Higher serum bilirubin level as a protective factor for the development of diabetes in healthy Korean men: A 4 year retrospective longitudinal study

Metabolism: Clinical and Experimental

Volumn 63, Issue 1, 2014, Pages 87-93

  Jung, Chang Hee ^a   Lee, Min Jung ^a   Kang, Yu Mi ^a   Hwang, Jenie Yoonoo ^b   Jang, Jung Eun ^a   Leem, Jaechan ^a   Park, Joong Yeol ^a   Kim, Hong Kyu ^a,b   Lee, Woo Je ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b University of Ulsan   (South Korea)

Author keywords

Antioxidant; Bilirubin; Type 2 diabetes

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; C REACTIVE PROTEIN; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; URIC ACID; VANADIC ACID;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; EXERCISE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; INCIDENCE; KOREA; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; OBSERVATIONAL STUDY; OXIDATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SMOKING; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ALANINE AMINOTRANSFERASE; ALT; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; AST; BILIRUBIN; BLOOD PRESSURE; BMI; BODY MASS INDEX; BP; CARDIOVASCULAR DISEASE; CVD; FASTING PLASMA GLUCOSE; FPG; GAMMA-GLUTAMYLTRANSFERASE; GGT; HBA1C; HDL-C; HEME OXYGENASE; HEMOGLOBIN A1C; HIGH SENSITIVE C-REACTIVE PROTEIN; HIGH-DENSITY LIPOPROTEIN CHOLESTEROL; HMOX; HOMA-IR; HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE; HSCRP; LDL-C; LOW-DENSITY LIPOPROTEIN CHOLESTEROL; NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEYS; NHANES; RELATIVE RISK; RR; TG; THYROID STIMULATING HORMONE; TRIGLYCERIDES; TSH; TYPE 2 DIABETES; WAIST CIRCUMFERENCE; WC;

ADULT; AGED; AGED, 80 AND OVER; BILIRUBIN; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; HUMANS; INCIDENCE; INSULIN RESISTANCE; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; REFERENCE VALUES; REPUBLIC OF KOREA; RETROSPECTIVE STUDIES; TRIGLYCERIDES;

EID: 84890130280     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.09.011     Document Type: Article

References (34)

1. I.M. Arias The excretion of conjugated bilirubin by the liver cell Medicine (Baltimore) 45 1966 513 515
2. R. Stocker, Y. Yamamoto, and A.F. McDonagh Bilirubin is an antioxidant of possible physiological importance Science 235 1987 1043 1046
3. D.E. Baranano, M. Rao, and C.D. Ferris Biliverdin reductase: a major physiologic cytoprotectant Proc Natl Acad Sci U S A 99 2002 16093 16098
4. L. Djousse, D. Levy, and L.A. Cupples Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study Am J Cardiol 87 2001 1196 1200
5. A.R. Bhuiyan, S.R. Srinivasan, and W. Chen Association of serum bilirubin with pulsatile arterial function in asymptomatic young adults: the Bogalusa Heart Study Metabolism 57 2008 612 616
6. S.S. Han, K.Y. Na, and D.W. Chae High serum bilirubin is associated with the reduced risk of diabetes mellitus and diabetic nephropathy Tohoku J Exp Med 221 2010 133 140
7. P. Cheriyath, V.S. Gorrepati, and I. Peters High total bilirubin as a protective factor for diabetes mellitus: an analysis of NHANES data from 1999-2006 J Clin Med Res 2 2010 201 206
8. K.M. Kwon, J.H. Kam, and M.Y. Kim Inverse association between total bilirubin and metabolic syndrome in rural korean women J Womens Health (Larchmt) 20 2011 963 969
9. Y. Wu, M. Li, and M. Xu Low serum total bilirubin concentrations are associated with increased prevalence of metabolic syndrome in Chinese J Diabetes 3 2011 217 224
10. H.J. Chin, Y.R. Song, and H.S. Kim The bilirubin level is negatively correlated with the incidence of hypertension in normotensive Korean population J Korean Med Sci 24 Suppl 2009 S50 S56
11. Z. Jenko-Praznikar, A. Petelin, and M. Jurdana Serum bilirubin levels are lower in overweight asymptomatic middle-aged adults: an early indicator of metabolic syndrome? Metabolism 62 2013 976 985
12. G.T. Ko, J.C. Chan, and J. Woo Serum bilirubin and cardiovascular risk factors in a Chinese population J Cardiovasc Risk 3 1996 459 463
13. T. Inoguchi, S. Sasaki, and K. Kobayashi Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes JAMA 298 2007 1398 1400
14. H. Kimm, J.E. Yun, and J. Jo Low serum bilirubin level as an independent predictor of stroke incidence: a prospective study in Korean men and women Stroke 40 2009 3422 3427
15. American Diabetes Association Standards of medical care in diabetes - 2013 Diabetes Care 36 2013 S11 S66
16. L. Vitek The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases Front Pharmacol 3 2012 55
17. K. Bernhard, G. Ritzel, and K.U. Steiner Uber eine biologische Bedeutung der Gallenfarbstoffe. Bilirubin und Biliverdin als Antioxydantien fur das Vitamin A und die essentiellen Fettsauren Helv Chim Acta 37 1954 306 313
18. T.W. Sedlak, M. Saleh, and D.S. Higginson Bilirubin and glutathione have complementary antioxidant and cytoprotective roles Proc Natl Acad Sci U S A 106 2009 5171 5176
19. T.W. Wu, K.P. Fung, and C.C. Yang Unconjugated bilirubin inhibits the oxidation of human low-density-lipoprotein better than trolox Life Sci 54 1994 Pl477 Pl481
20. A. Ceriello, and E. Motz Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited Arterioscler Thromb Vasc Biol 24 2004 816 823
21. L. Vítek, and H.A. Schwertner The heme catabolic pathway and its protective effects on oxidative stressâ€mediated diseases. In: Makowski GS, editor Adv Clin Chem 43 2007 1 57
22. H.J. Hwang, S.W. Lee, and S.H. Kim Relationship between bilirubin and C-reactive protein Clin Chem Lab Med 49 2011 1823 1828
23. D.R. Matthews, J.P. Hosker, and A.S. Rudenski Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419
24. R. Stocker, and M.A. Perrella Heme oxygenase-1: a novel drug target for atherosclerotic diseases? Circulation 114 2006 2178 2189
25. J.F. Ndisang, and A. Jadhav Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in Goto-Kakizaki rats Endocrinology 150 2009 2627 2636
26. P. Blancou, V. Tardif, and T. Simon Immunoregulatory properties of heme oxygenase-1 Methods Mol Biol 677 2011 247 268
27. J.C. Jonas, Y. Guiot, and J. Rahier Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP Diabetologia 46 2003 1234 1244
28. W. Bao, F. Song, and X. Li Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus PLoS One 5 2010 e12371
29. S.M. Grundy Hypertriglyceridemia, insulin resistance, and the metabolic syndrome Am J Cardiol 83 1999 25F 29F
30. L.Y. Lin, H.K. Kuo, and J.J. Hwang Serum bilirubin is inversely associated with insulin resistance and metabolic syndrome among children and adolescents Atherosclerosis 203 2009 563 568
31. P.J. Bosma, J.R. Chowdhury, and C. Bakker The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome N Engl J Med 333 1995 1171 1175
32. H.A. Schwertner Association of smoking and low serum bilirubin antioxidant concentrations Atherosclerosis 136 1998 383 387
33. S.D. Zucker, P.S. Horn, and K.E. Sherman Serum bilirubin levels in the U.S. population: gender effect and inverse correlation with colorectal cancer Hepatology 40 2004 827 835
34. D.L. Swift, N.M. Johannsen, and C.P. Earnest Effect of different doses of aerobic exercise training on total bilirubin levels Med Sci Sports Exerc 44 2012 569 574