메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages 106-111

Role of NADPH oxidases in the redox biology of liver fibrosis

Author keywords

Hepatocyte; Inflammation; Myofibroblast; NOX; Stellate cell; TGF beta

Indexed keywords

REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT; ANTIOXIDANT; ANTIVIRUS AGENT; ENZYME INHIBITOR; SCLEROPROTEIN;

EID: 84937571378     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2015.07.005     Document Type: Review
Times cited : (135)

References (68)
  • 1
    • 84875094295 scopus 로고    scopus 로고
    • Hepatic regeneration and the epithelial to mesenchymal transition
    • Xue Z.-F., Wu X.-M., Liu M. Hepatic regeneration and the epithelial to mesenchymal transition. World J. Gastroenterol. 2013, 19:1380-1386. 10.3748/wjg.v19.i9.1380.
    • (2013) World J. Gastroenterol. , vol.19 , pp. 1380-1386
    • Xue, Z.-F.1    Wu, X.-M.2    Liu, M.3
  • 2
    • 84885590292 scopus 로고    scopus 로고
    • Cellular mechanisms of tissue fibrosis. 5. Novel insights into liver fibrosis
    • Mallat A., Lotersztajn S. Cellular mechanisms of tissue fibrosis. 5. Novel insights into liver fibrosis. Am. J. Physiol. Cell Physiol. 2013, 305:C789-C799. 10.1152/ajpcell.00230.2013.
    • (2013) Am. J. Physiol. Cell Physiol. , vol.305 , pp. C789-C799
    • Mallat, A.1    Lotersztajn, S.2
  • 3
    • 84877141184 scopus 로고    scopus 로고
    • Evolving therapies for liver fibrosis
    • Schuppan D., Kim Y.O. Evolving therapies for liver fibrosis. J. Clin. Invest. 2013, 123:1887-1901. 10.1172/JCI66028.
    • (2013) J. Clin. Invest. , vol.123 , pp. 1887-1901
    • Schuppan, D.1    Kim, Y.O.2
  • 5
    • 84896826716 scopus 로고    scopus 로고
    • Hepatic inflammation and progressive liver fibrosis in chronic liver disease
    • Czaja A.J. Hepatic inflammation and progressive liver fibrosis in chronic liver disease. World J. Gastroenterol. 2014, 20:2515-2532. 10.3748/wjg.v20.i10.2515.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 2515-2532
    • Czaja, A.J.1
  • 6
    • 79954570719 scopus 로고    scopus 로고
    • Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases
    • Barnes J.L., Gorin Y. Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int. 2011, 79:944-956. 10.1038/ki.2010.516.
    • (2011) Kidney Int. , vol.79 , pp. 944-956
    • Barnes, J.L.1    Gorin, Y.2
  • 7
    • 84930724636 scopus 로고    scopus 로고
    • The Transforming Growth Factor-Beta (TGF-β) in liver fibrosis
    • Springer, A. Moustakas, K. Miyazawa (Eds.)
    • Fabregat I., Sancho P. The Transforming Growth Factor-Beta (TGF-β) in liver fibrosis. TGF-Β in Human Disease 2013, 255-277. Springer. A. Moustakas, K. Miyazawa (Eds.).
    • (2013) TGF-Β in Human Disease , pp. 255-277
    • Fabregat, I.1    Sancho, P.2
  • 8
    • 84882827495 scopus 로고    scopus 로고
    • Decoding cell death signals in liver inflammation
    • Brenner C., Galluzzi L., Kepp O., Kroemer G. Decoding cell death signals in liver inflammation. J. Hepatol. 2013, 59:583-594. 10.1016/j.jhep.2013.03.033.
    • (2013) J. Hepatol. , vol.59 , pp. 583-594
    • Brenner, C.1    Galluzzi, L.2    Kepp, O.3    Kroemer, G.4
  • 9
    • 0036094259 scopus 로고    scopus 로고
    • Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis
    • Kitamura K., Nakamoto Y., Akiyama M., Fujii C., Kondo T., Kobayashi K., et al. Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis. Lab. Investig. J. Tech. Methods Pathol. 2002, 82:571-583.
    • (2002) Lab. Investig. J. Tech. Methods Pathol. , vol.82 , pp. 571-583
    • Kitamura, K.1    Nakamoto, Y.2    Akiyama, M.3    Fujii, C.4    Kondo, T.5    Kobayashi, K.6
  • 11
    • 1542406446 scopus 로고    scopus 로고
    • NOX enzymes and the biology of reactive oxygen
    • Lambeth JD NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol. 2004, 4:181-189. 10.1038/nri1312.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 181-189
  • 13
    • 84882757943 scopus 로고    scopus 로고
    • Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death
    • Dunning S., Ur Rehman A., Tiebosch M.H., Hannivoort R.A., Haijer F.W., Woudenberg J., et al. Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death. Biochim. Biophys. Acta 2013, 1832:2027-2034. 10.1016/j.bbadis.2013.07.008.
    • (2013) Biochim. Biophys. Acta , vol.1832 , pp. 2027-2034
    • Dunning, S.1    Ur Rehman, A.2    Tiebosch, M.H.3    Hannivoort, R.A.4    Haijer, F.W.5    Woudenberg, J.6
  • 15
    • 79954558900 scopus 로고    scopus 로고
    • Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells
    • Novo E., Busletta C., Bonzo L.V., di, Povero D., Paternostro C., Mareschi K., et al. Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells. J. Hepatol. 2011, 54:964-974. 10.1016/j.jhep.2010.09.022.
    • (2011) J. Hepatol. , vol.54 , pp. 964-974
    • Novo, E.1    Busletta, C.2    Bonzo, L.V.3    di Povero, D.4    Paternostro, C.5    Mareschi, K.6
  • 16
    • 79951575880 scopus 로고    scopus 로고
    • α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β
    • Foo N.-P., Lin S.-H., Lee Y.-H., Wu M.-J., Wang Y.-J. α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β. Toxicology 2011, 282:39-46. 10.1016/j.tox.2011.01.009.
    • (2011) Toxicology , vol.282 , pp. 39-46
    • Foo, N.-P.1    Lin, S.-H.2    Lee, Y.-H.3    Wu, M.-J.4    Wang, Y.-J.5
  • 17
    • 84856284247 scopus 로고    scopus 로고
    • Ascorbic acid supplementation down-regulates the alcohol induced oxidative stress, hepatic stellate cell activation, cytotoxicity and mRNA levels of selected fibrotic genes in guinea pigs
    • Abhilash P.A., Harikrishnan R., Indira M. Ascorbic acid supplementation down-regulates the alcohol induced oxidative stress, hepatic stellate cell activation, cytotoxicity and mRNA levels of selected fibrotic genes in guinea pigs. Free Radic. Res. 2012, 46:204-213. 10.3109/10715762.2011.647691.
    • (2012) Free Radic. Res. , vol.46 , pp. 204-213
    • Abhilash, P.A.1    Harikrishnan, R.2    Indira, M.3
  • 18
    • 0036790718 scopus 로고    scopus 로고
    • Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C
    • Yadav D., Hertan H.I., Schweitzer P., Norkus E.P., Pitchumoni C.S. Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C. Am. J. Gastroenterol. 2002, 97:2634-2639. 10.1111/j.1572-0241.2002.06041.x.
    • (2002) Am. J. Gastroenterol. , vol.97 , pp. 2634-2639
    • Yadav, D.1    Hertan, H.I.2    Schweitzer, P.3    Norkus, E.P.4    Pitchumoni, C.S.5
  • 19
    • 54049122222 scopus 로고    scopus 로고
    • Chronic viral hepatitis C, oxidative stress and the coagulation/fibrinolysis system in haemodialysis patients
    • Pawlak K., Zolbach K., Borawski J., Mysliwiec M., Kovalchuk O., Chyczewski L., et al. Chronic viral hepatitis C, oxidative stress and the coagulation/fibrinolysis system in haemodialysis patients. Thromb. Res. 2008, 123:166-170. 10.1016/j.thromres.2008.02.012.
    • (2008) Thromb. Res. , vol.123 , pp. 166-170
    • Pawlak, K.1    Zolbach, K.2    Borawski, J.3    Mysliwiec, M.4    Kovalchuk, O.5    Chyczewski, L.6
  • 20
    • 0035719180 scopus 로고    scopus 로고
    • Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3
    • MacDonald G.A., Bridle K.R., Ward P.J., Walker N.I., Houglum K., George D.K., et al. Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3. J. Gastroenterol. Hepatol. 2001, 16:599-606.
    • (2001) J. Gastroenterol. Hepatol. , vol.16 , pp. 599-606
    • MacDonald, G.A.1    Bridle, K.R.2    Ward, P.J.3    Walker, N.I.4    Houglum, K.5    George, D.K.6
  • 21
    • 29144531843 scopus 로고    scopus 로고
    • Clinicopathological significance of oxidative cellular damage in non-alcoholic fatty liver diseases
    • Seki S., Kitada T., Sakaguchi H. Clinicopathological significance of oxidative cellular damage in non-alcoholic fatty liver diseases. Hepatol. Res. Off. J. Jpn. Soc. Hepatol. 2005, 33:132-134. 10.1016/j.hepres.2005.09.020.
    • (2005) Hepatol. Res. Off. J. Jpn. Soc. Hepatol. , vol.33 , pp. 132-134
    • Seki, S.1    Kitada, T.2    Sakaguchi, H.3
  • 22
    • 84920434932 scopus 로고    scopus 로고
    • Steatosis-induced proteins adducts withlipid peroxidation products and nuclear electrophilic stress in hepatocytes
    • Anavi S., Ni Z., Tirosh O., Fedorova M. Steatosis-induced proteins adducts withlipid peroxidation products and nuclear electrophilic stress in hepatocytes. Redox Biol. 2015, 4:158-168. 10.1016/j.redox.2014.12.009.
    • (2015) Redox Biol. , vol.4 , pp. 158-168
    • Anavi, S.1    Ni, Z.2    Tirosh, O.3    Fedorova, M.4
  • 24
    • 79960286223 scopus 로고    scopus 로고
    • Signal transduction by reactive oxygen species
    • Finkel T. Signal transduction by reactive oxygen species. J. Cell Biol. 2011, 194:7-15. 10.1083/jcb.201102095.
    • (2011) J. Cell Biol. , vol.194 , pp. 7-15
    • Finkel, T.1
  • 25
    • 84882727355 scopus 로고    scopus 로고
    • Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species
    • Samarakoon R., Dobberfuhl A.D., Cooley C., Overstreet J.M., Patel S., Goldschmeding R., et al. Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species. Cell Signal. 2013, 25:2198-2209. 10.1016/j.cellsig.2013.07.007.
    • (2013) Cell Signal. , vol.25 , pp. 2198-2209
    • Samarakoon, R.1    Dobberfuhl, A.D.2    Cooley, C.3    Overstreet, J.M.4    Patel, S.5    Goldschmeding, R.6
  • 26
    • 84901316606 scopus 로고    scopus 로고
    • Cellular mechanisms and physiological consequences of redox-dependent signalling
    • Holmström K.M., Finkel T. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat. Rev. Mol. Cell Biol. 2014, 15:411-421. 10.1038/nrm3801.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 411-421
    • Holmström, K.M.1    Finkel, T.2
  • 27
    • 53849124696 scopus 로고    scopus 로고
    • NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?
    • Guichard C., Moreau R., Pessayre D., Epperson T.K., Krause K.-H. NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?. Biochem. Soc. Trans. 2008, 36:920-929. 10.1042/BST0360920.
    • (2008) Biochem. Soc. Trans. , vol.36 , pp. 920-929
    • Guichard, C.1    Moreau, R.2    Pessayre, D.3    Epperson, T.K.4    Krause, K.-H.5
  • 28
    • 69949114515 scopus 로고    scopus 로고
    • NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
    • Hecker L., Vittal R., Jones T., Jagirdar R., Luckhardt T.R., Horowitz J.C., et al. NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat. Med. 2009, 15:1077-1081. 10.1038/nm.2005.
    • (2009) Nat. Med. , vol.15 , pp. 1077-1081
    • Hecker, L.1    Vittal, R.2    Jones, T.3    Jagirdar, R.4    Luckhardt, T.R.5    Horowitz, J.C.6
  • 30
    • 78649913769 scopus 로고    scopus 로고
    • Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy
    • Sedeek M., Callera G., Montezano A., Gutsol A., Heitz F., Szyndralewiez C., et al. Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy. Am. J. Physiol. Ren. Physiol. 2010, 299:F1348-F1358. 10.1152/ajprenal.00028.2010.
    • (2010) Am. J. Physiol. Ren. Physiol. , vol.299 , pp. F1348-F1358
    • Sedeek, M.1    Callera, G.2    Montezano, A.3    Gutsol, A.4    Heitz, F.5    Szyndralewiez, C.6
  • 31
    • 75149174337 scopus 로고    scopus 로고
    • NAD(P)H oxidase mediates TGF-β1-induced activation of kidney myofibroblasts
    • Bondi C.D., Manickam N., Lee D.Y., Block K., Gorin Y., Abboud H.E., et al. NAD(P)H oxidase mediates TGF-β1-induced activation of kidney myofibroblasts. J. Am. Soc. Nephrol. 2010, 21:93-102. 10.1681/ASN.2009020146.
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 93-102
    • Bondi, C.D.1    Manickam, N.2    Lee, D.Y.3    Block, K.4    Gorin, Y.5    Abboud, H.E.6
  • 32
    • 27644456575 scopus 로고    scopus 로고
    • NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts
    • Cucoranu I., Clempus R., Dikalova A., Phelan P.J., Ariyan S., Dikalov S., et al. NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ. Res. 2005, 97:900-907. 10.1161/01.RES.0000187457.24338.3D.
    • (2005) Circ. Res. , vol.97 , pp. 900-907
    • Cucoranu, I.1    Clempus, R.2    Dikalova, A.3    Phelan, P.J.4    Ariyan, S.5    Dikalov, S.6
  • 33
    • 77957946240 scopus 로고    scopus 로고
    • Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis
    • De Minicis S., Seki E., Paik Y.-H., Österreicher C.H., Kodama Y., Kluwe J., et al. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology 2010, 52:1420-1430. 10.1002/hep.23804.
    • (2010) Hepatology , vol.52 , pp. 1420-1430
    • De Minicis, S.1    Seki, E.2    Paik, Y.-H.3    Österreicher, C.H.4    Kodama, Y.5    Kluwe, J.6
  • 34
    • 80052023895 scopus 로고    scopus 로고
    • NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation
    • Cui W., Matsuno K., Iwata K., Ibi M., Matsumoto M., Zhang J., et al. NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation. Hepatology 2011, 54:949-958. 10.1002/hep.24465.
    • (2011) Hepatology , vol.54 , pp. 949-958
    • Cui, W.1    Matsuno, K.2    Iwata, K.3    Ibi, M.4    Matsumoto, M.5    Zhang, J.6
  • 35
    • 79955091590 scopus 로고    scopus 로고
    • The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice
    • Paik Y.-H., Iwaisako K., Seki E., Inokuchi S., Schnabl B., Osterreicher C.H., et al. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology 2011, 53:1730-1741. 10.1002/hep.24281.
    • (2011) Hepatology , vol.53 , pp. 1730-1741
    • Paik, Y.-H.1    Iwaisako, K.2    Seki, E.3    Inokuchi, S.4    Schnabl, B.5    Osterreicher, C.H.6
  • 36
    • 33645243410 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo
    • Zhan S.-S., Jiang J.X., Wu J., Halsted C., Friedman S.L., Zern M.A., et al. Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo. Hepatology 2006, 43:435-443. 10.1002/hep.21093.
    • (2006) Hepatology , vol.43 , pp. 435-443
    • Zhan, S.-S.1    Jiang, J.X.2    Wu, J.3    Halsted, C.4    Friedman, S.L.5    Zern, M.A.6
  • 37
    • 84872491620 scopus 로고    scopus 로고
    • Nox4 modulates collagen production stimulated by transforming growth factor β1 in vivo and in vitro
    • Chan E.C., Peshavariya H.M., Liu G.-S., Jiang F., Lim S.-Y., Dusting G.J. Nox4 modulates collagen production stimulated by transforming growth factor β1 in vivo and in vitro. Biochem. Biophys. Res. Commun. 2013, 430:918-925. 10.1016/j.bbrc.2012.11.138.
    • (2013) Biochem. Biophys. Res. Commun. , vol.430 , pp. 918-925
    • Chan, E.C.1    Peshavariya, H.M.2    Liu, G.-S.3    Jiang, F.4    Lim, S.-Y.5    Dusting, G.J.6
  • 38
    • 79952179447 scopus 로고    scopus 로고
    • ROS signaling by NOX4 drives fibroblast-to-myofibroblast differentiation in the diseased prostatic stroma
    • Sampson N., Koziel R., Zenzmaier C., Bubendorf L., Plas E., Jansen-Dürr P., et al. ROS signaling by NOX4 drives fibroblast-to-myofibroblast differentiation in the diseased prostatic stroma. Mol. Endocrinol. 2011, 25:503-515. 10.1210/me.2010-0340.
    • (2011) Mol. Endocrinol. , vol.25 , pp. 503-515
    • Sampson, N.1    Koziel, R.2    Zenzmaier, C.3    Bubendorf, L.4    Plas, E.5    Jansen-Dürr, P.6
  • 39
    • 84893415235 scopus 로고    scopus 로고
    • NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses
    • Jiang F., Liu G.-S., Dusting G.J., Chan E.C. NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses. Redox Biol. 2014, 2:267-272. 10.1016/j.redox.2014.01.012.
    • (2014) Redox Biol. , vol.2 , pp. 267-272
    • Jiang, F.1    Liu, G.-S.2    Dusting, G.J.3    Chan, E.C.4
  • 40
    • 33847651241 scopus 로고    scopus 로고
    • TGF-beta dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells
    • Proell V., Carmona-Cuenca I., Murillo M.M., Huber H., Fabregat I., Mikulits W. TGF-beta dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells. Comp. Hepatol. 2007, 6:1. 10.1186/1476-5926-6-1.
    • (2007) Comp. Hepatol. , vol.6 , pp. 1
    • Proell, V.1    Carmona-Cuenca, I.2    Murillo, M.M.3    Huber, H.4    Fabregat, I.5    Mikulits, W.6
  • 41
    • 84862290446 scopus 로고    scopus 로고
    • Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831 a novel NOX4/NOX1 inhibitor in vivo
    • Jiang J.X., Chen X., Serizawa N., Szyndralewiez C., Page P., Schroder K., et al. Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831 a novel NOX4/NOX1 inhibitor in vivo. Free Radic. Biol. Med. 2012, 53:289-296. 10.1016/j.freeradbiomed.2012.05.007.
    • (2012) Free Radic. Biol. Med. , vol.53 , pp. 289-296
    • Jiang, J.X.1    Chen, X.2    Serizawa, N.3    Szyndralewiez, C.4    Page, P.5    Schroder, K.6
  • 42
    • 84866851052 scopus 로고    scopus 로고
    • NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development
    • Sancho P., Mainez J., Crosas-Molist E., Roncero C., Fernandez-Rodriguez C.M., Pinedo F., et al. NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development. PLoS ONE 2012, 7. 10.1371/journal.pone.0045285.
    • (2012) PLoS ONE , vol.7
    • Sancho, P.1    Mainez, J.2    Crosas-Molist, E.3    Roncero, C.4    Fernandez-Rodriguez, C.M.5    Pinedo, F.6
  • 43
    • 84938093088 scopus 로고    scopus 로고
    • Hepatocyte NADPH oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice
    • Bettaieb A., Jiang J.X., Sasaki Y., Chao T.-I., Kiss Z., Chen X., et al. Hepatocyte NADPH oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice. Gastroenterology 2015, 10.1053/j.gastro.2015.04.009.
    • (2015) Gastroenterology
    • Bettaieb, A.1    Jiang, J.X.2    Sasaki, Y.3    Chao, T.-I.4    Kiss, Z.5    Chen, X.6
  • 44
    • 63349112427 scopus 로고    scopus 로고
    • Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration
    • Aram G., Potter J.J., Liu X., Wang L., Torbenson M.S., Mezey E. Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. Hepatology 2009, 49:911-919. 10.1002/hep.22708.
    • (2009) Hepatology , vol.49 , pp. 911-919
    • Aram, G.1    Potter, J.J.2    Liu, X.3    Wang, L.4    Torbenson, M.S.5    Mezey, E.6
  • 45
    • 77957342908 scopus 로고    scopus 로고
    • Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo
    • Jiang J.X., Venugopal S., Serizawa N., Chen X., Scott F., Li Y., et al. Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo. Gastroenterology 2010, 139:1375-1384. 10.1053/j.gastro.2010.05.074.
    • (2010) Gastroenterology , vol.139 , pp. 1375-1384
    • Jiang, J.X.1    Venugopal, S.2    Serizawa, N.3    Chen, X.4    Scott, F.5    Li, Y.6
  • 46
    • 80053616414 scopus 로고    scopus 로고
    • Reciprocal regulation of NADPH oxidases and the cyclooxygenase-2 pathway
    • Sancho P., Martín-Sanz P., Fabregat I. Reciprocal regulation of NADPH oxidases and the cyclooxygenase-2 pathway. Free Radic. Biol. Med. 2011, 51:1789-1798. 10.1016/j.freeradbiomed.2011.08.011.
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 1789-1798
    • Sancho, P.1    Martín-Sanz, P.2    Fabregat, I.3
  • 47
    • 77957342908 scopus 로고    scopus 로고
    • NOX2 plays a key role in stellate cell activation and liver fibrogenesis in vivo
    • 1375-84.e4
    • Jiang J.X., Venugopal S., Serizawa N., Chen X., Scott F., Li Y., et al. NOX2 plays a key role in stellate cell activation and liver fibrogenesis in vivo. Gastroenterology 2010, 139. 1375-84.e4. 10.1053/j.gastro.2010.05.074.
    • (2010) Gastroenterology , vol.139
    • Jiang, J.X.1    Venugopal, S.2    Serizawa, N.3    Chen, X.4    Scott, F.5    Li, Y.6
  • 48
    • 0347318117 scopus 로고    scopus 로고
    • Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes.
    • Herrera B., Murillo M.M., Alvarez-Barrientos A., Beltrán J., Fernández M., Fabregat I. Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes. Free Radic. Biol. Med. 2004, 36:16-26. 10.1016/j.freeradbiomed.2003.09.020.
    • (2004) Free Radic. Biol. Med. , vol.36 , pp. 16-26
    • Herrera, B.1    Murillo, M.M.2    Alvarez-Barrientos, A.3    Beltrán, J.4    Fernández, M.5    Fabregat, I.6
  • 50
    • 55549098874 scopus 로고    scopus 로고
    • Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity
    • Carmona-Cuenca I., Roncero C., Sancho P., Caja L., Fausto N., Fernández M., et al. Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. J. Hepatol. 2008, 49:965-976. 10.1016/j.jhep.2008.07.021.
    • (2008) J. Hepatol. , vol.49 , pp. 965-976
    • Carmona-Cuenca, I.1    Roncero, C.2    Sancho, P.3    Caja, L.4    Fausto, N.5    Fernández, M.6
  • 51
    • 70350212686 scopus 로고    scopus 로고
    • Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-β-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.
    • Caja L., Sancho P., Bertran E., Iglesias-Serret D., Gil J., Fabregat I. Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-β-induced cell death through impairing up-regulation of the NADPH oxidase NOX4. Cancer Res. 2009, 69:7595-7602. 10.1158/0008-5472.CAN-09-1482.
    • (2009) Cancer Res. , vol.69 , pp. 7595-7602
    • Caja, L.1    Sancho, P.2    Bertran, E.3    Iglesias-Serret, D.4    Gil, J.5    Fabregat, I.6
  • 52
    • 58549101268 scopus 로고    scopus 로고
    • The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms
    • Sancho P., Bertran E., Caja L., Carmona-Cuenca I., Murillo M.M., Fabregat I. The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms. Biochim. Biophys. Acta 2009, 1793:253-263. 10.1016/j.bbamcr.2008.09.003.
    • (2009) Biochim. Biophys. Acta , vol.1793 , pp. 253-263
    • Sancho, P.1    Bertran, E.2    Caja, L.3    Carmona-Cuenca, I.4    Murillo, M.M.5    Fabregat, I.6
  • 53
    • 79952575436 scopus 로고    scopus 로고
    • The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells.
    • Sancho P., Fabregat I. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem. Pharmacol. 2011, 81:917-924. 10.1016/j.bcp.2011.01.007.
    • (2011) Biochem. Pharmacol. , vol.81 , pp. 917-924
    • Sancho, P.1    Fabregat, I.2
  • 55
    • 84926305528 scopus 로고    scopus 로고
    • Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice
    • Jia D., Duan F., Peng P., Sun L., Ruan Y., Gu J. Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice. PloS One 2015, 10:e0121939. 10.1371/journal.pone.0121939.
    • (2015) PloS One , vol.10 , pp. e0121939
    • Jia, D.1    Duan, F.2    Peng, P.3    Sun, L.4    Ruan, Y.5    Gu, J.6
  • 56
    • 84902073708 scopus 로고    scopus 로고
    • Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliary cirrhosis
    • Serviddio G., Bellanti F., Stanca E., Lunetti P., Blonda M., Tamborra R., et al. Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliary cirrhosis. Free Radic. Biol. Med. 2014, 73:117-126. 10.1016/j.freeradbiomed.2014.05.002.
    • (2014) Free Radic. Biol. Med. , vol.73 , pp. 117-126
    • Serviddio, G.1    Bellanti, F.2    Stanca, E.3    Lunetti, P.4    Blonda, M.5    Tamborra, R.6
  • 58
    • 84866403209 scopus 로고    scopus 로고
    • Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis
    • Von Montfort C., Matias N., Fernandez A., Fucho R., Conde de la Rosa L., Martinez-Chantar M.L., et al. Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J. Hepatol. 2012, 57:852-859. 10.1016/j.jhep.2012.05.024.
    • (2012) J. Hepatol. , vol.57 , pp. 852-859
    • Von Montfort, C.1    Matias, N.2    Fernandez, A.3    Fucho, R.4    Conde de la Rosa, L.5    Martinez-Chantar, M.L.6
  • 59
    • 84892390481 scopus 로고    scopus 로고
    • Superoxide anion radicals activate hepatic stellate cells after entry through chloride channels: a new target in liver fibrosis
    • Den Hartog G.J.M., Qi S., van Tilburg J.H.O., Koek G.H., Bast A. Superoxide anion radicals activate hepatic stellate cells after entry through chloride channels: a new target in liver fibrosis. Eur. J. Pharmacol. 2014, 724:140-144. 10.1016/j.ejphar.2013.12.033.
    • (2014) Eur. J. Pharmacol. , vol.724 , pp. 140-144
    • Den Hartog, G.J.M.1    Qi, S.2    van Tilburg, J.H.O.3    Koek, G.H.4    Bast, A.5
  • 60
    • 78951476859 scopus 로고    scopus 로고
    • HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB
    • Lin W., Wu G., Li S., Weinberg E.M., Kumthip K., Peng L.F., et al. HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB. J. Biol. Chem. 2011, 286:2665-2674. 10.1074/jbc.M110.168286.
    • (2011) J. Biol. Chem. , vol.286 , pp. 2665-2674
    • Lin, W.1    Wu, G.2    Li, S.3    Weinberg, E.M.4    Kumthip, K.5    Peng, L.F.6
  • 61
    • 77954101086 scopus 로고    scopus 로고
    • Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis
    • Kawata K., Kobayashi Y., Souda K., Kawamura K., Sumiyoshi S., Takahashi Y., et al. Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis. Antioxid. Redox Signal. 2010, 13:259-268. 10.1089/ars.2009.2903.
    • (2010) Antioxid. Redox Signal. , vol.13 , pp. 259-268
    • Kawata, K.1    Kobayashi, Y.2    Souda, K.3    Kawamura, K.4    Sumiyoshi, S.5    Takahashi, Y.6
  • 62
    • 81555219192 scopus 로고    scopus 로고
    • Long-term ursodeoxycholate improves circulating redox changes in primary biliary cirrhotic patients
    • Grattagliano I., Palmieri V.O., Portincasa P., Minerva F., Palasciano G. Long-term ursodeoxycholate improves circulating redox changes in primary biliary cirrhotic patients. Clin. Biochem. 2011, 44:1400-1404. 10.1016/j.clinbiochem.2011.09.008.
    • (2011) Clin. Biochem. , vol.44 , pp. 1400-1404
    • Grattagliano, I.1    Palmieri, V.O.2    Portincasa, P.3    Minerva, F.4    Palasciano, G.5
  • 63
    • 84923225348 scopus 로고    scopus 로고
    • Suppression of oxidative stress and improvement of liver functions in mice by ursolic acid via LKB1-AMP-activated protein kinase signaling
    • Yang Y., Zhao Z., Liu Y., Kang X., Zhang H., Meng M. Suppression of oxidative stress and improvement of liver functions in mice by ursolic acid via LKB1-AMP-activated protein kinase signaling. J. Gastroenterol. Hepatol. 2015, 30:609-618. 10.1111/jgh.12723.
    • (2015) J. Gastroenterol. Hepatol. , vol.30 , pp. 609-618
    • Yang, Y.1    Zhao, Z.2    Liu, Y.3    Kang, X.4    Zhang, H.5    Meng, M.6
  • 64
    • 84879160597 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy
    • Hernández-Gea V., Hilscher M., Rozenfeld R., Lim M.P., Nieto N., Werner S., et al. Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. J. Hepatol. 2013, 59:98-104. 10.1016/j.jhep.2013.02.016.
    • (2013) J. Hepatol. , vol.59 , pp. 98-104
    • Hernández-Gea, V.1    Hilscher, M.2    Rozenfeld, R.3    Lim, M.P.4    Nieto, N.5    Werner, S.6
  • 66
    • 84866950669 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide phosphate oxidase (NOX) in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent
    • Aoyama T., Paik Y.-H., Watanabe S., Laleu B., Gaggini F., Fioraso-Cartier L., et al. Nicotinamide adenine dinucleotide phosphate oxidase (NOX) in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatolology 2012, 56:2316-2327. 10.1002/hep.25938.
    • (2012) Hepatolology , vol.56 , pp. 2316-2327
    • Aoyama, T.1    Paik, Y.-H.2    Watanabe, S.3    Laleu, B.4    Gaggini, F.5    Fioraso-Cartier, L.6
  • 67
    • 77956629716 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth
    • Senturk S., Mumcuoglu M., Gursoy-Yuzugullu O., Cingoz B., Akcali K.C., Ozturk M. Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth. Hepatology 2010, 52:966-974. 10.1002/hep.23769.
    • (2010) Hepatology , vol.52 , pp. 966-974
    • Senturk, S.1    Mumcuoglu, M.2    Gursoy-Yuzugullu, O.3    Cingoz, B.4    Akcali, K.C.5    Ozturk, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.