Ascorbic acid supplementation down-regulates the alcohol induced oxidative stress, hepatic stellate cell activation, cytotoxicity and mRNA levels of selected fibrotic genes in guinea pigs

Free Radical Research

Volumn 46, Issue 2, 2012, Pages 204-213

  Abhilash, P A ^a   Harikrishnan, R ^a   Indira, M ^a  

^a UNIVERSITY OF KERALA   (India)

Author keywords

abstention; collagen; liver fibrosis; oxidative stress; reactive oxygen species

Indexed keywords

ALCOHOL; ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; ASCORBIC ACID; CASPASE 3; COLLAGEN; CYTOCHROME P450 2E1; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; GUINEA PIG; LIPID PEROXIDATION; LIVER FIBROSIS; LIVER PROTECTION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; STELLATE CELL; VITAMIN SUPPLEMENTATION;

ANIMALS; ASCORBIC ACID; BIOLOGICAL MARKERS; CASPASE 3; COLLAGEN TYPE I; CYTOCHROME P-450 CYP2E1; DOWN-REGULATION; FREE RADICAL SCAVENGERS; GUINEA PIGS; HEPATIC STELLATE CELLS; LIPID PEROXIDATION; LIVER; LIVER CIRRHOSIS, ALCOHOLIC; MALE; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; CAVIA;

EID: 84856284247     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2011.647691     Document Type: Article

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