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Volumn 19, Issue 9, 2013, Pages 1380-1386

Hepatic regeneration and the epithelial to mesenchymal transition

Author keywords

Epithelial to mesenchymal transition; Epithelial to mesenchymal transition like; Fibrosis; Hepatocyte; Hepatocyte stellate cells; Liver; Regeneration; Transforming growth factor

Indexed keywords

ALBUMIN; ALPHA SMOOTH MUSCLE ACTIN; CALVASCULIN; COLLAGEN TYPE 1; CYTOKERATIN; INTERLEUKIN 6; OSTEOGENIC PROTEIN 1; SCATTER FACTOR; SONIC HEDGEHOG PROTEIN; TRANSFERRIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; UVOMORULIN; VIMENTIN;

EID: 84875094295     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i9.1380     Document Type: Article
Times cited : (25)

References (62)
  • 1
    • 43749088730 scopus 로고    scopus 로고
    • Wound repair and regeneration
    • [PMID: 18480812 DOI: 10.1038/nature07039]
    • Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature 2008; 453: 314-321. [PMID: 18480812 DOI: 10.1038/nature07039]
    • (2008) Nature , vol.453 , pp. 314-321
    • Gurtner, G.C.1    Werner, S.2    Barrandon, Y.3    Longaker, M.T.4
  • 2
    • 33847350691 scopus 로고    scopus 로고
    • Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    • [PMID: 17332879 DOI: 10.1172/JCI31487]
    • Wynn TA. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007; 117: 524-529. [PMID: 17332879 DOI: 10.1172/JCI31487]
    • (2007) J Clin Invest , vol.117 , pp. 524-529
    • Wynn, T.A.1
  • 3
    • 0030894449 scopus 로고    scopus 로고
    • Liver regeneration
    • [PMID: 9082986]
    • Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997; 276: 60-66. [PMID: 9082986]
    • (1997) Science , vol.276 , pp. 60-66
    • Michalopoulos, G.K.1    Defrances, M.C.2
  • 4
    • 0034007745 scopus 로고    scopus 로고
    • Liver regeneration
    • [PMID: 10728791 DOI: 10.1016/S0168-8278(00)80412-2]
    • Fausto N. Liver regeneration. J Hepatol 2000; 32: 19-31. [PMID: 10728791 DOI: 10.1016/S0168-8278(00)80412-2]
    • (2000) J Hepatol , vol.32 , pp. 19-31
    • Fausto, N.1
  • 5
    • 0346494264 scopus 로고    scopus 로고
    • Animal models of liver regeneration
    • [PMID: 14697862 DOI: 10.1016/S0142-9612(03)00508-8]
    • Palmes D, Spiegel HU. Animal models of liver regeneration. Biomaterials 2004; 25: 1601-1611. [PMID: 14697862 DOI: 10.1016/S0142-9612(03)00508-8]
    • (2004) Biomaterials , vol.25 , pp. 1601-1611
    • Palmes, D.1    Spiegel, H.U.2
  • 6
    • 5044232017 scopus 로고    scopus 로고
    • Liver regeneration: From myth to mechanism
    • [PMID: 15459664 DOI: 10.1038/nrm1489]
    • Taub R. Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol 2004; 5: 836-847. [PMID: 15459664 DOI: 10.1038/nrm1489]
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 836-847
    • Taub, R.1
  • 7
    • 0028353410 scopus 로고
    • Replacement of diseased mouse liver by hepatic cell transplantation
    • [PMID: 8108734]
    • Rhim JA, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. Replacement of diseased mouse liver by hepatic cell transplantation. Science 1994; 263: 1149-1152. [PMID: 8108734]
    • (1994) Science , vol.263 , pp. 1149-1152
    • Rhim, J.A.1    Sandgren, E.P.2    Degen, J.L.3    Palmiter, R.D.4    Brinster, R.L.5
  • 8
    • 0030715611 scopus 로고    scopus 로고
    • Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes
    • [PMID: 9358753]
    • Overturf K, al-Dhalimy M, Ou CN, Finegold M, Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol 1997; 151: 1273-1280. [PMID: 9358753]
    • (1997) Am J Pathol , vol.151 , pp. 1273-1280
    • Overturf, K.1    Al-Dhalimy, M.2    Ou, C.N.3    Finegold, M.4    Grompe, M.5
  • 9
    • 14244252656 scopus 로고    scopus 로고
    • Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury
    • [PMID: 15726663 DOI: 10.1002/hep.20600]
    • Michalopoulos GK, Barua L, Bowen WC. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology 2005; 41: 535-544. [PMID: 15726663 DOI: 10.1002/hep.20600]
    • (2005) Hepatology , vol.41 , pp. 535-544
    • Michalopoulos, G.K.1    Barua, L.2    Bowen, W.C.3
  • 10
    • 39149115049 scopus 로고    scopus 로고
    • Stem cells, cell transplantation and liver repopulation
    • [PMID: 18187050 DOI: 10.1016/j.bbadis.2007.12.004]
    • Oertel M, Shafritz DA. Stem cells, cell transplantation and liver repopulation. Biochim Biophys Acta 2008; 1782: 61-74. [PMID: 18187050 DOI: 10.1016/j.bbadis.2007.12.004]
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 61-74
    • Oertel, M.1    Shafritz, D.A.2
  • 12
    • 32044436238 scopus 로고    scopus 로고
    • Liver regeneration
    • [PMID: 16447274 DOI: 10.1002/ hep.20969]
    • Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology 2006; 43: S45-S53. [PMID: 16447274 DOI: 10.1002/ hep.20969]
    • (2006) Hepatology , vol.43
    • Fausto, N.1    Campbell, J.S.2    Riehle, K.J.3
  • 13
    • 85035392112 scopus 로고    scopus 로고
    • Liver fibrosis
    • [PMID: 15690074 DOI: 10.1172/JCI24282]
    • Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005; 115: 209-218. [PMID: 15690074 DOI: 10.1172/JCI24282]
    • (2005) J Clin Invest , vol.115 , pp. 209-218
    • Bataller, R.1    Brenner, D.A.2
  • 14
    • 68849091034 scopus 로고    scopus 로고
    • A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice
    • [PMID: 19620784]
    • He S, Atkinson C, Qiao F, Cianflone K, Chen X, Tomlinson S. A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice. J Clin Invest 2009; 119: 2304-2316. [PMID: 19620784]
    • (2009) J Clin Invest , vol.119 , pp. 2304-2316
    • He, S.1    Atkinson, C.2    Qiao, F.3    Cianflone, K.4    Chen, X.5    Tomlinson, S.6
  • 15
    • 34547599359 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces an epithelialto-mesenchymal transition state in mouse hepatocytes in vitro
    • [PMID: 17513865 DOI: 10.1074/jbc.M700998200]
    • Kaimori A, Potter J, Kaimori JY, Wang C, Mezey E, Koteish A. Transforming growth factor-beta1 induces an epithelialto-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem 2007; 282: 22089-22101. [PMID: 17513865 DOI: 10.1074/jbc.M700998200]
    • (2007) J Biol Chem , vol.282 , pp. 22089-22101
    • Kaimori, A.1    Potter, J.2    Kaimori, J.Y.3    Wang, C.4    Mezey, E.5    Koteish, A.6
  • 16
    • 67650957717 scopus 로고    scopus 로고
    • Stem cells and liver regeneration
    • [PMID: 19470389 DOI: 10.1053/j.gastro.2009.05.044]
    • Duncan AW, Dorrell C, Grompe M. Stem cells and liver regeneration. Gastroenterology 2009; 137: 466-481. [PMID: 19470389 DOI: 10.1053/j.gastro.2009.05.044]
    • (2009) Gastroenterology , vol.137 , pp. 466-481
    • Duncan, A.W.1    Dorrell, C.2    Grompe, M.3
  • 18
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • [PMID: 10644669]
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000; 275: 2247-2250. [PMID: 10644669]
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 19
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • [PMID: 18471545 DOI: 10.1053/ j.gastro.2008.03.003]
    • Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008; 134: 1655-1669. [PMID: 18471545 DOI: 10.1053/ j.gastro.2008.03.003]
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 20
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • [PMID: 18161745 DOI: 10.1002/ path.2277]
    • Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008; 214: 199-210. [PMID: 18161745 DOI: 10.1002/ path.2277]
    • (2008) J Pathol , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 21
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • [PMID: 18195085 DOI: 10.1152/physrev.00013.2007]
    • Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008; 88: 125-172. [PMID: 18195085 DOI: 10.1152/physrev.00013.2007]
    • (2008) Physiol Rev , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 22
    • 33847363203 scopus 로고    scopus 로고
    • Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
    • [PMID: 17332881 DOI: 10.1172/ JCI30542]
    • Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 2007; 117: 539-548. [PMID: 17332881 DOI: 10.1172/ JCI30542]
    • (2007) J Clin Invest , vol.117 , pp. 539-548
    • Iredale, J.P.1
  • 23
    • 0029929999 scopus 로고    scopus 로고
    • Relationship between hepatocyte proliferative activity and liver functional reserve in human cirrhosis
    • [PMID: 8621125 DOI: 10.1002/hep.510230510]
    • Delhaye M, Louis H, Degraef C, Le Moine O, Devière J, Gulbis B, Jacobovitz D, Adler M, Galand P. Relationship between hepatocyte proliferative activity and liver functional reserve in human cirrhosis. Hepatology 1996; 23: 1003-1011. [PMID: 8621125 DOI: 10.1002/hep.510230510]
    • (1996) Hepatology , vol.23 , pp. 1003-1011
    • Delhaye, M.1    Louis, H.2    Degraef, C.3    Le Moine, O.4    Devière, J.5    Gulbis, B.6    Jacobovitz, D.7    Adler, M.8    Galand, P.9
  • 24
    • 0026581696 scopus 로고
    • Analysis of proliferating hepatocytes using a monoclonal antibody against proliferating cell nuclear antigen/cyclin in embedded tissues from various liver diseases fixed in formaldehyde
    • [PMID: 1346735]
    • Kawakita N, Seki S, Sakaguchi H, Yanai A, Kuroki T, Mizoguchi Y, Kobayashi K, Monna T. Analysis of proliferating hepatocytes using a monoclonal antibody against proliferating cell nuclear antigen/cyclin in embedded tissues from various liver diseases fixed in formaldehyde. Am J Pathol 1992; 140: 513-520. [PMID: 1346735]
    • (1992) Am J Pathol , vol.140 , pp. 513-520
    • Kawakita, N.1    Seki, S.2    Sakaguchi, H.3    Yanai, A.4    Kuroki, T.5    Mizoguchi, Y.6    Kobayashi, K.7    Monna, T.8
  • 25
    • 0034681457 scopus 로고    scopus 로고
    • Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
    • [PMID: 10678830 DOI: 10.1126/science.287.5456.1253]
    • Rudolph KL, Chang S, Millard M, Schreiber-Agus N, De-Pinho RA. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science 2000; 287: 1253-1258. [PMID: 10678830 DOI: 10.1126/science.287.5456.1253]
    • (2000) Science , vol.287 , pp. 1253-1258
    • Rudolph, K.L.1    Chang, S.2    Millard, M.3    Schreiber-Agus, N.4    De-Pinho, R.A.5
  • 26
    • 0029076880 scopus 로고
    • Telomere shortening in chronic liver diseases
    • [PMID: 7779103 DOI: 10.1006/ bbrc.1995.1774]
    • Kitada T, Seki S, Kawakita N, Kuroki T, Monna T. Telomere shortening in chronic liver diseases. Biochem Biophys Res Commun 1995; 211: 33-39. [PMID: 7779103 DOI: 10.1006/ bbrc.1995.1774]
    • (1995) Biochem Biophys Res Commun , vol.211 , pp. 33-39
    • Kitada, T.1    Seki, S.2    Kawakita, N.3    Kuroki, T.4    Monna, T.5
  • 28
    • 14944374756 scopus 로고    scopus 로고
    • Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage
    • [PMID: 15608677 DOI: 10.1038/sj.onc.1208308]
    • Wiemann SU, Satyanarayana A, Buer J, Kamino K, Manns MP, Rudolph KL. Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage. Oncogene 2005; 24: 1501-1509. [PMID: 15608677 DOI: 10.1038/sj.onc.1208308]
    • (2005) Oncogene , vol.24 , pp. 1501-1509
    • Wiemann, S.U.1    Satyanarayana, A.2    Buer, J.3    Kamino, K.4    Manns, M.P.5    Rudolph, K.L.6
  • 29
    • 2542601615 scopus 로고    scopus 로고
    • Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
    • [PMID: 15185286 DOI: 10.1002/hep.20214]
    • Fausto N. Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 2004; 39: 1477-1487. [PMID: 15185286 DOI: 10.1002/hep.20214]
    • (2004) Hepatology , vol.39 , pp. 1477-1487
    • Fausto, N.1
  • 31
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • [PMID: 14679171 DOI: 10.1172/JCI20530]
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112: 1776-1784. [PMID: 14679171 DOI: 10.1172/JCI20530]
    • (2003) J Clin Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 32
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease
    • [PMID: 19487820 DOI: 10.1172/ JCI38019]
    • Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 2009; 119: 1438-1449. [PMID: 19487820 DOI: 10.1172/ JCI38019]
    • (2009) J Clin Invest , vol.119 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 33
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • [PMID: 19487818 DOI: 10.1172/JCI39104]
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-1428. [PMID: 19487818 DOI: 10.1172/JCI39104]
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 34
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • [PMID: 19487819 DOI: 10.1172/JCI36183]
    • Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009; 119: 1429-1437. [PMID: 19487819 DOI: 10.1172/JCI36183]
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 35
    • 0031044484 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition of cultured rat neonatal hepatocytes is differentially regulated in response to epidermal growth factor and dimethyl sulfoxide
    • [PMID: 9049205 DOI: 10.1002/hep.510250318]
    • Pagan R, Martín I, Llobera M, Vilaró S. Epithelial-mesenchymal transition of cultured rat neonatal hepatocytes is differentially regulated in response to epidermal growth factor and dimethyl sulfoxide. Hepatology 1997; 25: 598-606. [PMID: 9049205 DOI: 10.1002/hep.510250318]
    • (1997) Hepatology , vol.25 , pp. 598-606
    • Pagan, R.1    Martín, I.2    Llobera, M.3    Vilaró, S.4
  • 36
    • 0344406127 scopus 로고    scopus 로고
    • The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes
    • [PMID: 12496370]
    • Valdés F, Alvarez AM, Locascio A, Vega S, Herrera B, Fernández M, Benito M, Nieto MA, Fabregat I. The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes. Mol Cancer Res 2002; 1: 68-78. [PMID: 12496370]
    • (2002) Mol Cancer Res , vol.1 , pp. 68-78
    • Valdés, F.1    Alvarez, A.M.2    Locascio, A.3    Vega, S.4    Herrera, B.5    Fernández, M.6    Benito, M.7    Nieto, M.A.8    Fabregat, I.9
  • 37
    • 0038724267 scopus 로고    scopus 로고
    • Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition
    • [PMID: 12506029 DOI: 10.1182/blood-2002-05-1341]
    • Chagraoui J, Lepage-Noll A, Anjo A, Uzan G, Charbord P. Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition. Blood 2003; 101: 2973-2982. [PMID: 12506029 DOI: 10.1182/blood-2002-05-1341]
    • (2003) Blood , vol.101 , pp. 2973-2982
    • Chagraoui, J.1    Lepage-Noll, A.2    Anjo, A.3    Uzan, G.4    Charbord, P.5
  • 39
    • 0036322007 scopus 로고    scopus 로고
    • Evidence that fibroblasts derive from epithelium during tissue fibrosis
    • [PMID: 12163453 DOI: 10.1172/JCI15518]
    • Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002; 110: 341-350. [PMID: 12163453 DOI: 10.1172/JCI15518]
    • (2002) J Clin Invest , vol.110 , pp. 341-350
    • Iwano, M.1    Plieth, D.2    Danoff, T.M.3    Xue, C.4    Okada, H.5    Neilson, E.G.6
  • 40
    • 60649089997 scopus 로고    scopus 로고
    • Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells
    • [PMID: 19249678 DOI: 10.1016/j.ccr.2009.01.023]
    • Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y. Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 2009; 15: 195-206. [PMID: 19249678 DOI: 10.1016/j.ccr.2009.01.023]
    • (2009) Cancer Cell , vol.15 , pp. 195-206
    • Kudo-Saito, C.1    Shirako, H.2    Takeuchi, T.3    Kawakami, Y.4
  • 41
    • 65349113680 scopus 로고    scopus 로고
    • Inflamed snail speeds metastasis
    • [PMID: 19411063 DOI: 10.1016/ j.ccr.2009.04.003]
    • Yang CC, Wolf DA. Inflamed snail speeds metastasis. Cancer Cell 2009; 15: 355-357. [PMID: 19411063 DOI: 10.1016/ j.ccr.2009.04.003]
    • (2009) Cancer Cell , vol.15 , pp. 355-357
    • Yang, C.C.1    Wolf, D.A.2
  • 42
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • [PMID: 17562716 DOI: 10.1074/ jbc.M700194200]
    • Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, Kalluri R. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007; 282: 23337-23347. [PMID: 17562716 DOI: 10.1074/ jbc.M700194200]
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6    Kalluri, R.7
  • 46
    • 51349133312 scopus 로고    scopus 로고
    • Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways
    • [PMID: 18712785 DOI: 10.1002/hep.22397]
    • Nitta T, Kim JS, Mohuczy D, Behrns KE. Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways. Hepatology 2008; 48: 909-919. [PMID: 18712785 DOI: 10.1002/hep.22397]
    • (2008) Hepatology , vol.48 , pp. 909-919
    • Nitta, T.1    Kim, J.S.2    Mohuczy, D.3    Behrns, K.E.4
  • 47
    • 38549143883 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease
    • [PMID: 18059363 DOI: 10.1038/labinvest.3700704]
    • Rygiel KA, Robertson H, Marshall HL, Pekalski M, Zhao L, Booth TA, Jones DE, Burt AD, Kirby JA. Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease. Lab Invest 2008; 88: 112-123. [PMID: 18059363 DOI: 10.1038/labinvest.3700704]
    • (2008) Lab Invest , vol.88 , pp. 112-123
    • Rygiel, K.A.1    Robertson, H.2    Marshall, H.L.3    Pekalski, M.4    Zhao, L.5    Booth, T.A.6    Jones, D.E.7    Burt, A.D.8    Kirby, J.A.9
  • 50
    • 41549118422 scopus 로고    scopus 로고
    • The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer
    • [PMID: 18218671 DOI: 10.1152/ajpgi.00543.2007]
    • Omenetti A, Diehl AM. The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol 2008; 294: G595-G598. [PMID: 18218671 DOI: 10.1152/ajpgi.00543.2007]
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294
    • Omenetti, A.1    Diehl, A.M.2
  • 52
    • 77950597707 scopus 로고    scopus 로고
    • Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
    • [PMID: 20052656 DOI: 10.1002/hep.23368]
    • Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 2010; 51: 1027-1036. [PMID: 20052656 DOI: 10.1002/hep.23368]
    • (2010) Hepatology , vol.51 , pp. 1027-1036
    • Taura, K.1    Miura, K.2    Iwaisako, K.3    Osterreicher, C.H.4    Kodama, Y.5    Penz-Osterreicher, M.6    Brenner, D.A.7
  • 53
    • 79955123951 scopus 로고    scopus 로고
    • Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis
    • [PMID: 21520179 DOI: 10.1002/hep.24206]
    • Chu AS, Diaz R, Hui JJ, Yanger K, Zong Y, Alpini G, Stanger BZ, Wells RG. Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis. Hepatology 2011; 53: 1685-1695. [PMID: 21520179 DOI: 10.1002/hep.24206]
    • (2011) Hepatology , vol.53 , pp. 1685-1695
    • Chu, A.S.1    Diaz, R.2    Hui, J.J.3    Yanger, K.4    Zong, Y.5    Alpini, G.6    Stanger, B.Z.7    Wells, R.G.8
  • 54
    • 0032556952 scopus 로고    scopus 로고
    • p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells
    • [PMID: 9467956 DOI: 10.1038/sj.onc.1201543]
    • Cayrol C, Knibiehler M, Ducommun B. p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. Oncogene 1998; 16: 311-320. [PMID: 9467956 DOI: 10.1038/sj.onc.1201543]
    • (1998) Oncogene , vol.16 , pp. 311-320
    • Cayrol, C.1    Knibiehler, M.2    Ducommun, B.3
  • 57
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • [PMID: 16123809]
    • Zavadil J, Böttinger EP. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005; 24: 5764-5774. [PMID: 16123809]
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Böttinger, E.P.2
  • 59
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • [PMID: 12808448 DOI: 10.1038/nm888]
    • Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003; 9: 964-968. [PMID: 12808448 DOI: 10.1038/nm888]
    • (2003) Nat Med , vol.9 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3    Mammoto, T.4    Charytan, D.5    Strutz, F.6    Kalluri, R.7
  • 61
    • 36549011761 scopus 로고    scopus 로고
    • Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
    • [PMID: 18022723 DOI: 10.1016/j.jhep.2007.07.032]
    • Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, Sicklick JK, Li YX, Diehl AM. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol 2008; 48: 98-106. [PMID: 18022723 DOI: 10.1016/j.jhep.2007.07.032]
    • (2008) J Hepatol , vol.48 , pp. 98-106
    • Yang, L.1    Wang, Y.2    Mao, H.3    Fleig, S.4    Omenetti, A.5    Brown, K.D.6    Sicklick, J.K.7    Li, Y.X.8    Diehl, A.M.9
  • 62
    • 46349101715 scopus 로고    scopus 로고
    • Hedgehog-mediated paracrine interaction between hepatic stellate cells and marrow-derived mesenchymal stem cells
    • [PMID: 18486597 DOI: 10.1016/j.bbrc.2008.05.029]
    • Lin N, Tang Z, Deng M, Zhong Y, Lin J, Yang X, Xiang P, Xu R. Hedgehog-mediated paracrine interaction between hepatic stellate cells and marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun 2008; 372: 260-265. [PMID: 18486597 DOI: 10.1016/j.bbrc.2008.05.029]
    • (2008) Biochem Biophys Res Commun , vol.372 , pp. 260-265
    • Lin, N.1    Tang, Z.2    Deng, M.3    Zhong, Y.4    Lin, J.5    Yang, X.6    Xiang, P.7    Xu, R.8


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