메뉴 건너뛰기




Volumn 129, Issue 1, 2015, Pages 1-25

Looking to the horizon: The role of bilirubin in the development and prevention of age-related chronic diseases

Author keywords

All cause mortality; Bile pigment; Bilirubin; Biomarker; Cancer; Cardiovascular disease; Chronic disease; Gilbert's syndrome

Indexed keywords

BILE PIGMENT; BILIRUBIN; BIOLOGICAL MARKER;

EID: 84937511631     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20140566     Document Type: Review
Times cited : (136)

References (246)
  • 1
    • 84889805741 scopus 로고    scopus 로고
    • Bilirubin-induced neurologic damage-mechanisms and management approaches
    • Watchko, J.F. and Tiribelli, C. (2013) Bilirubin-induced neurologic damage-mechanisms and management approaches. N. Engl. J. Med. 369, 2021-2030.
    • (2013) N. Engl. J. Med , vol.369 , pp. 2021-2030
    • Watchko, J.F.1    Tiribelli, C.2
  • 3
    • 84891086514 scopus 로고    scopus 로고
    • Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway
    • Qaisiya, M., Coda Zabetta, C.D., Bellarosa, C. and Tiribelli, C. (2014) Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway. Cell. Signal. 26, 512-520.
    • (2014) Cell. Signal , vol.26 , pp. 512-520
    • Qaisiya, M.1    Coda Zabetta, C.D.2    Bellarosa, C.3    Tiribelli, C.4
  • 5
    • 0023132858 scopus 로고
    • Bilirubin is an antioxidant of possible physiological importance
    • Stocker, R., Yamamoto, Y., McDonagh, A.F., Glazer, A.N. and Ames, B.N. (1987) Bilirubin is an antioxidant of possible physiological importance. Science 235, 1043-1046.
    • (1987) Science , vol.235 , pp. 1043-1046
    • Stocker, R.1    Yamamoto, Y.2    McDonagh, A.F.3    Glazer, A.N.4    Ames, B.N.5
  • 6
    • 84875750146 scopus 로고    scopus 로고
    • Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection
    • Bulmer, A.C., Verkade, H.J. and Wagner, K.H. (2013) Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection. Prog. Lipid. Res. 52, 193-205.
    • (2013) Prog. Lipid. Res , vol.52 , pp. 193-205
    • Bulmer, A.C.1    Verkade, H.J.2    Wagner, K.H.3
  • 7
    • 0024601475 scopus 로고
    • Antioxidant properties of conjugated bilirubin and biliverdin: biologically relevant scavenging of hypochlorous acid
    • Stocker, R. and Peterhans, E. (1989) Antioxidant properties of conjugated bilirubin and biliverdin: biologically relevant scavenging of hypochlorous acid. Free Radic. Res. Commun. 6, 57-66.
    • (1989) Free Radic. Res. Commun , vol.6 , pp. 57-66
    • Stocker, R.1    Peterhans, E.2
  • 8
    • 34247121549 scopus 로고    scopus 로고
    • The anti-mutagenic and antioxidant effects of bile pigments in the Ames Salmonella test
    • Bulmer, A.C., Ried, K., Coombes, J.S., Blanchfield, J.T., Toth, I. and Wagner, K.H. (2007) The anti-mutagenic and antioxidant effects of bile pigments in the Ames Salmonella test. Mutat. Res. 629, 122-132.
    • (2007) Mutat. Res , vol.629 , pp. 122-132
    • Bulmer, A.C.1    Ried, K.2    Coombes, J.S.3    Blanchfield, J.T.4    Toth, I.5    Wagner, K.H.6
  • 9
    • 84867494699 scopus 로고    scopus 로고
    • In vitro antioxidant capacity and antigenotoxic properties of protoporphyrin and structurally related tetrapyrroles
    • Molzer, C., Huber, H., Steyrer, A., Ziesel, G., Ertl, A., Plavotic, A., Wallner, M., Bulmer, A.C. and Wagner, K.H. (2012) In vitro antioxidant capacity and antigenotoxic properties of protoporphyrin and structurally related tetrapyrroles. Free Radic. Res. 46, 1369-1377.
    • (2012) Free Radic. Res , vol.46 , pp. 1369-1377
    • Molzer, C.1    Huber, H.2    Steyrer, A.3    Ziesel, G.4    Ertl, A.5    Plavotic, A.6    Wallner, M.7    Bulmer, A.C.8    Wagner, K.H.9
  • 10
    • 84884198470 scopus 로고    scopus 로고
    • Extracellular and intracellular anti-mutagenic effects of bile pigments in the Salmonella typhimurium reverse mutation assay
    • Molzer, C., Huber, H., Diem, K., Wallner, M., Bulmer, A.C. and Wagner, K.H. (2013) Extracellular and intracellular anti-mutagenic effects of bile pigments in the Salmonella typhimurium reverse mutation assay. Toxicol. In Vitro 27, 433-437.
    • (2013) Toxicol. In Vitro , vol.27 , pp. 433-437
    • Molzer, C.1    Huber, H.2    Diem, K.3    Wallner, M.4    Bulmer, A.C.5    Wagner, K.H.6
  • 11
    • 84886813361 scopus 로고    scopus 로고
    • Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide
    • Molzer, C., Huber, H., Steyrer, A., Ziesel, G.V., Wallner, M., Hong, H.T., Blanchfield, J.T., Bulmer, A.C. and Wagner, K.H. (2013) Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide. J. Nat. Prod. 76, 1958-1965.
    • (2013) J. Nat. Prod , vol.76 , pp. 1958-1965
    • Molzer, C.1    Huber, H.2    Steyrer, A.3    Ziesel, G.V.4    Wallner, M.5    Hong, H.T.6    Blanchfield, J.T.7    Bulmer, A.C.8    Wagner, K.H.9
  • 12
    • 0027948692 scopus 로고
    • Structural basis of antimutagenicity of chemicals towards 4-nitroquinoline 1-oxide in Salmonella typhimurium
    • De Flora, S., Rosenkranz, H.S. and Klopman, G. (1994) Structural basis of antimutagenicity of chemicals towards 4-nitroquinoline 1-oxide in Salmonella typhimurium. Mutagenesis 9, 39-45.
    • (1994) Mutagenesis , vol.9 , pp. 39-45
    • De Flora, S.1    Rosenkranz, H.S.2    Klopman, G.3
  • 13
    • 13844323154 scopus 로고
    • Experimental databases on inhibition of the bacterial mutagenicity of 4-nitroquinoline 1-oxide and cigarette smoke
    • Camoirano, A., Balansky, R.M., Bennicelli, C., Izzotti, A., D'Agostini, F. and De Flora, S. (1994) Experimental databases on inhibition of the bacterial mutagenicity of 4-nitroquinoline 1-oxide and cigarette smoke. Mutat. Res. 317, 89-109.
    • (1994) Mutat. Res , vol.317 , pp. 89-109
    • Camoirano, A.1    Balansky, R.M.2    Bennicelli, C.3    Izzotti, A.4    D'Agostini, F.5    De Flora, S.6
  • 15
    • 25144435988 scopus 로고    scopus 로고
    • Impact of serum bilirubin on human diseases
    • Vitek, L. (2005) Impact of serum bilirubin on human diseases. Pediatrics 115, 1411-1412.
    • (2005) Pediatrics , vol.115 , pp. 1411-1412
    • Vitek, L.1
  • 16
    • 33845613215 scopus 로고    scopus 로고
    • The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases
    • Vitek, L. and Schwertner, H.A. (2007) The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases. Adv. Clin. Chem. 43, 1-57.
    • (2007) Adv. Clin. Chem , vol.43 , pp. 1-57
    • Vitek, L.1    Schwertner, H.A.2
  • 17
    • 70449389954 scopus 로고    scopus 로고
    • Bilirubin chemistry and metabolism; harmful and protective aspects
    • Vitek, L. and Ostrow, J.D. (2009) Bilirubin chemistry and metabolism; harmful and protective aspects. Curr. Pharm. Des. 15, 2869-2883.
    • (2009) Curr. Pharm. Des , vol.15 , pp. 2869-2883
    • Vitek, L.1    Ostrow, J.D.2
  • 18
    • 41049098411 scopus 로고    scopus 로고
    • Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin
    • Schwertner, H.A. and Vitek, L. (2008) Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin. Atherosclerosis 198, 1-11.
    • (2008) Atherosclerosis , vol.198 , pp. 1-11
    • Schwertner, H.A.1    Vitek, L.2
  • 19
    • 77957735569 scopus 로고    scopus 로고
    • Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease
    • Lin, J.P., Vitek, L. and Schwertner, H.A. (2010) Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease. Clin. Chem. 56, 1535-1543.
    • (2010) Clin. Chem , vol.56 , pp. 1535-1543
    • Lin, J.P.1    Vitek, L.2    Schwertner, H.A.3
  • 20
    • 47649112255 scopus 로고    scopus 로고
    • Improved resistance to serum oxidation in Gilbert's syndrome: a mechanism for cardiovascular protection
    • Bulmer, A.C., Blanchfield, J.T., Toth, I., Fassett, R.G. and Coombes, J.S. (2008) Improved resistance to serum oxidation in Gilbert's syndrome: a mechanism for cardiovascular protection. Atherosclerosis 199, 390-396.
    • (2008) Atherosclerosis , vol.199 , pp. 390-396
    • Bulmer, A.C.1    Blanchfield, J.T.2    Toth, I.3    Fassett, R.G.4    Coombes, J.S.5
  • 23
    • 41549167737 scopus 로고    scopus 로고
    • Protective effects of serum bilirubin on peripheral vascular disease
    • Vitek, L. and Schwertner, H.A. (2008) Protective effects of serum bilirubin on peripheral vascular disease. Ann. Hepatol. 7, 94-95.
    • (2008) Ann. Hepatol , vol.7 , pp. 94-95
    • Vitek, L.1    Schwertner, H.A.2
  • 24
    • 12444296580 scopus 로고    scopus 로고
    • The impact of intestinal microflora on serum bilirubin levels
    • Vitek, L., Zelenka, J., Zadinova, M. and Malina, J. (2005) The impact of intestinal microflora on serum bilirubin levels. J. Hepatol. 42, 238-243.
    • (2005) J. Hepatol , vol.42 , pp. 238-243
    • Vitek, L.1    Zelenka, J.2    Zadinova, M.3    Malina, J.4
  • 25
    • 0035678766 scopus 로고    scopus 로고
    • Serum bilirubin and 10-year mortality risk in a Belgian population
    • Temme, E.H., Zhang, J., Schouten, E.G. and Kesteloot, H. (2001) Serum bilirubin and 10-year mortality risk in a Belgian population. Cancer Causes Control 12, 887-894.
    • (2001) Cancer Causes Control , vol.12 , pp. 887-894
    • Temme, E.H.1    Zhang, J.2    Schouten, E.G.3    Kesteloot, H.4
  • 26
    • 4644351861 scopus 로고    scopus 로고
    • Serum bilirubin levels in the U.S. population: gender effect and inverse correlation with colorectal cancer
    • Zucker, S.D., Horn, P.S. and Sherman, K.E. (2004) Serum bilirubin levels in the U.S. population: gender effect and inverse correlation with colorectal cancer. Hepatology 40, 827-835.
    • (2004) Hepatology , vol.40 , pp. 827-835
    • Zucker, S.D.1    Horn, P.S.2    Sherman, K.E.3
  • 28
    • 84865984236 scopus 로고    scopus 로고
    • The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases
    • Vitek, L. (2012) The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases. Front. Pharmacol. 3, 55.
    • (2012) Front. Pharmacol , vol.3 , pp. 55
    • Vitek, L.1
  • 29
    • 84860847145 scopus 로고    scopus 로고
    • A global view on the development of non communicable diseases
    • Wagner, K.H. and Brath, H. (2012) A global view on the development of non communicable diseases. Prev. Med. 54 (Suppl.), S38-S41.
    • (2012) Prev. Med , vol.54 , pp. S38-S41
    • Wagner, K.H.1    Brath, H.2
  • 30
    • 72949141584 scopus 로고
    • Bile pigment metabolism
    • Klatskin, G. (1961) Bile pigment metabolism. Annu. Rev. Med. 12, 211-250.
    • (1961) Annu. Rev. Med , vol.12 , pp. 211-250
    • Klatskin, G.1
  • 31
    • 0016591776 scopus 로고
    • The enzymatic formation of bilirubin
    • Schmid, R. and McDonagh, A.F. (1975) The enzymatic formation of bilirubin. Ann. N. Y. Acad. Sci. 244, 533-552.
    • (1975) Ann. N. Y. Acad. Sci , vol.244 , pp. 533-552
    • Schmid, R.1    McDonagh, A.F.2
  • 32
    • 33645945014 scopus 로고    scopus 로고
    • Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
    • Ryter, S.W., Alam, J. and Choi, A.M. (2006) Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 86, 583-650.
    • (2006) Physiol. Rev , vol.86 , pp. 583-650
    • Ryter, S.W.1    Alam, J.2    Choi, A.M.3
  • 33
    • 20444390993 scopus 로고    scopus 로고
    • Bilirubin and the risk of common non-hepatic diseases
    • Rigato, I., Ostrow, J.D. and Tiribelli, C. (2005) Bilirubin and the risk of common non-hepatic diseases. Trends Mol. Med. 11, 277-283.
    • (2005) Trends Mol. Med , vol.11 , pp. 277-283
    • Rigato, I.1    Ostrow, J.D.2    Tiribelli, C.3
  • 34
    • 0018396166 scopus 로고
    • Bilirubin. Solubility and interaction with albumin and phospholipid
    • Brodersen, R. (1979) Bilirubin. Solubility and interaction with albumin and phospholipid. J. Biol. Chem. 254, 2364-2369.
    • (1979) J. Biol. Chem , vol.254 , pp. 2364-2369
    • Brodersen, R.1
  • 35
  • 36
    • 0033774170 scopus 로고    scopus 로고
    • Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance
    • Kamisako, T., Kobayashi, Y., Takeuchi, K., Ishihara, T., Higuchi, K., Tanaka, Y., Gabazza, E.C. and Adachi, Y. (2000) Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. J. Gastroenterol. 35, 659-664.
    • (2000) J. Gastroenterol , vol.35 , pp. 659-664
    • Kamisako, T.1    Kobayashi, Y.2    Takeuchi, K.3    Ishihara, T.4    Higuchi, K.5    Tanaka, Y.6    Gabazza, E.C.7    Adachi, Y.8
  • 37
    • 84864759122 scopus 로고    scopus 로고
    • Liver function from Y to Z
    • Arias, I.M. (2012) Liver function from Y to Z. J. Clin. Invest. 122, 2763-2764.
    • (2012) J. Clin. Invest , vol.122 , pp. 2763-2764
    • Arias, I.M.1
  • 38
    • 0009705058 scopus 로고
    • Enzymatic mechanisms of hormone metabolism. II. Mechanism of hormonal glucuronide formation
    • Isselbacher, K.J. (1956) Enzymatic mechanisms of hormone metabolism. II. Mechanism of hormonal glucuronide formation. Recent Prog. Hormone Res. 12, 134-146.
    • (1956) Recent Prog. Hormone Res , vol.12 , pp. 134-146
    • Isselbacher, K.J.1
  • 40
    • 0042834374 scopus 로고    scopus 로고
    • Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life
    • Vitek, L. and Carey, M.C. (2003) Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life. Eur. J. Clin. Invest. 33, 799-810.
    • (2003) Eur. J. Clin. Invest , vol.33 , pp. 799-810
    • Vitek, L.1    Carey, M.C.2
  • 41
    • 36949087377 scopus 로고
    • Enterohepatic circulation of bilirubin
    • Lester, R., Ostrow, J.D. and Schmid, R. (1961) Enterohepatic circulation of bilirubin. Nature 192, 372.
    • (1961) Nature , vol.192 , pp. 372
    • Lester, R.1    Ostrow, J.D.2    Schmid, R.3
  • 42
    • 0004190061 scopus 로고
    • Enterohepatic circulation of unconjugated bilirubin in man
    • Gilbertsen, A.S., Bossenmaier, I. and Cardinal, R. (1962) Enterohepatic circulation of unconjugated bilirubin in man. Nature 196, 141-142.
    • (1962) Nature , vol.196 , pp. 141-142
    • Gilbertsen, A.S.1    Bossenmaier, I.2    Cardinal, R.3
  • 44
    • 0038541723 scopus 로고    scopus 로고
    • Intestinal colonization leading to fecal urobilinoid excretion may play a role in the pathogenesis of neonatal jaundice
    • Vitek, L., Kotal, P., Jirsa, M., Malina, J., Cerna, M., Chmelar, D. and Fevery, J. (2000) Intestinal colonization leading to fecal urobilinoid excretion may play a role in the pathogenesis of neonatal jaundice. J. Pediatr. Gastroenterol. Nutr. 30, 294-298.
    • (2000) J. Pediatr. Gastroenterol. Nutr , vol.30 , pp. 294-298
    • Vitek, L.1    Kotal, P.2    Jirsa, M.3    Malina, J.4    Cerna, M.5    Chmelar, D.6    Fevery, J.7
  • 45
    • 4544386856 scopus 로고    scopus 로고
    • Antioxidant activities of bile pigments
    • Stocker, R. (2004) Antioxidant activities of bile pigments. Antioxid. Redox Signal. 6, 841-849.
    • (2004) Antioxid. Redox Signal , vol.6 , pp. 841-849
    • Stocker, R.1
  • 47
    • 67649518897 scopus 로고    scopus 로고
    • Mortality associated with bilirubin levels in insurance applicants
    • Fulks, M., Stout, R.L. and Dolan, V.F. (2009) Mortality associated with bilirubin levels in insurance applicants. J. Insur. Med. 41, 49-53.
    • (2009) J. Insur. Med , vol.41 , pp. 49-53
    • Fulks, M.1    Stout, R.L.2    Dolan, V.F.3
  • 48
    • 84899628727 scopus 로고    scopus 로고
    • The relationship between total bilirubin levels and total mortality in older adults: the United States National Health and Nutrition Examination Survey (NHANES) 1999-2014
    • Ong, K.L., Allison, M.A., Cheung, B.M., Wu, B.J., Barter, P.J. and Rye, K.A. (2014) The relationship between total bilirubin levels and total mortality in older adults: the United States National Health and Nutrition Examination Survey (NHANES) 1999-2014. PLOS ONE 9, e94479.
    • (2014) PLOS ONE , vol.9
    • Ong, K.L.1    Allison, M.A.2    Cheung, B.M.3    Wu, B.J.4    Barter, P.J.5    Rye, K.A.6
  • 49
    • 84860415023 scopus 로고    scopus 로고
    • Usefulness of serum bilirubin and cardiorespiratory fitness as predictors of mortality in men
    • Ajja, R., Lee, D.C., Sui, X., Church, T.S. and Steven, N.B. (2011) Usefulness of serum bilirubin and cardiorespiratory fitness as predictors of mortality in men. Am. J. Cardiol. 108, 1438-1442.
    • (2011) Am. J. Cardiol , vol.108 , pp. 1438-1442
    • Ajja, R.1    Lee, D.C.2    Sui, X.3    Church, T.S.4    Steven, N.B.5
  • 50
    • 84870251882 scopus 로고    scopus 로고
    • Cardiovascular events as a function of serum bilirubin levels in a large, statin-treated cohort
    • Horsfall, L.J., Nazareth, I. and Petersen, I. (2012) Cardiovascular events as a function of serum bilirubin levels in a large, statin-treated cohort. Circulation 126, 2556-2564.
    • (2012) Circulation , vol.126 , pp. 2556-2564
    • Horsfall, L.J.1    Nazareth, I.2    Petersen, I.3
  • 51
    • 84897599946 scopus 로고    scopus 로고
    • Gilbert's syndrome and the risk of death: a population-based cohort study
    • Horsfall, L.J., Nazareth, I., Pereira, S.P. and Petersen, I. (2013) Gilbert's syndrome and the risk of death: a population-based cohort study. J. Gastroenterol. Hepatol. 28, 1643-1647.
    • (2013) J. Gastroenterol. Hepatol , vol.28 , pp. 1643-1647
    • Horsfall, L.J.1    Nazareth, I.2    Pereira, S.P.3    Petersen, I.4
  • 53
    • 0028819709 scopus 로고
    • Serum bilirubin and risk of ischemic heart disease in middle-aged British men
    • Breimer, L.H., Wannamethee, G., Ebrahim, S. and Shaper, A.G. (1995) Serum bilirubin and risk of ischemic heart disease in middle-aged British men. Clin. Chem. 41, 1504-1508.
    • (1995) Clin. Chem , vol.41 , pp. 1504-1508
    • Breimer, L.H.1    Wannamethee, G.2    Ebrahim, S.3    Shaper, A.G.4
  • 54
    • 0038047678 scopus 로고    scopus 로고
    • Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-analysis of published studies
    • Novotny, L. and Vitek, L. (2003) Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-analysis of published studies. Exp. Biol. Med. 228, 568-571.
    • (2003) Exp. Biol. Med , vol.228 , pp. 568-571
    • Novotny, L.1    Vitek, L.2
  • 55
    • 79953004070 scopus 로고    scopus 로고
    • Serum bilirubin links UGT1A1*28 polymorphism and predicts long-term cardiovascular events and mortality in chronic hemodialysis patients
    • Chen, Y.H., Hung, S.C. and Tarng, D.C. (2011) Serum bilirubin links UGT1A1*28 polymorphism and predicts long-term cardiovascular events and mortality in chronic hemodialysis patients. Clin. J. Am. Soc. Nephrol. 6, 567-574.
    • (2011) Clin. J. Am. Soc. Nephrol , vol.6 , pp. 567-574
    • Chen, Y.H.1    Hung, S.C.2    Tarng, D.C.3
  • 56
    • 84865134092 scopus 로고    scopus 로고
    • Association of arterial stiffness with serum bilirubin levels in established coronary artery disease
    • Zhu, C., Xiong, Z., Zheng, Z., Chen, Y., Chen, X. and Qian, X. (2012) Association of arterial stiffness with serum bilirubin levels in established coronary artery disease. Intern. Med. 51, 2083-2089.
    • (2012) Intern. Med , vol.51 , pp. 2083-2089
    • Zhu, C.1    Xiong, Z.2    Zheng, Z.3    Chen, Y.4    Chen, X.5    Qian, X.6
  • 57
    • 77649232070 scopus 로고    scopus 로고
    • Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women
    • Ohnaka, K., Kono, S., Inoguchi, T., Yin, G., Morita, M., Adachi, M., Kawate, H. and Takayanagi, R. (2010) Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women. Diabetes Res. Clin. Pract. 88, 103-110.
    • (2010) Diabetes Res. Clin. Pract , vol.88 , pp. 103-110
    • Ohnaka, K.1    Kono, S.2    Inoguchi, T.3    Yin, G.4    Morita, M.5    Adachi, M.6    Kawate, H.7    Takayanagi, R.8
  • 58
    • 33845613215 scopus 로고    scopus 로고
    • The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases
    • Vitek, L. and Schwertner, H.A. (2007) The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases. Adv. Clin. Chem. 43, 1-57.
    • (2007) Adv. Clin. Chem , vol.43 , pp. 1-57
    • Vitek, L.1    Schwertner, H.A.2
  • 59
    • 70449389954 scopus 로고    scopus 로고
    • Bilirubin chemistry and metabolism; harmful and protective aspects
    • Vitek, L. and Ostrow, J.D. (2009) Bilirubin chemistry and metabolism; harmful and protective aspects. Curr. Pharm. Des. 15, 2869-2883.
    • (2009) Curr. Pharm. Des , vol.15 , pp. 2869-2883
    • Vitek, L.1    Ostrow, J.D.2
  • 60
    • 84875750146 scopus 로고    scopus 로고
    • Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection
    • Bulmer, A.C., Verkade, H.J. and Wagner, K.H. (2013) Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection. Prog. Lipid Res. 52, 193-205.
    • (2013) Prog. Lipid Res , vol.52 , pp. 193-205
    • Bulmer, A.C.1    Verkade, H.J.2    Wagner, K.H.3
  • 61
    • 84904343067 scopus 로고    scopus 로고
    • Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations
    • Boon, A.C., Bulmer, A.C., Coombes, J.S. and Fassett, R.G. (2014) Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations. Am. J. Physiol. Renal Physiol. 307, F123-F136.
    • (2014) Am. J. Physiol. Renal Physiol , vol.307 , pp. F123-F136
    • Boon, A.C.1    Bulmer, A.C.2    Coombes, J.S.3    Fassett, R.G.4
  • 64
    • 0028084319 scopus 로고
    • Association of low serum concentration of bilirubin with increased risk of coronary artery disease
    • Schwertner, H.A., Jackson, W.G. and Tolan, G. (1994) Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin. Chem. 40, 18-23.
    • (1994) Clin. Chem , vol.40 , pp. 18-23
    • Schwertner, H.A.1    Jackson, W.G.2    Tolan, G.3
  • 66
    • 33748445757 scopus 로고    scopus 로고
    • The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis
    • Vitek, L., Novotny, L., Sperl, M., Holaj, R. and Spacil, J. (2006) The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis. Cerebrovasc. Dis. 21, 408-414.
    • (2006) Cerebrovasc. Dis , vol.21 , pp. 408-414
    • Vitek, L.1    Novotny, L.2    Sperl, M.3    Holaj, R.4    Spacil, J.5
  • 69
    • 84904394519 scopus 로고    scopus 로고
    • Association of bilirubin with coronary artery calcification and cardiovascular events in the general population without known liver disease: the Heinz Nixdorf Recall study
    • Mahabadi, A.A., Lehmann, N., Mohlenkamp, S., Kalsch, H., Bauer, M., Schulz, R., Moebus, S., Jockel, K.H., Erbel, R. and Heusch, G. (2014) Association of bilirubin with coronary artery calcification and cardiovascular events in the general population without known liver disease: the Heinz Nixdorf Recall study. Clin. Res. Cardiol. 103, 647-653.
    • (2014) Clin. Res. Cardiol , vol.103 , pp. 647-653
    • Mahabadi, A.A.1    Lehmann, N.2    Mohlenkamp, S.3    Kalsch, H.4    Bauer, M.5    Schulz, R.6    Moebus, S.7    Jockel, K.H.8    Erbel, R.9    Heusch, G.10
  • 70
    • 84884800870 scopus 로고    scopus 로고
    • The effect of Gilbert's syndrome on the dispersions of QT interval and P-wave: an observational study
    • Cure, E., Yuce, S., Cicek, Y. and Cure, M.C. (2013) The effect of Gilbert's syndrome on the dispersions of QT interval and P-wave: an observational study. Anadolu Kardiyol. Derg. 13, 559-565.
    • (2013) Anadolu Kardiyol. Derg , vol.13 , pp. 559-565
    • Cure, E.1    Yuce, S.2    Cicek, Y.3    Cure, M.C.4
  • 71
    • 42449124766 scopus 로고    scopus 로고
    • Bilirubin would be the indispensable component for some of the most important therapeutic effects of Calculus Bovis (Niuhuang)
    • Qin, X.F. (2008) Bilirubin would be the indispensable component for some of the most important therapeutic effects of Calculus Bovis (Niuhuang). Chin. Med. J. (Engl.) 121, 480.
    • (2008) Chin. Med. J. (Engl.) , vol.121 , pp. 480
    • Qin, X.F.1
  • 72
    • 84860489636 scopus 로고    scopus 로고
    • The novel antidote Bezoar Bovis prevents the cardiotoxicity of toad (Bufo bufo gargarizans Canto) venom in mice
    • Ma, H., Zhou, J., Jiang, J., Duan, J., Xu, H., Tang, Y., Lv, G., Zhang, J., Zhan, Z. and Ding, A. (2012) The novel antidote Bezoar Bovis prevents the cardiotoxicity of toad (Bufo bufo gargarizans Canto) venom in mice. Exp. Toxicol. Pathol. 64, 417-423.
    • (2012) Exp. Toxicol. Pathol , vol.64 , pp. 417-423
    • Ma, H.1    Zhou, J.2    Jiang, J.3    Duan, J.4    Xu, H.5    Tang, Y.6    Lv, G.7    Zhang, J.8    Zhan, Z.9    Ding, A.10
  • 73
    • 84858798279 scopus 로고    scopus 로고
    • Bilirubin attenuates bufadienolide-induced ventricular arrhythmias and cardiac dysfunction in guinea-pigs by reducing elevated intracellular Na+ levels
    • Ma, H., Zhang, J., Jiang, J., Zhou, J., Xu, H., Zhan, Z., Wu, Q. and Duan, J. (2012) Bilirubin attenuates bufadienolide-induced ventricular arrhythmias and cardiac dysfunction in guinea-pigs by reducing elevated intracellular Na+ levels. Cardiovasc. Toxicol. 12, 83-89.
    • (2012) Cardiovasc. Toxicol , vol.12 , pp. 83-89
    • Ma, H.1    Zhang, J.2    Jiang, J.3    Zhou, J.4    Xu, H.5    Zhan, Z.6    Wu, Q.7    Duan, J.8
  • 74
    • 37549065092 scopus 로고    scopus 로고
    • Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004
    • Perlstein, T.S., Pande, R.L., Beckman, J.A. and Creager, M.A. (2008) Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004. Arterioscler. Thromb. Vasc. Biol. 28, 166-172.
    • (2008) Arterioscler. Thromb. Vasc. Biol , vol.28 , pp. 166-172
    • Perlstein, T.S.1    Pande, R.L.2    Beckman, J.A.3    Creager, M.A.4
  • 75
    • 49949108687 scopus 로고    scopus 로고
    • Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999-2004
    • Perlstein, T.S., Pande, R.L., Creager, M.A., Weuve, J. and Beckman, J.A. (2008) Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999-2004. Am. J. Med. 121, 781-788.
    • (2008) Am. J. Med , vol.121 , pp. 781-788
    • Perlstein, T.S.1    Pande, R.L.2    Creager, M.A.3    Weuve, J.4    Beckman, J.A.5
  • 76
    • 84899683230 scopus 로고    scopus 로고
    • Bilirubin levels and their association with carotid intima media thickness and high-sensitivity C-reactive protein in patients with psoriasis vulgaris
    • Balta, S., Balta, I., Mikhailidis, D.P., Ozturk, C., Demirkol, S., Celik, T., Kilic, S., Demir, M. and Iyisoy, A. (2014) Bilirubin levels and their association with carotid intima media thickness and high-sensitivity C-reactive protein in patients with psoriasis vulgaris. Am. J. Clin. Dermatol. 15, 137-142.
    • (2014) Am. J. Clin. Dermatol , vol.15 , pp. 137-142
    • Balta, S.1    Balta, I.2    Mikhailidis, D.P.3    Ozturk, C.4    Demirkol, S.5    Celik, T.6    Kilic, S.7    Demir, M.8    Iyisoy, A.9
  • 77
    • 30044437464 scopus 로고    scopus 로고
    • Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women
    • Erdogan, D., Gullu, H., Yildirim, E., Tok, D., Kirbas, I., Ciftci, O., Baycan, S.T. and Muderrisoglu, H. (2006) Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women. Atherosclerosis 184, 431-437.
    • (2006) Atherosclerosis , vol.184 , pp. 431-437
    • Erdogan, D.1    Gullu, H.2    Yildirim, E.3    Tok, D.4    Kirbas, I.5    Ciftci, O.6    Baycan, S.T.7    Muderrisoglu, H.8
  • 78
    • 80052720863 scopus 로고    scopus 로고
    • TGR5: a novel target for weight maintenance and glucose metabolism
    • Chen, X., Lou, G., Meng, Z. and Huang, W. (2011) TGR5: a novel target for weight maintenance and glucose metabolism. Exp. Diabetes Res. 2011, 853501.
    • (2011) Exp. Diabetes Res , vol.2011
    • Chen, X.1    Lou, G.2    Meng, Z.3    Huang, W.4
  • 79
    • 84864104998 scopus 로고    scopus 로고
    • Serum total bilirubin concentration is inversely correlated with Framingham risk score in Koreans
    • Kim, K.M., Kim, B.T., Park, S.B., Cho, D.Y., Je, S.H. and Kim, K.N. (2012) Serum total bilirubin concentration is inversely correlated with Framingham risk score in Koreans. Arch. Med. Res. 43, 288-293.
    • (2012) Arch. Med. Res , vol.43 , pp. 288-293
    • Kim, K.M.1    Kim, B.T.2    Park, S.B.3    Cho, D.Y.4    Je, S.H.5    Kim, K.N.6
  • 80
    • 84895478668 scopus 로고    scopus 로고
    • Intraperitoneal bilirubin administration decreases infarct area in a rat coronary ischemia/reperfusion model
    • Ben-Amotz, R., Bonagura, J., Velayutham, M., Hamlin, R., Burns, P. and Adin, C. (2014) Intraperitoneal bilirubin administration decreases infarct area in a rat coronary ischemia/reperfusion model. Front. Physiol. 5, 53.
    • (2014) Front. Physiol , vol.5 , pp. 53
    • Ben-Amotz, R.1    Bonagura, J.2    Velayutham, M.3    Hamlin, R.4    Burns, P.5    Adin, C.6
  • 85
  • 88
    • 84887998662 scopus 로고    scopus 로고
    • Effects of total bilirubin on the prevalence of osteoporosis in postmenopausal women without potential liver disease
    • Bian, L.Q., Li, R.Z., Zhang, Z.Y., Jin, Y.J., Kang, H.W., Fang, Z.Z., Park, Y.S. and Choi, Y.H. (2013) Effects of total bilirubin on the prevalence of osteoporosis in postmenopausal women without potential liver disease. J. Bone Miner. Metab. 31, 637-643.
    • (2013) J. Bone Miner. Metab , vol.31 , pp. 637-643
    • Bian, L.Q.1    Li, R.Z.2    Zhang, Z.Y.3    Jin, Y.J.4    Kang, H.W.5    Fang, Z.Z.6    Park, Y.S.7    Choi, Y.H.8
  • 89
    • 84883020249 scopus 로고    scopus 로고
    • Bilirubin influences the clinical presentation of pre-eclampsia
    • Breslin, E., Kaufmann, A. and Quenby, S. (2013) Bilirubin influences the clinical presentation of pre-eclampsia. Eur. J. Obstet. Gyn. Reprod. Biol. 170, 111-113.
    • (2013) Eur. J. Obstet. Gyn. Reprod. Biol , vol.170 , pp. 111-113
    • Breslin, E.1    Kaufmann, A.2    Quenby, S.3
  • 90
    • 84891631575 scopus 로고    scopus 로고
    • Cardiovascular risk and psoriasis: beyond the traditional risk factors
    • Coumbe, A.G., Pritzker, M.R. and Duprez, D.A. (2014) Cardiovascular risk and psoriasis: beyond the traditional risk factors. Am. J. Med. 127, 12-18.
    • (2014) Am. J. Med , vol.127 , pp. 12-18
    • Coumbe, A.G.1    Pritzker, M.R.2    Duprez, D.A.3
  • 91
    • 43949101340 scopus 로고    scopus 로고
    • Cardiovascular disease risk awareness in systemic lupus erythematosus patients
    • Scalzi, L.V., Ballou, S.P., Park, J.Y., Redline, S. and Kirchner, H.L. (2008) Cardiovascular disease risk awareness in systemic lupus erythematosus patients. Arthritis Rheum. 58, 1458-1464.
    • (2008) Arthritis Rheum , vol.58 , pp. 1458-1464
    • Scalzi, L.V.1    Ballou, S.P.2    Park, J.Y.3    Redline, S.4    Kirchner, H.L.5
  • 94
    • 84906099391 scopus 로고    scopus 로고
    • Inflammation, lipid metabolism and cardiovascular risk in rheumatoid arthritis: a qualitative relationship?
    • Garcia-Gomez, C., Bianchi, M., de la Fuente, D., Badimon, L., Padro, T., Corbella, E. and Pinto, X. (2014) Inflammation, lipid metabolism and cardiovascular risk in rheumatoid arthritis: a qualitative relationship? World J. Orthop. 5, 304-311.
    • (2014) World J. Orthop , vol.5 , pp. 304-311
    • Garcia-Gomez, C.1    Bianchi, M.2    de la Fuente, D.3    Badimon, L.4    Padro, T.5    Corbella, E.6    Pinto, X.7
  • 95
    • 77957131202 scopus 로고    scopus 로고
    • Risk of arterial cardiovascular diseases in patients with multiple sclerosis: a population-based cohort study
    • Christiansen, C.F., Christensen, S., Farkas, D.K., Miret, M., Sorensen, H.T. and Pedersen, L. (2010) Risk of arterial cardiovascular diseases in patients with multiple sclerosis: a population-based cohort study. Neuroepidemiology 35, 267-274.
    • (2010) Neuroepidemiology , vol.35 , pp. 267-274
    • Christiansen, C.F.1    Christensen, S.2    Farkas, D.K.3    Miret, M.4    Sorensen, H.T.5    Pedersen, L.6
  • 96
    • 84879411538 scopus 로고    scopus 로고
    • Measures of cardiovascular risk and subclinical atherosclerosis in a cohort of women with a remote history of preeclampsia
    • McDonald, S.D., Ray, J., Teo, K., Jung, H., Salehian, O., Yusuf, S. and Lonn, E. (2013) Measures of cardiovascular risk and subclinical atherosclerosis in a cohort of women with a remote history of preeclampsia. Atherosclerosis 229, 234-239.
    • (2013) Atherosclerosis , vol.229 , pp. 234-239
    • McDonald, S.D.1    Ray, J.2    Teo, K.3    Jung, H.4    Salehian, O.5    Yusuf, S.6    Lonn, E.7
  • 98
    • 84880133226 scopus 로고    scopus 로고
    • Increased cardiovascular risk in patients with chronic obstructive pulmonary disease and the potential mechanisms linking the two conditions: a review
    • Ghoorah, K., De Soyza, A. and Kunadian, V. (2013) Increased cardiovascular risk in patients with chronic obstructive pulmonary disease and the potential mechanisms linking the two conditions: a review. Cardiol. Rev. 21, 196-202.
    • (2013) Cardiol. Rev , vol.21 , pp. 196-202
    • Ghoorah, K.1    De Soyza, A.2    Kunadian, V.3
  • 99
    • 0023132858 scopus 로고
    • Bilirubin is an antioxidant of possible physiological importance
    • Stocker, R., Yamamoto, Y., McDonagh, A.F., Glazer, A.N. and Ames, B.N. (1987) Bilirubin is an antioxidant of possible physiological importance. Science 235, 1043-1046.
    • (1987) Science , vol.235 , pp. 1043-1046
    • Stocker, R.1    Yamamoto, Y.2    McDonagh, A.F.3    Glazer, A.N.4    Ames, B.N.5
  • 100
    • 0029868642 scopus 로고    scopus 로고
    • Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins
    • Wu, T.W., Fung, K.P., Wu, J., Yang, C.C. and Weisel, R.D. (1996) Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins. Biochem. Pharmacol. 51, 859-862.
    • (1996) Biochem. Pharmacol , vol.51 , pp. 859-862
    • Wu, T.W.1    Fung, K.P.2    Wu, J.3    Yang, C.C.4    Weisel, R.D.5
  • 101
    • 0028313015 scopus 로고
    • Unconjugated bilirubin inhibits the oxidation of human low density lipoprotein better than Trolox
    • Wu, T.W., Fung, K.P. and Yang, C.C. (1994) Unconjugated bilirubin inhibits the oxidation of human low density lipoprotein better than Trolox. Life Sci. 54, P477-P481.
    • (1994) Life Sci , vol.54 , pp. P477-P481
    • Wu, T.W.1    Fung, K.P.2    Yang, C.C.3
  • 103
    • 34250323134 scopus 로고    scopus 로고
    • Urinary excretion of oxidative metabolites of bilirubin in subjects with Gilbert syndrome
    • Vitek, L., Kraslova, I., Muchova, L., Novotny, L. and Yamaguchi, T. (2007) Urinary excretion of oxidative metabolites of bilirubin in subjects with Gilbert syndrome. J. Gastroenterol. Hepatol. 22, 841-845.
    • (2007) J. Gastroenterol. Hepatol , vol.22 , pp. 841-845
    • Vitek, L.1    Kraslova, I.2    Muchova, L.3    Novotny, L.4    Yamaguchi, T.5
  • 104
    • 27744588300 scopus 로고    scopus 로고
    • Decreased levels of advanced glycation end-products in patients with Gilbert syndrome
    • Kalousova, M., Novotny, L., Zima, T., Braun, M. and Vitek, L. (2005) Decreased levels of advanced glycation end-products in patients with Gilbert syndrome. Cell. Mol. Biol. 51, 387-392.
    • (2005) Cell. Mol. Biol , vol.51 , pp. 387-392
    • Kalousova, M.1    Novotny, L.2    Zima, T.3    Braun, M.4    Vitek, L.5
  • 105
    • 84861047353 scopus 로고    scopus 로고
    • Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome
    • Boon, A.C., Hawkins, C.L., Bisht, K., Coombes, J.S., Bakrania, B., Wagner, K.H. and Bulmer, A.C. (2012) Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. Free Radic. Biol. Med. 52, 2120-2127.
    • (2012) Free Radic. Biol. Med , vol.52 , pp. 2120-2127
    • Boon, A.C.1    Hawkins, C.L.2    Bisht, K.3    Coombes, J.S.4    Bakrania, B.5    Wagner, K.H.6    Bulmer, A.C.7
  • 106
    • 34548855958 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress
    • Datla, S.R., Dusting, G.J., Mori, T.A., Taylor, C.J., Croft, K.D. and Jiang, F. (2007) Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress. Hypertension 50, 636-642.
    • (2007) Hypertension , vol.50 , pp. 636-642
    • Datla, S.R.1    Dusting, G.J.2    Mori, T.A.3    Taylor, C.J.4    Croft, K.D.5    Jiang, F.6
  • 107
    • 27744592135 scopus 로고    scopus 로고
    • Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats
    • Lanone, S., Bloc, S., Foresti, R., Almolki, A., Taille, C., Callebert, J., Conti, M., Goven, D., Aubier, M., Dureuil, B. et al. (2005) Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats. FASEB J. 19, 1890-1892.
    • (2005) FASEB J , vol.19 , pp. 1890-1892
    • Lanone, S.1    Bloc, S.2    Foresti, R.3    Almolki, A.4    Taille, C.5    Callebert, J.6    Conti, M.7    Goven, D.8    Aubier, M.9    Dureuil, B.10
  • 108
    • 0034081041 scopus 로고    scopus 로고
    • Comparison of various lipid, lipoprotein, and bilirubin combinations as risk factors for predicting coronary artery disease
    • Schwertner, H.A. and Fischer, Jr, J.R. (2000) Comparison of various lipid, lipoprotein, and bilirubin combinations as risk factors for predicting coronary artery disease. Atherosclerosis 150, 381-387.
    • (2000) Atherosclerosis , vol.150 , pp. 381-387
    • Schwertner, H.A.1    Fischer, J.R.2
  • 110
    • 84878535419 scopus 로고    scopus 로고
    • Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome
    • Wallner, M., Marculescu, R., Doberer, D., Wolzt, M., Wagner, O., Vitek, L., Bulmer, A.C. and Wagner, K.H. (2013) Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome. Clin. Sci. 125, 257-264.
    • (2013) Clin. Sci , vol.125 , pp. 257-264
    • Wallner, M.1    Marculescu, R.2    Doberer, D.3    Wolzt, M.4    Wagner, O.5    Vitek, L.6    Bulmer, A.C.7    Wagner, K.H.8
  • 111
    • 84973484231 scopus 로고    scopus 로고
    • The relationship between gamma-glutamyltransferase (GGT), bilirubin (Bil) and small dense low-density lipoprotein (sdLDL) in asymptomatic subjects attending a clinic for screening dyslipidaemias
    • Kotani, K., Tsuzaki, K. and Sakane, N. (2014) The relationship between gamma-glutamyltransferase (GGT), bilirubin (Bil) and small dense low-density lipoprotein (sdLDL) in asymptomatic subjects attending a clinic for screening dyslipidaemias. Ann. Acad. Med. Singap. 43, 216-219.
    • (2014) Ann. Acad. Med. Singap , vol.43 , pp. 216-219
    • Kotani, K.1    Tsuzaki, K.2    Sakane, N.3
  • 112
    • 80052000289 scopus 로고    scopus 로고
    • Relationship between unconjugated hyperbilirubinemia and lipoprotein spectrum
    • Ocadlik, I., Hlinstakova, S. and Oravec, S. (2011) Relationship between unconjugated hyperbilirubinemia and lipoprotein spectrum. Neuro Endocrinol. Lett. 32, 360-364.
    • (2011) Neuro Endocrinol. Lett , vol.32 , pp. 360-364
    • Ocadlik, I.1    Hlinstakova, S.2    Oravec, S.3
  • 113
    • 84920573648 scopus 로고    scopus 로고
    • A decrease in total bilirubin predicted hyper-LDL cholesterolemia in a health screening population
    • Oda, E. (2014) A decrease in total bilirubin predicted hyper-LDL cholesterolemia in a health screening population. Atherosclerosis 235, 334-338.
    • (2014) Atherosclerosis , vol.235 , pp. 334-338
    • Oda, E.1
  • 114
    • 84876532416 scopus 로고    scopus 로고
    • Relationship between serum bilirubin and remnant lipoprotein cholesterol level
    • Kamisako, T., Masuda, S. and Tanaka, Y. (2013) Relationship between serum bilirubin and remnant lipoprotein cholesterol level. Clin. Lab. 59, 435-438.
    • (2013) Clin. Lab , vol.59 , pp. 435-438
    • Kamisako, T.1    Masuda, S.2    Tanaka, Y.3
  • 115
    • 84857693224 scopus 로고    scopus 로고
    • Triglycerides: how much credit do they deserve?
    • Kohli, P. and Cannon, C.P. (2012) Triglycerides: how much credit do they deserve? Med. Clin. North. Am. 96, 39-55.
    • (2012) Med. Clin. North. Am , vol.96 , pp. 39-55
    • Kohli, P.1    Cannon, C.P.2
  • 116
    • 73349132993 scopus 로고    scopus 로고
    • Thinking beyond low-density lipoprotein cholesterol: strategies to further reduce cardiovascular risk
    • Sharma, R.K., Singh, V.N. and Reddy, H.K. (2009) Thinking beyond low-density lipoprotein cholesterol: strategies to further reduce cardiovascular risk. Vasc. Health Risk Manag. 5, 793-799.
    • (2009) Vasc. Health Risk Manag , vol.5 , pp. 793-799
    • Sharma, R.K.1    Singh, V.N.2    Reddy, H.K.3
  • 117
    • 38949171001 scopus 로고    scopus 로고
    • Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial
    • Miller, M., Cannon, C.P., Murphy, S.A., Qin, J., Ray, K.K. and Braunwald, E.; PROVE IT-TIMI 22 investigators (2008) Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial. J. Am. Coll. Cardiol. 51, 724-730.
    • (2008) J. Am. Coll. Cardiol , vol.51 , pp. 724-730
    • Miller, M.1    Cannon, C.P.2    Murphy, S.A.3    Qin, J.4    Ray, K.K.5    Braunwald, E.6
  • 118
    • 0035177104 scopus 로고    scopus 로고
    • Remnant-like particle (RLP) cholesterol is an independent cardiovascular disease risk factor in women: results from the Framingham Heart Study
    • McNamara, J.R., Shah, P.K., Nakajima, K., Cupples, L.A., Wilson, P.W., Ordovas, J.M. and Schaefer, E.J. (2001) Remnant-like particle (RLP) cholesterol is an independent cardiovascular disease risk factor in women: results from the Framingham Heart Study. Atherosclerosis 154, 229-236.
    • (2001) Atherosclerosis , vol.154 , pp. 229-236
    • McNamara, J.R.1    Shah, P.K.2    Nakajima, K.3    Cupples, L.A.4    Wilson, P.W.5    Ordovas, J.M.6    Schaefer, E.J.7
  • 119
    • 67651109078 scopus 로고    scopus 로고
    • Acute effect of weight loss on levels of total bilirubin in obese, cardiovascular high-risk patients: an analysis from the lead-in period of the Sibutramine Cardiovascular Outcome trial
    • Andersson, C., Weeke, P., Fosbol, E.L., Brendorp, B., Kober, L., Coutinho, W., Sharma, A.M., Van Gaal, L., Finer, N., James, W.P. et al. (2009) Acute effect of weight loss on levels of total bilirubin in obese, cardiovascular high-risk patients: an analysis from the lead-in period of the Sibutramine Cardiovascular Outcome trial. Metabolism 58, 1109-1115.
    • (2009) Metabolism , vol.58 , pp. 1109-1115
    • Andersson, C.1    Weeke, P.2    Fosbol, E.L.3    Brendorp, B.4    Kober, L.5    Coutinho, W.6    Sharma, A.M.7    Van Gaal, L.8    Finer, N.9    James, W.P.10
  • 121
    • 34748876803 scopus 로고    scopus 로고
    • Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes
    • Inoguchi, T., Sasaki, S., Kobayashi, K., Takayanagi, R. and Yamada, T. (2007) Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes. JAMA 298, 1398-1400.
    • (2007) JAMA , vol.298 , pp. 1398-1400
    • Inoguchi, T.1    Sasaki, S.2    Kobayashi, K.3    Takayanagi, R.4    Yamada, T.5
  • 123
    • 84879425307 scopus 로고    scopus 로고
    • Unconjugated bilirubin, a potent endogenous antioxidant, is decreased in patients with non-alcoholic steatohepatitis and advanced fibrosis
    • Salomone, F., Li Volti, G., Rosso, C., Grosso, G. and Bugianesi, E. (2013) Unconjugated bilirubin, a potent endogenous antioxidant, is decreased in patients with non-alcoholic steatohepatitis and advanced fibrosis. J. Gastroenterol. Hepatol. 28, 1202-1208.
    • (2013) J. Gastroenterol. Hepatol , vol.28 , pp. 1202-1208
    • Salomone, F.1    Li Volti, G.2    Rosso, C.3    Grosso, G.4    Bugianesi, E.5
  • 125
    • 84896870948 scopus 로고    scopus 로고
    • Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation
    • Dong, H., Huang, H., Yun, X., Kim, D.S., Yue, Y., Wu, H., Sutter, A., Chavin, K.D., Otterbein, L.E., Adams, D.B. et al. (2014) Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation. Endocrinology 155, 818-828.
    • (2014) Endocrinology , vol.155 , pp. 818-828
    • Dong, H.1    Huang, H.2    Yun, X.3    Kim, D.S.4    Yue, Y.5    Wu, H.6    Sutter, A.7    Chavin, K.D.8    Otterbein, L.E.9    Adams, D.B.10
  • 127
    • 84908648821 scopus 로고    scopus 로고
    • The inverse association of incident cardiovascular disease with plasma bilirubin is unaffected by adiponectin
    • Dullaart, R.P., Boersema, J., Lefrandt, J.D., Wolffenbuttel, B.H. and Bakker, S.J. (2014) The inverse association of incident cardiovascular disease with plasma bilirubin is unaffected by adiponectin. Atherosclerosis 235, 380-383.
    • (2014) Atherosclerosis , vol.235 , pp. 380-383
    • Dullaart, R.P.1    Boersema, J.2    Lefrandt, J.D.3    Wolffenbuttel, B.H.4    Bakker, S.J.5
  • 129
    • 84890416299 scopus 로고    scopus 로고
    • The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study
    • Cure, E., Cicek, Y., Cumhur Cure, M., Yuce, S., Kirbas, A. and Yilmaz, A. (2013) The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study. Anadolu Kardiyol. Derg. 13, 791-796.
    • (2013) Anadolu Kardiyol. Derg , vol.13 , pp. 791-796
    • Cure, E.1    Cicek, Y.2    Cumhur Cure, M.3    Yuce, S.4    Kirbas, A.5    Yilmaz, A.6
  • 130
    • 84927175625 scopus 로고    scopus 로고
    • Serum bilirubin as a predictor of incident metabolic syndrome: a 4-year retrospective longitudinal study of 6205 initially healthy Korean men
    • Lee, M.J., Jung, C.H., Kang, Y.M., Hwang, J.Y., Jang, J.E., Leem, J., Park, J.Y., Kim, H.K. and Lee, W.J. (2014) Serum bilirubin as a predictor of incident metabolic syndrome: a 4-year retrospective longitudinal study of 6205 initially healthy Korean men. Diabetes Metab. 40, 305-309.
    • (2014) Diabetes Metab , vol.40 , pp. 305-309
    • Lee, M.J.1    Jung, C.H.2    Kang, Y.M.3    Hwang, J.Y.4    Jang, J.E.5    Leem, J.6    Park, J.Y.7    Kim, H.K.8    Lee, W.J.9
  • 131
    • 84890130280 scopus 로고    scopus 로고
    • Higher serum bilirubin level as a protective factor for the development of diabetes in healthy Korean men: a 4 year retrospective longitudinal study
    • Jung, C.H., Lee, M.J., Kang, Y.M., Hwang, J.Y., Jang, J.E., Leem, J., Park, J.Y., Kim, H.K. and Lee, W.J. (2014) Higher serum bilirubin level as a protective factor for the development of diabetes in healthy Korean men: a 4 year retrospective longitudinal study. Metabolism 63, 87-93.
    • (2014) Metabolism , vol.63 , pp. 87-93
    • Jung, C.H.1    Lee, M.J.2    Kang, Y.M.3    Hwang, J.Y.4    Jang, J.E.5    Leem, J.6    Park, J.Y.7    Kim, H.K.8    Lee, W.J.9
  • 133
    • 84876495389 scopus 로고    scopus 로고
    • Plasma total bilirubin levels predict amputation events in type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
    • Chan, K.H., O'Connell, R.L., Sullivan, D.R., Hoffmann, L.S., Rajamani, K., Whiting, M., Donoghoe, M.W., Vanhala, M., Hamer, A., Yu, B. et al. (2013) Plasma total bilirubin levels predict amputation events in type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Diabetologia 56, 724-736.
    • (2013) Diabetologia , vol.56 , pp. 724-736
    • Chan, K.H.1    O'Connell, R.L.2    Sullivan, D.R.3    Hoffmann, L.S.4    Rajamani, K.5    Whiting, M.6    Donoghoe, M.W.7    Vanhala, M.8    Hamer, A.9    Yu, B.10
  • 134
    • 84874950329 scopus 로고    scopus 로고
    • Association of low bilirubin levels and promoter variations in UGT1A1 gene with diabetes mellitus type 2
    • Jiraskova, A., Jovanovska, J., Skrha, J. and Vitek, L. (2011) Association of low bilirubin levels and promoter variations in UGT1A1 gene with diabetes mellitus type 2. Hepatol. Int. 5, 37.
    • (2011) Hepatol. Int , vol.5 , pp. 37
    • Jiraskova, A.1    Jovanovska, J.2    Skrha, J.3    Vitek, L.4
  • 136
    • 84896346292 scopus 로고    scopus 로고
    • A critical and comprehensive insight on heme oxygenase and related products including carbon monoxide, bilirubin, biliverdin and ferritin in type-1 and type-2 diabetes
    • Mishra, M. and Ndisang, J.F. (2014) A critical and comprehensive insight on heme oxygenase and related products including carbon monoxide, bilirubin, biliverdin and ferritin in type-1 and type-2 diabetes. Curr. Pharm. Des. 20, 1370-1391.
    • (2014) Curr. Pharm. Des , vol.20 , pp. 1370-1391
    • Mishra, M.1    Ndisang, J.F.2
  • 137
    • 84896990821 scopus 로고    scopus 로고
    • The relationship of the anti-oxidant bilirubin with free thyroxine is modified by insulin resistance in euthyroid subjects
    • Deetman, P.E., Bakker, S.J., Kwakernaak, A.J., Navis, G. and Dullaart, R.P. (2014) The relationship of the anti-oxidant bilirubin with free thyroxine is modified by insulin resistance in euthyroid subjects. PLOS ONE 9, e90886.
    • (2014) PLOS ONE , vol.9
    • Deetman, P.E.1    Bakker, S.J.2    Kwakernaak, A.J.3    Navis, G.4    Dullaart, R.P.5
  • 138
    • 70450189795 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis: from pathophysiology to practice
    • Libby, P., Ridker, P.M. and Hansson, G.K. (2009) Inflammation in atherosclerosis: from pathophysiology to practice. J. Am. Coll. Cardiol. 54, 2129-2138.
    • (2009) J. Am. Coll. Cardiol , vol.54 , pp. 2129-2138
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 139
    • 0006966385 scopus 로고
    • Defensive role of bilirubinemia in pneumococcal infection
    • Najib-Farah, M.D. (1937) Defensive role of bilirubinemia in pneumococcal infection. Lancet 229, 505-506.
    • (1937) Lancet , vol.229 , pp. 505-506
    • Najib-Farah, M.D.1
  • 141
    • 0030573972 scopus 로고    scopus 로고
    • Unconjugated bilirubin inhibits in vitro cytotoxic T lymphocyte activity of human lymphocytes
    • Haga, Y., Tempero, M.A. and Zetterman, R.K. (1996) Unconjugated bilirubin inhibits in vitro cytotoxic T lymphocyte activity of human lymphocytes. Biochim. Biophys. Acta 1317, 65-70.
    • (1996) Biochim. Biophys. Acta , vol.1317 , pp. 65-70
    • Haga, Y.1    Tempero, M.A.2    Zetterman, R.K.3
  • 143
    • 69449104516 scopus 로고    scopus 로고
    • Proinflammatory cytokines in CRP baseline regulation
    • Eklund, C.M. (2009) Proinflammatory cytokines in CRP baseline regulation. Adv. Clin. Chem. 48, 111-136.
    • (2009) Adv. Clin. Chem , vol.48 , pp. 111-136
    • Eklund, C.M.1
  • 144
    • 80755187935 scopus 로고    scopus 로고
    • Relationship between bilirubin and C-reactive protein
    • Hwang, H.J., Lee, S.W. and Kim, S.H. (2011) Relationship between bilirubin and C-reactive protein. Clin. Chem. Lab. Med. 49, 1823-1828.
    • (2011) Clin. Chem. Lab. Med , vol.49 , pp. 1823-1828
    • Hwang, H.J.1    Lee, S.W.2    Kim, S.H.3
  • 145
    • 41049085191 scopus 로고    scopus 로고
    • Relationship between serum bilirubin and markers of inflammation and oxidative stress
    • Vitek, L., Malikova, I., Kvasnicka, J., Benakova, H. and Novotny, L. (2007) Relationship between serum bilirubin and markers of inflammation and oxidative stress. J. Gastroenterol. Hepatol. 22, A235.
    • (2007) J. Gastroenterol. Hepatol , vol.22 , pp. A235
    • Vitek, L.1    Malikova, I.2    Kvasnicka, J.3    Benakova, H.4    Novotny, L.5
  • 147
    • 0142095224 scopus 로고    scopus 로고
    • C-reactive protein and atherothrombosis-beyond a biomarker: an actual partaker of lesion formation
    • Verma, S. and Yeh, E.T. (2003) C-reactive protein and atherothrombosis-beyond a biomarker: an actual partaker of lesion formation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285, R1253-R1256.
    • (2003) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.285 , pp. R1253-R1256
    • Verma, S.1    Yeh, E.T.2
  • 148
    • 84920693819 scopus 로고    scopus 로고
    • Endogenous tetrapyrroles influence leukocyte responses to lipopolysaccharide in human blood: pre-clinical evidence demonstrating the anti-inflammatory potential of biliverdin
    • Bisht, K., Tampe, J., Shing, C., Bakrania, B., Winearls, J., Fraser, J., Wagner, K.H. and Bulmer, A.C. (2014) Endogenous tetrapyrroles influence leukocyte responses to lipopolysaccharide in human blood: pre-clinical evidence demonstrating the anti-inflammatory potential of biliverdin. J. Clin. Cell. Immunol. 5, 1000218.
    • (2014) J. Clin. Cell. Immunol , vol.5
    • Bisht, K.1    Tampe, J.2    Shing, C.3    Bakrania, B.4    Winearls, J.5    Fraser, J.6    Wagner, K.H.7    Bulmer, A.C.8
  • 149
    • 84892699525 scopus 로고    scopus 로고
    • Unconjugated bilirubin inhibits collagen induced platelet activation
    • Kundur, A.R., Bulmer, A.C. and Singh, I. (2014) Unconjugated bilirubin inhibits collagen induced platelet activation. Platelets 25, 45-50.
    • (2014) Platelets , vol.25 , pp. 45-50
    • Kundur, A.R.1    Bulmer, A.C.2    Singh, I.3
  • 151
    • 84901479808 scopus 로고    scopus 로고
    • Platelet volume indices are associated with high residual platelet reactivity after antiplatelet therapy in patients undergoing percutaneous coronary intervention
    • Kim, Y.G., Suh, J.W., Yoon, C.H., Oh, I.Y., Cho, Y.S., Youn, T.J., Chae, I.H. and Choi, D.J. (2014) Platelet volume indices are associated with high residual platelet reactivity after antiplatelet therapy in patients undergoing percutaneous coronary intervention. J. Atheroscler. Thromb. 21, 445-453.
    • (2014) J. Atheroscler. Thromb , vol.21 , pp. 445-453
    • Kim, Y.G.1    Suh, J.W.2    Yoon, C.H.3    Oh, I.Y.4    Cho, Y.S.5    Youn, T.J.6    Chae, I.H.7    Choi, D.J.8
  • 152
    • 84879941268 scopus 로고    scopus 로고
    • The effects of Gilbert's syndrome on the mean platelet volume and other hematological parameters
    • Cure, M.C., Cure, E., Kirbas, A., Cicek, A.C. and Yuce, S. (2013) The effects of Gilbert's syndrome on the mean platelet volume and other hematological parameters. Blood Coagul. Fibrinolysis 24, 484-488.
    • (2013) Blood Coagul. Fibrinolysis , vol.24 , pp. 484-488
    • Cure, M.C.1    Cure, E.2    Kirbas, A.3    Cicek, A.C.4    Yuce, S.5
  • 153
    • 17244361897 scopus 로고    scopus 로고
    • Relationship between serum bilirubin and coagulation test results in 1-month-old infants
    • Tiker, F., Gurakan, B. and Tarcan, A. (2005) Relationship between serum bilirubin and coagulation test results in 1-month-old infants. Indian J. Pediatr. 72, 205-207.
    • (2005) Indian J. Pediatr , vol.72 , pp. 205-207
    • Tiker, F.1    Gurakan, B.2    Tarcan, A.3
  • 156
    • 77951160872 scopus 로고    scopus 로고
    • Bilirubin effect on endothelial adhesion molecules expression is mediated by the NF-kappaB signaling pathway
    • Mazzone, G.L., Rigato, I., Ostrow, J.D. and Tiribelli, C. (2009) Bilirubin effect on endothelial adhesion molecules expression is mediated by the NF-kappaB signaling pathway. Biosci. Trends 3, 151-157.
    • (2009) Biosci. Trends , vol.3 , pp. 151-157
    • Mazzone, G.L.1    Rigato, I.2    Ostrow, J.D.3    Tiribelli, C.4
  • 157
    • 79952276358 scopus 로고    scopus 로고
    • Unconjugated bilirubin modulates nitric oxide production via iNOS regulation
    • Mazzone, G.L., Rigato, I. and Tiribelli, C. (2010) Unconjugated bilirubin modulates nitric oxide production via iNOS regulation. Biosci. Trends 4, 244-248.
    • (2010) Biosci. Trends , vol.4 , pp. 244-248
    • Mazzone, G.L.1    Rigato, I.2    Tiribelli, C.3
  • 159
    • 67349088999 scopus 로고    scopus 로고
    • Soluble CD40 ligand and soluble P-selectin levels in Gilbert's syndrome: a link to protection against atherosclerosis?
    • Tapan, S., Dogru, T., Tasci, I., Ercin, C.N., Ozgurtas, T. and Erbil, M.K. (2009) Soluble CD40 ligand and soluble P-selectin levels in Gilbert's syndrome: a link to protection against atherosclerosis? Clin. Biochem. 42, 791-795.
    • (2009) Clin. Biochem , vol.42 , pp. 791-795
    • Tapan, S.1    Dogru, T.2    Tasci, I.3    Ercin, C.N.4    Ozgurtas, T.5    Erbil, M.K.6
  • 161
    • 84860847500 scopus 로고    scopus 로고
    • Essential roles of raf/extracellular signal-regulated kinase/mitogen-activated protein kinase pathway, YY1, and Ca2+ influx in growth arrest of human vascular smooth muscle cells by bilirubin
    • Stoeckius, M., Erat, A., Fujikawa, T., Hiromura, M., Koulova, A., Otterbein, L., Bianchi, C., Tobiasch, E., Dagon, Y., Sellke, F.W. et al. (2012) Essential roles of raf/extracellular signal-regulated kinase/mitogen-activated protein kinase pathway, YY1, and Ca2+ influx in growth arrest of human vascular smooth muscle cells by bilirubin. J. Biol. Chem. 287, 15418-15426.
    • (2012) J. Biol. Chem , vol.287 , pp. 15418-15426
    • Stoeckius, M.1    Erat, A.2    Fujikawa, T.3    Hiromura, M.4    Koulova, A.5    Otterbein, L.6    Bianchi, C.7    Tobiasch, E.8    Dagon, Y.9    Sellke, F.W.10
  • 166
    • 84869473350 scopus 로고    scopus 로고
    • Inhibition of PTEN expression and activity by angiotensin II induces proliferation and migration of vascular smooth muscle cells
    • Dong, X., Yu, L.G., Sun, R., Cheng, Y.N., Cao, H., Yang, K.M., Dong, Y.N., Wu, Y. and Guo, X.L. (2013) Inhibition of PTEN expression and activity by angiotensin II induces proliferation and migration of vascular smooth muscle cells. J. Cell. Biochem. 114, 174-182.
    • (2013) J. Cell. Biochem , vol.114 , pp. 174-182
    • Dong, X.1    Yu, L.G.2    Sun, R.3    Cheng, Y.N.4    Cao, H.5    Yang, K.M.6    Dong, Y.N.7    Wu, Y.8    Guo, X.L.9
  • 167
    • 84875082749 scopus 로고    scopus 로고
    • Decreased serum bilirubin is associated with arterial stiffness in men
    • Li, Y., Meng, S.Y., Meng, C.C., Yu, W.G. and Wang, R.T. (2013) Decreased serum bilirubin is associated with arterial stiffness in men. Nutr. Metab. Cardiovasc. Dis. 23, 375-381.
    • (2013) Nutr. Metab. Cardiovasc. Dis , vol.23 , pp. 375-381
    • Li, Y.1    Meng, S.Y.2    Meng, C.C.3    Yu, W.G.4    Wang, R.T.5
  • 168
    • 84880265311 scopus 로고    scopus 로고
    • Serum total bilirubin is inversely associated with brachial-ankle pulse wave velocity in men with hypertension
    • Zhang, Z.Y., Bian, L.Q., Jae, S.Y., Sung, J.D. and Choi, Y.H. (2013) Serum total bilirubin is inversely associated with brachial-ankle pulse wave velocity in men with hypertension. Heart Vessels 28, 453-460.
    • (2013) Heart Vessels , vol.28 , pp. 453-460
    • Zhang, Z.Y.1    Bian, L.Q.2    Jae, S.Y.3    Sung, J.D.4    Choi, Y.H.5
  • 169
    • 30044437464 scopus 로고    scopus 로고
    • Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women
    • Erdogan, D., Gullu, H., Yildirim, E., Tok, D., Kirbas, I., Ciftci, O., Baycan, S.T. and Muderrisoglu, H. (2006) Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women. Atherosclerosis 184, 431-437.
    • (2006) Atherosclerosis , vol.184 , pp. 431-437
    • Erdogan, D.1    Gullu, H.2    Yildirim, E.3    Tok, D.4    Kirbas, I.5    Ciftci, O.6    Baycan, S.T.7    Muderrisoglu, H.8
  • 170
    • 33847017691 scopus 로고    scopus 로고
    • Low serum bilirubin concentrations are associated with impaired aortic elastic properties, but not impaired left ventricular diastolic function
    • Caliskan, M., Erdogan, D., Gullu, H., Tok, D., Bilgi, M. and Muderrisoglu, H. (2007) Low serum bilirubin concentrations are associated with impaired aortic elastic properties, but not impaired left ventricular diastolic function. Int. J. Clin. Pract. 61, 218-224.
    • (2007) Int. J. Clin. Pract , vol.61 , pp. 218-224
    • Caliskan, M.1    Erdogan, D.2    Gullu, H.3    Tok, D.4    Bilgi, M.5    Muderrisoglu, H.6
  • 174
  • 177
    • 84862804281 scopus 로고    scopus 로고
    • Association between serum total bilirubin level and leukoaraiosis in Korean adults
    • Park, B.J., Shim, J.Y., Lee, H.R., Kang, H.T., Lee, J.H. and Lee, Y.J. (2012) Association between serum total bilirubin level and leukoaraiosis in Korean adults. Clin. Biochem. 45, 289-292.
    • (2012) Clin. Biochem , vol.45 , pp. 289-292
    • Park, B.J.1    Shim, J.Y.2    Lee, H.R.3    Kang, H.T.4    Lee, J.H.5    Lee, Y.J.6
  • 178
    • 84857040277 scopus 로고    scopus 로고
    • Mean platelet volume (MPV) is associated with leukoaraiosis in the apparently healthy elderly
    • Kang, S.J., Park, B.J., Shim, J.Y., Lee, H.R., Hong, J.M. and Lee, Y.J. (2012) Mean platelet volume (MPV) is associated with leukoaraiosis in the apparently healthy elderly. Arch. Gerontol. Geriatr. 54, e118-e121.
    • (2012) Arch. Gerontol. Geriatr , vol.54 , pp. e118-e121
    • Kang, S.J.1    Park, B.J.2    Shim, J.Y.3    Lee, H.R.4    Hong, J.M.5    Lee, Y.J.6
  • 180
    • 84902479763 scopus 로고    scopus 로고
    • Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes
    • Szabó, M., Veres, Z., Bátai-Konczos, A., Kékesi, O., Kis, E., Szabó, K. and Jemnitz, K. (2014) Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes. Toxicol. In Vitro 28, 1136-1143.
    • (2014) Toxicol. In Vitro , vol.28 , pp. 1136-1143
    • Szabó, M.1    Veres, Z.2    Bátai-Konczos, A.3    Kékesi, O.4    Kis, E.5    Szabó, K.6    Jemnitz, K.7
  • 181
    • 84864770840 scopus 로고    scopus 로고
    • Effects of statin treatments and polymorphisms in UGT1A1 and SLCO1B1 on serum bilirubin levels in Chinese patients with hypercholesterolaemia
    • Hu, M. and Tomlinson, B. (2012) Effects of statin treatments and polymorphisms in UGT1A1 and SLCO1B1 on serum bilirubin levels in Chinese patients with hypercholesterolaemia. Atherosclerosis 223, 427-432.
    • (2012) Atherosclerosis , vol.223 , pp. 427-432
    • Hu, M.1    Tomlinson, B.2
  • 182
    • 82955187697 scopus 로고    scopus 로고
    • Association of lower total bilirubin level with statin usage: the United States National Health and Nutrition Examination Survey 1999-2008
    • Ong, K.L., Wu, B.J., Cheung, B.M., Barter, P.J. and Rye, KA. (2011) Association of lower total bilirubin level with statin usage: the United States National Health and Nutrition Examination Survey 1999-2008. Atherosclerosis 219, 728-733.
    • (2011) Atherosclerosis , vol.219 , pp. 728-733
    • Ong, K.L.1    Wu, B.J.2    Cheung, B.M.3    Barter, P.J.4    Rye, K.A.5
  • 183
    • 84859897760 scopus 로고    scopus 로고
    • Statin use and serum bilirubin levels
    • Vítek, L., Muchová, L. and Zák, A. (2011) Statin use and serum bilirubin levels. Atherosclerosis 219, 969.
    • (2011) Atherosclerosis , vol.219 , pp. 969
    • Vítek, L.1    Muchová, L.2    Zák, A.3
  • 184
    • 80051806943 scopus 로고    scopus 로고
    • Serum bilirubin levels in familial hypercholesterolemia: a new risk marker for cardiovascular disease?
    • de Sauvage Nolting, P.R., Kusters, D.M., Hutten, B.A. and Kastelein, J.J. (2011) Serum bilirubin levels in familial hypercholesterolemia: a new risk marker for cardiovascular disease? J. Lipid Res. 52, 1755-1759.
    • (2011) J. Lipid Res , vol.52 , pp. 1755-1759
    • de Sauvage Nolting, P.R.1    Kusters, D.M.2    Hutten, B.A.3    Kastelein, J.J.4
  • 185
    • 27544468948 scopus 로고    scopus 로고
    • In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation
    • Zhang, D., Chando, T.J., Everett, D.W., Patten, C.J., Dehal, S.S. and Humphreys, W.G. (2005) In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation. Drug Metab. Dispos. 33, 1729-1739.
    • (2005) Drug Metab. Dispos , vol.33 , pp. 1729-1739
    • Zhang, D.1    Chando, T.J.2    Everett, D.W.3    Patten, C.J.4    Dehal, S.S.5    Humphreys, W.G.6
  • 188
    • 58149339903 scopus 로고    scopus 로고
    • Vivo-morpholinos: a non-peptide transporter delivers morpholinos into a wide array of mouse tissues
    • Morcos, P.A., Li, Y. and Jiang, S. (2008) Vivo-morpholinos: a non-peptide transporter delivers morpholinos into a wide array of mouse tissues. Biotechniques 45, 613-623.
    • (2008) Biotechniques , vol.45 , pp. 613-623
    • Morcos, P.A.1    Li, Y.2    Jiang, S.3
  • 189
    • 77957597205 scopus 로고    scopus 로고
    • Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension
    • Vera, T. and Stec, D.E. (2010) Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299, R1044-R1049.
    • (2010) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.299 , pp. R1044-R1049
    • Vera, T.1    Stec, D.E.2
  • 190
    • 63449133262 scopus 로고    scopus 로고
    • Gene knockdowns in adult animals: PPMOs and vivo-morpholinos
    • Moulton, J.D. and Jiang, S. (2009) Gene knockdowns in adult animals: PPMOs and vivo-morpholinos. Molecules 25, 1304-1323.
    • (2009) Molecules , vol.25 , pp. 1304-1323
    • Moulton, J.D.1    Jiang, S.2
  • 191
    • 84896461111 scopus 로고    scopus 로고
    • Using genetic variation for establishing causality of cardiovascular risk factors: overcoming confounding and reverse causality
    • Smit, R.A., Trompet, S., de Craen, A.J. and Jukema, J.W. (2014) Using genetic variation for establishing causality of cardiovascular risk factors: overcoming confounding and reverse causality. Neth. Heart J. 22, 186-189.
    • (2014) Neth. Heart J , vol.22 , pp. 186-189
    • Smit, R.A.1    Trompet, S.2    de Craen, A.J.3    Jukema, J.W.4
  • 192
    • 0036167545 scopus 로고    scopus 로고
    • Serum levels of micronutrients, antioxidants and total antioxidant status predict risk of breast cancer in a case control study
    • Ching, S., Ingram, D., Hahnel, R., Beilby, J. and Rossi, E. (2002) Serum levels of micronutrients, antioxidants and total antioxidant status predict risk of breast cancer in a case control study. J. Nutr. 132, 303-306.
    • (2002) J. Nutr , vol.132 , pp. 303-306
    • Ching, S.1    Ingram, D.2    Hahnel, R.3    Beilby, J.4    Rossi, E.5
  • 195
    • 0021280703 scopus 로고
    • Influence of sex and sex steroids on bilirubin uridine diphosphate-glucuronosyltransferase activity of rat liver
    • Muraca, M. and Fevery, J. (1984) Influence of sex and sex steroids on bilirubin uridine diphosphate-glucuronosyltransferase activity of rat liver. Gastroenterology 87, 308-313.
    • (1984) Gastroenterology , vol.87 , pp. 308-313
    • Muraca, M.1    Fevery, J.2
  • 196
    • 33750975372 scopus 로고    scopus 로고
    • The role of estrogen in the initiation of breast cancer
    • Russo, J. and Russo, I.H. (2006) The role of estrogen in the initiation of breast cancer. J. Steroid Biochem. Mol. Biol. 102, 89-96.
    • (2006) J. Steroid Biochem. Mol. Biol , vol.102 , pp. 89-96
    • Russo, J.1    Russo, I.H.2
  • 197
    • 33747879659 scopus 로고    scopus 로고
    • Hormones and cardiovascular health in women
    • ESHRE Capri Workshop Group (2006) Hormones and cardiovascular health in women. Hum. Reprod. Update 12, 483-497.
    • (2006) Hum. Reprod. Update , vol.12 , pp. 483-497
  • 199
    • 0028608788 scopus 로고
    • Serum albumin, bilirubin, and uric acid and the anatomic site-specific incidence of colon cancer
    • Ko, W.F., Helzlsouer, K.J. and Comstock, G.W. (1994) Serum albumin, bilirubin, and uric acid and the anatomic site-specific incidence of colon cancer. J. Natl. Cancer Inst. 86, 1874-1875.
    • (1994) J. Natl. Cancer Inst , vol.86 , pp. 1874-1875
    • Ko, W.F.1    Helzlsouer, K.J.2    Comstock, G.W.3
  • 202
    • 84892769574 scopus 로고    scopus 로고
    • UGT1A1*28 polymorphism in chronic lymphocytic leukemia: the first investigation of the polymorphism in disease susceptibility and its specific cytogenetic abnormalities
    • Karakosta, M., Kalotychou, V., Kostakis, A., Pantelias, G., Rombos, I., Kouraklis, G. and Manola, K.N. (2014) UGT1A1*28 polymorphism in chronic lymphocytic leukemia: the first investigation of the polymorphism in disease susceptibility and its specific cytogenetic abnormalities. Acta Haematol. 132, 59-67.
    • (2014) Acta Haematol , vol.132 , pp. 59-67
    • Karakosta, M.1    Kalotychou, V.2    Kostakis, A.3    Pantelias, G.4    Rombos, I.5    Kouraklis, G.6    Manola, K.N.7
  • 203
    • 78650634202 scopus 로고    scopus 로고
    • Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies
    • Bonassi, S., El-Zein, R., Bolognesi, C. and Fenech, M. (2011) Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies. Mutagenesis 26, 93-100.
    • (2011) Mutagenesis , vol.26 , pp. 93-100
    • Bonassi, S.1    El-Zein, R.2    Bolognesi, C.3    Fenech, M.4
  • 205
    • 16544369859 scopus 로고    scopus 로고
    • Bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter polymorphisms and HPRT, glycophorin A, and micronuclei mutant frequencies in human blood
    • Grant, D.J., Hall, I.J., Eastmond, D.A., Jones, I.M. and Bell, D.A. (2004) Bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter polymorphisms and HPRT, glycophorin A, and micronuclei mutant frequencies in human blood. Mutat. Res. 560, 1-10.
    • (2004) Mutat. Res , vol.560 , pp. 1-10
    • Grant, D.J.1    Hall, I.J.2    Eastmond, D.A.3    Jones, I.M.4    Bell, D.A.5
  • 207
    • 0030946410 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase-mediated protection against in vitro DNA oxidation and micronucleus formation initiated by phenytoin and its embryotoxic metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin
    • Kim, P.M., Winn, L.M., Parman, T. and Wells, P.G. (1997) UDP-glucuronosyltransferase-mediated protection against in vitro DNA oxidation and micronucleus formation initiated by phenytoin and its embryotoxic metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin. J. Pharmacol. Exp. Ther. 280, 200-209.
    • (1997) J. Pharmacol. Exp. Ther , vol.280 , pp. 200-209
    • Kim, P.M.1    Winn, L.M.2    Parman, T.3    Wells, P.G.4
  • 208
    • 0028956177 scopus 로고
    • Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts
    • Vienneau, D.S., DeBoni, U. and Wells, P.G. (1995) Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts. Cancer Res. 55, 1045-1051.
    • (1995) Cancer Res , vol.55 , pp. 1045-1051
    • Vienneau, D.S.1    DeBoni, U.2    Wells, P.G.3
  • 209
    • 0001130357 scopus 로고
    • Hereditary acholuric jaundice in a new mutant strain of rats
    • Gunn, C.H. (1938) Hereditary acholuric jaundice in a new mutant strain of rats. J. Hered. 29, 137-139.
    • (1938) J. Hered , vol.29 , pp. 137-139
    • Gunn, C.H.1
  • 210
    • 0027312075 scopus 로고
    • Binding of polycyclic planar mutagens to chlorophyllin resulting in inhibition of the mutagenic activity
    • Arimoto, S., Fukuoka, S., Itome, C., Nakano, H., Rai, H. and Hayatsu, H. (1993) Binding of polycyclic planar mutagens to chlorophyllin resulting in inhibition of the mutagenic activity. Mutat. Res. 287, 293-305.
    • (1993) Mutat. Res , vol.287 , pp. 293-305
    • Arimoto, S.1    Fukuoka, S.2    Itome, C.3    Nakano, H.4    Rai, H.5    Hayatsu, H.6
  • 211
    • 84896869139 scopus 로고    scopus 로고
    • Circular dichroism study of the interaction between mutagens and bilirubin bound to different binding sites of serum albumins
    • Orlov, S., Goncharova, I. and Urbanova, M. (2014) Circular dichroism study of the interaction between mutagens and bilirubin bound to different binding sites of serum albumins. Spectrochim. Acta A Mol. Biol. Spectrosc. 126, 68-75.
    • (2014) Spectrochim. Acta A Mol. Biol. Spectrosc , vol.126 , pp. 68-75
    • Orlov, S.1    Goncharova, I.2    Urbanova, M.3
  • 213
    • 4644344388 scopus 로고    scopus 로고
    • Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization
    • Keshavan, P., Schwemberger, S.J., Smith, D.L., Babcock, G.F. and Zucker, S.D. (2004) Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization. Int. J. Cancer 112, 433-445.
    • (2004) Int. J. Cancer , vol.112 , pp. 433-445
    • Keshavan, P.1    Schwemberger, S.J.2    Smith, D.L.3    Babcock, G.F.4    Zucker, S.D.5
  • 216
    • 34447279020 scopus 로고    scopus 로고
    • Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment
    • Markesbery, W.R. and Lovell, M.A. (2007) Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch. Neurol. 64, 954-956.
    • (2007) Arch. Neurol , vol.64 , pp. 954-956
    • Markesbery, W.R.1    Lovell, M.A.2
  • 217
    • 84864104998 scopus 로고    scopus 로고
    • Serum total bilirubin concentration is inversely correlated with Framingham risk score in Koreans
    • Kim, K.M., Kim, B.T., Park, S.B., Cho, D.Y., Je, S.H. and Kim, K.N. (2012) Serum total bilirubin concentration is inversely correlated with Framingham risk score in Koreans. Arch. Med. Res. 43, 288-293.
    • (2012) Arch. Med. Res , vol.43 , pp. 288-293
    • Kim, K.M.1    Kim, B.T.2    Park, S.B.3    Cho, D.Y.4    Je, S.H.5    Kim, K.N.6
  • 218
    • 0035194145 scopus 로고    scopus 로고
    • Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide
    • Butterfield, D.A., Drake, J., Pocernich, C. and Castegna, A. (2001) Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends Mol. Med. 7, 548-554.
    • (2001) Trends Mol. Med , vol.7 , pp. 548-554
    • Butterfield, D.A.1    Drake, J.2    Pocernich, C.3    Castegna, A.4
  • 219
    • 84877072330 scopus 로고    scopus 로고
    • Amyloid beta-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression
    • Butterfield, D.A., Swomley, A.M. and Sultana, R. (2013) Amyloid beta-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression. Antioxid. Redox Signal. 19, 823-835.
    • (2013) Antioxid. Redox Signal , vol.19 , pp. 823-835
    • Butterfield, D.A.1    Swomley, A.M.2    Sultana, R.3
  • 221
    • 84886872345 scopus 로고    scopus 로고
    • The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation
    • Barone, E., Di Domenico, F., Mancuso, C. and Butterfield, D.A. (2014) The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation. Neurobiol. Dis. 62, 144-159.
    • (2014) Neurobiol. Dis , vol.62 , pp. 144-159
    • Barone, E.1    Di Domenico, F.2    Mancuso, C.3    Butterfield, D.A.4
  • 222
    • 1842608814 scopus 로고    scopus 로고
    • Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress
    • Schipper, H.M. (2004) Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress. Ann. N.Y. Acad. Sci. 1012, 84-93.
    • (2004) Ann. N.Y. Acad. Sci , vol.1012 , pp. 84-93
    • Schipper, H.M.1
  • 223
    • 0030976868 scopus 로고    scopus 로고
    • Increased plasma bilirubin in Parkinson patients on L-dopa: evidence against the free radical hypothesis?
    • Scigliano, G., Girotti, F., Soliveri, P., Musicco, M., Radice, D. and Caraceni, T. (1997) Increased plasma bilirubin in Parkinson patients on L-dopa: evidence against the free radical hypothesis? Ital. J. Neurol. Sci. 18, 69-72.
    • (1997) Ital. J. Neurol. Sci , vol.18 , pp. 69-72
    • Scigliano, G.1    Girotti, F.2    Soliveri, P.3    Musicco, M.4    Radice, D.5    Caraceni, T.6
  • 224
  • 226
    • 0042886948 scopus 로고    scopus 로고
    • Serum bilirubin concentration in patients with amyotrophic lateral sclerosis
    • Ilzecka, J. and Stelmasiak, Z. (2003) Serum bilirubin concentration in patients with amyotrophic lateral sclerosis. Clin. Neurol. Neurosurg. 105, 237-240.
    • (2003) Clin. Neurol. Neurosurg , vol.105 , pp. 237-240
    • Ilzecka, J.1    Stelmasiak, Z.2
  • 227
    • 0026334728 scopus 로고
    • Coincidence of schizophrenia and hyperbilirubinemia
    • Muller, N., Schiller, P. and Ackenheil, M. (1991) Coincidence of schizophrenia and hyperbilirubinemia. Pharmacopsychiatr 24, 225-228.
    • (1991) Pharmacopsychiatr , vol.24 , pp. 225-228
    • Muller, N.1    Schiller, P.2    Ackenheil, M.3
  • 228
    • 0033695697 scopus 로고    scopus 로고
    • Schizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome)
    • Miyaoka, T., Seno, H., Itoga, M., Iijima, M., Inagaki, T. and Horiguchi, J. (2000) Schizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome). J. Clin. Psychiatry 61, 868-871.
    • (2000) J. Clin. Psychiatry , vol.61 , pp. 868-871
    • Miyaoka, T.1    Seno, H.2    Itoga, M.3    Iijima, M.4    Inagaki, T.5    Horiguchi, J.6
  • 229
    • 0032557858 scopus 로고    scopus 로고
    • Reduced status of plasma total antioxidant capacity in schizophrenia
    • Yao, J.K., Reddy, R., McElhinny, L.G. and van Kammen, D.P. (1998) Reduced status of plasma total antioxidant capacity in schizophrenia. Schizophr. Res. 32, 1-8.
    • (1998) Schizophr. Res , vol.32 , pp. 1-8
    • Yao, J.K.1    Reddy, R.2    McElhinny, L.G.3    van Kammen, D.P.4
  • 232
    • 0036501115 scopus 로고    scopus 로고
    • Effects of light on low nocturnal bilirubin in winter depression: a preliminary report
    • Oren, D.A., Desan, P.H., Boutros, N., Anand, A. and Charney, D.S. (2002) Effects of light on low nocturnal bilirubin in winter depression: a preliminary report. Biol. Psychiatry 51, 422-425.
    • (2002) Biol. Psychiatry , vol.51 , pp. 422-425
    • Oren, D.A.1    Desan, P.H.2    Boutros, N.3    Anand, A.4    Charney, D.S.5
  • 233
    • 0032536014 scopus 로고    scopus 로고
    • Tweaking the human circadian clock with light
    • Oren, D.A. and Terman, M. (1998) Tweaking the human circadian clock with light. Science 279, 333-334.
    • (1998) Science , vol.279 , pp. 333-334
    • Oren, D.A.1    Terman, M.2
  • 235
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group (2001) Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin. Pharmacol. Ther. 69, 89-95.
    • (2001) Clin. Pharmacol. Ther , vol.69 , pp. 89-95
  • 236
    • 52949109838 scopus 로고    scopus 로고
    • Use of conventional and-omics based methods for health claims of dietary antioxidants: a critical overview
    • Knasmuller, S., Nersesyan, A., Misik, M., Gerner, C., Mikulits, W., Ehrlich, V., Hoelzl, C., Szakmary, A. and Wagner, K.H. (2008) Use of conventional and-omics based methods for health claims of dietary antioxidants: a critical overview. Br. J. Nutr. 9 (E Suppl. 1), ES3-ES52.
    • (2008) Br. J. Nutr , vol.9 , Issue.E SUPPL. 1 , pp. ES3-ES52
    • Knasmuller, S.1    Nersesyan, A.2    Misik, M.3    Gerner, C.4    Mikulits, W.5    Ehrlich, V.6    Hoelzl, C.7    Szakmary, A.8    Wagner, K.H.9
  • 237
    • 33744457002 scopus 로고    scopus 로고
    • Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine
    • Weber, M. and Hamm, C. (2006) Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine. Heart 92, 843-849.
    • (2006) Heart , vol.92 , pp. 843-849
    • Weber, M.1    Hamm, C.2
  • 238
    • 67650094848 scopus 로고    scopus 로고
    • International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes: Diabetes Care 2009;32(7):1327-1334
    • Gillett, M.J. (2009) International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes: Diabetes Care 2009;32(7):1327-1334. Clin. Biochem. Rev. 30, 197-200.
    • (2009) Clin. Biochem. Rev , vol.30 , pp. 197-200
    • Gillett, M.J.1
  • 240
    • 0037469177 scopus 로고    scopus 로고
    • Clinical application of C-reactive protein for cardiovascular disease detection and prevention
    • Ridker, P.M. (2003) Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 107, 363-369.
    • (2003) Circulation , vol.107 , pp. 363-369
    • Ridker, P.M.1
  • 241
    • 84928239194 scopus 로고    scopus 로고
    • Guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health
    • European Food Safety Authority (EFSA) Panel on Dietetic Products (2011) Guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health. EFSA J. 9, 2474.
    • (2011) EFSA J , vol.9 , pp. 2474
  • 242
    • 0346218110 scopus 로고    scopus 로고
    • Proportions, odds, and risk
    • Sistrom, C.L. and Garvan, C.W. (2004) Proportions, odds, and risk. Radiology 230, 12-19.
    • (2004) Radiology , vol.230 , pp. 12-19
    • Sistrom, C.L.1    Garvan, C.W.2
  • 243
    • 84920686542 scopus 로고    scopus 로고
    • Bilirubin, platelet activation and heart disease: a missing link to cardiovascular protection in Gilbert's syndrome?
    • Kundur, A.R., Bulmer, A.C. and Singh, I. (2015) Bilirubin, platelet activation and heart disease: a missing link to cardiovascular protection in Gilbert's syndrome? Atherosclerosis 239, 73-84.
    • (2015) Atherosclerosis , vol.239 , pp. 73-84
    • Kundur, A.R.1    Bulmer, A.C.2    Singh, I.3
  • 246
    • 2542577882 scopus 로고    scopus 로고
    • Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle
    • Sedlak, T.W. and Snyder, S.H. (2004) Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics 113, 1776-1782.
    • (2004) Pediatrics , vol.113 , pp. 1776-1782
    • Sedlak, T.W.1    Snyder, S.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.