PROTEIN; HEDGEHOG PROTEINS; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HOLOPROSENCEPHALY; MATERNAL EXPOSURE; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; MUTATION; NEURAL TUBE DEFECTS; PHENOTYPE; SIGNAL TRANSDUCTION;

ERINACEIDAE; MUS;

EID: 84868088488     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002999     Document Type: Article

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