Superoxide anion radicals activate hepatic stellate cells after entry through chloride channels: A new target in liver fibrosis

European Journal of Pharmacology

Volumn 724, Issue 1, 2014, Pages 140-144

  Den Hartog, Gertjan J M ^a   Qi, Shufan ^a   Van Tilburg, Jonathan H O ^a   Koek, Ger H ^b   Bast, Aalt ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Smooth muscle actin; Collagen; Hepatic stellate cells; Superoxide anion radicals; Transforming growth factor

Indexed keywords

(2 CYCLOPENTYL 6,7 DICHLORO 2 METHYL 1 OXO 5 INDANYLOXY)ACETIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; ALPHA SMOOTH MUSCLE ACTIN; CHLORIDE CHANNEL; COLLAGEN; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOKINE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TEMPOL; TRANSFORMING GROWTH FACTOR BETA1;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CYTOKINE RELEASE; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER FIBROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL;

4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID DISODIUM SALT HYDRATE (DIDS, PUBCHEM CID: 4294801); 5-NITRO-2-(3-PHENYLPROPYL-AMINO) BENZOIC ACID (NPPB, PUBCHEM CID: 4549); COLLAGEN; HEPATIC STELLATE CELLS; INDANYLOXYACETIC ACID (IAA-94, PUBCHEM CID: 656717); SUPEROXIDE ANION RADICALS; TEMPOL (PUBCHEM CID: 137994); TRANSFORMING GROWTH FACTOR-Β; Α SMOOTH MUSCLE ACTIN;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ACTINS; CELL LINE; CHLORIDE CHANNELS; GLYCOLATES; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; NITROBENZOATES; SUPEROXIDES; TRANSFORMING GROWTH FACTOR BETA1; XANTHINE; XANTHINE OXIDASE;

EID: 84892390481     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.12.033     Document Type: Article

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