메뉴 건너뛰기




Volumn 307, Issue 2, 2014, Pages

Circulating bilirubin and defense against kidney disease and cardiovascular mortality: Mechanisms contributing to protection in clinical investigations

Author keywords

All cause mortality; Antioxidant; Bile pigment; Hemodialysis; NADPH oxidase; Tetrapyrrole

Indexed keywords

ALBUMIN; BILIRUBIN; C REACTIVE PROTEIN; CREATININE;

EID: 84904343067     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00039.2014     Document Type: Review
Times cited : (75)

References (199)
  • 1
    • 15044365735 scopus 로고    scopus 로고
    • Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated, perfused rat kidney
    • Adin CA, Croker BP, Agarwal A. Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated, perfused rat kidney. Am J Physiol Renal Physiol 288: F778-F784, 2005.
    • (2005) Am J Physiol Renal Physiol , vol.288
    • Adin, C.A.1    Croker, B.P.2    Agarwal, A.3
  • 2
    • 0024345512 scopus 로고
    • Multiple plasma exchanges successfully maintain a young adult patient with Crigler-Najjar syndrome type I
    • Ahmed P, Pratt A, Land VJ, Flye MW, Chaplin H. Multiple plasma exchanges successfully maintain a young adult patient with Crigler-Najjar syndrome type I. J Clin Apher 5: 17-20, 1989.
    • (1989) J Clin Apher , vol.5 , pp. 17-20
    • Ahmed, P.1    Pratt, A.2    Land, V.J.3    Flye, M.W.4    Chaplin, H.5
  • 3
    • 84860415023 scopus 로고    scopus 로고
    • Usefulness of serum bilirubin and cardiorespiratory fitness as predictors of mortality in men
    • Ajja R, Lee DC, Sui X, Church TS, Steven NB. Usefulness of serum bilirubin and cardiorespiratory fitness as predictors of mortality in men. Am J Cardiol 108: 1438-1442, 2011.
    • (2011) Am J Cardiol , vol.108 , pp. 1438-1442
    • Ajja, R.1    Lee, D.C.2    Sui, X.3    Church, T.S.4    Steven, N.B.5
  • 4
    • 0035146346 scopus 로고    scopus 로고
    • Impaired endothelium-dependent vasodilatation in renal failure in humans
    • Annuk M, Lind L, Linde T, Fellström B. Impaired endothelium-dependent vasodilatation in renal failure in humans. Nephrol Dial Transplant 16: 302-306, 2001.
    • (2001) Nephrol Dial Transplant , vol.16 , pp. 302-306
    • Annuk, M.1    Lind, L.2    Linde, T.3    Fellström, B.4
  • 7
    • 33748872860 scopus 로고    scopus 로고
    • The pathology of jaundice-related renal insufficiency: Cholemic nephrosis revisited
    • Betjes MG, Bajema I. The pathology of jaundice-related renal insufficiency: cholemic nephrosis revisited. J Nephrol 19: 229-233, 2006.
    • (2006) J Nephrol , vol.19 , pp. 229-233
    • Betjes, M.G.1    Bajema, I.2
  • 8
    • 73849083538 scopus 로고    scopus 로고
    • Vascular calcification and ESRD: A hard target
    • Bhan I, Thadhani R. Vascular calcification and ESRD: a hard target. Clin J Am Soc Nephrol 4: S102-S105, 2009.
    • (2009) Clin J Am Soc Nephrol , vol.4
    • Bhan, I.1    Thadhani, R.2
  • 9
    • 42949118681 scopus 로고    scopus 로고
    • Association of serum bilirubin with pulsatile arterial function in asymptomatic young adults: The Bogalusa Heart Study
    • Bhuiyan AR, Srinivasan SR, Chen W, Sultana A, Berenson GS. Association of serum bilirubin with pulsatile arterial function in asymptomatic young adults: the Bogalusa Heart Study. Metabolism 57: 612-616, 2008.
    • (2008) Metabolism , vol.57 , pp. 612-616
    • Bhuiyan, A.R.1    Srinivasan, S.R.2    Chen, W.3    Sultana, A.4    Berenson, G.S.5
  • 10
    • 0035725506 scopus 로고    scopus 로고
    • Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    • Blacher J, Guerin AP, Pannier B, Marchais SJ, London GM. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension 38: 938-942, 2001.
    • (2001) Hypertension , vol.38 , pp. 938-942
    • Blacher, J.1    Guerin, A.P.2    Pannier, B.3    Marchais, S.J.4    London, G.M.5
  • 13
    • 84861047353 scopus 로고    scopus 로고
    • Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome
    • Boon AC, Hawkins CL, Bisht K, Coombes JS, Bakrania B, Wagner KH, Bulmer AC. Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. Free Radic Biol Med 52: 2120-2127, 2012.
    • (2012) Free Radic Biol Med , vol.52 , pp. 2120-2127
    • Boon, A.C.1    Hawkins, C.L.2    Bisht, K.3    Coombes, J.S.4    Bakrania, B.5    Wagner, K.H.6    Bulmer, A.C.7
  • 14
    • 33644782017 scopus 로고    scopus 로고
    • New cellular and molecular immune pathways in ischemia/reperfusion injury
    • Boros P, Bromberg JS. New cellular and molecular immune pathways in ischemia/reperfusion injury. Am J Transplant 6: 652-658, 2006.
    • (2006) Am J Transplant , vol.6 , pp. 652-658
    • Boros, P.1    Bromberg, J.S.2
  • 16
    • 38749128753 scopus 로고    scopus 로고
    • Oxidative stress and chronic kidney disease
    • Brown SA. Oxidative stress and chronic kidney disease. Vet Clin N Am-Small 38: 157-166, vi, 2008.
    • (2008) Vet Clin N Am-Small , vol.38
    • Brown, S.A.1
  • 17
    • 47649112255 scopus 로고    scopus 로고
    • Improved resistance to serum oxidation in Gilbert's syndrome: A mechanism for cardiovascular protection
    • Bulmer AC, Blanchfield JT, Toth I, Fassett RG, Coornbes JS. Improved resistance to serum oxidation in Gilbert's syndrome: a mechanism for cardiovascular protection. Atherosclerosis 199: 390-396, 2008.
    • (2008) Atherosclerosis , vol.199 , pp. 390-396
    • Bulmer, A.C.1    Blanchfield, J.T.2    Toth, I.3    Fassett, R.G.4    Coornbes, J.S.5
  • 18
    • 81355143343 scopus 로고    scopus 로고
    • Bile pigment pharmacokinetics and absorption in the rat: Therapeutic potential for enteral administration
    • Bulmer AC, Coombes JS, Blanchfield JT, Toth I, Fassett RG, Taylor SM. Bile pigment pharmacokinetics and absorption in the rat: therapeutic potential for enteral administration. Brit J Pharmacol 164: 1857-1870, 2011.
    • (2011) Brit J Pharmacol , vol.164 , pp. 1857-1870
    • Bulmer, A.C.1    Coombes, J.S.2    Blanchfield, J.T.3    Toth, I.4    Fassett, R.G.5    Taylor, S.M.6
  • 19
    • 84875750146 scopus 로고    scopus 로고
    • Bilirubin and beyond: A review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection
    • Bulmer AC, Verkade HJ, Wagner KH. Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection. Prog Lipid Res 52: 193-205, 2012.
    • (2012) Prog Lipid Res , vol.52 , pp. 193-205
    • Bulmer, A.C.1    Verkade, H.J.2    Wagner, K.H.3
  • 20
    • 0030708939 scopus 로고    scopus 로고
    • Oxidation of neutrophil glutathione and protein thiols by myeloperoxidase-derived hypochlorous acid
    • Carr AC, Winterbourn CC. Oxidation of neutrophil glutathione and protein thiols by myeloperoxidase-derived hypochlorous acid. Biochem J 327: 275-281, 1997.
    • (1997) Biochem J , vol.327 , pp. 275-281
    • Carr, A.C.1    Winterbourn, C.C.2
  • 23
    • 79953004070 scopus 로고    scopus 로고
    • Serum bilirubin links UGT1A1*28 polymorphism and predicts long-term cardiovascular events and mortality in chronic hemodialysis patients
    • Chen YH, Hung SC, Tarng DC. Serum bilirubin links UGT1A1*28 polymorphism and predicts long-term cardiovascular events and mortality in chronic hemodialysis patients. Clin J Am Soc Nephrol 6: 567-574, 2011.
    • (2011) Clin J Am Soc Nephrol , vol.6 , pp. 567-574
    • Chen, Y.H.1    Hung, S.C.2    Tarng, D.C.3
  • 25
    • 62449095700 scopus 로고    scopus 로고
    • The bilirubin level is negatively correlated with the incidence of hypertension in normotensive Korean population
    • Chin HJ, Song YR, Kim HS, Park M, Yoon HJ, Na KY, Kim Y, Chae DW, Kim S. The bilirubin level is negatively correlated with the incidence of hypertension in normotensive Korean population. J Korean Med Sci 24 Suppl: S50-S56, 2009.
    • (2009) J Korean Med Sci , vol.24 , Issue.SUPPL.
    • Chin, H.J.1    Song, Y.R.2    Kim, H.S.3    Park, M.4    Yoon, H.J.5    Na, K.Y.6    Kim, Y.7    Chae, D.W.8    Kim, S.9
  • 28
    • 84856723098 scopus 로고    scopus 로고
    • Antioxidant therapy in hemodialysis patients: A systematic review
    • Coombes JS, Fassett RG. Antioxidant therapy in hemodialysis patients: a systematic review. Kidney Int 81: 233-246, 2012.
    • (2012) Kidney Int , vol.81 , pp. 233-246
    • Coombes, J.S.1    Fassett, R.G.2
  • 30
    • 84884800870 scopus 로고    scopus 로고
    • The effect of Gilbert's syndrome on the dispersions of QT interval and P-wave: An observational study
    • Cure E, Yuce S, Cicek Y, Cure MC. The effect of Gilbert's syndrome on the dispersions of QT interval and P-wave: an observational study. Anadolu Kardiyol Derg 13: 559-565, 2013.
    • (2013) Anadolu Kardiyol Derg , vol.13 , pp. 559-565
    • Cure, E.1    Yuce, S.2    Cicek, Y.3    Cure, M.C.4
  • 31
    • 2942733214 scopus 로고    scopus 로고
    • Role of endothelial dysfunction in atherosclerosis
    • Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 109: III27-III32, 2004.
    • (2004) Circulation , vol.109
    • Davignon, J.1    Ganz, P.2
  • 34
    • 0033655899 scopus 로고    scopus 로고
    • Thiol-based antioxidants
    • Deneke SM. Thiol-based antioxidants. Curr Top Cell Regul 36: 151-180, 2000.
    • (2000) Curr Top Cell Regul , vol.36 , pp. 151-180
    • Deneke, S.M.1
  • 35
    • 0029129079 scopus 로고
    • Hyperbilirubinemia results in reduced oxidative injury in neonatal gunnrats exposed to hyperoxia
    • Dennery PA, Mcdonagh AF, Spitz DR, Rodgers PA, Stevenson DK. Hyperbilirubinemia results in reduced oxidative injury in neonatal gunnrats exposed to hyperoxia. Free Radic Bio Med 19: 395-404, 1995.
    • (1995) Free Radic Bio Med , vol.19 , pp. 395-404
    • Dennery, P.A.1    McDonagh, A.F.2    Spitz, D.R.3    Rodgers, P.A.4    Stevenson, D.K.5
  • 36
    • 78049437396 scopus 로고    scopus 로고
    • The use of targeted biomarkers for chronic kidney disease
    • Devarajan P. The use of targeted biomarkers for chronic kidney disease. Adv Chronic Kidney Dis 17: 469-479, 2010.
    • (2010) Adv Chronic Kidney Dis , vol.17 , pp. 469-479
    • Devarajan, P.1
  • 39
    • 30044437464 scopus 로고    scopus 로고
    • Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women
    • Erdogan D, Gullu H, Yildirim E, Tok D, Kirbas I, Ciftci O, Baycan ST, Muderrisoglu H. Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women. Atherosclerosis 184: 431-437, 2006.
    • (2006) Atherosclerosis , vol.184 , pp. 431-437
    • Erdogan, D.1    Gullu, H.2    Yildirim, E.3    Tok, D.4    Kirbas, I.5    Ciftci, O.6    Baycan, S.T.7    Muderrisoglu, H.8
  • 43
    • 0036498731 scopus 로고    scopus 로고
    • Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil
    • Fertrin KY, Goncalves MS, Saad ST, Costa FF. Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil. Am J Med Genet 108: 117-119, 2002.
    • (2002) Am J Med Genet , vol.108 , pp. 117-119
    • Fertrin, K.Y.1    Goncalves, M.S.2    Saad, S.T.3    Costa, F.F.4
  • 44
    • 42149136735 scopus 로고    scopus 로고
    • Bilirubin in clinical practice: A review
    • Fevery J. Bilirubin in clinical practice: a review. Liver Int 28: 592-605, 2008.
    • (2008) Liver Int , vol.28 , pp. 592-605
    • Fevery, J.1
  • 46
    • 4544369860 scopus 로고    scopus 로고
    • Vascular calcification in patients with end-stage renal disease
    • Floege J, Ketteler M. Vascular calcification in patients with end-stage renal disease. Nephrol Dial Transplant 19, Suppl 5: V59-V66, 2004.
    • (2004) Nephrol Dial Transplant , vol.19 , Issue.SUPPL. 5
    • Floege, J.1    Ketteler, M.2
  • 48
    • 48249085391 scopus 로고    scopus 로고
    • Oxidative stress as a major culprit in kidney disease in diabetes
    • Forbes JM, Coughlan MT, Cooper ME. Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 57: 1446-1454, 2008.
    • (2008) Diabetes , vol.57 , pp. 1446-1454
    • Forbes, J.M.1    Coughlan, M.T.2    Cooper, M.E.3
  • 49
    • 0024239038 scopus 로고
    • Antioxidant defenses and lipid peroxidation in human blood plasma
    • Frei B, Stocker R, Ames BN. Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci USA 85: 9748-9752, 1988.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9748-9752
    • Frei, B.1    Stocker, R.2    Ames, B.N.3
  • 50
    • 77958086954 scopus 로고    scopus 로고
    • Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase
    • Fujii M, Inoguchi T, Sasaki S, Maeda Y, Zheng J, Kobayashi K, Takayanagi R. Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase. Kidney Int 78: 905-919, 2010.
    • (2010) Kidney Int , vol.78 , pp. 905-919
    • Fujii, M.1    Inoguchi, T.2    Sasaki, S.3    Maeda, Y.4    Zheng, J.5    Kobayashi, K.6    Takayanagi, R.7
  • 53
    • 0019195506 scopus 로고
    • The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
    • Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376, 1980.
    • (1980) Nature , vol.288 , pp. 373-376
    • Furchgott, R.F.1    Zawadzki, J.V.2
  • 55
    • 9644276844 scopus 로고    scopus 로고
    • Vascular calcification mechanisms
    • Giachelli CM. Vascular calcification mechanisms. J Am Soc Nephrol 15: 2959-2964, 2004.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2959-2964
    • Giachelli, C.M.1
  • 57
    • 20444410007 scopus 로고    scopus 로고
    • Nephropathy induced by contrast media: Pathogenesis, risk factors and preventive strategies
    • Goldenberg I, Matetzky S. Nephropathy induced by contrast media: pathogenesis, risk factors and preventive strategies. CMAJ 172: 1461-1471, 2005.
    • (2005) CMAJ , vol.172 , pp. 1461-1471
    • Goldenberg, I.1    Matetzky, S.2
  • 58
    • 79959394398 scopus 로고    scopus 로고
    • Cardiovascular complications in CKD patients: Role of oxidative stress
    • Gosmanova EO, Le NA. Cardiovascular complications in CKD patients: role of oxidative stress. Cardiol Res Pract 2011: 156326, 2011.
    • (2011) Cardiol Res Pract , vol.2011 , pp. 156326
    • Gosmanova, E.O.1    Le, N.A.2
  • 62
    • 33947497538 scopus 로고    scopus 로고
    • Endothelial dysfunction: Cardiovascular risk factors, therapy, and outcome
    • Hadi HA, Carr CS, Al Suwaidi J. Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome. Vasc Health Risk Manag 1: 183-198, 2005.
    • (2005) Vasc Health Risk Manag , vol.1 , pp. 183-198
    • Hadi, H.A.1    Carr, C.S.2    Al Suwaidi, J.3
  • 63
    • 1342267473 scopus 로고    scopus 로고
    • Further evidence of altered redox status of hyperbilirubinaemic patients: Role of bilirubin in Gilbert syndrome
    • Hagymási K, Kocsis I, Lengyel G, Sipos P, Fehér J, Blázovics A. Further evidence of altered redox status of hyperbilirubinaemic patients: role of bilirubin in Gilbert syndrome. Acta Biol Szeged 47: 131-134, 2003.
    • (2003) Acta Biol Szeged , vol.47 , pp. 131-134
    • Hagymási, K.1    Kocsis, I.2    Lengyel, G.3    Sipos, P.4    Fehér, J.5    Blázovics, A.6
  • 65
    • 77955887671 scopus 로고    scopus 로고
    • High serum bilirubin is associated with the reduced risk of diabetes mellitus and diabetic nephropathy
    • Han SS, Na KY, Chae DW, Kim YS, Kim S, Chin HJ. High serum bilirubin is associated with the reduced risk of diabetes mellitus and diabetic nephropathy. Tohoku J Exp Med 221: 133-140, 2010.
    • (2010) Tohoku J Exp Med , vol.221 , pp. 133-140
    • Han, S.S.1    Na, K.Y.2    Chae, D.W.3    Kim, Y.S.4    Kim, S.5    Chin, H.J.6
  • 66
    • 0033927997 scopus 로고    scopus 로고
    • Reactive oxygen species stimulate p44/42 mitogen-activated protein kinase and induce p27(Kip1): Role in angiotensin II-mediated hypertrophy of proximal tubular cells
    • Hannken T, Schroeder R, Zahner G, Stahl RA, Wolf G. Reactive oxygen species stimulate p44/42 mitogen-activated protein kinase and induce p27(Kip1): role in angiotensin II-mediated hypertrophy of proximal tubular cells. J Am Soc Nephrol 11: 1387-1397, 2000.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 1387-1397
    • Hannken, T.1    Schroeder, R.2    Zahner, G.3    Stahl, R.A.4    Wolf, G.5
  • 67
    • 77953496550 scopus 로고    scopus 로고
    • Core concepts: Bilirubin metabolism
    • Hansen TWR. Core concepts: bilirubin metabolism. NeoRev 11: e316-e322, 2010.
    • (2010) NeoRev , vol.11
    • Hansen, T.W.R.1
  • 68
    • 32944466080 scopus 로고    scopus 로고
    • Pathogenesis of contrast-induced nephropathy
    • Heinrich M, Uder M. Pathogenesis of contrast-induced nephropathy. Am J Roentgenol 185: 1079, 2005.
    • (2005) Am J Roentgenol , vol.185 , pp. 1079
    • Heinrich, M.1    Uder, M.2
  • 70
    • 0036833743 scopus 로고    scopus 로고
    • The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremia
    • Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM. The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int 62: 1524-1538, 2002.
    • (2002) Kidney Int , vol.62 , pp. 1524-1538
    • Himmelfarb, J.1    Stenvinkel, P.2    Ikizler, T.A.3    Hakim, R.M.4
  • 73
    • 79958857303 scopus 로고    scopus 로고
    • Association of serum bilirubin levels with albuminuria in patients with essential hypertension
    • Huang SS, Huang PH, Chiang KH, Chen JW, Lin SJ. Association of serum bilirubin levels with albuminuria in patients with essential hypertension. Clin Biochem 44: 859-863, 2011.
    • (2011) Clin Biochem , vol.44 , pp. 859-863
    • Huang, S.S.1    Huang, P.H.2    Chiang, K.H.3    Chen, J.W.4    Lin, S.J.5
  • 74
    • 84864670255 scopus 로고    scopus 로고
    • Association of serum bilirubin with contrast-induced nephropathy and future cardiovascular events in patients undergoing coronary intervention
    • Huang SS, Huang PH, Wu TC, Chen JW, Lin SJ. Association of serum bilirubin with contrast-induced nephropathy and future cardiovascular events in patients undergoing coronary intervention. PLoS ONE 7: e42594, 2012.
    • (2012) PLoS ONE , vol.7
    • Huang, S.S.1    Huang, P.H.2    Wu, T.C.3    Chen, J.W.4    Lin, S.J.5
  • 75
    • 77955057984 scopus 로고    scopus 로고
    • Inverse relationship between fasting direct bilirubin and metabolic syndrome in Korean adults
    • Hwang HJ, Kim SH. Inverse relationship between fasting direct bilirubin and metabolic syndrome in Korean adults. Clin Chim Acta 411: 1496-1501, 2010.
    • (2010) Clin Chim Acta , vol.411 , pp. 1496-1501
    • Hwang, H.J.1    Kim, S.H.2
  • 76
    • 0033065908 scopus 로고    scopus 로고
    • Threshold concentration of unbound bilirubin to induce neurological deficits in a patient with type I Crigler-Najjar syndrome
    • Ihara H, Hashizume N, Shimizu N, Aoki T. Threshold concentration of unbound bilirubin to induce neurological deficits in a patient with type I Crigler-Najjar syndrome. Ann Clin Biochem 36: 347-352, 1999.
    • (1999) Ann Clin Biochem , vol.36 , pp. 347-352
    • Ihara, H.1    Hashizume, N.2    Shimizu, N.3    Aoki, T.4
  • 77
    • 34748876803 scopus 로고    scopus 로고
    • Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes
    • Inoguchi T, Sasaki S, Kobayashi K, Takayanagi R, Yamada T. Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes. JAMA 298: 1398-1400, 2007.
    • (2007) JAMA , vol.298 , pp. 1398-1400
    • Inoguchi, T.1    Sasaki, S.2    Kobayashi, K.3    Takayanagi, R.4    Yamada, T.5
  • 78
    • 0032413678 scopus 로고    scopus 로고
    • Biochemical and molecular aspects of genetic disorders of bilirubin metabolism
    • Iyanagi T, Emi Y, Ikushiro Si. Biochemical and molecular aspects of genetic disorders of bilirubin metabolism. Biochim Biophys Acta 1407: 173-184, 1998.
    • (1998) Biochim Biophys Acta , vol.1407 , pp. 173-184
    • Iyanagi, T.1    Emi, Y.2    Ikushiro, S.3
  • 80
    • 84886745461 scopus 로고    scopus 로고
    • The molecular basis for the immunomodulatory activities of unconjugated bilirubin
    • Jangi S, Otterbein L, Robson S. The molecular basis for the immunomodulatory activities of unconjugated bilirubin. Int J Biochem Cell Biol 45: 2843-2851, 2013.
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 2843-2851
    • Jangi, S.1    Otterbein, L.2    Robson, S.3
  • 81
    • 33750260791 scopus 로고    scopus 로고
    • NO modulates NADPH oxidase function via heme oxygenase-1 in human endothelial cells
    • Jiang F, Roberts SJ, Datla S, Dusting GJ. NO modulates NADPH oxidase function via heme oxygenase-1 in human endothelial cells. Hypertension 48: 950-957, 2006.
    • (2006) Hypertension , vol.48 , pp. 950-957
    • Jiang, F.1    Roberts, S.J.2    Datla, S.3    Dusting, G.J.4
  • 82
    • 79957959298 scopus 로고    scopus 로고
    • The clinical syndrome of bilirubin-induced neurologic dysfunction
    • Johnson L, Bhutani VK. The clinical syndrome of bilirubin-induced neurologic dysfunction. Semin Perinatol 35: 101-113, 2011.
    • (2011) Semin Perinatol , vol.35 , pp. 101-113
    • Johnson, L.1    Bhutani, V.K.2
  • 83
  • 84
    • 0042031556 scopus 로고    scopus 로고
    • Bilirubin rinse: A simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning
    • Kato Y, Shimazu M, Kondo M, Uchida K, Kumamoto Y, Wakabayashi G, Kitajima M, Suematsu M. Bilirubin rinse: a simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning. Hepatology 38: 364-373, 2003.
    • (2003) Hepatology , vol.38 , pp. 364-373
    • Kato, Y.1    Shimazu, M.2    Kondo, M.3    Uchida, K.4    Kumamoto, Y.5    Wakabayashi, G.6    Kitajima, M.7    Suematsu, M.8
  • 85
    • 33846871945 scopus 로고    scopus 로고
    • Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivo
    • Kirkby K, Baylis C, Agarwal A, Croker B, Archer L, Adin C. Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivo. Am J Physiol Renal Physiol 292: F888-F894, 2007.
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Kirkby, K.1    Baylis, C.2    Agarwal, A.3    Croker, B.4    Archer, L.5    Adin, C.6
  • 87
    • 84877279887 scopus 로고    scopus 로고
    • Early evolution and correlates of urine albumin excretion in patients presenting with acutely decompensated heart failure
    • Koyama S, Sato Y, Tanada Y, Fujiwara H, Takatsu Y. Early evolution and correlates of urine albumin excretion in patients presenting with acutely decompensated heart failure. Circ Heart Fail 6: 227-232, 2013.
    • (2013) Circ Heart Fail , vol.6 , pp. 227-232
    • Koyama, S.1    Sato, Y.2    Tanada, Y.3    Fujiwara, H.4    Takatsu, Y.5
  • 90
    • 84892699525 scopus 로고    scopus 로고
    • Unconjugated bilirubin inhibits collagen induced platelet activation
    • Kundur AR, Bulmer AC, Singh I. Unconjugated bilirubin inhibits collagen induced platelet activation. Platelets 25: 45-50, 2014.
    • (2014) Platelets , vol.25 , pp. 45-50
    • Kundur, A.R.1    Bulmer, A.C.2    Singh, I.3
  • 91
    • 0026035905 scopus 로고
    • Bilirubin inhibits the activation of superoxide-producing NADPH oxidase in a neutrophil cell-free system
    • Kwak JY, Takeshige K, Cheung BS, Minakami S. Bilirubin inhibits the activation of superoxide-producing NADPH oxidase in a neutrophil cell-free system. Biochim Biophys Acta 1076: 369-373, 1991.
    • (1991) Biochim Biophys Acta , vol.1076 , pp. 369-373
    • Kwak, J.Y.1    Takeshige, K.2    Cheung, B.S.3    Minakami, S.4
  • 92
    • 77956022045 scopus 로고    scopus 로고
    • Bilirubin exerts renoprotective effects in angiotensin II-hypertension
    • LeBlanc RM, Navar LG, Botros FT. Bilirubin exerts renoprotective effects in angiotensin II-hypertension. Am J Med Sci 340: 144-146, 2010.
    • (2010) Am J Med Sci , vol.340 , pp. 144-146
    • LeBlanc, R.M.1    Navar, L.G.2    Botros, F.T.3
  • 93
    • 48749114764 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein and oxidative stress in the development of glomerulosclerosis
    • Lee HS, Song CY. Oxidized low-density lipoprotein and oxidative stress in the development of glomerulosclerosis. Am J Nephrol 29: 62-70, 2009.
    • (2009) Am J Nephrol , vol.29 , pp. 62-70
    • Lee, H.S.1    Song, C.Y.2
  • 95
    • 80052921322 scopus 로고    scopus 로고
    • Oxidative stress and inflammation: Implications in uremia and hemodialysis
    • Libetta C, Sepe V, Esposito P, Galli F, Dal Canton A. Oxidative stress and inflammation: implications in uremia and hemodialysis. Clin Biochem 44: 1189-1198, 2011.
    • (2011) Clin Biochem , vol.44 , pp. 1189-1198
    • Libetta, C.1    Sepe, V.2    Esposito, P.3    Galli, F.4    Dal Canton, A.5
  • 100
  • 101
    • 84892419044 scopus 로고    scopus 로고
    • Correlations between serum bilirubin levels and diabetic nephropathy progression among Japanese type 2 diabetes patients: A prospective cohort study [Diabetes Distress and Care Registry at Tenri (DDCRT 5)]
    • Mashitani T, Hayashino Y, Okamura S, Tsujii S, Ishii H. Correlations between serum bilirubin levels and diabetic nephropathy progression among Japanese type 2 diabetes patients: a prospective cohort study [Diabetes Distress and Care Registry at Tenri (DDCRT 5)]. Diabetes Care 37: 252-258, 2013.
    • (2013) Diabetes Care , vol.37 , pp. 252-258
    • Mashitani, T.1    Hayashino, Y.2    Okamura, S.3    Tsujii, S.4    Ishii, H.5
  • 102
    • 77951160872 scopus 로고    scopus 로고
    • Bilirubin effect on endothelial adhesion molecules expression is mediated by the NFkappaB signaling pathway
    • Mazzone GL, Rigato I, Ostrow JD, Tiribelli C. Bilirubin effect on endothelial adhesion molecules expression is mediated by the NFkappaB signaling pathway. Biosci Trends 3: 151-157, 2009.
    • (2009) Biosci Trends , vol.3 , pp. 151-157
    • Mazzone, G.L.1    Rigato, I.2    Ostrow, J.D.3    Tiribelli, C.4
  • 103
    • 79952276358 scopus 로고    scopus 로고
    • Unconjugated bilirubin modulates nitric oxide production via iNOS regulation
    • Mazzone GL, Rigato I, Tiribelli C. Unconjugated bilirubin modulates nitric oxide production via iNOS regulation. Biosci Trends 4: 244-248, 2010.
    • (2010) Biosci Trends , vol.4 , pp. 244-248
    • Mazzone, G.L.1    Rigato, I.2    Tiribelli, C.3
  • 104
    • 84883760615 scopus 로고    scopus 로고
    • Serum bilirubin may serve as a marker for increased heme oxygenase activity and inducibility in tissues-a rationale for the versatile health protection associated with elevated plasma bilirubin
    • McCarty MF. Serum bilirubin may serve as a marker for increased heme oxygenase activity and inducibility in tissues-a rationale for the versatile health protection associated with elevated plasma bilirubin. Med Hypotheses 81: 607-610, 2013.
    • (2013) Med Hypotheses , vol.81 , pp. 607-610
    • McCarty, M.F.1
  • 105
    • 41549152928 scopus 로고    scopus 로고
    • Contrast-induced acute kidney injury
    • McCullough PA. Contrast-induced acute kidney injury. J Am Coll Cardiol 51: 1419-1428, 2008.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1419-1428
    • McCullough, P.A.1
  • 107
    • 0032522255 scopus 로고    scopus 로고
    • Bilirubin is an effective antioxidant of peroxynitrite-mediated protein oxidation in human blood plasma
    • Minetti M, Mallozzi C, Di Stasi AM, Pietraforte D. Bilirubin is an effective antioxidant of peroxynitrite-mediated protein oxidation in human blood plasma. Arch Biochem Biophys 352: 165-174, 1998.
    • (1998) Arch Biochem Biophys , vol.352 , pp. 165-174
    • Minetti, M.1    Mallozzi, C.2    Di Stasi, A.M.3    Pietraforte, D.4
  • 108
    • 80052661487 scopus 로고    scopus 로고
    • Relationship of hepatic and renal dysfunction with haemorrheological parameters in Plasmodium falciparum malaria
    • Misra DP, Das S, Pattnaik M, Singh SC, Jena RK. Relationship of hepatic and renal dysfunction with haemorrheological parameters in Plasmodium falciparum malaria. J Assoc Physicians India 59: 552-556, 2011.
    • (2011) J Assoc Physicians India , vol.59 , pp. 552-556
    • Misra, D.P.1    Das, S.2    Pattnaik, M.3    Singh, S.C.4    Jena, R.K.5
  • 109
    • 0034051716 scopus 로고    scopus 로고
    • Hemodialysis impairs endothelial function via oxidative stress: Effects of vitamin E-coated dialyzer
    • Miyazaki H, Matsuoka H, Itabe H, Usui M, Ueda S, Okuda S, Imaizumi T. Hemodialysis impairs endothelial function via oxidative stress: effects of vitamin E-coated dialyzer. Circulation 101: 1002-1006, 2000.
    • (2000) Circulation , vol.101 , pp. 1002-1006
    • Miyazaki, H.1    Matsuoka, H.2    Itabe, H.3    Usui, M.4    Ueda, S.5    Okuda, S.6    Imaizumi, T.7
  • 110
    • 4644231530 scopus 로고    scopus 로고
    • Pathophysiology of vascular calcification in chronic kidney disease
    • Moe SM, Chen NX. Pathophysiology of vascular calcification in chronic kidney disease. Circ Res 95: 560-567, 2004.
    • (2004) Circ Res , vol.95 , pp. 560-567
    • Moe, S.M.1    Chen, N.X.2
  • 115
    • 0027490428 scopus 로고
    • Bilirubin attenuates radical-mediated damage to serum albumin
    • Neuzil J, Stocker R. Bilirubin attenuates radical-mediated damage to serum albumin. FEBS Lett 331: 281-284, 1993.
    • (1993) FEBS Lett , vol.331 , pp. 281-284
    • Neuzil, J.1    Stocker, R.2
  • 116
    • 82155162466 scopus 로고    scopus 로고
    • Vascular calcification in patients with chronic kidney disease
    • Nitta K. Vascular calcification in patients with chronic kidney disease. Ther Apher Dial 15: 513-521, 2011.
    • (2011) Ther Apher Dial , vol.15 , pp. 513-521
    • Nitta, K.1
  • 118
    • 0038047678 scopus 로고    scopus 로고
    • Inverse relationship between serum bilirubin and atherosclerosis in men: A meta-analysis of published studies
    • Novotny L, Vitek L. Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-analysis of published studies. Exp Biol Med (Maywood) 228: 568-571, 2003.
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 568-571
    • Novotny, L.1    Vitek, L.2
  • 119
    • 84864100272 scopus 로고    scopus 로고
    • Hypobilirubinemia might be a possible risk factor of end-stage kidney disease independently of estimated glomerular filtration rate
    • Oda E, Aoyagi R, Aizawa Y. Hypobilirubinemia might be a possible risk factor of end-stage kidney disease independently of estimated glomerular filtration rate. Kidney Blood Press Res 36: 47-54, 2012.
    • (2012) Kidney Blood Press Res , vol.36 , pp. 47-54
    • Oda, E.1    Aoyagi, R.2    Aizawa, Y.3
  • 120
    • 84877811017 scopus 로고    scopus 로고
    • Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis
    • Oh SW, Lee ES, Kim S, Na KY, Chae DW, Chin HJ. Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis. BMC Nephrol 14: 105, 2013.
    • (2013) BMC Nephrol , vol.14 , pp. 105
    • Oh, S.W.1    Lee, E.S.2    Kim, S.3    Na, K.Y.4    Chae, D.W.5    Chin, H.J.6
  • 125
    • 0028110519 scopus 로고
    • Structure and binding of unconjugated bilirubin: Relevance for physiological and pathophysiological function
    • Ostrow JD, Mukerjee P, Tiribelli C. Structure and binding of unconjugated bilirubin: relevance for physiological and pathophysiological function. J Lipid Res 35: 1715-1737, 1994.
    • (1994) J Lipid Res , vol.35 , pp. 1715-1737
    • Ostrow, J.D.1    Mukerjee, P.2    Tiribelli, C.3
  • 126
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87: 315-424, 2007.
    • (2007) Physiol Rev , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 128
    • 84872567507 scopus 로고    scopus 로고
    • The Association between low serum bilirubin and carotid atherosclerosis in subjects with type 2 diabetes
    • Park BH, Nho HJ, Cho CG. The Association between low serum bilirubin and carotid atherosclerosis in subjects with type 2 diabetes. Endocrinol Metab 27: 126-131, 2012.
    • (2012) Endocrinol Metab , vol.27 , pp. 126-131
    • Park, B.H.1    Nho, H.J.2    Cho, C.G.3
  • 129
    • 84865964718 scopus 로고    scopus 로고
    • Bilirubin inhibits neointima formation and vascular smooth muscle cell proliferation and migration
    • Peyton KJ, Shebib AR, Azam MA, Liu XM, Tulis DA, Durante W. Bilirubin inhibits neointima formation and vascular smooth muscle cell proliferation and migration. Front Pharmacol 3: 48, 2012.
    • (2012) Front Pharmacol , vol.3 , pp. 48
    • Peyton, K.J.1    Shebib, A.R.2    Azam, M.A.3    Liu, X.M.4    Tulis, D.A.5    Durante, W.6
  • 130
    • 66849091772 scopus 로고    scopus 로고
    • Role of oxidative stress in contrast-induced acute kidney injury in diabetes mellitus
    • Pflueger A, Abramowitz D, Calvin AD. Role of oxidative stress in contrast-induced acute kidney injury in diabetes mellitus. Med Sci Monit 15: RA125-RA136, 2009.
    • (2009) Med Sci Monit , vol.15
    • Pflueger, A.1    Abramowitz, D.2    Calvin, A.D.3
  • 133
    • 0037138580 scopus 로고    scopus 로고
    • Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease?
    • Raggi P, Boulay A, Chasan-Taber S, Amin N, Dillon M, Burke SK, Chertow GM. Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 39: 695-701, 2002.
    • (2002) J Am Coll Cardiol , vol.39 , pp. 695-701
    • Raggi, P.1    Boulay, A.2    Chasan-Taber, S.3    Amin, N.4    Dillon, M.5    Burke, S.K.6    Chertow, G.M.7
  • 135
    • 0027534090 scopus 로고
    • Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis
    • Raines EW, Ross R. Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis. Br Heart J 69: S30-S37, 1993.
    • (1993) Br Heart J , vol.69
    • Raines, E.W.1    Ross, R.2
  • 136
    • 1642480042 scopus 로고    scopus 로고
    • Evaluation of the nitric oxide production in rat renal artery smooth muscle cells culture exposed to radiocontrast agents
    • Ribeiro L, de Assuncao e Silva F, Kurihara RS, Schor N, Mieko E, Higa S. Evaluation of the nitric oxide production in rat renal artery smooth muscle cells culture exposed to radiocontrast agents. Kidney Int 65: 589-596, 2004.
    • (2004) Kidney Int , vol.65 , pp. 589-596
    • Ribeiro, L.1    de Assuncao e Silva, F.2    Kurihara, R.S.3    Schor, N.4    Mieko, E.5    Higa, S.6
  • 138
    • 33747601865 scopus 로고    scopus 로고
    • Cardiovascular biomarkers in CKD: Pathophysiology and implications for clinical management of cardiac disease
    • Roberts MA, Hare DL, Ratnaike S, Ierino FL. Cardiovascular biomarkers in CKD: pathophysiology and implications for clinical management of cardiac disease. Am J Kidney Dis 48: 341-360, 2006.
    • (2006) Am J Kidney Dis , vol.48 , pp. 341-360
    • Roberts, M.A.1    Hare, D.L.2    Ratnaike, S.3    Ierino, F.L.4
  • 139
    • 84865998135 scopus 로고    scopus 로고
    • Bile pigments in pulmonary and vascular disease
    • Ryter SW. Bile pigments in pulmonary and vascular disease. Front Pharmacol 3: 2012.
    • (2012) Front Pharmacol , vol.3
    • Ryter, S.W.1
  • 140
    • 84896800542 scopus 로고    scopus 로고
    • Higher serum direct bilirubin levels were associated with a lower risk of incident chronic kidney disease in middle aged korean men
    • Ryu S, Chang Y, Zhang Y, Woo HY, Kwon MJ, Park H, Lee KB, Son HJ, Cho J, Guallar E. Higher serum direct bilirubin levels were associated with a lower risk of incident chronic kidney disease in middle aged korean men. PLoS ONE 9: e75178, 2014.
    • (2014) PLoS ONE , vol.9
    • Ryu, S.1    Chang, Y.2    Zhang, Y.3    Woo, H.Y.4    Kwon, M.J.5    Park, H.6    Lee, K.B.7    Son, H.J.8    Cho, J.9    Guallar, E.10
  • 142
    • 2542577882 scopus 로고    scopus 로고
    • Bilirubin benefits: Cellular protection by a biliverdin reductase antioxidant cycle
    • Sedlak TW, Snyder SH. Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics 113: 1776-1782, 2004.
    • (2004) Pediatrics , vol.113 , pp. 1776-1782
    • Sedlak, T.W.1    Snyder, S.H.2
  • 143
    • 80052561697 scopus 로고    scopus 로고
    • Arterial calcification in chronic kidney disease: Key roles for calcium and phosphate
    • Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM. Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res 109: 697-711, 2011.
    • (2011) Circ Res , vol.109 , pp. 697-711
    • Shanahan, C.M.1    Crouthamel, M.H.2    Kapustin, A.3    Giachelli, C.M.4
  • 144
    • 79959627309 scopus 로고    scopus 로고
    • Relationship of serum bilirubin concentration to kidney function and 24-hour urine protein in Korean adults
    • Shin HS, Jung YS, Rim H. Relationship of serum bilirubin concentration to kidney function and 24-hour urine protein in Korean adults. BMC Nephrol 12: 29, 2011.
    • (2011) BMC Nephrol , vol.12 , pp. 29
    • Shin, H.S.1    Jung, Y.S.2    Rim, H.3
  • 145
    • 33947303700 scopus 로고    scopus 로고
    • The vascular biology of calcification
    • Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 20: 103-109, 2007.
    • (2007) Semin Dial , vol.20 , pp. 103-109
    • Shroff, R.C.1    Shanahan, C.M.2
  • 147
    • 84879879657 scopus 로고    scopus 로고
    • Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2 pathway
    • Song S, Wang S, Ma J, Yao L, Xing H, Zhang L, Liao L, Zhu D. Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2 pathway. Exp Cell Res 319: 1973-1987, 2013.
    • (2013) Exp Cell Res , vol.319 , pp. 1973-1987
    • Song, S.1    Wang, S.2    Ma, J.3    Yao, L.4    Xing, H.5    Zhang, L.6    Liao, L.7    Zhu, D.8
  • 148
    • 77953723529 scopus 로고    scopus 로고
    • Calcific uremic arteriolopathy: Pathophysiology, reactive oxygen species and therapeutic approaches
    • Sowers KM, Hayden MR. Calcific uremic arteriolopathy: pathophysiology, reactive oxygen species and therapeutic approaches. Oxid Med Cell Longev 3: 109-121, 2010.
    • (2010) Oxid Med Cell Longev , vol.3 , pp. 109-121
    • Sowers, K.M.1    Hayden, M.R.2
  • 150
    • 79957947773 scopus 로고    scopus 로고
    • Bilirubin production and the risk of bilirubin neurotoxicity
    • Stevenson DK, Vreman HJ, Wong RJ. Bilirubin production and the risk of bilirubin neurotoxicity. Semin Perinatol 35: 121-126, 2011.
    • (2011) Semin Perinatol , vol.35 , pp. 121-126
    • Stevenson, D.K.1    Vreman, H.J.2    Wong, R.J.3
  • 151
    • 0023445053 scopus 로고
    • Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile
    • Stocker R, Ames BN. Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile. Proc Natl Acad Sci USA 84: 8130-8134, 1987.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8130-8134
    • Stocker, R.1    Ames, B.N.2
  • 153
    • 4644310560 scopus 로고    scopus 로고
    • Role of oxidative modifications in atherosclerosis
    • Stocker R, Keaney JF Jr. Role of oxidative modifications in atherosclerosis. Physiol Rev 84: 1381-1478, 2004.
    • (2004) Physiol Rev , vol.84 , pp. 1381-1478
    • Stocker, R.1    Keaney Jr., J.F.2
  • 154
    • 0024588311 scopus 로고
    • Synergistic interaction between vitamin E and the bile pigments bilirubin and biliverdin
    • Stocker R, Peterhans E. Synergistic interaction between vitamin E and the bile pigments bilirubin and biliverdin. Biochim Biophys Acta 1002: 238-244, 1989.
    • (1989) Biochim Biophys Acta , vol.1002 , pp. 238-244
    • Stocker, R.1    Peterhans, E.2
  • 155
  • 157
    • 84888584408 scopus 로고    scopus 로고
    • Relation of conjugated bilirubin concentrations to the presence of coronary artery calcium
    • Sung KC, Shin J, Lim YH, Wild SH, Byrne CD. Relation of conjugated bilirubin concentrations to the presence of coronary artery calcium. Am J Cardiol 112: 1873-1879, 2013.
    • (2013) Am J Cardiol , vol.112 , pp. 1873-1879
    • Sung, K.C.1    Shin, J.2    Lim, Y.H.3    Wild, S.H.4    Byrne, C.D.5
  • 160
    • 67349088999 scopus 로고    scopus 로고
    • Soluble CD40 ligand and soluble P-selectin levels in Gilbert's syndrome: A link to protection against atherosclerosis?
    • Tapan S, Dogru T, Tasci I, Ercin CN, Ozgurtas T, Erbil MK. Soluble CD40 ligand and soluble P-selectin levels in Gilbert's syndrome: a link to protection against atherosclerosis? Clin Biochem 42: 791-795, 2009.
    • (2009) Clin Biochem , vol.42 , pp. 791-795
    • Tapan, S.1    Dogru, T.2    Tasci, I.3    Ercin, C.N.4    Ozgurtas, T.5    Erbil, M.K.6
  • 162
    • 70349501469 scopus 로고    scopus 로고
    • Relationship of serum bilirubin concentrations to kidney function and albuminuria in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001-2006
    • Targher G, Bosworth C, Kendrick J, Smits G, Lippi G, Chonchol M. Relationship of serum bilirubin concentrations to kidney function and albuminuria in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001-2006. Clin Chem Lab Med 47: 1055-1062, 2009.
    • (2009) Clin Chem Lab Med , vol.47 , pp. 1055-1062
    • Targher, G.1    Bosworth, C.2    Kendrick, J.3    Smits, G.4    Lippi, G.5    Chonchol, M.6
  • 163
    • 70449399294 scopus 로고    scopus 로고
    • Redox state, oxidative stress, and molecular mechanisms of protective and toxic effects of bilirubin on cells
    • Tell G, Gustincich S. Redox state, oxidative stress, and molecular mechanisms of protective and toxic effects of bilirubin on cells. Curr Pharm Des 15: 2908-2914, 2009.
    • (2009) Curr Pharm Des , vol.15 , pp. 2908-2914
    • Tell, G.1    Gustincich, S.2
  • 165
    • 59849122428 scopus 로고    scopus 로고
    • Serum creatinine and bilirubin predict renal failure and mortality in patients with spontaneous bacterial peritonitis: A retrospective study
    • Terg R, Gadano A, Cartier M, Casciato P, Lucero R, Munoz A, Romero G, Levi D, Terg G, Miguez C, Abecasis R. Serum creatinine and bilirubin predict renal failure and mortality in patients with spontaneous bacterial peritonitis: a retrospective study. Liver Int 29: 415-419, 2009.
    • (2009) Liver Int , vol.29 , pp. 415-419
    • Terg, R.1    Gadano, A.2    Cartier, M.3    Casciato, P.4    Lucero, R.5    Munoz, A.6    Romero, G.7    Levi, D.8    Terg, G.9    Miguez, C.10    Abecasis, R.11
  • 169
    • 84896495799 scopus 로고    scopus 로고
    • Association of serum bilirubin levels with development and progression of albuminuria, and decline in estimated glomerular filtration rate in patients with type 2 diabetes mellitus
    • Toya K, Babazono T, Hanai K, Uchigata Y. Association of serum bilirubin levels with development and progression of albuminuria, and decline in estimated glomerular filtration rate in patients with type 2 diabetes mellitus. J Diabetes Investig 5: 228-235, 2013.
    • (2013) J Diabetes Investig , vol.5 , pp. 228-235
    • Toya, K.1    Babazono, T.2    Hanai, K.3    Uchigata, Y.4
  • 171
    • 84879693007 scopus 로고    scopus 로고
    • Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction
    • van Slambrouck CM, Salem F, Meehan SM, Chang A. Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction. Kidney Int 84: 192-197, 2013.
    • (2013) Kidney Int , vol.84 , pp. 192-197
    • van Slambrouck, C.M.1    Salem, F.2    Meehan, S.M.3    Chang, A.4
  • 173
    • 69249110515 scopus 로고    scopus 로고
    • Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice
    • Vera T, Granger JP, Stec DE. Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. Am J Physiol Regul Integr Comp Physiol 297: R738-R743, 2009.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297
    • Vera, T.1    Granger, J.P.2    Stec, D.E.3
  • 174
    • 77957597205 scopus 로고    scopus 로고
    • Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension
    • Vera T, Stec DE. Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 299: R1044-R1049, 2010.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.299
    • Vera, T.1    Stec, D.E.2
  • 175
    • 18744424934 scopus 로고    scopus 로고
    • The association of elevated serum bilirubin levels and coronary heart disease
    • Vitek L. The association of elevated serum bilirubin levels and coronary heart disease. J Hepatol 39: 881-882, 2003.
    • (2003) J Hepatol , vol.39 , pp. 881-882
    • Vitek, L.1
  • 176
    • 84865984236 scopus 로고    scopus 로고
    • The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases
    • doi: 10.3389/ fphar.2012.00055. eCollection 2012
    • Vitek L. The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases. Front Pharmacol 3: 55, 2012. doi: 10.3389/ fphar.2012.00055. eCollection 2012.
    • (2012) Front Pharmacol , vol.3 , pp. 55
    • Vitek, L.1
  • 178
    • 33748445757 scopus 로고    scopus 로고
    • The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis
    • Vitek L, Novotny L, Sperl M, Holaj R, Spacil J. The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis. Cerebrovasc Dis 21: 408-414, 2006.
    • (2006) Cerebrovasc Dis , vol.21 , pp. 408-414
    • Vitek, L.1    Novotny, L.2    Sperl, M.3    Holaj, R.4    Spacil, J.5
  • 180
    • 84878535419 scopus 로고    scopus 로고
    • Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome
    • Wallner M, Marculescu R, Doberer D, Wolzt M, Wagner O, Vitek L, Bulmer AC, Wagner KH. Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome. Clin Sci (Lond) 125: 257-264, 2013.
    • (2013) Clin Sci (Lond) , vol.125 , pp. 257-264
    • Wallner, M.1    Marculescu, R.2    Doberer, D.3    Wolzt, M.4    Wagner, O.5    Vitek, L.6    Bulmer, A.C.7    Wagner, K.H.8
  • 182
    • 6344265401 scopus 로고    scopus 로고
    • Genetics and the risk of neonatal hyperbilirubinemia: Commentary on the article by Huang et al. on page 682
    • Watchko JF. Genetics and the risk of neonatal hyperbilirubinemia: commentary on the article by Huang et al. on page 682. Pediatr Res 56: 677-678, 2004.
    • (2004) Pediatr Res , vol.56 , pp. 677-678
    • Watchko, J.F.1
  • 184
    • 84865966045 scopus 로고    scopus 로고
    • Go green: The antiinflammatory effects of biliverdin reductase
    • Wegiel B, Otterbein L. Go green: the antiinflammatory effects of biliverdin reductase. Front Pharmacol 3: 2012.
    • (2012) Front Pharmacol , vol.3
    • Wegiel, B.1    Otterbein, L.2
  • 185
    • 0035752908 scopus 로고    scopus 로고
    • Oxidative stress in glomerulonephritis
    • Wojcicka G, Beltowski J. Oxidative stress in glomerulonephritis. Postepy Hig Med Dosw 55: 855-869, 2001.
    • (2001) Postepy Hig Med Dosw , vol.55 , pp. 855-869
    • Wojcicka, G.1    Beltowski, J.2
  • 187
    • 0029868642 scopus 로고    scopus 로고
    • Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins
    • Wu TW, Fung KP, Wu J, Yang CC, Weisel RD. Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins. Biochem Pharmacol 51: 859-862, 1996.
    • (1996) Biochem Pharmacol , vol.51 , pp. 859-862
    • Wu, T.W.1    Fung, K.P.2    Wu, J.3    Yang, C.C.4    Weisel, R.D.5
  • 188
    • 0028313015 scopus 로고
    • Unconjugated bilirubin inhibits the oxidation of human low density lipoprotein better than Trolox
    • Wu TW, Fung KP, Yang CC. Unconjugated bilirubin inhibits the oxidation of human low density lipoprotein better than Trolox. Life Sci 54: P477-P481, 1994.
    • (1994) Life Sci , vol.54
    • Wu, T.W.1    Fung, K.P.2    Yang, C.C.3
  • 189
    • 84904368866 scopus 로고    scopus 로고
    • Effect of maintenance hemodialysis in serum bilirubin
    • Wu X, Feng AQ, Huang Y, Chen Y. Effect of maintenance hemodialysis in serum bilirubin. China J Modern Med 15: 1413-1417, 2005.
    • (2005) China J Modern Med , vol.15 , pp. 1413-1417
    • Wu, X.1    Feng, A.Q.2    Huang, Y.3    Chen, Y.4
  • 191
    • 0029982710 scopus 로고    scopus 로고
    • Role of bilirubin as an antioxidant in an ischemia-reperfusion of rat liver and induction of heme oxygenase
    • Yamaguchi T, Terakado M, Horio F, Aoki K, Tanaka M, Nakajima H. Role of bilirubin as an antioxidant in an ischemia-reperfusion of rat liver and induction of heme oxygenase. Biochem Biophys Res Commun 223: 129-135, 1996.
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 129-135
    • Yamaguchi, T.1    Terakado, M.2    Horio, F.3    Aoki, K.4    Tanaka, M.5    Nakajima, H.6
  • 194
    • 38449092222 scopus 로고    scopus 로고
    • Relationships among renal function loss within the normal to mildly impaired range, arterial stiffness, inflammation, and oxidative stress
    • Yoshida M, Tomiyama H, Yamada J, Koji Y, Shiina K, Nagata M, Yamashina A. Relationships among renal function loss within the normal to mildly impaired range, arterial stiffness, inflammation, and oxidative stress. Clin J Am Soc Nephrol 2: 1118-1124, 2007.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 1118-1124
    • Yoshida, M.1    Tomiyama, H.2    Yamada, J.3    Koji, Y.4    Shiina, K.5    Nagata, M.6    Yamashina, A.7
  • 197
    • 84862821826 scopus 로고    scopus 로고
    • Inverse relation of total serum bilirubin to coronary artery calcification score detected by multidetector computed tomography in males
    • Zhang ZY, Bian LQ, Kim SJ, Zhou CC, Choi YH. Inverse relation of total serum bilirubin to coronary artery calcification score detected by multidetector computed tomography in males. Clin Cardiol 35: 301-306, 2012.
    • (2012) Clin Cardiol , vol.35 , pp. 301-306
    • Zhang, Z.Y.1    Bian, L.Q.2    Kim, S.J.3    Zhou, C.C.4    Choi, Y.H.5
  • 199
    • 84865134092 scopus 로고    scopus 로고
    • Association of arterial stiffness with serum bilirubin levels in established coronary artery disease
    • Zhu C, Xiong Z, Zheng Z, Chen Y, Chen X, Qian X. Association of arterial stiffness with serum bilirubin levels in established coronary artery disease. Intern Med 51: 2083-2089, 2012.
    • (2012) Intern Med , vol.51 , pp. 2083-2089
    • Zhu, C.1    Xiong, Z.2    Zheng, Z.3    Chen, Y.4    Chen, X.5    Qian, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.