The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the ts65dn mouse model for down syndrome

Journal of Biological Chemistry

Volumn 288, Issue 29, 2013, Pages 20817-20829

  Trazzi, Stefania ^a   Fuchs, Claudia ^a   Valli, Emanuele ^b   Perini, Giovanni ^b   Bartesaghi, Renata ^a   Ciani, Elisabetta ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEINS; BRAIN DEVELOPMENT; DIFFERENT DOMAINS; DOWN SYNDROME; MENTAL RETARDATION; MOUSE MODELS; NEURITES; NEUROGENESIS;

GENE EXPRESSION; HANDICAPPED PERSONS;

NEURONS;

AMYLOID PRECURSOR PROTEIN; JANUS KINASE; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOREGULATION; BINDING AFFINITY; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; GENE OVEREXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MALE; MOLECULAR CLONING; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURITE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS PARTICLE;

APP; ASTROGLIOGENESIS; CELL CULTURE; DOWN SYNDROME; NEURITE OUTGROWTH; NEUROBIOLOGY; NEURODEVELOPMENT; NEUROGENESIS; NEUROPROGENITOR CELL;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASTROCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CELL SHAPE; DISEASE MODELS, ANIMAL; DOWN SYNDROME; FEMALE; GENE SILENCING; HEDGEHOG PROTEINS; HIPPOCAMPUS; HUMANS; INTERLEUKIN-6; MALE; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; NEURAL STEM CELLS; NEURITES; NEUROGENESIS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRISOMY;

EID: 84880528267     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.451088     Document Type: Article

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