Sonic hedgehog is cytoprotective against oxidative challenge in a cellular model of amyotrophic lateral sclerosis

Journal of Molecular Neuroscience

Volumn 47, Issue 1, 2012, Pages 31-41

  Peterson, Randy ^a   Turnbull, John ^a  

^a MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

Amyotrophic lateral sclerosis; HT22 cell culture; Oxidative stress; Sonic hedgehog

Indexed keywords

CYCLOPAMINE; HYDROGEN PEROXIDE; MICRORNA; RECOMBINANT PROTEIN; SONIC HEDGEHOG PROTEIN; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BRAIN PROTECTION; NERVE CELL NECROSIS; OXIDATIVE STRESS; PROTEIN EXPRESSION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL LINE; HEDGEHOG PROTEINS; HUMANS; HYDROGEN PEROXIDE; MICE; NEURONS; OXIDANTS; OXIDATIVE STRESS;

ERINACEIDAE; MUS;

EID: 84859709125     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9660-x     Document Type: Article

References (41)

1. ALS Online Genetic Database. http://alsod.iop.kcl.ac.uk/
2. Barber SC, Shaw PJ (2010) Oxidative stress in ALS: key role in motor neuron injury and therapeutic target. Free Radic Biol Med 48:629-641
3. Bond C, Tang Y, Podlasek CA (2008) Neural influences on sonic hedgehog and apoptosis in the rat penis. Biol Reprod 78:947-956 (Pubitemid 351657369)
4. Briscoe J (2009) Making a grade: sonic hedgehog signalling and the control of neural cell fate. EMBO J 28:457-465
5. Cai C, Thorne J, Grabel L (2008) Hedgehog serves as a mitogen and survival factor during embryonic stem cell neurogenesis. Stem Cells (Dayton, Ohio) 26:1097-1108
6. Calcutt NA, Allendoerfer KL, Mizisin AP, Middlemas A, Freshwater JD, Burgers M, Ranciato R, Delcroix JD, Taylor FR, Shapiro R, Strauch K, Dudek H, Engber TM, Galdes A, Rubin LL, Tomlinson DR (2003) Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. J Clin Invest 111:507-514 (Pubitemid 36228008)
7. Chari NS, McDonnell TJ (2007) The sonic hedgehog signaling network in development and neoplasia. Adv Anat Pathol 14:344-352 (Pubitemid 47312290)
8. Cheng SY, Bishop JM (2002) Suppressor of Fused represses Glimediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc Natl Acad Sci USA 99:5442-5447 (Pubitemid 34411567)
9. Cohen MM Jr (2010) Sonic hedgehog signaling update. Am J Med Genet A 152A(8):1875-1914
10. Dass B, Iravani MM, Huang C, Barsoum J, Engber TM, Galdes A, Jenner P (2005) Sonic hedgehog delivered by an adeno-associated virus protects dopaminergic neurones against 6-OHDA toxicity in the rat. J Neural Transm 112:763-778 (Pubitemid 40655568)
11. Dellovade T, Romer JT, Curran T, Rubin LL (2006) The hedgehog pathway and neurological disorders. Ann Rev Neurosci 29:539-563 (Pubitemid 44476855)
12. Farzan SF, Singh S, Schilling NS, Robbins DJ (2008) The adventures of sonichedgehog in development and repair: III. Hedgehog processing and biological activity. Am J Physiol 294:G844-G849 (Pubitemid 351520053)
13. Ferrante RJ, Shinobu LA, Schulz JB, Matthews RT, Thomas CE, Kowall NW, Gurney ME, Beal MF (1997) Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation. Ann Neurol 42:326-334 (Pubitemid 27391116)
14. Ferretti E, De Smaele E, Miele E, Laneve P, Po A, Pelloni M, Paganelli A, Di Marcotullio L, Caffarelli E, Screpanti I, Bozzoni I, Gulino A (2008) Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J 27:2616-2627
15. Hall ED, Andrus PK, Oostveen JA, Fleck TJ, Gurney ME (1998) Relationship ofoxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS. J Neurosci Res 53:66-77 (Pubitemid 28308982)
16. Humke EW, Dorn KV, Milenkovic L, Scott MP, Rohatgi R (2010) The output of Hedgehog signaling is controlled by the dynamic association between suppressor of fused and the Gli proteins. Genes Dev 24:670-682
17. Hurtado-Lorenzo A, Millan E, Gonzalez-Nicolini V, Suwelack D, Castro MG, Lowenstein PR (2004) Differentiation and transcription factor gene therapy in experimental Parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration. Mol Ther 10:507-524 (Pubitemid 39193167)
18. Jiao J, Chen DF (2008) Induction of neurogenesis in nonconventional neurogenic regions of the adult central nervous system by niche astrocyte-produced signals. Stem cells (Dayton, Ohio) 26:1221-1230
19. Kondo T, Johnson SA, Yoder MC, Romand R, Hashino E (2005) Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells. Proc Natl Acad Sci USA 102:4789-4794 (Pubitemid 40471532)
20. Lanius RA, Krieger C, Wagey R, Shaw CA (1993) Increased [35S]glutathione binding sites in spinal cords from patients with sporadic amyotrophic lateral sclerosis. Neurosci Lett 163:89-92
21. Lauth M, Toftgard R (2007) Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy. Cell Cycle (Georgetown, TX) 6:2458-2463 (Pubitemid 350058663)
22. Lee M, Hyun DH, Halliwell B, Jenner P (2001) Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative stress and cell death induced by hydrogen peroxide, 4-hydroxynonenal or serum deprivation: potentiation of injury by ALS-related mutant superoxide dismutases and protection by Bcl-2. J Neurochem 78:209-220 (Pubitemid 32664402)
23. Li L, Li Y, Ji X, Zhang B, Wei H, Luo Y (2008) The effects of retinoic acid on the expression of neurogranin after experimental cerebral ischemia. Brain Res 1226:234-240
24. Ma X, Peterson R, Turnbull J (2011) Adenylyl cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93ASOD1 mice. BMC Neurosci 12(1):71
25. Maher P, Davis JB (1996) The role of monoamine metabolism in oxidative glutamate toxicity. J Neurosci 16:6394-6401 (Pubitemid 26337363)
26. Miao N, Wang M, Ott JA, D'Alessandro JS, Woolf TM, Bumcrot DA, Mahanthappa NK, Pang K (1997) Sonic hedgehog promotes survival of specific CNS neuron populations and protects these cells from Toxic insults in vitro. J Neurosci 17(15):5891-5899 (Pubitemid 27310503)
27. Mir M, Asensio VJ, Tolosa L, Gou-Fabregas M, Soler RM, Llado J, Olmos G (2009) Tumor necrosis factor alpha and interferon gamma cooperatively induce oxidative stress and motoneuron death in rat spinal cord embryonic explants. Neuroscience 162:959-971
28. Morgan DM (1998) Tetrazolium (MTT) assay for cellular viability and activity. Methods Mol Biol (Clifton, NJ) 79:179-183
29. Palma V, Lim DA, Dahmane N, Sanchez P, Brionne TC, Herzberg CD, Gitton Y, Carleton A, Alvarez-Buylla A, Ruiz i Altaba A (2005) Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development (Cambridge, England) 132:335-344 (Pubitemid 40268283)
30. Pasinelli P, Brown RH (2006) Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nature Rev 7:710-723 (Pubitemid 44267495)
31. Pedersen WA, Fu W, Keller JN, Markesbery WR, Appel S, Smith RG, Kasarskis E, Mattson MP (1998) Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Ann Neurol 44:819-824 (Pubitemid 28516055)
32. Rosen DR (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362 (6415):59-62
33. Rothstein JD (2009) Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol 65(Suppl 1):S3-S9
34. Schiffer D, Fiano V (2004) Astrogliosis in ALS: possible interpretations according to pathogenetic hypotheses. Amyotroph Lateral Scler Other Motor Neuron Disord 5:22-25 (Pubitemid 38618731)
35. Shaw IC, Fitzmaurice PS, Mitchell JD, Lynch PG (1995) Studies on cellular free radical protection mechanisms in the anterior horn from patients with amyotrophic lateral sclerosis. Neurodegeneration 4:391-396 (Pubitemid 26016927)
36. So PL, Yip PK, Bunting S, Wong LF, Mazarakis ND, Hall S, McMahon S, Maden M, Corcoran JP (2006) Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth. Dev Biol 298:167-175 (Pubitemid 44425438)
37. Stanton BZ, Peng LF (2010) Small-molecule modulators of the sonic hedgehog signaling pathway. Mol Biosyst 6:44-54
38. Stecca B, Ruiz i Altaba A (2002) The therapeutic potential of modulators of the hedgehog-Gli signaling pathway. J Biol 1:9
39. Stenkamp DL, Satterfield R, Muhunthan K, Sherpa T, Vihtelic TS, Cameron DA (2008) Age-related cone abnormalities in zebrafish with genetic lesions in sonic hedgehog. Invest Ophthalmol Vis Sci 49:4631-4640
40. Tsuboi K, Shults CW (2002) Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease. Exp Neurol 173:95-104 (Pubitemid 34081729)
41. Wang Y, Imitola J, Rasmussen S, O'Connor KC, Khoury SJ (2008) Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. Ann Neurol 64:417-427