Suppression of oxidative stress and improvement of liver functions in mice by ursolic acid via LKB1-AMP-activated protein kinase signaling

Journal of Gastroenterology and Hepatology (Australia)

Volumn 30, Issue 3, 2015, Pages 609-618

  Yang, Yongbin ^a   Zhao, Zhanxue ^a   Liu, Yuanjun ^a   Kang, Xianjiang ^a   Zhang, Haisong ^b   Meng, Ming ^a  

^a HEBEI UNIVERSITY   (China)

^b Department of Pharmacy Bethune Medical Sergeant Academy   (China)

Author keywords

AMPK; Fibrosis; Inflammation; Liver; Oxidative stress; Ursolic acid

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CASPASE 3; CASPASE 7; CYCLOOXYGENASE 2; ETHIDIUM BROMIDE; GLUTATHIONE PEROXIDASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PROTEIN KINASE LKB1; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; URSOLIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; PTGS2 PROTEIN, MOUSE; STK11 PROTEIN, MOUSE; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LIVER CELL; LIVER FIBROSIS; LIVER FUNCTION; LIVER INJURY; LIVER PROTECTION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CHEMICAL PHENOMENA; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; LIVER CIRRHOSIS; LIVER DISEASES; METABOLISM; PHYSIOLOGY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELLS, CULTURED; CYCLOOXYGENASE 2; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; LIPOPOLYSACCHARIDES; LIVER CIRRHOSIS; LIVER DISEASES; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 84923225348     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12723     Document Type: Article

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